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WO1996001430A3 - Screening for nuc inhibitors - Google Patents

Screening for nuc inhibitors Download PDF

Info

Publication number
WO1996001430A3
WO1996001430A3 PCT/US1995/008328 US9508328W WO9601430A3 WO 1996001430 A3 WO1996001430 A3 WO 1996001430A3 US 9508328 W US9508328 W US 9508328W WO 9601430 A3 WO9601430 A3 WO 9601430A3
Authority
WO
WIPO (PCT)
Prior art keywords
nuc
protein
screening
agents
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1995/008328
Other languages
French (fr)
Other versions
WO1996001430A2 (en
Inventor
Ranjan Mukherjee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ligand Pharmaceuticals Inc
Original Assignee
Ligand Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ligand Pharmaceuticals Inc filed Critical Ligand Pharmaceuticals Inc
Priority to AU29571/95A priority Critical patent/AU2957195A/en
Priority to EP95925440A priority patent/EP0769146A2/en
Priority to JP8503950A priority patent/JPH10502454A/en
Publication of WO1996001430A2 publication Critical patent/WO1996001430A2/en
Publication of WO1996001430A3 publication Critical patent/WO1996001430A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/721—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)

Abstract

This invention provides methods for screening for agents useful for treatment of diseases and pathological conditions affected by the level of NUC protein activity. These agents reduce or relieve the repression of PPARα protein and TR protein transcription activation activity by NUC protein. The selected novel or unique agents can be used to treat hyperlipidemia, hypercholesteremia and hyperlipoproteinemia.
PCT/US1995/008328 1994-07-01 1995-06-29 Screening for nuc inhibitors Ceased WO1996001430A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU29571/95A AU2957195A (en) 1994-07-01 1995-06-29 Screening for nuc inhibitors
EP95925440A EP0769146A2 (en) 1994-07-01 1995-06-29 Screening for nuc inhibitors
JP8503950A JPH10502454A (en) 1994-07-01 1995-06-29 Screening for NUC inhibitors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27063594A 1994-07-01 1994-07-01
US08/270,635 1994-07-01

Publications (2)

Publication Number Publication Date
WO1996001430A2 WO1996001430A2 (en) 1996-01-18
WO1996001430A3 true WO1996001430A3 (en) 1996-10-10

Family

ID=23032149

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1995/008328 Ceased WO1996001430A2 (en) 1994-07-01 1995-06-29 Screening for nuc inhibitors

Country Status (5)

Country Link
EP (1) EP0769146A2 (en)
JP (1) JPH10502454A (en)
AU (1) AU2957195A (en)
CA (1) CA2193685A1 (en)
WO (1) WO1996001430A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7098025B1 (en) 1997-07-25 2006-08-29 Ligand Pharmaceuticals Incorporated Human peroxisome proliferator activated receptor gamma (pparγ) gene regulatory sequences and uses therefor
US7635708B2 (en) 1996-12-11 2009-12-22 Dana-Farber Cancer Institute Methods and pharmaceutical compositions for inhibiting tumor cell growth

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6242196B1 (en) 1997-12-11 2001-06-05 Dana-Farber Cancer Institute Methods and pharmaceutical compositions for inhibiting tumor cell growth
EP1083891B1 (en) 1998-06-02 2003-03-12 Arthromics PLC Compounds which interact with the thyroid hormone receptor for the treatment of fibrotic disease
WO2006033891A2 (en) 2004-09-16 2006-03-30 Merck & Co., Inc. Compounds for the treatment of dyslipidemia and other lipid disorders

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995011974A2 (en) * 1993-10-22 1995-05-04 Ligand Pharmaceuticals, Inc. Human peroxisome proliferator activated receptor
WO1995018533A1 (en) * 1994-01-04 1995-07-13 The Trustees Of The University Of Pennsylvania Methods and compounds affecting adipocyte differentiation and obesity
WO1996001317A2 (en) * 1994-07-01 1996-01-18 The Salk Institute For Biological Studies Mammalian peroxisome proliferator-activated receptors and uses thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995011974A2 (en) * 1993-10-22 1995-05-04 Ligand Pharmaceuticals, Inc. Human peroxisome proliferator activated receptor
WO1995018533A1 (en) * 1994-01-04 1995-07-13 The Trustees Of The University Of Pennsylvania Methods and compounds affecting adipocyte differentiation and obesity
WO1996001317A2 (en) * 1994-07-01 1996-01-18 The Salk Institute For Biological Studies Mammalian peroxisome proliferator-activated receptors and uses thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
A. SCHMIDT ET AL.: "Identification of a new member of the steroid hormone receptor superfamily that is activated by a peroxisome proliferator and fatty acids.", MOLECULAR ENDOCRINOLOGY, vol. 6, no. 10, 1992, WASHINGTON DC USA, pages 749 - 784, XP000579262 *
F. CHEN ET AL.: "Identification of two mPPAR related receptors and evidence for the existence of five subfamily members", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 196, no. 2, 1993, NEW YORK NY USA, pages 671 - 677, XP000577084 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7635708B2 (en) 1996-12-11 2009-12-22 Dana-Farber Cancer Institute Methods and pharmaceutical compositions for inhibiting tumor cell growth
US7098025B1 (en) 1997-07-25 2006-08-29 Ligand Pharmaceuticals Incorporated Human peroxisome proliferator activated receptor gamma (pparγ) gene regulatory sequences and uses therefor

Also Published As

Publication number Publication date
AU2957195A (en) 1996-01-25
EP0769146A2 (en) 1997-04-23
CA2193685A1 (en) 1996-01-18
JPH10502454A (en) 1998-03-03
WO1996001430A2 (en) 1996-01-18

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