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WO1994008977A1 - Caprolactames substitues et leurs derives, utiles dans le traitement du sida - Google Patents

Caprolactames substitues et leurs derives, utiles dans le traitement du sida Download PDF

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Publication number
WO1994008977A1
WO1994008977A1 PCT/US1993/009807 US9309807W WO9408977A1 WO 1994008977 A1 WO1994008977 A1 WO 1994008977A1 US 9309807 W US9309807 W US 9309807W WO 9408977 A1 WO9408977 A1 WO 9408977A1
Authority
WO
WIPO (PCT)
Prior art keywords
substituted
alkyl
hydrogen
following
nr13r14
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1993/009807
Other languages
English (en)
Inventor
Carl Nicholas Hodge
Christina Howard Fernandez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Pharma Co
Original Assignee
DuPont Merck Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DuPont Merck Pharmaceutical Co filed Critical DuPont Merck Pharmaceutical Co
Priority to AU53595/94A priority Critical patent/AU5359594A/en
Publication of WO1994008977A1 publication Critical patent/WO1994008977A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/06—Seven-membered rings having the hetero atoms in positions 1 and 4 not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D245/00—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms
    • C07D245/02—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D255/00—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00
    • C07D255/02—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00 not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02—Seven-membered rings
    • C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D267/10—Seven-membered rings having the hetero atoms in positions 1 and 4 not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Nouveaux caprolactames substitués de la formule (I), comprenant des 4-azacaprolactames, et dérivés desdits caprolactames qui inhibent la protéase du VIH et sont utiles pour traiter le sida. Des compositions pharmaceutiques contenant ces caprolactames substitués et des méthodes d'utilisation desdits caprolactames dans le traitement du sida sont également décrits.
PCT/US1993/009807 1992-10-22 1993-10-20 Caprolactames substitues et leurs derives, utiles dans le traitement du sida Ceased WO1994008977A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU53595/94A AU5359594A (en) 1992-10-22 1993-10-20 Substituted caprolactams and derivatives thereof useful for treatment of aids

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US96506192A 1992-10-22 1992-10-22
US07/965,061 1992-10-22

Publications (1)

Publication Number Publication Date
WO1994008977A1 true WO1994008977A1 (fr) 1994-04-28

Family

ID=25509378

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1993/009807 Ceased WO1994008977A1 (fr) 1992-10-22 1993-10-20 Caprolactames substitues et leurs derives, utiles dans le traitement du sida

Country Status (2)

Country Link
AU (1) AU5359594A (fr)
WO (1) WO1994008977A1 (fr)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994022840A1 (fr) * 1993-03-30 1994-10-13 The Du Pont Merck Pharmaceutical Company Caprolactames substitues et leurs derives pour le traitement d'affections liees au vih
WO1996005180A1 (fr) * 1994-08-09 1996-02-22 Abbott Laboratories 1,2,4,-triazacycloheptanes inhibant la protease de retrovirus
US5610294A (en) * 1991-10-11 1997-03-11 The Du Pont Merck Pharmaceutical Company Substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors
US5683999A (en) * 1995-03-17 1997-11-04 The Dupont Merck Pharmaceutical Company Cyclic urea HIV protease inhibitors
US5763469A (en) * 1995-08-22 1998-06-09 The Dupont Merck Pharmaceutical Company Substituted cyclic ureas and derivatives thereof useful as retroviral protease inhibitors
US6313110B1 (en) 1999-06-02 2001-11-06 Dupont Pharmaceuticals Company Substituted 2H-1,3-diazapin-2-one useful as an HIV protease inhibitor
USRE37781E1 (en) 1991-10-11 2002-07-02 Dupont Pharmaceuticals Company Substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors
WO2007074171A1 (fr) * 2005-12-29 2007-07-05 Immupharma France Sa Heterocycles aza destines au traitement du paludisme ou du sida
US7777030B2 (en) 2005-12-29 2010-08-17 Centre National de la Recherge Scientifique (CNRS) Compositions and methods for the treatment and prevention of disease

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992009297A1 (fr) * 1990-11-30 1992-06-11 Smithkline Beecham Corporation Inhibiteurs de la protease du vih

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992009297A1 (fr) * 1990-11-30 1992-06-11 Smithkline Beecham Corporation Inhibiteurs de la protease du vih

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5610294A (en) * 1991-10-11 1997-03-11 The Du Pont Merck Pharmaceutical Company Substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors
USRE37781E1 (en) 1991-10-11 2002-07-02 Dupont Pharmaceuticals Company Substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors
US5663333A (en) * 1992-10-22 1997-09-02 The Dupont Merck Pharmaceutical Company Substituted 1,4-diazapine caprolactams useful for treatment of HIV disease
WO1994022840A1 (fr) * 1993-03-30 1994-10-13 The Du Pont Merck Pharmaceutical Company Caprolactames substitues et leurs derives pour le traitement d'affections liees au vih
WO1996005180A1 (fr) * 1994-08-09 1996-02-22 Abbott Laboratories 1,2,4,-triazacycloheptanes inhibant la protease de retrovirus
US5683999A (en) * 1995-03-17 1997-11-04 The Dupont Merck Pharmaceutical Company Cyclic urea HIV protease inhibitors
US5763469A (en) * 1995-08-22 1998-06-09 The Dupont Merck Pharmaceutical Company Substituted cyclic ureas and derivatives thereof useful as retroviral protease inhibitors
US6313110B1 (en) 1999-06-02 2001-11-06 Dupont Pharmaceuticals Company Substituted 2H-1,3-diazapin-2-one useful as an HIV protease inhibitor
WO2007074171A1 (fr) * 2005-12-29 2007-07-05 Immupharma France Sa Heterocycles aza destines au traitement du paludisme ou du sida
US7777030B2 (en) 2005-12-29 2010-08-17 Centre National de la Recherge Scientifique (CNRS) Compositions and methods for the treatment and prevention of disease

Also Published As

Publication number Publication date
AU5359594A (en) 1994-05-09

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