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WO1996001634B1 - Compositions a base d'oxytretracycline a action prolongee - Google Patents

Compositions a base d'oxytretracycline a action prolongee

Info

Publication number
WO1996001634B1
WO1996001634B1 PCT/GB1995/001583 GB9501583W WO9601634B1 WO 1996001634 B1 WO1996001634 B1 WO 1996001634B1 GB 9501583 W GB9501583 W GB 9501583W WO 9601634 B1 WO9601634 B1 WO 9601634B1
Authority
WO
WIPO (PCT)
Prior art keywords
amount
composition
magnesium
composition according
oxytetracycline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB1995/001583
Other languages
English (en)
Other versions
WO1996001634A1 (fr
Filing date
Publication date
Priority claimed from GB9413873A external-priority patent/GB9413873D0/en
Priority to DE69531736T priority Critical patent/DE69531736T2/de
Priority to AU28043/95A priority patent/AU707366B2/en
Priority to JP50417996A priority patent/JP4025925B2/ja
Priority to AT95923502T priority patent/ATE249224T1/de
Priority to CA002194576A priority patent/CA2194576C/fr
Application filed filed Critical
Priority to NZ288717A priority patent/NZ288717A/en
Priority to DK95923502T priority patent/DK0769951T3/da
Priority to EP95923502A priority patent/EP0769951B1/fr
Publication of WO1996001634A1 publication Critical patent/WO1996001634A1/fr
Publication of WO1996001634B1 publication Critical patent/WO1996001634B1/fr
Anticipated expiration legal-status Critical
Priority to US09/617,795 priority patent/US6310053B1/en
Ceased legal-status Critical Current

Links

Abstract

Une composition injectable présentant un effet résiduel supérieur avec des effets préjudiciables réduits tels que la douleur sur le site d'injection, le gonflement, l'irritation des tissus ou la nécrose, et contenant comme principe actif un composé de tétracycline, soit comme base libre soit comme sel de celle-ci avec un acide physiologiquement acceptable, transformé en complexe avec une dose sensiblement équimolaire d'un composé de magnésium et solubilisé dans un système de solvants miscibles à l'eau comprenant soit (i) a) du glycérol formal en une quantité comprise entre environ 10 et environ 50 % v/v; avec b) du polyethylène-glycol en une quantité comprise entre environ 1 et 15 % v/v; ou (ii) environ 25 à environ 75 % v/v de N-méthylpyrrolidone, ladite composition contenant facultativement un agent modificateur de pH en une dose suffisante pour maintenir un pH physiochimiquement acceptable, le solde étant constitué d'eau q.s.
PCT/GB1995/001583 1994-07-09 1995-07-05 Compositions a base d'oxytretracycline a action prolongee Ceased WO1996001634A1 (fr)

Priority Applications (9)

Application Number Priority Date Filing Date Title
EP95923502A EP0769951B1 (fr) 1994-07-09 1995-07-05 Compositions a base d'oxytretracycline a action prolongee
DK95923502T DK0769951T3 (da) 1994-07-09 1995-07-05 Langtidsvirkende oxytetracyclinpræparat
JP50417996A JP4025925B2 (ja) 1994-07-09 1995-07-05 長時間作用オキシテトラサイクリン組成物
AT95923502T ATE249224T1 (de) 1994-07-09 1995-07-05 Oxytetracyclin enthaltendes arzneimittel mit verzögerter wirksoffabgabe
CA002194576A CA2194576C (fr) 1994-07-09 1995-07-05 Compositions a base d'oxytretracycline a action prolongee
DE69531736T DE69531736T2 (de) 1994-07-09 1995-07-05 Oxytetracyclin enthaltendes arzneimittel mit verzögerter wirksoffabgabe
NZ288717A NZ288717A (en) 1994-07-09 1995-07-05 Long-acting tetracycline medicaments formed from tetracycline complexed with a magnesium compound and solubilised in a mixture of glycerol formal and polyethylene glycol
AU28043/95A AU707366B2 (en) 1994-07-09 1995-07-05 Long-acting oxytetracycline composition
US09/617,795 US6310053B1 (en) 1995-07-05 2000-07-17 Long-acting oxytetracycline composition

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9413873.2 1994-07-09
GB9413873A GB9413873D0 (en) 1994-07-09 1994-07-09 Long-acting oxytetracycline composition

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US76547597A Continuation 1994-07-09 1997-04-08

Publications (2)

Publication Number Publication Date
WO1996001634A1 WO1996001634A1 (fr) 1996-01-25
WO1996001634B1 true WO1996001634B1 (fr) 1996-02-15

Family

ID=10758078

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1995/001583 Ceased WO1996001634A1 (fr) 1994-07-09 1995-07-05 Compositions a base d'oxytretracycline a action prolongee

Country Status (13)

Country Link
EP (1) EP0769951B1 (fr)
JP (2) JP4025925B2 (fr)
CN (1) CN1081461C (fr)
AT (1) ATE249224T1 (fr)
AU (1) AU707366B2 (fr)
DE (1) DE69531736T2 (fr)
DK (1) DK0769951T3 (fr)
ES (1) ES2204958T3 (fr)
GB (1) GB9413873D0 (fr)
MX (1) MX9700287A (fr)
NZ (1) NZ288717A (fr)
PT (1) PT769951E (fr)
WO (1) WO1996001634A1 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2130069B1 (es) * 1997-04-10 2000-03-01 Basf Labiana S A Preparacion farmaceutica con liberacion retardada del producto activo.
HUP0002125A3 (en) * 1997-05-06 2001-01-29 Norbrook Lab Ltd Newry Improvements in or relating to long-acting antimicrobials
US6239112B1 (en) * 1998-07-09 2001-05-29 Merial, Inc. Water miscible macrolide solutions
GB9928343D0 (en) * 1999-11-30 2000-01-26 Vericore Ltd Addition of tetracyclines to animal foodstuffs
US6428975B1 (en) * 2000-01-14 2002-08-06 Blue Ridge Pharmaceuticals, Inc. Methods for determining the presence or absence of microorganisms in lipid-containing compositions
RU2178698C1 (ru) * 2000-11-28 2002-01-27 Закрытое Акционерное Общество "Нита-Фарм" Способ получения композиции магниевого комплекса окситетрациклина пролонгированного действия
NO20014746D0 (no) 2001-09-28 2001-09-28 Clas M Kjoelberg Smertelindrende middel
ES2315123B1 (es) * 2006-09-25 2009-12-30 Divasa-Farmavic, S.A. Composiciones farmaceuticas estables de tetraciclinas en solucion, procedimiento para su obtencion y sus usos.
JP6025712B2 (ja) 2010-05-12 2016-11-16 レンペックス・ファーマシューティカルズ・インコーポレイテッド テトラサイクリン組成物
CN103271238B (zh) * 2013-05-10 2014-04-02 中国科学院亚热带农业生态研究所 一种饲料添加剂一乙醇胺的制备方法及应用
CN106309357A (zh) * 2016-11-08 2017-01-11 河南益华动物药业有限公司 兽用盐酸土霉素凝胶植入剂及其制备方法
CN110693826A (zh) * 2019-11-18 2020-01-17 成都新亨药业有限公司 一种兽用长效土霉素注射液及其制备方法
CN111035614B (zh) * 2019-12-20 2024-02-02 北京喜禽药业有限公司 一种高含量土霉素注射液及其制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE747255A (fr) * 1969-03-13 1970-09-14 Diamond Shamrock Corp Compositions injectables d'oxytétracycline
DE2001604C2 (de) * 1970-01-15 1983-04-14 Pfizer Gmbh, 7500 Karlsruhe Verwendung von Polyäthylenglykol zur Herstellung von Oxytetracyclinlösungen zur parenteralen, peroralen und lokalen Anwendung
US4259331A (en) * 1979-04-16 1981-03-31 Pfizer Inc. Oxytetracycline compositions
CA1163197A (fr) * 1980-04-10 1984-03-06 Herman Horn Composes d'oxytetracycline injectables
NL178941C (nl) * 1982-06-15 1986-06-16 Aesculaap Bv Werkwijze voor de bereiding van een waterig oxytetracyclinepreparaat.
IE74244B1 (en) * 1985-10-01 1997-07-16 Bimeda Res Dev Ltd A process for preparing an antibiotic composition
US5075295A (en) * 1989-12-12 1991-12-24 Boehringer Ingelheim Animal Health, Inc. Novel oxytetracycline compositions

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