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WO1996009074B1 - Utilisation d'un virus a adn non mammalien en vue de l'expression d'un gene exogene dans une cellule mammalienne - Google Patents

Utilisation d'un virus a adn non mammalien en vue de l'expression d'un gene exogene dans une cellule mammalienne

Info

Publication number
WO1996009074B1
WO1996009074B1 PCT/US1995/011456 US9511456W WO9609074B1 WO 1996009074 B1 WO1996009074 B1 WO 1996009074B1 US 9511456 W US9511456 W US 9511456W WO 9609074 B1 WO9609074 B1 WO 9609074B1
Authority
WO
WIPO (PCT)
Prior art keywords
promoters
genome
promoter
gene
nucleic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1995/011456
Other languages
English (en)
Other versions
WO1996009074A1 (fr
Filing date
Publication date
Priority claimed from US08/311,157 external-priority patent/US5871986A/en
Application filed filed Critical
Priority to EP95934407A priority Critical patent/EP0785803A4/fr
Priority to AU36750/95A priority patent/AU702830B2/en
Priority to JP8510940A priority patent/JPH10506530A/ja
Publication of WO1996009074A1 publication Critical patent/WO1996009074A1/fr
Publication of WO1996009074B1 publication Critical patent/WO1996009074B1/fr
Priority to MXPA/A/1997/002132A priority patent/MXPA97002132A/xx
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Abstract

L'invention a pour objet un procédé d'expression d'un gène exogène dans une cellule mammalienne. Le procédé consiste à infecter la cellule à l'aide d'un virus non mammalien (par exemple un baculovirus) dont le génome est porteur d'un gène exogène, et à cultiver la cellule dans des conditions permettant l'expression du gène. Les gènes exogènes sont introduits dans les cellules mammaliennes à l'aide d'un vecteur de transfert tel que celui représenté dans la figure. L'invention concerne également un procédé permettant de traiter un trouble lié à une carence génique chez un mammifère. On introduit dans une cellule une quantité thérapeutique efficace d'un virus dont le génome est porteur d'un gène exogène, et on cultive ladite cellule dans des conditions permettant l'expression du gène exogène chez un mammifère.
PCT/US1995/011456 1994-09-23 1995-09-08 Utilisation d'un virus a adn non mammalien en vue de l'expression d'un gene exogene dans une cellule mammalienne Ceased WO1996009074A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP95934407A EP0785803A4 (fr) 1994-09-23 1995-09-08 Utilisation d'un virus a adn non mammalien en vue de l'expression d'un gene exogene dans une cellule mammalienne
AU36750/95A AU702830B2 (en) 1994-09-23 1995-09-08 Use of a non-mammalian dna virus to express an exogenous gene in a mammalian cell
JP8510940A JPH10506530A (ja) 1994-09-23 1995-09-08 哺乳類細胞において外来遺伝子を発現する非哺乳類ｄｎａウイルスの使用
MXPA/A/1997/002132A MXPA97002132A (en) 1994-09-23 1997-03-20 Use of a non-myamiferous dna virus to express an exogenous gene in a mamif cell

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/311,157 1994-09-23
US08/311,157 US5871986A (en) 1994-09-23 1994-09-23 Use of a baculovirus to express and exogenous gene in a mammalian cell
US08/486,341 1995-06-07
US08/486,341 US5731182A (en) 1994-09-23 1995-06-07 Non-mammalian DNA virus to express an exogenous gene in a mammalian cell

Publications (2)

Publication Number Publication Date
WO1996009074A1 WO1996009074A1 (fr) 1996-03-28
WO1996009074B1 true WO1996009074B1 (fr) 1996-05-09

Family

ID=26977767

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1995/011456 Ceased WO1996009074A1 (fr) 1994-09-23 1995-09-08 Utilisation d'un virus a adn non mammalien en vue de l'expression d'un gene exogene dans une cellule mammalienne

Country Status (10)

Country Link
US (1) US6238914B1 (fr)
EP (1) EP0785803A4 (fr)
JP (1) JPH10506530A (fr)
CN (1) CN1172435A (fr)
AU (1) AU702830B2 (fr)
CA (1) CA2200835A1 (fr)
IL (1) IL115267A0 (fr)
OA (1) OA10408A (fr)
TW (1) TW464500B (fr)
WO (1) WO1996009074A1 (fr)

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AU4266597A (en) * 1996-09-11 1998-04-14 General Hospital Corporation, The Use of a non-mammalian dna virus to express an exogenous gene in a mammalian cell
CA2264966A1 (fr) 1996-09-11 1998-03-19 The General Hospital Corporation Virus a adn non mammalien qui possede une proteine de coque modifiee
US6183993B1 (en) 1996-09-11 2001-02-06 The General Hospital Corporation Complement-resistant non-mammalian DNA viruses and uses thereof
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IT1291135B1 (it) * 1997-04-08 1998-12-29 Angeletti P Ist Richerche Bio Vettori ricombinanti utilizzabili in terapia genica
FR2761994B1 (fr) * 1997-04-11 1999-06-18 Centre Nat Rech Scient Preparation de recepteurs membranaires a partir de baculovirus extracellulaires
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US6106825A (en) * 1997-05-07 2000-08-22 University Of Florida Entomopoxvirus-vertebrate gene delivery vector and method
DE19735593C2 (de) * 1997-08-15 1999-08-26 Hepavec Ag Fuer Gentherapie Hüllprotein-modifizierter Baculovirus-Vektor für die Gentherapie
US6346415B1 (en) 1997-10-21 2002-02-12 Targeted Genetics Corporation Transcriptionally-activated AAV inverted terminal repeats (ITRS) for use with recombinant AAV vectors
US6933145B1 (en) 1998-05-29 2005-08-23 University Of Florida Research Foundation, Inc. Materials and methods for delivery and expression of heterologous DNA in vertebrate cells
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TWI288779B (en) * 2002-03-28 2007-10-21 Blasticon Biotech Forschung Dedifferentiated, programmable stem cells of monocytic origin, and their production and use
JP2003286198A (ja) * 2002-03-29 2003-10-07 Japan Science & Technology Corp 増殖因子等を提示するタンパク質中空ナノ粒子を用いる治療薬剤
JP2003286199A (ja) * 2002-03-29 2003-10-07 Japan Science & Technology Corp タンパク質中空ナノ粒子を用いる肝臓疾患治療用薬剤
WO2004030631A2 (fr) * 2002-10-01 2004-04-15 Chiron Corporation Compositions anticancereuses et contre les maladies infectieuses, et procedes d'utilisation correspondants
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EP1869191B1 (fr) * 2005-03-22 2012-12-26 Agency for Science, Technology and Research Nouveau promoteur spécifique neural cellulaire et baculovirus, et procédé d'apport de gènes
US20080044855A1 (en) * 2006-03-22 2008-02-21 Yan Xu System for regulated and enhanced baculovirus mediated transient transgene expression in mammalian cells
FR2966841A1 (fr) * 2010-11-02 2012-05-04 Inst Nat De Rech Agronomique Inra Vecteurs derives de densovirus pour le transfert de gene chez l'insecte
CN102199629A (zh) * 2011-03-29 2011-09-28 中国科学院武汉病毒研究所 用于提高杆状病毒对哺乳动物细胞转导效率的方法
US9616114B1 (en) 2014-09-18 2017-04-11 David Gordon Bermudes Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
JP6961171B2 (ja) 2017-05-22 2021-11-05 武田薬品工業株式会社 血友病ｂの遺伝子治療のための、発現の増加を伴う組換えｆｉｘをコードするウイルスベクター
US10995345B2 (en) 2017-09-12 2021-05-04 Biocapital Holdings, Llc Biological devices for producing oxidized zinc and applications thereof
KR20200127170A (ko) 2018-02-01 2020-11-10 호몰로지 메디슨, 인크. Pah 유전자 기능 복원을 위한 아데노-연관 바이러스 조성물 및 이의 사용 방법
US10610606B2 (en) 2018-02-01 2020-04-07 Homology Medicines, Inc. Adeno-associated virus compositions for PAH gene transfer and methods of use thereof
EP3755795A4 (fr) 2018-02-19 2022-07-20 Homology Medicines, Inc. Compositions de virus adéno-associé destinées à restaurer la fonction du gène f8 et leurs procédés d'utilisation
US11298414B2 (en) * 2018-08-10 2022-04-12 Nantbio, Inc. Cellular adjuvants for viral infection
TW202140791A (zh) 2020-01-13 2021-11-01 美商霍蒙拉奇醫藥公司 治療苯酮尿症之方法
TW202208632A (zh) 2020-05-27 2022-03-01 美商同源醫藥公司 用於恢復ｐａｈ基因功能的腺相關病毒組成物及其使用方法

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US4879236A (en) * 1984-05-16 1989-11-07 The Texas A&M University System Method for producing a recombinant baculovirus expression vector
FR2579224B1 (fr) * 1985-03-25 1987-05-22 Genetica Procede de preparation microbiologique de la serum-albumine humaine
US5004687A (en) * 1985-05-21 1991-04-02 University Of Georgia Research Foundation, Inc. Insect virus vector with broadened host range
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US5656465A (en) * 1994-05-04 1997-08-12 Therion Biologics Corporation Methods of in vivo gene delivery
US5871986A (en) * 1994-09-23 1999-02-16 The General Hospital Corporation Use of a baculovirus to express and exogenous gene in a mammalian cell

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