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WO1996006604B1 - Procedes d'identification et de traitement de tumeurs resistantes - Google Patents

Procedes d'identification et de traitement de tumeurs resistantes

Info

Publication number
WO1996006604B1
WO1996006604B1 PCT/US1995/011125 US9511125W WO9606604B1 WO 1996006604 B1 WO1996006604 B1 WO 1996006604B1 US 9511125 W US9511125 W US 9511125W WO 9606604 B1 WO9606604 B1 WO 9606604B1
Authority
WO
WIPO (PCT)
Prior art keywords
mrp
use according
pages
compound
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1995/011125
Other languages
English (en)
Other versions
WO1996006604A3 (fr
WO1996006604A2 (fr
Filing date
Publication date
Priority claimed from US08/298,644 external-priority patent/US5543428A/en
Priority claimed from DE19944432563 external-priority patent/DE4432563C2/de
Application filed filed Critical
Priority to US08/793,659 priority Critical patent/US6235785B1/en
Priority to AU35434/95A priority patent/AU3543495A/en
Priority to EP95932371A priority patent/EP0777472A2/fr
Priority to JP8508977A priority patent/JPH10505348A/ja
Publication of WO1996006604A2 publication Critical patent/WO1996006604A2/fr
Publication of WO1996006604A3 publication Critical patent/WO1996006604A3/fr
Publication of WO1996006604B1 publication Critical patent/WO1996006604B1/fr
Anticipated expiration legal-status Critical
Priority to US09/836,567 priority patent/US20020013370A1/en
Priority to US09/836,429 priority patent/US6673813B2/en
Ceased legal-status Critical Current

Links

Abstract

L'invention concerne un procédé d'identification et d'inversion de la résistance multiple aux anticancéreux d'une tumeur, qui consiste à administrer une certaine quantité de n'importe lequel des composés définis dans cette invention, cette quantité étant suffisante pour réaliser l'inversion de la résistance multiple aux anticancéreux.
PCT/US1995/011125 1994-08-31 1995-08-31 Procedes d'identification et de traitement de tumeurs resistantes Ceased WO1996006604A2 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
US08/793,659 US6235785B1 (en) 1994-08-31 1995-08-31 Methods for identifying and treating resistant tumors
AU35434/95A AU3543495A (en) 1994-08-31 1995-08-31 Methods for identifying and treating resistant tumors
EP95932371A EP0777472A2 (fr) 1994-08-31 1995-08-31 Procedes d'identification et de traitement de tumeurs resistantes
JP8508977A JPH10505348A (ja) 1994-08-31 1995-08-31 耐性腫瘍の同定および治療方法
US09/836,429 US6673813B2 (en) 1994-08-31 2001-04-17 Methods for identifying and treating resistant tumors
US09/836,567 US20020013370A1 (en) 1994-08-31 2001-04-17 Methods for identifying and treating resistant tumors

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/298,644 US5543428A (en) 1994-08-31 1994-08-31 Method for treating resistant tumors
US08/298,644 1994-08-31
DEP4432563.0 1994-09-13
DE19944432563 DE4432563C2 (de) 1994-09-13 1994-09-13 Verwendung von amphiphilen Anionen zur Verminderung der Zytostatika-Resistenz durch Hemmung des durch das MRP-Protein vermittelten Membrantransports

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US08/793,659 Continuation-In-Part US6235785B1 (en) 1994-08-31 1995-08-31 Methods for identifying and treating resistant tumors

Publications (3)

Publication Number Publication Date
WO1996006604A2 WO1996006604A2 (fr) 1996-03-07
WO1996006604A3 WO1996006604A3 (fr) 1996-08-01
WO1996006604B1 true WO1996006604B1 (fr) 1996-09-12

Family

ID=25940080

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1995/011125 Ceased WO1996006604A2 (fr) 1994-08-31 1995-08-31 Procedes d'identification et de traitement de tumeurs resistantes

Country Status (6)

Country Link
US (3) US6235785B1 (fr)
EP (2) EP0777472A2 (fr)
JP (1) JPH10505348A (fr)
AU (1) AU3543495A (fr)
CA (1) CA2198752A1 (fr)
WO (1) WO1996006604A2 (fr)

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Publication number Priority date Publication date Assignee Title
AU3543495A (en) * 1994-08-31 1996-03-22 Deutsches Krebsforschungszentrum Methods for identifying and treating resistant tumors
US6994853B1 (en) * 1998-09-25 2006-02-07 Trion Pharma Gmbh Time-staggered utilization of tumor cells in combination with intact antibodies for immunization
WO2001034197A2 (fr) * 1999-11-11 2001-05-17 Eli Lilly And Company Combinaisons oncolytiques aux fins du traitement de cancer
CN1237968C (zh) * 2000-05-09 2006-01-25 克赖顿大学 抑制癌细胞的增殖和诱导其凋亡的方法
CA2423141A1 (fr) 2000-09-27 2002-04-04 Merck & Co., Inc. Derives d'acide benzopyrancarboxylique utilises pour le traitement du diabete et des troubles lipidiques
AU2002248221B2 (en) 2000-10-31 2006-08-17 Merck & Co., Inc. Benzopyrancarboxylic acid derivatives for the treatment of diabetes and lipid disorders
PL363362A1 (en) * 2001-02-20 2004-11-15 Bristol-Myers Squibb Company Treatment of refractory tumors using epothilone derivatives
US10500178B2 (en) 2015-03-13 2019-12-10 The Board Of Trustees Of The Leland Stanford Junior University LTB4 inhibition to prevent and treat human lymphedema
US10107437B2 (en) * 2015-09-15 2018-10-23 Mustang Sampling Llc Tooling friendly adapter for insertion probe access
WO2017095724A1 (fr) 2015-11-30 2017-06-08 Merck Sharp & Dohme Corp. Sulfonamides d'aryle utilisés en tant qu'antagonistes de blt1
US10336733B2 (en) 2015-11-30 2019-07-02 Merk Sharp & Dohme Corp. Aryl acylsulfonamides as BLT1 antagonists
US10370368B2 (en) 2015-11-30 2019-08-06 Merck Sharp & Dohme Corp. Aryl acylsulfonamides as BLT1 antagonists
EP3383869B1 (fr) 2015-11-30 2023-06-28 Merck Sharp & Dohme LLC Sulfonamides d'aryle utilisés en tant qu'antagonistes de blt1

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4211791A (en) 1975-09-23 1980-07-08 Beecham Group Limited Indanediones
US4200577A (en) 1975-09-23 1980-04-29 Beecham Group Limited Coumarin derivatives
US4889871A (en) * 1987-05-29 1989-12-26 G. D. Searle & Co. Alkoxy-substituted dihydrobenzopyran-2-carboxylate derivatives
US5216024A (en) 1987-07-28 1993-06-01 Baylor College Of Medicine Cell growth inhibitors and methods of treating cancer and cell proliferative diseases
US5216172A (en) 1988-02-24 1993-06-01 Ajinomoto Co., Inc. 1,4-dihydropyridine-4-aryl-2,6-dimethyl-3,5-dicarboxylates useful as agents against drug resistant tumor cells
JPH02218654A (ja) * 1988-10-12 1990-08-31 Ono Pharmaceut Co Ltd 安息香酸誘導体、それらの製造方法およびそれらを含有する薬剤
ZA925185B (en) 1991-07-18 1993-04-29 Hoffmann La Roche Dithianes.
PH30449A (en) 1991-11-25 1997-05-28 Lilly Co Eli Substituted phenyl phenol leukotriene antagonists
IL116942A (en) * 1991-11-25 2000-02-29 Lilly Co Eli 2-phenyl-4,5-disubstituted phenol derivatives as chemical intermediates for substituted phenyl phenol leukotriene antagonists
ATE182582T1 (de) 1992-02-06 1999-08-15 Merrell Pharma Inc Umkehr der mehrfachresistenz gegen medikamente durch triphenyl-piperidin derivate
DE69304895T2 (de) 1992-02-06 1997-02-06 Merrell Pharma Inc Aufhebung von Multi-Drug-Resistenz durch Tetraarylethylene
WO1994006938A1 (fr) 1992-09-17 1994-03-31 The Board Of Trustees Of The University Of Illinois Procedes destines a eviter une resistance a une therapie polymedicamenteuse dans des cellules cancereuses
IL107462A0 (en) * 1992-11-05 1994-02-27 Lilly Co Eli Drug resistance-conferring protein, antibodies reactive therewith and utilities thereof
US5324743A (en) * 1992-12-10 1994-06-28 Eli Lilly And Company Leukotriene B4 antagonists
US5643909A (en) 1993-04-19 1997-07-01 Syntex (U.S.A.) Inc. 10,11-Methanodibenzosuberane derivatives
US5387685A (en) 1993-07-16 1995-02-07 American Cyanamid Co MDR reversal agents
RU94037233A (ru) * 1993-10-15 1996-08-27 Эли Лилли энд Компани (US) Применение 2-фенил-3-ароилбензотиофенов для лечения лекарственноустойчивых новообразований
US5543428A (en) 1994-08-31 1996-08-06 Eli Lilly And Company Method for treating resistant tumors
AU3543495A (en) * 1994-08-31 1996-03-22 Deutsches Krebsforschungszentrum Methods for identifying and treating resistant tumors

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