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WO1995019974A3 - Composes a base de calixarene presentant une activite antibacterienne, antifongique, anticancereuse et anti-vih - Google Patents

Composes a base de calixarene presentant une activite antibacterienne, antifongique, anticancereuse et anti-vih Download PDF

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Publication number
WO1995019974A3
WO1995019974A3 PCT/IE1995/000008 IE9500008W WO9519974A3 WO 1995019974 A3 WO1995019974 A3 WO 1995019974A3 IE 9500008 W IE9500008 W IE 9500008W WO 9519974 A3 WO9519974 A3 WO 9519974A3
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WIPO (PCT)
Prior art keywords
calixarene
compounds
based compounds
antifungal
anticancer
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Ceased
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PCT/IE1995/000008
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English (en)
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WO1995019974B1 (fr
WO1995019974A2 (fr
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Stephen J Harris
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Priority to AU15453/95A priority Critical patent/AU1545395A/en
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Publication of WO1995019974A3 publication Critical patent/WO1995019974A3/fr
Publication of WO1995019974B1 publication Critical patent/WO1995019974B1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/27—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups
    • C07C205/35—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/27—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups
    • C07C205/35—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/36—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
    • C07C205/37—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
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    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/74—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
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    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/08—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
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    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/12—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/16—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/36—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
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    • C07C245/02—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides
    • C07C245/06—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides with nitrogen atoms of azo groups bound to carbon atoms of six-membered aromatic rings
    • C07C245/08—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides with nitrogen atoms of azo groups bound to carbon atoms of six-membered aromatic rings with the two nitrogen atoms of azo groups bound to carbon atoms of six-membered aromatic rings, e.g. azobenzene
    • C—CHEMISTRY; METALLURGY
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/11—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/16—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
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    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
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    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/708—Ethers
    • C07C69/712—Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring
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    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/14—Nitrogen atoms
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
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    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
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    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
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    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
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  • Biotechnology (AREA)
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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Composés à base de calixarène présentant une activité biologique et notamment antibactérienne, antifongique, anticancéreuse et antivirale. Il s'avère que certains composés présentent une activité anti-VIH. Les composés sont des calixarènes ou oxacalixarènes, des oligomères acycliques de phényle-formol, des dérivés de cyclotrivératrylène, des dérivés cycliques tétramères de résorcinol-aldéhyde appelés composés de Hogberg, et des dérivés cycliques tétramères de pyrogallol-aldéhyde.
PCT/IE1995/000008 1994-01-24 1995-01-24 Composes a base de calixarene presentant une activite antibacterienne, antifongique, anticancereuse et anti-vih Ceased WO1995019974A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU15453/95A AU1545395A (en) 1994-01-24 1995-01-24 Calixarene-based compounds having antibacterial, antifungal, anticancer-hiv activity

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IES940057 1994-01-24
IE940057 1994-01-24

Publications (3)

Publication Number Publication Date
WO1995019974A2 WO1995019974A2 (fr) 1995-07-27
WO1995019974A3 true WO1995019974A3 (fr) 1995-09-21
WO1995019974B1 WO1995019974B1 (fr) 1995-11-16

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ID=11040267

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Application Number Title Priority Date Filing Date
PCT/IE1995/000008 Ceased WO1995019974A2 (fr) 1994-01-24 1995-01-24 Composes a base de calixarene presentant une activite antibacterienne, antifongique, anticancereuse et anti-vih

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AU (1) AU1545395A (fr)
WO (1) WO1995019974A2 (fr)

Cited By (1)

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US8642656B2 (en) 2004-10-04 2014-02-04 Regents Of The University Of Minnesota Calixarene-based peptide conformation mimetics, methods of use, and methods of making

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EP1038871B1 (fr) * 1997-12-09 2004-03-17 Cosmo Research Institute Derives sulfones de sulfures phenoles cycliques, leur procede de preparation, agents de separation et de recuperation contenant des sulfures phenoles cycliques, procedes de separation et de recuperation utilisant ces agents, et compositions de medicaments contenant lesdits sulfures
NL1008988C2 (nl) * 1998-04-24 1999-10-26 Stichting Tech Wetenschapp Calixareenverbinding en een selectief molecuul voorzien van een dergelijke verbinding.
WO1999063929A2 (fr) * 1998-06-08 1999-12-16 Advanced Medicine, Inc. Inhibiteurs multiliaison de proteine triglyceride transferase microsomique
EP1345884A1 (fr) * 2000-12-01 2003-09-24 Aids Care Pharma Limited Composes antiviraux
DK1372551T3 (da) 2001-03-08 2009-01-12 Univ Pennsylvania Faciale amphifile polymerer som anti-infektionsmidler
IE20020449A1 (en) * 2002-05-31 2003-12-10 Aids Care Pharma Ltd Anti-viral compounds
DE10226099A1 (de) * 2002-06-12 2004-01-08 Jörg Martin Dipl.-Chem. Dormann Filtermaterial für Toxine, Bakterien, Viren und andere physiologische Schadstoffe
EP2471525A3 (fr) 2003-03-17 2012-12-12 The Trustees Of The University Of Pennsylvania Polymères amphiphiles faciaux et oligomères et leurs utilisations
AU2003229567A1 (en) * 2003-03-24 2004-10-18 Centre National De La Recherche Scientifique New calix arene compounds, their process of preparation and their use, particularly as enzymatic mimes
US7338977B2 (en) * 2003-11-25 2008-03-04 Aids Care Pharma Limited Anti-viral compounds
US8222456B2 (en) 2004-01-23 2012-07-17 The Trustees Of The University Of Pennsylvania Facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers and uses thereof
JP5304648B2 (ja) * 2007-08-23 2013-10-02 Ｊｓｒ株式会社 感放射線性組成物及び化合物
FR2939666B1 (fr) * 2008-12-17 2012-11-30 Irsn Formulations cosmetiques et pharmaceutiques de molecules de calix[6]arenes
FR2974012A1 (fr) 2011-04-12 2012-10-19 Univ Nancy 1 Henri Poincare Utilisation de calixarenes dans le traitement des infections bacteriennes
FR2974013B1 (fr) * 2011-04-12 2017-02-17 Univ De Nancy 1 Henri Poincare Utilisation de calixarenes associes avec un antibiotique dans le traitement des infections bacteriennes
EP2743249B1 (fr) * 2011-08-12 2019-07-24 Mitsubishi Gas Chemical Company, Inc. Composé cyclique ainsi que procédé de fabrication de celui-ci, composition, et procédé de formation de motif de réserve
CN103946204B (zh) * 2011-11-18 2016-08-24 三菱瓦斯化学株式会社 环状化合物、其制造方法、辐射敏感组合物及抗蚀图案形成方法
CN103958455A (zh) * 2011-11-18 2014-07-30 三菱瓦斯化学株式会社 环状化合物、其制造方法、辐射敏感组合物及抗蚀图案形成方法
US20150368213A1 (en) * 2014-06-20 2015-12-24 The University of Montana, Missoula, MT Novel Inhibitors of System Xc-
CN107043364B (zh) * 2016-02-05 2020-04-03 徐州医学院 氧杂杯[4]芳烃衍生物及其应用
CN107325810A (zh) * 2017-06-29 2017-11-07 广东医科大学 一种穴状多羟基荧光化合物及其应用
CN112771042A (zh) * 2018-09-28 2021-05-07 重庆复创医药研究有限公司 作为蛋白激酶抑制剂的萘啶酮和吡啶基嘧啶酮类化合物
FI20185841A1 (fi) * 2018-10-08 2020-04-09 Aalto Univ Foundation Sr Makrosykliset yhdisteet ja niiden käytöt
CN115252869B (zh) * 2022-08-18 2023-06-06 南通大学 一种促进血管再生的纳米敷料及其制备方法

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US8716343B2 (en) 2004-10-04 2014-05-06 Regents Of The University Of Minnesota Calixarene-based peptide conformation mimetics, methods of use, and methods of making

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