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WO1994021675A3 - T cell epitopes of ryegrass pollen allergen - Google Patents

T cell epitopes of ryegrass pollen allergen Download PDF

Info

Publication number
WO1994021675A3
WO1994021675A3 PCT/US1994/002537 US9402537W WO9421675A3 WO 1994021675 A3 WO1994021675 A3 WO 1994021675A3 US 9402537 W US9402537 W US 9402537W WO 9421675 A3 WO9421675 A3 WO 9421675A3
Authority
WO
WIPO (PCT)
Prior art keywords
peptides
lol
allergen
cell epitopes
diagnostic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1994/002537
Other languages
French (fr)
Other versions
WO1994021675A2 (en
Inventor
Irwin J Griffith
Mei-Chang Kuo
Mohammad Luqman
Stephen Palmer Powers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Immulogic Pharmaceutical Corp
Original Assignee
Immulogic Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immulogic Pharmaceutical Corp filed Critical Immulogic Pharmaceutical Corp
Priority to EP94912761A priority Critical patent/EP0688338A1/en
Priority to AU65175/94A priority patent/AU684501B2/en
Priority to JP6521096A priority patent/JPH08509966A/en
Priority to FI954269A priority patent/FI954269A0/en
Priority to NZ263913A priority patent/NZ263913A/en
Publication of WO1994021675A2 publication Critical patent/WO1994021675A2/en
Publication of WO1994021675A3 publication Critical patent/WO1994021675A3/en
Priority to NO953571A priority patent/NO953571L/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/16—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Botany (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The present invention provides isolated peptides of Lol p I, a major protein allergen of the species Lolium perenne. Peptides within the scope of the invention comprise at least one T cell epitope, or preferably at least two T cell epitopes of a protein allergen of Lol p I. The invention also provides modified peptides having similar or enhanced therapeutic or diagnostic properties as the corresponding, naturally-occurring allergen or portion thereof, but having additional properties, e.g., reduced side effects. The invention further provides nucleic acid sequences coding for peptides of the invention. Methods of treatment and diagnosis of sensitivity to Lol p I or an allergen immunologically related to Lol p I in an individual (such as Dac g I, Poa p I, or Phl p I) also are provided. Compositions for therapeutic, diagnostic or reagent uses comprising one or more peptides of the invention are also provided.
PCT/US1994/002537 1993-03-12 1994-03-09 T cell epitopes of ryegrass pollen allergen Ceased WO1994021675A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
EP94912761A EP0688338A1 (en) 1993-03-12 1994-03-09 T cell epitopes of ryegrass pollen allergen
AU65175/94A AU684501B2 (en) 1993-03-12 1994-03-09 T cell epitopes of ryegrass pollen allergen
JP6521096A JPH08509966A (en) 1993-03-12 1994-03-09 T cell epitopes of ryegrass pollen allergen
FI954269A FI954269A0 (en) 1993-03-12 1994-03-09 T cell epitopes of ryegrass pollen allergen
NZ263913A NZ263913A (en) 1993-03-12 1994-03-09 Lol pi protein allergen from ryegrass and related peptides coding sequences, vectors, protein production and use
NO953571A NO953571L (en) 1993-03-12 1995-09-11 T-cell epitopes of common raigress pollen allergen

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3100193A 1993-03-12 1993-03-12
US08/031,001 1993-03-12

Publications (2)

Publication Number Publication Date
WO1994021675A2 WO1994021675A2 (en) 1994-09-29
WO1994021675A3 true WO1994021675A3 (en) 1994-11-10

Family

ID=21857138

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1994/002537 Ceased WO1994021675A2 (en) 1993-03-12 1994-03-09 T cell epitopes of ryegrass pollen allergen

Country Status (10)

Country Link
EP (1) EP0688338A1 (en)
JP (1) JPH08509966A (en)
AU (1) AU684501B2 (en)
CA (1) CA2157596A1 (en)
FI (1) FI954269A0 (en)
IL (1) IL108940A0 (en)
NO (1) NO953571L (en)
NZ (1) NZ263913A (en)
WO (1) WO1994021675A2 (en)
ZA (1) ZA941708B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8652485B2 (en) 2007-08-15 2014-02-18 Circassia Limited Peptide for vaccine
US9168295B2 (en) 2007-06-01 2015-10-27 Circassia Limited Vaccine peptide combinations

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5858689A (en) * 1993-07-22 1999-01-12 Ludwig Institute For Cancer Research Isolated peptides derived from the gage tumor rejection antigen precursor and uses thereof
SE9402089D0 (en) 1994-06-14 1994-06-14 Rudolf Valenta Recombinant allergen, fragments thereof, corresponding recombinant DNA molecules, vectors and hosts containing the DNA molecules, diagnostic and therapeutic uses of said allergens and fragments
US6759234B1 (en) 1994-09-02 2004-07-06 Immulogic Pharmaceutical Corporation Compositions and methods for administering to humans, peptides capable of down regulating an antigen specific immune response
NZ273815A (en) * 1994-09-02 1999-05-28 Immulogic Pharma Corp Peptide compositions for treating protein allergies or autoimmune diseases containing at least two isolated and purified peptides
US6737406B1 (en) 1996-03-21 2004-05-18 Circassia, Ltd. Cryptic peptides and method for their identification
US5817463A (en) * 1996-06-28 1998-10-06 Abbott Laboratories Nucleic acid primers and probes for detecting Mycoplasma pneumoniae
AU743647B2 (en) 1998-01-31 2002-01-31 Mt. Sinai School Of Medicine Of New York University Methods and reagents for decreasing allergic reactions
US7879977B2 (en) 1998-01-31 2011-02-01 University Of Arkansas Methods and reagents for decreasing clinical reaction to allergy
US8246945B2 (en) 2000-04-06 2012-08-21 University Of Arkansas Methods and reagents for decreasing clinical reaction to allergy
US8153414B2 (en) 2000-04-06 2012-04-10 Allertein Therapeutics, Llc Microbial delivery system
FR2809415B1 (en) * 2000-05-29 2004-10-08 Tabacs & Allumettes Ind CLONING AND SEQUENCING OF DAC G1 ALLERGEN FROM DACTILYS GLOMERATA POLLEN, ITS PREPARATION AND ITS USE
AUPR779201A0 (en) * 2001-09-20 2001-10-11 University Of Melbourne, The Immunotherapeutic and immunoprophylactic reagents
AU2003213861B2 (en) * 2002-04-02 2010-04-29 Circassia Limited Immunotherapeutic and immunoprophylactic reagents
AUPS148202A0 (en) * 2002-04-02 2002-05-09 Monash University Immunotherapeutic and immunoprophylactic reagents
SG173523A1 (en) * 2009-02-05 2011-09-29 Circassia Ltd Peptides for vaccine
EP2249162A1 (en) * 2009-04-30 2010-11-10 Stallergenes Sa Method for grass species identification
WO2017004561A1 (en) 2015-07-01 2017-01-05 Alk-Abelló A/S Peptide combinations and uses thereof for treating grass allergy
WO2019038668A1 (en) 2017-08-21 2019-02-28 Glycom A/S Synthetic composition for reducing allergy symptoms

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989009260A1 (en) * 1988-03-23 1989-10-05 The University Of Melbourne Ryegrass pollen allergen
WO1992003550A1 (en) * 1990-08-17 1992-03-05 The University Of Melbourne Ryegrass pollen allergen
WO1993004174A1 (en) * 1991-08-16 1993-03-04 The University Of Melbourne Ryegrass pollen allergen

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989009260A1 (en) * 1988-03-23 1989-10-05 The University Of Melbourne Ryegrass pollen allergen
WO1992003550A1 (en) * 1990-08-17 1992-03-05 The University Of Melbourne Ryegrass pollen allergen
WO1993004174A1 (en) * 1991-08-16 1993-03-04 The University Of Melbourne Ryegrass pollen allergen

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9168295B2 (en) 2007-06-01 2015-10-27 Circassia Limited Vaccine peptide combinations
US8652485B2 (en) 2007-08-15 2014-02-18 Circassia Limited Peptide for vaccine
US9340580B2 (en) 2007-08-15 2016-05-17 Circassia Limited Peptide with multiple epitopes

Also Published As

Publication number Publication date
FI954269L (en) 1995-09-12
AU684501B2 (en) 1997-12-18
NO953571L (en) 1995-11-10
FI954269A7 (en) 1995-09-12
ZA941708B (en) 1994-10-05
JPH08509966A (en) 1996-10-22
WO1994021675A2 (en) 1994-09-29
CA2157596A1 (en) 1994-09-29
IL108940A0 (en) 1994-06-24
FI954269A0 (en) 1995-09-12
NO953571D0 (en) 1995-09-11
AU6517594A (en) 1994-10-11
EP0688338A1 (en) 1995-12-27
NZ263913A (en) 1997-10-24

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