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WO1995000501B1 - Phenyl heterocycles as cyclooxygenase-2 inhibitors - Google Patents

Phenyl heterocycles as cyclooxygenase-2 inhibitors

Info

Publication number
WO1995000501B1
WO1995000501B1 PCT/CA1994/000318 CA9400318W WO9500501B1 WO 1995000501 B1 WO1995000501 B1 WO 1995000501B1 CA 9400318 W CA9400318 W CA 9400318W WO 9500501 B1 WO9500501 B1 WO 9500501B1
Authority
WO
WIPO (PCT)
Prior art keywords
cyclooxygenase
inhibitors
phenyl
formula
phenyl heterocycles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CA1994/000318
Other languages
French (fr)
Other versions
WO1995000501A3 (en
WO1995000501A2 (en
Filing date
Publication date
Priority claimed from US08/179,467 external-priority patent/US5474995A/en
Priority to BR9406979A priority Critical patent/BR9406979A/en
Priority to HU9503319A priority patent/HU227913B1/en
Priority to JP7502268A priority patent/JP2977137B2/en
Priority to UA95125420A priority patent/UA48939C2/en
Priority to DK94918259T priority patent/DK0705254T3/en
Priority to PL94312196A priority patent/PL178203B1/en
Priority to NZ267386A priority patent/NZ267386A/en
Priority to SI9430145T priority patent/SI0705254T1/en
Priority to SK1502-95A priority patent/SK284114B6/en
Priority to DE69410092T priority patent/DE69410092T2/en
Priority to KR1019950705562A priority patent/KR100215358B1/en
Application filed filed Critical
Priority to RO95-02214A priority patent/RO115354B1/en
Priority to EP94918259A priority patent/EP0705254B1/en
Priority to RU96100763/04A priority patent/RU2131423C1/en
Priority to AU69674/94A priority patent/AU6967494A/en
Publication of WO1995000501A2 publication Critical patent/WO1995000501A2/en
Publication of WO1995000501A3 publication Critical patent/WO1995000501A3/en
Publication of WO1995000501B1 publication Critical patent/WO1995000501B1/en
Priority to FI956119A priority patent/FI112222B/en
Priority to BG100247A priority patent/BG63161B1/en
Priority to NO955256A priority patent/NO307253B1/en
Anticipated expiration legal-status Critical
Priority to FI20012510A priority patent/FI114913B/en
Ceased legal-status Critical Current

Links

Abstract

The invention encompasses the novel compound of formula (I) useful in the treatment of cyclooxygenase-2 mediated diseases. The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of formula (I).

Claims

AMENDED CLAIMS
[received by the International Bureau on 24 April 1995 (24.04.95); original claim 25 amended; new claim 26 added (1 page)]
Figure imgf000003_0001
(c2) oxidizing the compound of formula LV to yield a compound of formula XXXIII.
26. A process according to Claim 19, 20, 21, 22, 24 or 25 wherein the compound of formula XXXIII is (a) 3-(3,4-Difluorophenyl)-4-(4-(methylsulfonyl)phenyl)-2-
(5 )-furanone, or (b) 3-phenyl-4-(4-(methylsulfonyl)phenyl)-2-(5i¥)-furanone.
PCT/CA1994/000318 1993-06-24 1994-06-09 Phenyl heterocycles as cyclooxygenase-2 inhibitors Ceased WO1995000501A2 (en)

Priority Applications (19)

Application Number Priority Date Filing Date Title
EP94918259A EP0705254B1 (en) 1993-06-24 1994-06-09 Phenyl heterocycles as cyclooxygenase-2 inhibitors
RO95-02214A RO115354B1 (en) 1993-06-24 1994-06-09 PHENYLHETEROCYCLIC COMPOUNDS, PROCESSES FOR THEIR PREPARATION, PREPARATION INTERMEDIATE, PHARMACEUTICAL COMPOSITION AND METHOD FOR TREATMENT OF AN INFLAMATIVE INFECTION
JP7502268A JP2977137B2 (en) 1993-06-24 1994-06-09 Phenyl heterocycle as cyclooxygenase-2 inhibitor
UA95125420A UA48939C2 (en) 1993-06-24 1994-06-09 Disubstituted furanons, methods for synthesis, pharmaceutical composition, method for treating inflammatory disease, intermediate substances
DK94918259T DK0705254T3 (en) 1993-06-24 1994-06-09 Phenyl heterocyclic compounds as cyclooxygenase-2 inhibitors
PL94312196A PL178203B1 (en) 1993-06-24 1994-06-09 Heterocyclic phenyl compounds as inhibitors of cyclooxygenase-2
NZ267386A NZ267386A (en) 1993-06-24 1994-06-09 Phenyl substituted heterocycles, preparation and pharmaceutical compositions thereof
HU9503319A HU227913B1 (en) 1993-06-24 1994-06-09 Phenyl heterocycles as cyclooxygenase-2 inhibitors
SK1502-95A SK284114B6 (en) 1993-06-24 1994-06-09 Phenylheterocyclic derivatives, processes for their preparation, their use and pharmaceutical compositions containing them
DE69410092T DE69410092T2 (en) 1993-06-24 1994-06-09 PHENYL HETEROCYCLEN AS CYCLOOXYGENASE-2 INHIBITORS
KR1019950705562A KR100215358B1 (en) 1993-06-24 1994-06-09 Phenyl heterocycle as cyclooxygenase-2 inhibitor
BR9406979A BR9406979A (en) 1993-06-24 1994-06-09 Compound, pharmaceutical composition for treating an inflammatory disease susceptible to treatment with a non-steroidal anti-inflammatory agent processes for treating an inflammatory disease and for preparing a pharmaceutically acceptable salt compound use of a non-steroidal anti-inflammatory pharmaceutical composition compound
RU96100763/04A RU2131423C1 (en) 1993-06-24 1994-06-09 Disubstituted furanones, thiazoles and pentenones as inhibitors of cyclooxygenase, method of their synthesis, pharmaceutical composition and method of patient treatment
AU69674/94A AU6967494A (en) 1993-06-24 1994-06-09 Phenyl heterocycles as cyclooxygenase-2 inhibitors
SI9430145T SI0705254T1 (en) 1993-06-24 1994-06-09 Phenyl heterocycles as cyclooxygenase-2 inhibitors
FI956119A FI112222B (en) 1993-06-24 1995-12-19 A process for the preparation of novel therapeutically useful furanone derivatives
BG100247A BG63161B1 (en) 1993-06-24 1995-12-21 Phenylheterocyclic compounds as inhibitors of cyclooxygenase-2
NO955256A NO307253B1 (en) 1993-06-24 1995-12-22 Phenyl heterocycles as cyclooxygenase-2 inhibitors
FI20012510A FI114913B (en) 1993-06-24 2001-12-19 Process for the preparation of therapeutically useful furanone derivatives and a starting material useful in the process

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US8219693A 1993-06-24 1993-06-24
US082,196 1993-06-24
US08/179,467 US5474995A (en) 1993-06-24 1994-01-10 Phenyl heterocycles as cox-2 inhibitors
US179,467 1994-01-10

Publications (3)

Publication Number Publication Date
WO1995000501A2 WO1995000501A2 (en) 1995-01-05
WO1995000501A3 WO1995000501A3 (en) 1995-04-13
WO1995000501B1 true WO1995000501B1 (en) 1995-05-26

Family

ID=26767192

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA1994/000318 Ceased WO1995000501A2 (en) 1993-06-24 1994-06-09 Phenyl heterocycles as cyclooxygenase-2 inhibitors

Country Status (36)

Country Link
US (5) US5474995A (en)
EP (4) EP0980866A3 (en)
JP (1) JP2977137B2 (en)
KR (1) KR100215358B1 (en)
CN (2) CN1058008C (en)
AT (1) ATE165825T1 (en)
AU (1) AU6967494A (en)
BG (1) BG63161B1 (en)
BR (1) BR9406979A (en)
CA (5) CA2176973C (en)
CY (1) CY2098B1 (en)
CZ (1) CZ288175B6 (en)
DE (1) DE69410092T2 (en)
DK (1) DK0705254T3 (en)
ES (1) ES2115237T3 (en)
FI (2) FI112222B (en)
HK (1) HK1027474A1 (en)
HR (1) HRP940373A2 (en)
HU (1) HU227913B1 (en)
IL (3) IL110031A (en)
LV (1) LV12209B (en)
MX (1) MX9404749A (en)
NO (1) NO307253B1 (en)
NZ (1) NZ267386A (en)
PL (1) PL178203B1 (en)
RO (1) RO115354B1 (en)
RU (1) RU2131423C1 (en)
SA (1) SA94150039B1 (en)
SG (1) SG52703A1 (en)
SI (1) SI0705254T1 (en)
SK (1) SK284114B6 (en)
TW (1) TW326042B (en)
UA (1) UA48939C2 (en)
WO (1) WO1995000501A2 (en)
YU (1) YU49053B (en)
ZA (1) ZA944501B (en)

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US9034585B2 (en) 2005-10-11 2015-05-19 Health Diagnostic Laboratory, Inc. Diabetes-related biomarkers and methods of use thereof

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