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WO1996007434A1 - Ameliorations apportees a des agents de contraste - Google Patents

Ameliorations apportees a des agents de contraste Download PDF

Info

Publication number
WO1996007434A1
WO1996007434A1 PCT/GB1995/002109 GB9502109W WO9607434A1 WO 1996007434 A1 WO1996007434 A1 WO 1996007434A1 GB 9502109 W GB9502109 W GB 9502109W WO 9607434 A1 WO9607434 A1 WO 9607434A1
Authority
WO
WIPO (PCT)
Prior art keywords
contrast agent
polymer
formula
agent
integer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB1995/002109
Other languages
English (en)
Inventor
Jo Klaveness
Pål RONGVED
Per Strande
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare AS
Original Assignee
Nycomed Imaging AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CZ97694A priority Critical patent/CZ69497A3/cs
Priority to EP95930653A priority patent/EP0779821B1/fr
Priority to JP50931296A priority patent/JP3843327B2/ja
Priority to DE69526093T priority patent/DE69526093T2/de
Priority to AU33966/95A priority patent/AU701907B2/en
Priority to AT95930653T priority patent/ATE214948T1/de
Application filed by Nycomed Imaging AS filed Critical Nycomed Imaging AS
Priority to BR9508888A priority patent/BR9508888A/pt
Priority to US08/610,257 priority patent/US5990263A/en
Publication of WO1996007434A1 publication Critical patent/WO1996007434A1/fr
Priority to NO19970995A priority patent/NO313270B1/no
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/48—Diagnostic techniques
    • A61B8/481—Diagnostic techniques involving the use of contrast agents, e.g. microbubbles introduced into the bloodstream
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/62—Compostable, hydrosoluble or hydrodegradable materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable

Definitions

  • contrast agents comprising gas- containing or gas-generating polymer microparticles and/or microballoons characterised in that the polymer is a biodegradable polymer containing units of formula
  • contrast agents which may be used in diagnostic applications such as ultrasound and MR imaging, exhibit good storage stability coupled with good stability and contrast effect in vivo following administration, often for several passages of circulation.
  • the contrast agents are, however, thereafter readily biodegradable in vivo by virtue of the susceptibility of the units of formula (I) to degradation by common esterase enzymes.
  • the present invention concerns contrast agents which fall within the overall scope of the above- mentioned WO 93/17718 but which are not specifically disclosed thereby.
  • This novel class of contrast agents is particularly advantageous by virtue of the agents' excellent stability and contrast effect in vivo and the fact that the agents degrade in the body to products which are well-tolerated and in most cases are endogenous.
  • contrast agents have been found to exhibit very sharp ultrasound contrast effects in animal tests, for example providing both myocardial contrast enhancement in dogs in all parts of the ventricular wall and excellent contrast enhancement of the kidney. Echogenicity may also be retained following uptake of the contrast agents by the reticuloendothelial system, permitting use as a macrophage imaging agent.
  • Solvents such as camphene are of advantage in that they are biotolerated, so that it is not necessary to remove all solvent residues from the contrast agent prior to administration.
  • Such high- melting solvents may also be advantageous in processes in which the emulsion is frozen and lyophilised, since they will rapidly solidify under these conditions and so may enhance the structural integrity of the resulting microparticulate contrast agent.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Materials Engineering (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Surgery (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Acoustics & Sound (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Transplantation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Steroid Compounds (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
  • Polyethers (AREA)

Abstract

L'invention se rapporte à des agents de contraste comprenant des microparticules et/ou microbilles polymères renfermant un gaz, le polymère étant un polymère biodégradable comprenant des unités de répétition de la formule (II) (dans laquelle a est un nombre entier de 9 à 19 et b un nombre entier de 1 à 8). Ces agents de contraste peuvent être utilisés dans des applications diagnostiques, telles que l'imagerie ultrasonore et l'imagerie par résonance magnétique. Les polymères sont nouveaux et sont également revendiqués en soi.
PCT/GB1995/002109 1994-09-05 1995-09-06 Ameliorations apportees a des agents de contraste Ceased WO1996007434A1 (fr)

Priority Applications (9)

Application Number Priority Date Filing Date Title
EP95930653A EP0779821B1 (fr) 1994-09-06 1995-09-06 Ameliorations apportees a des agents de contraste
JP50931296A JP3843327B2 (ja) 1994-09-06 1995-09-06 造影剤におけるまたは造影剤に関する改良
DE69526093T DE69526093T2 (de) 1994-09-06 1995-09-06 Verbesserungen in den oder in bezug zu kontrastmitteln
AU33966/95A AU701907B2 (en) 1994-09-06 1995-09-06 Improvements in or relating to contrast agents
AT95930653T ATE214948T1 (de) 1994-09-06 1995-09-06 Verbesserungen in den oder in bezug zu kontrastmitteln
CZ97694A CZ69497A3 (en) 1994-09-06 1995-09-06 Contrast agent
BR9508888A BR9508888A (pt) 1994-09-06 1995-09-06 Agente de contraste utilização de um agente de contraste processos para gerar imagens melhoradas de um corpo humano ou de animal não humano e para preparar de um agente de contraste e um polímero polímeros biodegradáveis e implante cirúrgico
US08/610,257 US5990263A (en) 1994-09-05 1996-03-04 Contrast agents
NO19970995A NO313270B1 (no) 1994-09-06 1997-03-04 Forbedringer i og i forhold til kontrastmidler

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9417941A GB9417941D0 (en) 1994-09-06 1994-09-06 Improvements in or relating to contrast agents
GB9417941.3 1994-09-06

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US08/610,257 Continuation-In-Part US5990263A (en) 1994-09-05 1996-03-04 Contrast agents

Publications (1)

Publication Number Publication Date
WO1996007434A1 true WO1996007434A1 (fr) 1996-03-14

Family

ID=10760921

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1995/002109 Ceased WO1996007434A1 (fr) 1994-09-05 1995-09-06 Ameliorations apportees a des agents de contraste

Country Status (17)

Country Link
US (1) US5990263A (fr)
EP (1) EP0779821B1 (fr)
JP (1) JP3843327B2 (fr)
CN (1) CN1079266C (fr)
AT (1) ATE214948T1 (fr)
AU (1) AU701907B2 (fr)
BR (1) BR9508888A (fr)
CA (1) CA2199047A1 (fr)
CZ (1) CZ69497A3 (fr)
DE (1) DE69526093T2 (fr)
ES (1) ES2174958T3 (fr)
GB (1) GB9417941D0 (fr)
HU (1) HUT77368A (fr)
IL (1) IL115181A (fr)
NO (1) NO313270B1 (fr)
WO (1) WO1996007434A1 (fr)
ZA (1) ZA957471B (fr)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998032468A1 (fr) * 1997-01-22 1998-07-30 Nycomed Imaging As Agents de contraste contenant deux types de microbulles remplies de gaz
EP0844016A3 (fr) * 1996-11-25 1998-11-18 Nycomed Imaging As Acides gras polyéthoxylénés comme tensio-actifs et leur utilisation
WO1999052564A1 (fr) * 1998-04-09 1999-10-21 Nycomed Imaging A.S Procede
EP0955065A1 (fr) * 1998-02-18 1999-11-10 Promefarm s.r.l. Agent de contraste échographique contenant Polyéthylène Glycol(PEG 4000)
US6054118A (en) * 1997-01-22 2000-04-25 Nycomed Imaging As Contrast agents comprising two types of gas-containing microparticles
WO2000021577A3 (fr) * 1998-10-09 2000-07-27 Nycomed Imaging As Compositions
WO2006018433A1 (fr) * 2004-08-18 2006-02-23 Bracco Research Sa Composition renfermant des microvesicules remplies de gaz, destinee a l'imagerie de contraste
US7025726B2 (en) 2004-01-22 2006-04-11 The Regents Of The University Of Nebraska Detection of endothelial dysfunction by ultrasonic imaging
US9364569B2 (en) 2003-02-04 2016-06-14 Bracco Suisse S.A. Ultrasound contrast agents and process for the preparation thereof
US9750821B2 (en) 2003-12-22 2017-09-05 Bracco Suisse S.A. Gas-filled microvesicle assembly for contrast imaging

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2410887C (fr) 2000-06-02 2012-07-24 Bracco Research Usa Composes pour le ciblage des cellules endotheliales, compositions les contenant et leurs procedes d'utilisation
US6962071B2 (en) * 2001-04-06 2005-11-08 Bracco Research S.A. Method for improved measurement of local physical parameters in a fluid-filled cavity
US8623822B2 (en) 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
JP2006514915A (ja) 2002-03-01 2006-05-18 ダイアックス、コープ Ｋｄｒおよびｖｅｇｆ／ｋｄｒ結合ペプチドならびに診断および治療におけるその使用
WO2004065621A1 (fr) 2002-03-01 2004-08-05 Dyax Corp. Peptides de liaison kdr et vegf/kdr et leur utilisation a des fins diagnostiques et therapeutiques
US7211240B2 (en) 2002-03-01 2007-05-01 Bracco International B.V. Multivalent constructs for therapeutic and diagnostic applications
US7794693B2 (en) 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
DK2284180T3 (en) 2003-03-03 2015-12-21 Dyax Corp Uses of peptides that specifically bind to the HGF receptor (cMET)
ES2351976T3 (es) 2003-04-29 2011-02-14 Avi Biopharma, Inc. Composiciones para mejorar el transporte y la eficacia antisentido de análogos de ácidos nucleicos en células.

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992004392A1 (fr) * 1990-09-07 1992-03-19 Holmes, Michael, John Polymeres contenant des unites de diesters
WO1992017212A1 (fr) * 1991-03-28 1992-10-15 Holmes, Michael, John Ameliorations concernant les agents de contraste
WO1993017718A1 (fr) * 1992-03-06 1993-09-16 Nycomed Imaging A/S Perfectionnements apportes aux agents de contraste
WO1995006518A1 (fr) * 1993-09-03 1995-03-09 Nycomed Imaging A/S Microbulles encapsulees par tensioactifs polymeres et leur utilisation dans l'imagerie par ultrasons
WO1995021631A1 (fr) * 1994-02-15 1995-08-17 Nycomed Imaging As Perfectionnements relatifs a des agents de contraste

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4004430A1 (de) * 1990-02-09 1991-08-14 Schering Ag Aus polyaldehyden aufgebaute kontrastmittel
AU636481B2 (en) * 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
DE4100470A1 (de) * 1991-01-09 1992-07-16 Byk Gulden Lomberg Chem Fab Echokontrastmittel
GB9106686D0 (en) * 1991-03-28 1991-05-15 Hafslund Nycomed As Improvements in or relating to contrast agents
CA2078388A1 (fr) * 1991-10-02 1993-04-03 Mridula Nair Particules d'emulsions biocompatibles
US5674468A (en) * 1992-03-06 1997-10-07 Nycomed Imaging As Contrast agents comprising gas-containing or gas-generating polymer microparticles or microballoons
GB9204918D0 (en) * 1992-03-06 1992-04-22 Nycomed As Chemical compounds
DE4219723A1 (de) * 1992-06-13 1993-12-16 Schering Ag Mikropartikel, Verfahren zu deren Herstellung, sowie die Verwendung dieser in der Diagnostik

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992004392A1 (fr) * 1990-09-07 1992-03-19 Holmes, Michael, John Polymeres contenant des unites de diesters
WO1992017212A1 (fr) * 1991-03-28 1992-10-15 Holmes, Michael, John Ameliorations concernant les agents de contraste
WO1993017718A1 (fr) * 1992-03-06 1993-09-16 Nycomed Imaging A/S Perfectionnements apportes aux agents de contraste
WO1995006518A1 (fr) * 1993-09-03 1995-03-09 Nycomed Imaging A/S Microbulles encapsulees par tensioactifs polymeres et leur utilisation dans l'imagerie par ultrasons
WO1995021631A1 (fr) * 1994-02-15 1995-08-17 Nycomed Imaging As Perfectionnements relatifs a des agents de contraste

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0844016A3 (fr) * 1996-11-25 1998-11-18 Nycomed Imaging As Acides gras polyéthoxylénés comme tensio-actifs et leur utilisation
US6054118A (en) * 1997-01-22 2000-04-25 Nycomed Imaging As Contrast agents comprising two types of gas-containing microparticles
JP2001508454A (ja) * 1997-01-22 2001-06-26 ニユコメド・イメージング・アクシエセルカペト ガスが充填された二つのタイプの微小気泡を含む造影剤
WO1998032468A1 (fr) * 1997-01-22 1998-07-30 Nycomed Imaging As Agents de contraste contenant deux types de microbulles remplies de gaz
EP0955065A1 (fr) * 1998-02-18 1999-11-10 Promefarm s.r.l. Agent de contraste échographique contenant Polyéthylène Glycol(PEG 4000)
WO1999052564A1 (fr) * 1998-04-09 1999-10-21 Nycomed Imaging A.S Procede
WO2000021577A3 (fr) * 1998-10-09 2000-07-27 Nycomed Imaging As Compositions
US9364569B2 (en) 2003-02-04 2016-06-14 Bracco Suisse S.A. Ultrasound contrast agents and process for the preparation thereof
US9750821B2 (en) 2003-12-22 2017-09-05 Bracco Suisse S.A. Gas-filled microvesicle assembly for contrast imaging
US7025726B2 (en) 2004-01-22 2006-04-11 The Regents Of The University Of Nebraska Detection of endothelial dysfunction by ultrasonic imaging
WO2006018433A1 (fr) * 2004-08-18 2006-02-23 Bracco Research Sa Composition renfermant des microvesicules remplies de gaz, destinee a l'imagerie de contraste
AU2005273865B2 (en) * 2004-08-18 2011-02-24 Bracco Suisse S.A. Gas-filled microvesicles composition for contrast imaging
CN103120799A (zh) * 2004-08-18 2013-05-29 博莱科瑞士股份有限公司 用于反差成像的充气微泡组合物
US9248204B2 (en) 2004-08-18 2016-02-02 Bracco Suisse S.A. Gas-filled microvesicles composition for contrast imaging
US10076580B2 (en) 2004-08-18 2018-09-18 Bracco Suisse S.A. Gas-filled microvesicles composition for contrast imaging

Also Published As

Publication number Publication date
US5990263A (en) 1999-11-23
GB9417941D0 (en) 1994-10-26
DE69526093D1 (de) 2002-05-02
ES2174958T3 (es) 2002-11-16
CN1079266C (zh) 2002-02-20
IL115181A0 (en) 1995-12-31
IL115181A (en) 1999-11-30
NO970995L (no) 1997-05-06
CN1157573A (zh) 1997-08-20
EP0779821B1 (fr) 2002-03-27
EP0779821A1 (fr) 1997-06-25
CA2199047A1 (fr) 1996-03-14
JP3843327B2 (ja) 2006-11-08
CZ69497A3 (en) 1997-10-15
ZA957471B (en) 1996-07-08
AU701907B2 (en) 1999-02-11
BR9508888A (pt) 1997-12-30
DE69526093T2 (de) 2002-11-28
JPH10505082A (ja) 1998-05-19
ATE214948T1 (de) 2002-04-15
NO313270B1 (no) 2002-09-09
HUT77368A (hu) 1998-03-30
NO970995D0 (no) 1997-03-04
AU3396695A (en) 1996-03-27

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