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WO1996005192A1 - Novel quinolone- or naphthyridonecarboxylic acid derivative or salt thereof - Google Patents

Novel quinolone- or naphthyridonecarboxylic acid derivative or salt thereof Download PDF

Info

Publication number
WO1996005192A1
WO1996005192A1 PCT/JP1995/001551 JP9501551W WO9605192A1 WO 1996005192 A1 WO1996005192 A1 WO 1996005192A1 JP 9501551 W JP9501551 W JP 9501551W WO 9605192 A1 WO9605192 A1 WO 9605192A1
Authority
WO
WIPO (PCT)
Prior art keywords
salt
acid derivative
optionally substituted
hydrogen
lower alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP1995/001551
Other languages
English (en)
French (fr)
Inventor
Yozo Todo
Kazuya Hayashi
Masahiro Takahata
Yasuo Watanabe
Hirokazu Narita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toyama Chemical Co Ltd
Original Assignee
Toyama Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP8507180A priority Critical patent/JP2994759B2/ja
Priority to US08/776,711 priority patent/US5935952A/en
Priority to EP95927967A priority patent/EP0775702B1/en
Priority to DK95927967T priority patent/DK0775702T3/da
Priority to AU31906/95A priority patent/AU692583B2/en
Priority to CA002196271A priority patent/CA2196271C/en
Priority to AT95927967T priority patent/ATE245638T1/de
Priority to DE69531350T priority patent/DE69531350T2/de
Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd
Priority to NZ290946A priority patent/NZ290946A/en
Priority to HU9701734A priority patent/HU228062B1/hu
Publication of WO1996005192A1 publication Critical patent/WO1996005192A1/ja
Priority to NO19970622A priority patent/NO312032B1/no
Priority to FI970578A priority patent/FI113652B/fi
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/22Tin compounds
    • C07F7/2208Compounds having tin linked only to carbon, hydrogen and/or halogen
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PCT/JP1995/001551 1994-08-12 1995-08-04 Novel quinolone- or naphthyridonecarboxylic acid derivative or salt thereof Ceased WO1996005192A1 (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
AT95927967T ATE245638T1 (de) 1994-08-12 1995-08-04 Neue chinolon- oder naphthyridoncarbonsäurederivate oder deren salze
EP95927967A EP0775702B1 (en) 1994-08-12 1995-08-04 Novel quinolone- or naphthyridonecarboxylic acid derivative or salt thereof
DK95927967T DK0775702T3 (da) 1994-08-12 1995-08-04 Hidtil ukendte quinolon- eller naphthylidoncarboxylsyrederivater eller salt deraf
AU31906/95A AU692583B2 (en) 1994-08-12 1995-08-04 Novel quinolone- or naphthyridonecarboxylic acid derivative or salt thereof
CA002196271A CA2196271C (en) 1994-08-12 1995-08-04 Quinolone- or naphthyridonecarboxylic acid derivative or salt thereof
DE69531350T DE69531350T2 (de) 1994-08-12 1995-08-04 Neue chinolon- oder naphthyridoncarbonsäurederivate oder deren salze
NZ290946A NZ290946A (en) 1994-08-12 1995-08-04 Quinolone- or naphthyridone-carboxylic acid derivatives
JP8507180A JP2994759B2 (ja) 1994-08-12 1995-08-04 新規なキノロン−またはナフチリドン−カルボン酸誘導体もしくはそれらの塩
US08/776,711 US5935952A (en) 1994-08-12 1995-08-04 Quinolone- or naphthylidone-carboxylic acid derivates or their salts
HU9701734A HU228062B1 (en) 1994-08-12 1995-08-04 Quinolone- carboxylic acid derivative and salt thereof
NO19970622A NO312032B1 (no) 1994-08-12 1997-02-11 Nye kinolon- eller naftylidonkarboksylsyre-derivater eller salter derav samt anvendelse derav
FI970578A FI113652B (fi) 1994-08-12 1997-02-11 Uusia kinoloni- tai naftyridonikarboksyylihappojohdannaisia tai niiden suola

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP21208394 1994-08-12
JP6/212083 1994-08-12

Publications (1)

Publication Number Publication Date
WO1996005192A1 true WO1996005192A1 (en) 1996-02-22

Family

ID=16616594

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1995/001551 Ceased WO1996005192A1 (en) 1994-08-12 1995-08-04 Novel quinolone- or naphthyridonecarboxylic acid derivative or salt thereof

Country Status (17)

Country Link
US (1) US5935952A (ja)
EP (1) EP0775702B1 (ja)
KR (1) KR100371723B1 (ja)
CN (1) CN1070191C (ja)
AT (1) ATE245638T1 (ja)
AU (1) AU692583B2 (ja)
CA (1) CA2196271C (ja)
DE (1) DE69531350T2 (ja)
DK (1) DK0775702T3 (ja)
ES (1) ES2203644T3 (ja)
FI (1) FI113652B (ja)
HU (1) HU228062B1 (ja)
IL (1) IL114875A (ja)
NO (1) NO312032B1 (ja)
NZ (1) NZ290946A (ja)
WO (1) WO1996005192A1 (ja)
ZA (1) ZA956713B (ja)

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997029102A1 (en) * 1996-02-09 1997-08-14 Toyama Chemical Co., Ltd. Quinolonecarboxylic acid derivatives or salts thereof
WO1999007682A1 (en) * 1997-08-08 1999-02-18 Toyama Chemical Co., Ltd. Quinolonecarboxylic acid derivatives or salts thereof
WO1999021849A1 (en) * 1997-10-27 1999-05-06 Toyama Chemical Co., Ltd. Processes for producing 7-isoindolinequinolonecarboxylic derivatives and intermediates therefor, salts of 7-isoindolinequinolonecarboxylic acids, hydrates thereof, and composition containing the same as active ingredient
US6011046A (en) * 1995-08-21 2000-01-04 Takeda Chemical Industries, Ltd. Quinone compound, its production and use as antioxidant
JP2000143631A (ja) * 1998-08-31 2000-05-26 Toyama Chem Co Ltd 7−ブロモ−キノロンカルボン酸誘導体の製造法
WO2000046223A1 (en) * 1999-02-05 2000-08-10 Toyama Chemical Co., Ltd. Tricyclic quinolonecarboxylic acid derivatives or salts thereof
WO2001066542A1 (en) * 2000-03-10 2001-09-13 Dainippon Pharmaceutical Co., Ltd. Pyridonecarboxylic acid derivatives
JP2006504620A (ja) * 2002-03-12 2006-02-09 ブリストル−マイヤーズ スクイブ カンパニー 快い味の経口懸濁液および方法
JP2006206595A (ja) * 2001-04-19 2006-08-10 Eisai Co Ltd 2−イミノピロリジン誘導体
JP2008031090A (ja) * 2006-07-28 2008-02-14 Toyota Central Res & Dev Lab Inc 有機スズ化合物及びその製造方法、並びに芳香族化合物誘導体の製造方法
US7375236B2 (en) 2003-02-19 2008-05-20 Eisai Co., Ltd. Methods for producing cyclic benzamidine derivatives
CN101298418B (zh) * 2008-06-13 2010-12-15 江苏康鹏农化有限公司 3-氧代-3-(2,4-二卤代-3-二氟甲氧基苯基)丙酸乙酯的制备方法
JP2017039733A (ja) * 2011-08-31 2017-02-23 大塚製薬株式会社 キノロン化合物

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY138335A (en) 1997-09-15 2009-05-29 Procter & Gamble Antimicrobial quinolones, their compositions and uses
WO2001029035A1 (en) 1999-10-19 2001-04-26 Sato Pharmaceutical Co., Ltd. 4-oxoquinolizine antimicrobials having 2-pyridone skeletons as the partial structure
JP4751557B2 (ja) 2000-03-07 2011-08-17 富山化学工業株式会社 抗菌キノロン薬のための有用な中間物としてのアルキル3−シクロプロピルアミノ−2−[2,4−ジブロモ−3−(ジフルオロメトキシ)ベンゾイル]−2−プロペノエートのワンポット合成法
US6525049B2 (en) 2000-07-05 2003-02-25 Pharmacia & Upjohn Company Pyrroloquinolones as antiviral agents
AU2001276748A1 (en) * 2000-08-08 2002-02-18 Daiichi Pharmaceutical Co., Ltd. Highly absorbable solid preparation
IL155678A0 (en) 2000-12-14 2003-11-23 Procter & Gamble Antimicrobial 2-pyridones, their compositions and uses
DK1341781T3 (da) 2000-12-14 2005-12-05 Procter & Gamble Antimikrobielle quinoloner
CA2647454A1 (en) 2006-03-28 2007-10-04 The Procter & Gamble Company A coupling process for preparing quinolone intermediates
DK2001862T3 (da) 2006-03-28 2011-08-08 Warner Chilcott Co Llc Malatsalte og polymorfe af (3S,5S)-7-[3-amino-5-methyl-piperidinyl]-1-cyklopropyl-1,4-dihydro-8-methoxy-4-oxo-3-quinolincarboxylsyre
CN102212056A (zh) * 2010-04-09 2011-10-12 山东轩竹医药科技有限公司 新的双环喹诺酮类化合物
CA2904387C (en) 2013-03-15 2021-12-07 Melinta Therapeutics, Inc. Methods of treating infections in overweight and obese patients using antibiotics

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61143365A (ja) * 1984-12-06 1986-07-01 フアイザー・インコーポレーテツド 置換ジヒドロキノロンカルボン酸
JPH01319463A (ja) * 1988-05-11 1989-12-25 Bayer Ag 7―置換キノロン―及びナフチリドン―カルボン酸誘導体

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3248507A1 (de) * 1982-12-29 1984-07-05 Bayer Ag, 5090 Leverkusen Mikrobizide mittel auf chinoloncarbonsaeure basis
JPH0262875A (ja) * 1988-05-23 1990-03-02 Wakunaga Pharmaceut Co Ltd 新規イソインドリン誘導体
US4945160A (en) * 1988-11-22 1990-07-31 Warner-Lambert Company Preparation of certain 7-substituted quinolones

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61143365A (ja) * 1984-12-06 1986-07-01 フアイザー・インコーポレーテツド 置換ジヒドロキノロンカルボン酸
JPH01319463A (ja) * 1988-05-11 1989-12-25 Bayer Ag 7―置換キノロン―及びナフチリドン―カルボン酸誘導体

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6011046A (en) * 1995-08-21 2000-01-04 Takeda Chemical Industries, Ltd. Quinone compound, its production and use as antioxidant
WO1997029102A1 (en) * 1996-02-09 1997-08-14 Toyama Chemical Co., Ltd. Quinolonecarboxylic acid derivatives or salts thereof
WO1999007682A1 (en) * 1997-08-08 1999-02-18 Toyama Chemical Co., Ltd. Quinolonecarboxylic acid derivatives or salts thereof
WO1999021849A1 (en) * 1997-10-27 1999-05-06 Toyama Chemical Co., Ltd. Processes for producing 7-isoindolinequinolonecarboxylic derivatives and intermediates therefor, salts of 7-isoindolinequinolonecarboxylic acids, hydrates thereof, and composition containing the same as active ingredient
JP2000143631A (ja) * 1998-08-31 2000-05-26 Toyama Chem Co Ltd 7−ブロモ−キノロンカルボン酸誘導体の製造法
WO2000046223A1 (en) * 1999-02-05 2000-08-10 Toyama Chemical Co., Ltd. Tricyclic quinolonecarboxylic acid derivatives or salts thereof
WO2001066542A1 (en) * 2000-03-10 2001-09-13 Dainippon Pharmaceutical Co., Ltd. Pyridonecarboxylic acid derivatives
JP2006206595A (ja) * 2001-04-19 2006-08-10 Eisai Co Ltd 2−イミノピロリジン誘導体
US7244730B2 (en) 2001-04-19 2007-07-17 Eisai Co., Ltd 2-iminopyrrolidine derivatives
US7304083B2 (en) 2001-04-19 2007-12-04 Eisai R&D Management Co., Ltd. 2-iminoimidazole derivatives (2)
US7476688B2 (en) 2001-04-19 2009-01-13 Eisai R&D Management Co., Ltd. Cyclic amidine derivatives
JP2006504620A (ja) * 2002-03-12 2006-02-09 ブリストル−マイヤーズ スクイブ カンパニー 快い味の経口懸濁液および方法
US7375236B2 (en) 2003-02-19 2008-05-20 Eisai Co., Ltd. Methods for producing cyclic benzamidine derivatives
JP2008031090A (ja) * 2006-07-28 2008-02-14 Toyota Central Res & Dev Lab Inc 有機スズ化合物及びその製造方法、並びに芳香族化合物誘導体の製造方法
CN101298418B (zh) * 2008-06-13 2010-12-15 江苏康鹏农化有限公司 3-氧代-3-(2,4-二卤代-3-二氟甲氧基苯基)丙酸乙酯的制备方法
JP2017039733A (ja) * 2011-08-31 2017-02-23 大塚製薬株式会社 キノロン化合物
JP2018150324A (ja) * 2011-08-31 2018-09-27 大塚製薬株式会社 キノロン化合物

Also Published As

Publication number Publication date
AU3190695A (en) 1996-03-07
NO312032B1 (no) 2002-03-04
FI970578A0 (fi) 1997-02-11
AU692583B2 (en) 1998-06-11
KR970704728A (ko) 1997-09-06
CN1158611A (zh) 1997-09-03
ES2203644T3 (es) 2004-04-16
EP0775702A1 (en) 1997-05-28
EP0775702B1 (en) 2003-07-23
NO970622L (no) 1997-04-10
FI970578L (fi) 1997-04-10
IL114875A (en) 1999-12-22
HU228062B1 (en) 2012-09-28
CA2196271C (en) 2007-01-09
NO970622D0 (no) 1997-02-11
ATE245638T1 (de) 2003-08-15
EP0775702A4 (en) 1997-11-05
DE69531350T2 (de) 2004-05-27
DK0775702T3 (da) 2003-08-18
HUT77314A (hu) 1998-03-30
IL114875A0 (en) 1995-12-08
NZ290946A (en) 1997-12-19
DE69531350D1 (de) 2003-08-28
KR100371723B1 (ko) 2003-03-15
ZA956713B (en) 1996-03-28
FI113652B (fi) 2004-05-31
CA2196271A1 (en) 1996-02-22
US5935952A (en) 1999-08-10
CN1070191C (zh) 2001-08-29

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