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WO1996002553B1 - DERIVES AMINO PURINE-β-D-RIBOFURANURONAMIDE - Google Patents

DERIVES AMINO PURINE-β-D-RIBOFURANURONAMIDE

Info

Publication number
WO1996002553B1
WO1996002553B1 PCT/EP1995/002837 EP9502837W WO9602553B1 WO 1996002553 B1 WO1996002553 B1 WO 1996002553B1 EP 9502837 W EP9502837 W EP 9502837W WO 9602553 B1 WO9602553 B1 WO 9602553B1
Authority
WO
WIPO (PCT)
Prior art keywords
alkylamino
alk
alkyl
group
guanidino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP1995/002837
Other languages
English (en)
Other versions
WO1996002553A2 (fr
WO1996002553A3 (fr
Filing date
Publication date
Priority claimed from GB9414193A external-priority patent/GB9414193D0/en
Application filed filed Critical
Priority to AU36982/95A priority Critical patent/AU3698295A/en
Publication of WO1996002553A2 publication Critical patent/WO1996002553A2/fr
Publication of WO1996002553A3 publication Critical patent/WO1996002553A3/fr
Publication of WO1996002553B1 publication Critical patent/WO1996002553B1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Abstract

L'invention concerne des dérivés amino purine-β-D-ribofuranuronamide de formule générale (I) ainsi que leurs sels et solvates. Dans cette formule, R1 est hydrogène, cycloalkyleC¿3-8? ou alkyleC1-6; A représente O, S, SO, SO2, un fragment hydrocarbure saturé possédant de 1 à 4 atomes de carbone ou bien un fragment hydrocarbure insaturé possédant de 2 à 4 atomes de carbone; R?2¿ est cycloalkyleC¿3-8?, cycloalkyleC3-8 alkyleC1-6, Alk1Y, -(CHR?5)¿m (Alk2)nZ ou bien cycloalkyleC3-8, cycloalkyleC3-8 alkyleC1-16 à substitution appropriée, pyrrolidin-3-yl, 2-oxopyrrolidin-4-yl, 2-oxopyrrolidin-5-yl, piperidin-3-yl ou piperidin-4-yl, et Q est oxygène ou soufre à condition que lorsque A représente O, S, SO ou bien SO2, Alk1 représente un groupe alkylèneC2-6. Ces composés de formule (I) ainsi que leurs sels et solvates s'utilisent en médecine comme agents anti-inflammatoires, notamment dans le traitement de patients atteints de manifestations inflammatoires, qui sont sujets à des lésions tissulaires à induction leucocytaire.
PCT/EP1995/002837 1994-07-14 1995-07-14 DERIVES AMINO PURINE-β-D-RIBOFURANURONAMIDE Ceased WO1996002553A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU36982/95A AU3698295A (en) 1994-07-14 1995-07-14 Amino purine-beta -d-ribofuranuronamide derivatives

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9414193A GB9414193D0 (en) 1994-07-14 1994-07-14 Compounds
GB9414193.4 1994-07-14

Publications (3)

Publication Number Publication Date
WO1996002553A2 WO1996002553A2 (fr) 1996-02-01
WO1996002553A3 WO1996002553A3 (fr) 1996-03-07
WO1996002553B1 true WO1996002553B1 (fr) 1996-03-28

Family

ID=10758311

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1995/002837 Ceased WO1996002553A2 (fr) 1994-07-14 1995-07-14 DERIVES AMINO PURINE-β-D-RIBOFURANURONAMIDE

Country Status (5)

Country Link
AU (1) AU3698295A (fr)
GB (1) GB9414193D0 (fr)
IL (1) IL114578A0 (fr)
WO (1) WO1996002553A2 (fr)
ZA (1) ZA955784B (fr)

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JP5006330B2 (ja) 2005-10-21 2012-08-22 ノバルティス アーゲー Ｉｌ１３に対するヒト抗体および治療的使用
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GB0601951D0 (en) 2006-01-31 2006-03-15 Novartis Ag Organic compounds
KR20080110925A (ko) 2006-04-21 2008-12-19 노파르티스 아게 아데노신 ａ２ａ 수용체 효능제로서 사용하기 위한 퓨린 유도체
JP2010504933A (ja) 2006-09-29 2010-02-18 ノバルティス アーゲー Ｐｉ３ｋ脂質キナーゼ阻害剤としてのピラゾロピリミジン
CA2667962A1 (fr) 2006-10-30 2008-05-08 Novartis Ag Composes heterocycliques en tant qu'agents anti-inflammatoires
WO2009006089A2 (fr) * 2007-06-29 2009-01-08 Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Agonistes des récepteurs d'adénosine a2
KR20100113557A (ko) 2008-01-11 2010-10-21 노파르티스 아게 키나제 억제제로서의 피리미딘
WO2010088335A1 (fr) 2009-01-29 2010-08-05 Novartis Ag Benzimidazoles substitués destinés au traitement d'astrocytomes
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WO2011018454A1 (fr) 2009-08-12 2011-02-17 Novartis Ag Composés hydrazone hétérocycliques et leurs utilisations pour traiter le cancer et l'inflammation
KR101721280B1 (ko) 2009-08-17 2017-03-29 인텔리카인, 엘엘씨 헤테로사이클릭 화합물 및 이의 용도
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US8637516B2 (en) 2010-09-09 2014-01-28 Irm Llc Compounds and compositions as TRK inhibitors
WO2012034095A1 (fr) 2010-09-09 2012-03-15 Irm Llc Composés et compositions comme inhibiteurs de trk
WO2012107500A1 (fr) 2011-02-10 2012-08-16 Novartis Ag Composés de [1, 2, 4] triazolo [4, 3 -b] pyridazine en tant qu'inhibiteurs de la tyrosine kinase c-met
WO2012116237A2 (fr) 2011-02-23 2012-08-30 Intellikine, Llc Composés hétérocycliques et leurs utilisations
US9102671B2 (en) 2011-02-25 2015-08-11 Novartis Ag Compounds and compositions as TRK inhibitors
WO2013038362A1 (fr) 2011-09-15 2013-03-21 Novartis Ag 3-(quinolin-6-ylthio)-[1,2,4]triazolo[4,3-a]pyradines substituées en position 6 à activité tyrosine kinase
CN104363914A (zh) 2011-11-23 2015-02-18 因特利凯有限责任公司 使用mTOR抑制剂的增强的治疗方案
AU2013211957B2 (en) 2012-01-26 2017-08-10 Inotek Pharmaceuticals Corporation Anhydrous polymorphs of (2R,3S,4R,5R)-5-(6-(cyclopentylamino)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl) } methyl nitrate and processes of preparation thereof
RU2660354C2 (ru) 2012-04-03 2018-07-05 Новартис Аг Комбинированные продукты, содержащие ингибиторы тирозинкиназ, и их применение
EA201591433A1 (ru) 2013-03-15 2015-12-30 Инотек Фармасьютикалс Корпорейшн Офтальмологические составы
JP2016512835A (ja) 2013-03-15 2016-05-09 インテリカイン， エルエルシー キナーゼ阻害剤の組み合わせ及びそれらの使用
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WO2016011658A1 (fr) 2014-07-25 2016-01-28 Novartis Ag Polythérapie
ES2831416T3 (es) 2014-07-31 2021-06-08 Novartis Ag Terapia de combinación de un inhibidor de MET y un inhibidor de EGFR
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TW202140550A (zh) 2020-01-29 2021-11-01 瑞士商諾華公司 使用抗ｔｓｌｐ抗體治療炎性或阻塞性氣道疾病之方法

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