WO1995013113B1 - Device for treating cancer and non-maligant tumors and methods - Google Patents
Device for treating cancer and non-maligant tumors and methodsInfo
- Publication number
- WO1995013113B1 WO1995013113B1 PCT/US1994/012842 US9412842W WO9513113B1 WO 1995013113 B1 WO1995013113 B1 WO 1995013113B1 US 9412842 W US9412842 W US 9412842W WO 9513113 B1 WO9513113 B1 WO 9513113B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- electrode
- treatment site
- tissue treatment
- fluid
- tissue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Abstract
A method of this invention for treating body tissues containing cancerous cells or non-malignant tumors with RF ablation, alone or in combination with systemic or localized chemotherapy comprising introducing a stylet comprising an electrode surface and a sleeve longitudinally moveable thereon into the vicinity of the body tissues, retracting the sleeve from a portion of the electrode surface, and supplying RF power to the electrode surface sufficient to heat the tissue to a temperature of above about 45 °C for a time to cause reduction of tissue mass in the vicinity of the electrode. The RF power supplied to the electrode surface is sufficient to effect a desiccated fluid diffusion barrier capsule surrounding the body tissue being treated. The stylet can include a hollow tube having fluid distribution ports therein, and the method can include the step of passing fluid through one or more distribution ports into the body tissue being treated. The fluid can be saline or a chemotherapeutic fluid such as liquid or gas containing a cytotoxic agent, for example. The fluid can be administered in a variety of procedures. The fluid can be passed through a distribution port into the body tissue before, during and/or after the RF power is supplied to the electrode surface, for example. Preferably, the fluid is introduced after a barrier capsule has been formed. The devices comprises electrodes having a hollow core and a closed sharpened distal tip. The electrode has a plurality of fluid distribution ports therein for distribution of fluid treatment agents into the tissue.
Claims
1. A method for ablating tissue at a tissue treatment site where dehydration of tissue at the tissue treatment site is reduced, the method comprising the steps of: a) introducing an Rf ablation device into a tissue treatment site, the device including a hollow tubular Rf electrode having a closed, sharpened distal tip, an electrode conductive surface for conducting Rf ablation, and a plurality of fluid distribution ports distributed along the length of the electrode for delivering chemotherapeutic agents to the tissue treatment site; and b) supplying Rf power to the electrode to produce a diffusion barrier capsule at the tissue treatment site wherein the position of the electrode relative to the tissue treatment site is varied sufficiently frequently to reduce dehydration of tissue at the tissue treatment site.
2. The method according to claim 1 , further including the step of passing fluid through the fluid distribution ports during ablation to reduce dehydration of tissue at the tissue treatment site.
3. The method according to claim 1 wherein the position of the electrode relative to the tissue treatment site is varied by at least 1 mm during ablation.
4. The method according to claim 2 wherein the position of the electrode relative to the tissue treatment site is varied by between about 1 and 3 mm.
5. The method according to claim 1 wherein the position of the electrode relative to the tissue treatment site is varied along a longitudinal axis of the electrode.
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6. The method according to claim 1 wherein the device further includes an electrode position modifier which varies the position of the electrode relative to the tissue treatment site sufficiently frequently during ablation to reduce dehydration of tissue at the tissue treatment site.
7. The method according to claim 1 further including the step of passing fluid through the fluid distribution ports during ablation to reduce dehydration of tissue at the tissue treatment site.
8. The method according to claim 7 wherein the position of the electrode relative to the tissue treatment site is varied by at least 1 mm during ablation.
9. The method according to claim 8 wherein the position of the electrode relative to the tissue treatment site is varied by between about 1 and 3 mm.
10. An Rf ablation device for delivering chemotherapeutic agents to a tissue treatment site and for creating a diffusion barrier capsule to impede diffusion of chemotherapeutic agents from the tissue treatment site, the ablation device comprising: a hollow tubular Rf electrode having a closed, sharpened distal tip and a conductive surface to which Rf power is supplied to heat the tissue treatment site to a temperature between about 45° C and 170°C to produce a diffusion barrier capsule, the Rf electrode also including a plurality of fluid distribution ports distributed along the length of the electrode for delivering chemotherapeutic agents to the tissue treatment site; and a fluid distribution port blocking implement positioned within the hollow tubular Rf electrode whose position within the electrode is adjustable to prevent fluid from passing through one or more of the plurality of fluid distribution ports.
11. An Rf ablation device according to claim 10 wherein the device further includes an insulating sleeve covering the electrode, the insulating sleeve being moveable along the length of the electrode to define an electrode conductive surface.
12. An Rf ablation device according to claim 10 wherein the electrode includes a plurality of conductive segments for delivering Rf energy, each conductive segment being insulated from neighboring segments and connected to a power delivery controller which controls the power delivered to each conductive segment.
13. An Rf ablation device according to claim 12 wherein the power delivery controller also controls the polarity of each conductive segment.
14. An Rf ablation device according to claim 12 wherein the device further includes an insulating sleeve covering the electrode, the insulating sleeve being moveable along the length of the electrode to define an electrode conductive surface.
15. An Rf ablation device according to claim 14 wherein the power delivery controller also controls the polarity of each conductive segment.
16. An Rf ablation device according to claim 10 wherein the tubular Rf electrode is composed of a shaped-memory metal.
17. An Rf ablation device according to claim 16 wherein the electrode further includes an insulating sleeve covering the electrode, the insulating sleeve being moveable along the length of the electrode to define an electrode conductive surface.
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18. An Rf ablation device according to claim 16 wherein the electrode includes a plurality of conductive segments for delivering Rf energy, each conductive segment being insulated from neighboring conductive segments and connected to a power delivery controller which controls the power delivered to each conductive segment.
19. An Rf ablation device according to claim 18 wherein the power delivery controller also controls the polarity of each conductive segment.
20. A method for delivering chemotherapeutic agents to a tissue treatment site and for impeding diffusion of the chemotherapeutic agents from the tissue treatment site through the creation of a diffusion barrier capsule, the method comprising the steps of: a) introducing an Rf ablation device into a tissue treatment site, the device including a hollow tubular Rf electrode having a closed, sharpened distal tip, an electrode conductive surface for conducting Rf ablation, and a plurality of fluid distribution ports distributed along the length of the electrode for delivering chemotherapeutic agents to the tissue treatment site; b) supplying Rf power to the electrode to produce a diffusion barrier capsule at the tissue treatment site; and c) introducing chemotherapeutic agents to the tissue treatment site through at least one of the fluid distribution ports, the diffusion barrier capsule impeding the diffusion of the chemotherapeutic agents from the tissue treatment site.
21. The method according to claim 20 wherein the device further includes a fluid distribution port blocking implement positioned within the hollow tubular Rf electrode, further comprising the step of position being adjustable of the blocking implement within the electrode being adjustable to prevent fluid from passing through one or more of the plurality of fluid distribution ports.
28
22. The method according to claim 20 further comprising the step of heating the body tissues to a temperature between about 80° C and 170°C in order to produce the diffusion barrier capsule.
23. The method according to claim 20 wherein the device further includes a moveable insulating sleeve covering the electrode, the method further comprising the step of positioning the insulating sleeve along the length of an electrode to define the electrode conductive surface.
24. The method according to claim 23 wherein the tubular Rf electrode is composed of a shaped-memory metal, the method further comprising the step of moving the insulating sleeve to expose a portion of the electrode wherein the portion of the electrode exposed reverts to its memory shape.
25. The method according to claim 20 further comprising the step of passing [wherein] fluid through the fluid distribution ports while Rf energy is supplied to the electrode in order to reduce dehydration of tissue at the tissue treatment site during ablation.
26. A method for delivering chemotherapeutic agents to a tissue treatment site and for impeding diffusion of the chemotherapeutic agents from the tissue treatment site through the creation of a diffusion barrier capsule, the method comprising the steps of: a) introducing an Rf ablation device into a tissue treatment site, the device including a hollow tubular Rf electrode having a closed, sharpened distal tip, an electrode conductive surface for conducting Rf ablation, and a plurality of fluid distribution ports distributed along the length of the electrode for delivering chemotherapeutic agents to the tissue treatment site, the device further including a fluid distribution port blocking implement positioned within the hollow tubular Rf electrode, the position of the blocking implement within the electrode being adjustable to prevent fluid from passing through one or more of the plurality of fluid distribution ports;
29 b) supplying Rf power to the electrode to produce a diffusion barrier capsule at the tissue treatment site; c) adjusting the position of the blocking implement to prevent fluid from passing through one or more of the plurality of fluid distribution ports; and d) introducing chemotherapeutic agents to the tissue treatment site through at least one fluid distribution port, the diffusion barrier capsule impeding the diffusion of the chemotherapeutic agents from the tissue treatment site.
27. A method for delivering chemotherapeutic agents to a tissue treatment site and for impeding diffusion of the chemotherapeutic agents from the tissue treatment site through the creation of a diffusion barrier capsule, the method comprising the steps of: a) introducing an Rf ablation device into a tissue treatment site, the device including a hollow tubular Rf electrode having a closed, sharpened distal tip, a plurality of fluid distribution ports distributed along the length of the electrode for delivering chemotherapeutic agents to the tissue treatment site, and a plurality of conductive segments for delivering Rf energy, each segment being insulated from neighboring segments and connected to a power delivery controller which controls the power delivered to each conductive segment; b) selecting the power delivered to each conductive segment using the power delivery controller; c) supplying Rf power to the electrode to produce a diffusion barrier capsule at the tissue treatment site; and d) introducing chemotherapeutic agents to the tissue treatment site through at least one fluid distribution port, the diffusion barrier capsule impeding the diffusion of the chemotherapeutic agents from the tissue treatment site.
30
28. A method according to claim 27 wherein the device further includes a fluid distribution port blocking implement positioned within the hollow tubular Rf electrode, the position of the blocking implement within the electrode being adjustable to prevent fluid from passing through one or more ports of the plurality of fluid distribution ports, the method comprising the further step of: adjusting the position of the blocking implement within the hollow tubular Rf electrode to prevent fluid from passing through one or more ports of the plurality of fluid distribution ports.
29. An Rf ablation device for inserting an Rf ablation electrode through tissue to a tissue site to be ablated, the Rf ablation device comprising: a rigid hollow needle having a needle lumen and an open, sharpened distal end adapted to penetrate tissue; a hollow Rf electrode positioned within the needle lumen and extendable beyond the distal end of the needle lumen, the Rf electrode having an electrode lumen and an open, distal end, the electrode lumen serving as a fluid conduit for delivering fluid through the open, distal end of the electrode; a fiber optic positioned within the electrode lumen for providing visualization during ablation, the fiber optic having a distal end proximally distanced from the electrode distal end; and a fluid delivery source for delivering fluid through the electrode lumen to simultaneously cleanse the fiber optic and irrigate the tissue ablation site.
30. An Rf ablation device according to claim 29 wherein the diameter of hollow Rf electrode is equal to or less than about 1 mm.
31. An Rf ablation device according to claim 29 wherein the Rf ablation device further includes an insulating sleeve surrounding the electrode, the insulating sleeve being moveable along the length of the electrode to control the amount of electrode surface exposed to the tissue.
3 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU10514/95A AU1051495A (en) | 1993-11-08 | 1994-11-08 | Device for treating cancer and non-maligant tumors and methods |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/148,439 US5458597A (en) | 1993-11-08 | 1993-11-08 | Device for treating cancer and non-malignant tumors and methods |
| US08/148,439 | 1993-11-08 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO1995013113A1 WO1995013113A1 (en) | 1995-05-18 |
| WO1995013113B1 true WO1995013113B1 (en) | 1995-06-29 |
Family
ID=22525775
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1994/012842 Ceased WO1995013113A1 (en) | 1993-11-08 | 1994-11-08 | Device for treating cancer and non-maligant tumors and methods |
Country Status (3)
| Country | Link |
|---|---|
| US (1) | US5458597A (en) |
| AU (1) | AU1051495A (en) |
| WO (1) | WO1995013113A1 (en) |
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-
1993
- 1993-11-08 US US08/148,439 patent/US5458597A/en not_active Expired - Lifetime
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1994
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- 1994-11-08 AU AU10514/95A patent/AU1051495A/en not_active Abandoned
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6997941B2 (en) | 1996-08-13 | 2006-02-14 | Oratec Interventions, Inc. | Method and apparatus for treating annular fissures in intervertebral discs |
| US7267683B2 (en) | 1996-08-13 | 2007-09-11 | Oratec Interventions, Inc. | Method for treating intervertebral discs |
| US7282061B2 (en) | 1996-08-13 | 2007-10-16 | Oratec Interventions, Inc. | Method of treating intervertebral disc |
| US7400930B2 (en) | 1996-08-13 | 2008-07-15 | Oratec Interventions, Inc. | Method for treating intervertebral discs |
| US7309336B2 (en) | 1996-10-23 | 2007-12-18 | Oratec Interventions, Inc. | Catheter for delivery of energy to a surgical site |
| US7069087B2 (en) | 2000-02-25 | 2006-06-27 | Oratec Interventions, Inc. | Apparatus and method for accessing and performing a function within an intervertebral disc |
| US7150747B1 (en) | 2003-01-22 | 2006-12-19 | Smith & Nephew, Inc. | Electrosurgical cutter |
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