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WO1993023007A1 - Compositions d'hygiene buccale contenant des materiaux a base de silice presentant une compatibilite amelioree - Google Patents

Compositions d'hygiene buccale contenant des materiaux a base de silice presentant une compatibilite amelioree Download PDF

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Publication number
WO1993023007A1
WO1993023007A1 PCT/US1993/004716 US9304716W WO9323007A1 WO 1993023007 A1 WO1993023007 A1 WO 1993023007A1 US 9304716 W US9304716 W US 9304716W WO 9323007 A1 WO9323007 A1 WO 9323007A1
Authority
WO
WIPO (PCT)
Prior art keywords
composition
silica
therapeutic agent
fluoride
compatibility
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1993/004716
Other languages
English (en)
Inventor
James Neil Pryor
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
WR Grace and Co Conn
WR Grace and Co
Original Assignee
WR Grace and Co Conn
WR Grace and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by WR Grace and Co Conn, WR Grace and Co filed Critical WR Grace and Co Conn
Priority to EP93911349A priority Critical patent/EP0641191A4/fr
Priority to JP6503818A priority patent/JPH08502034A/ja
Publication of WO1993023007A1 publication Critical patent/WO1993023007A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/25—Silicon; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Definitions

  • compositions such as dentifrices, lozenges, chewing gums, etc.
  • constituents such as therapeutic agents, carrier fluids, humectants, abrasives, thickeners, flavorings, fragrances, etc.
  • these constituents are typically selected based on various criteria such as cost, efficacy and compatibility.
  • Compatibility refers to the interaction between the various constituents when they are put together into a single composition. Compatibility is concerned with how any interaction between the various constituents may affect the efficacy of the individual constituents. While there may be situations where the efficacy of constituents is enhanced by combination in' a single composition, the goal often is to find combinations of constituents which have a minimum adverse interaction. Since the performance of the therapeutic agent(s) is generally most important for the overall performance of the dentifrice composition, the other constituents are often chosen based on their compatibility with the therapeutic agent(s) to be used.
  • Fluoride-based agents are most widely known and used for their proven anti-caries effects, however there are numerous other therapeutic agents which have been developed to address other oral care objectives such as fighting calculus, plaque, bacteria, etc.
  • U.S. Patent 5,015,467 (Smitherman) gives a good review and discussion of therapeutic agents for oral care.
  • non- fluoride agents include pyridinium salts such as cetyl pyridinium chloride (CPC) , guanidines such as chlorhexadine, triclosan, sanguinaria, zinc salts, copper salts, etc.
  • Silica particles have been widely used in oral care compositions as abrasives and/or thickeners, silica particles are generally porous, amorphous silicas having fine particle size. Typical silica particles have surface areas of about 50-800 m 2 /g. Silica particles used as abrasives generally have pore volumes of about 0.3-1.0 cc/g whereas silica particles used as thickeners may have pore higher pore volumes up to or greater than 1.5 cc/g. Conventional silicas generally have surface hydroxyl groups which are bonded to silicon atoms on the silica surface as SiOH (silanol) groups. Silicas used in dentifrice compositions generally have about 4-8 SiOH groups per nanometer squared.
  • Silica particles are known to exhibit good compatibility fluoride-based therapeutic agents. Although the silica particles have relatively large surface area, only a small amount of the fluoride species is adsorbed on the silica. Thus, most of the fluoride species in the composition remains available in the oral care composition to perform its therapeutic function in the oral cavity.
  • Non-fluoride therapeutic agents often contain nonionic or cationic species which tend to be adsorbed onto the silica surface. Thus, less of the therapeutic agent is available to perform its therapeutic function in the oral cavity. The problem is especially acute for high surface area/pore volume silicas which are used as thickeners.
  • the present invention solves the compatibility problem between silica and therapeutic agents, especially non-fluoride therapeutic agents.
  • the invention involves the modification of conventional silica and use of the modified silica in oral care compositions containing therapeutic agents.
  • the invention encompasses oral care compositions containing silica particles and at least one therapeutic agent wherein the improvement comprises using silica particles which have been at least partially
  • the thermal treatment embodiment involves heating the silica particles to cause dehydroxylation.
  • the heating is preferably performed at about 350°-850°C for a time sufficient to produce some increase in compatibility.
  • the invention encompasses oral care compositions containing silica particles and at least one therapeutic agent wherein the improvement comprises using silica particles which have been at least partially dehydroxylated by reacting the silica with a dehydroxylating agent selected from the group consisting of alcohols, silanes, and organosilanes.
  • the silica may be subjected to a combination of the thermal and chemical dehydroxylation treatments. While the two treatments may be carried out in any order, preferably the thermal treatment is performed prior to the chemical treatment.
  • modified silicas of the invention provide significantly improved compatibility with therapeutic agents, especially non-fluoride therapeutic agents.
  • the improved compatibility of the invention does not require highly acidic pH.
  • the invention involves the modification of conventional silicas used in oral care compositions by thermal and/or chemical treatment to improve the compatibility between the silica and therapeutic agents.
  • the thermal treatment may be performed by simply heating the silica to cause dehydroxylation.
  • the heating is performed at about 300°-850°C for about 1 - 3 hours.
  • the heating may be performed in air or any other suitable atmosphere.
  • the heating may be performed at reduced pressure to facilitate removal of gases evolving from the dehydroxylation (i.e. H0) .
  • the extent of thermal dehydroxylation can be measured by determining the loss on ignition (LOI) for the silica.
  • the LOI is determined by first predrying the sample at 130°C for about four hours. The predried sample is then calcined for two hours at about 960°C. The LOI is the % weight loss of the calcined sample compared to the weight of the predried sample.
  • the thermal dehydroxylation is performed to achieve silica having a loss on ignition of about 2% or less, more preferably about 1% or less.
  • Thermal dehydroxylation may be accompanied by reduction in porosity and surface area.
  • the thermal treatment is not performed to such an extent as to result in a loss of all porosity.
  • the thermally treated particles have a pore volume of at least about 0.3-1.5 cc/g.
  • the extent of thermal treatment which the silica particles can withstand may be partly a function of the porosity in the untreated particles.
  • Chemical treatment to dehydroxylate the silica may be used instead of or in addition to thermal dehy ⁇ droxylation.
  • Chemical dehydroxylation involves reacting surface hydroxyl groups on the silica with a dehydroxy ⁇ lation agent selected from the group consisting of alcohols, silanes, and organosilanes.
  • Preferred alcohols are methanol, ethanol, propanol, butanol and glycerol. Glycerol is most preferred since it is non-toxic and is widely used in commercial dentifrice formulae.
  • Chemical dehydroxylation may be performed by combining the silica with an excess amount of the dehydroxylation agent, preferably in the absence of water. The mixture is then reacted whereby some or all of the surface hydroxyl groups on the silica are replaced with a radical from the dehydroxylation agent. In the case of alcohols, an ester of the alcohol would be formed at the site where a hydroxyl group was located. The mixture may be heated to promote the reaction. Once the dehydroxylation reaction has occurred, the dehydroxylated silica may be recovered by filtration. The silica is then preferably dried or otherwise treated to remove unreacted dehydroxylation agent. If glycerol is used as the dehydroxylation agent, excess glycerol need not be removed from the silica surface assuming glycerol is to be used in the oral care composition.
  • the chemical dehydroxylation is preferably carried out enough to achieve at least some improvement in silica-therapeutic agent compatibility, more preferably at least some improvement in silica-non-fluoride thera ⁇ Commissionic agent compatibility.
  • the dehydroxy ⁇ lation reaction may be carried out to virtual completion.
  • chemical dehydroxylation generally does not result in loss of porosity. It may be advantageous to use a combination of the dehydroxylation treatments. For example, if substantially complete dehydroxylation is desired with some decrease in porosity, then a combination of thermal dehydroxylation followed by chemical dehydroxylation would be appropriate. Combinations of thermal treatments or combinations of chemical treatments can also be employed if desired. In general, chemical treatment is believed to provide better dehydroxylation of isolated surface hydroxyl groups whereas thermal dehydroxylation may provide more permanent dehydroxylation of adjacent hydroxyl pairs.
  • the measurement of extent of chemical dehydroxy- lation by measurement of LOI values may not be accurate because the radicals left at the former hydroxyl sites may also be volatilized during heating to determine LOI.
  • the compatibility of the silica with a particular therapeutic agent can be measured by comparing the availability or concentration of the therapeutic agent in a mixture at a reference pH before and after contact with the silica.
  • the compatibility of the silica may be expressed as the percentage ratio of concentration of the agent in the mixture after contact with the silica to the concentration of the agent in the mixture before silica addition.
  • the pH of the silica-containing mixture is preferably adjusted to the reference pH on addition of the silica.
  • the concentration after contact with silica is preferably measured after separation of the silica from the mixture.
  • the method of determining the concentration of the therapeutic agent may be any conventional method suitable for the particular agent (e.g. ultraviolet light absorption) .
  • the improvement in compatibility would simply in- volve comparison of the compatibility values for the untreated and treated silicas.
  • the compatibility test may be applied to all dehydroxylated silicas regardless of method of dehydroxylation. While any degree of im ⁇ provement in compatibility would be encompassed by the invention, preferably the thermal and/or chemical treat ⁇ ment of the invention results in at least about 5% improvement in compatibility in comparison with the untreated silica.
  • the silica treated in accordance with the invention may be any silica conventionally used in dentifrices or other oral care compositions.
  • the silica is an amorphous silica gel (e.g. a xerogel) or an amorphous precipitated silica.
  • Amorphous silica gels and precipitated silicas are typically used in dentifrices or other oral care compositions as abrasives and/or thickeners.
  • the treatments of the invention provide improved compatibility of the silica with therapeutic agents in general at pH values commonly used in dentifrice and other oral care compositions (e.g. about 6-7) .
  • the treatments also result in improved compatibility at more acidic or basic pH levels.
  • the invention is further illustrated by the following examples. The invention is not limited to the details of the examples.
  • Example 1 A 200g sample of silica xerogel (620 m 2 /g surface area, 0.35 cc/g pore volume, 8 ⁇ median particle size) was thermally treated for two hours in a muffle furnace at 760°C.
  • Loss on ignition (LOI) defined as the % weight loss during a two hour, 960°C calcination of a predried sample (130°C) , was used to estimate the extent of dehydroxylation of the silica gel.
  • the LOI value dropped from approximately 7% for the untreated silica to less than 2% for the 760°C treated sample indicating substantial dehydroxylation.
  • the thermally treated sample was then compared to the silica xerogel starting material for CPC compatibility (availability) using the following procedure: o
  • a stock solution of 1.2 wt.% CPC in deionized water was prepared.
  • Two 1.75 gram samples of the thermally treated and of untreated silica gel were slurried (i.e. four slurries total) into 42 ml aliquots of the stock solution.
  • the pH of one thermally treated silica gel slurry and one untreated silica gel slurry was adjusted to 6 pH using a small amount of 10% NaOH solution.
  • the pH of the remaining two slurries was adjusted to 7 pH using the same NaOH solution.
  • Example 2 A thermally treated xerogel similar to that described in Example 1 except calcined at 800°C was evaluated for chlorhexidine (ChlX) availability.
  • the testing procedure was analogous to that used for determination of CPC availability except that the stock solution consisted of a 1.0 wt.% chlorhexidine digluconate in deionized water, and the UV absorbance measurement used for to determine % ChlX remaining was performed using 254 nm wavelength radiation.
  • Example 3 A glycerol-reacted silica xerogel was prepared by slurrying 100 grams of the same xerogel starting material as Example 1 into 350 mis of glycerol and boiling the slurry under vacuum for 2 hours during which time the temperature of the slurry rose to approximately 200°C. 600 mis of anhydrous roethanol were then added to the viscous slurry, and the reacted silica was removed by centrifugation and decantation. The reacted silica was then reslurried in another 600 is of anhydrous methanol, to further wash the product free of unreacted glycerol, and then filtered.
  • the reacted silica product was then dried in a vacuum oven for 16 hours at 165°C in order to remove any remaining methanol solvent.
  • An LOI value of 24.5% confirmed the substantial reaction of glycerol with the silica xerogel surface.
  • Example 4 A sample of the glycerol-reacted silica xerogel prepared according to Example 3 was also evaluated for ChlX availability using the method given in Example 2. Results given in the table below again show a superior availability with the glycerol-reacted silica gel compared to the untreated silica gel from which it was prepared.
  • Example 2 A sample of the same silica xerogel starting material of Example 1 was treated by thermal dehydroxylation followed by glycerol reaction. The thermal treatment was identical to that described in Example 1 except that the temperature of the treatment was 705°C. It was followed by a glycerol reaction step identical to that described in Example 3. The resulting sample was tested for ChlX availability using the method described in Example 2.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cosmetics (AREA)

Abstract

On améliore la compatibilité de silices avec des agents thérapeutiques contenus dans des compositions d'hygiène buccale au moyen de la déshydroxylation de la silice par: a) traitement thermique et/ou b) réaction chimique avec un agent de déshydroxylation sélectionné à partir du groupe constitué par des alcools, des silanes et des organosilanes. L'invention apporte une amélioration particulièrement bénéfique à la compatibilité entre la silice et des agents thérapeutiques non fluorurés utilisés dans le dentifrice et dans d'autres compositions d'hygiène buccale.
PCT/US1993/004716 1992-05-19 1993-05-17 Compositions d'hygiene buccale contenant des materiaux a base de silice presentant une compatibilite amelioree Ceased WO1993023007A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP93911349A EP0641191A4 (fr) 1992-05-19 1993-05-17 Compositions d'hygiene buccale contenant des materiaux a base de silice presentant une compatibilite amelioree.
JP6503818A JPH08502034A (ja) 1992-05-19 1993-05-17 改良された適合性を有する、シリカ基剤の物質を含有する口腔内保護組成物

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US88541292A 1992-05-19 1992-05-19
US07/885,412 1992-05-19

Publications (1)

Publication Number Publication Date
WO1993023007A1 true WO1993023007A1 (fr) 1993-11-25

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PCT/US1993/004716 Ceased WO1993023007A1 (fr) 1992-05-19 1993-05-17 Compositions d'hygiene buccale contenant des materiaux a base de silice presentant une compatibilite amelioree

Country Status (4)

Country Link
EP (1) EP0641191A4 (fr)
JP (1) JPH08502034A (fr)
AU (1) AU4251693A (fr)
WO (1) WO1993023007A1 (fr)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998003153A1 (fr) * 1996-07-23 1998-01-29 Rhodia Chimie Silice compatible avec les aromes, son procede de preparation et compositions dentifrices la contenant
US6946119B2 (en) * 2003-02-14 2005-09-20 J.M. Huber Corporation Precipitated silica product with low surface area, dentifrices containing same, and processes
WO2010068474A2 (fr) 2008-11-25 2010-06-17 The Procter & Gamble Company Compositions d'hygiène bucco-dentaire contenant de la silice fondue
WO2011150004A2 (fr) 2010-05-25 2011-12-01 The Procter & Gamble Company Compositions pour soins d'hygiène buccodentaire et procédés de fabrication de compositions pour soins d'hygiène buccodentaire contenant de la silice à partir de matériaux végétaux
US8551457B2 (en) 2008-11-25 2013-10-08 The Procter & Gamble Company Oral care compositions comprising spherical fused silica
WO2014071284A2 (fr) 2012-11-05 2014-05-08 The Procter & Gamble Company Silice précipitée traitée thermiquement
US20140140938A1 (en) * 2012-11-19 2014-05-22 JM Huber Corporation Treated silicas and metal silicates for improved cleaning in dentifrice
US20140271900A1 (en) * 2013-03-15 2014-09-18 J.M. Huber Corporation High Cleaning Silica with Low Abrasion and Method for Making Same
EP2442872A4 (fr) * 2009-06-16 2015-05-20 Grace W R & Co Oxydes métalliques compatibles avec les cations, et compositions pour les soins de la bouche contenant les oxydes métalliques
US11052029B2 (en) 2009-06-16 2021-07-06 W. R. Grace & Co.-Conn. Cation compatible metal oxides and oral care compositions containing the metal oxides
WO2025021570A1 (fr) 2023-07-24 2025-01-30 Evonik Operations Gmbh Silice compatible avec le peroxyde
WO2025131994A1 (fr) 2023-12-22 2025-06-26 Evonik Operations Gmbh Silice calcinée par pulvérisation dans un réacteur à flamme

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3978205A (en) * 1973-04-11 1976-08-31 Lever Brothers Company Dentifrice including luster imparting agent
EP0315503A1 (fr) * 1987-11-04 1989-05-10 Rhone-Poulenc Chimie Silice pour compositions dentifrices compatible notamment avec la chlorhexidine
EP0317378A1 (fr) * 1987-11-04 1989-05-24 Rhone-Poulenc Chimie Silice pour compositions dentifrices compatible notamment avec le zinc

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3978205A (en) * 1973-04-11 1976-08-31 Lever Brothers Company Dentifrice including luster imparting agent
EP0315503A1 (fr) * 1987-11-04 1989-05-10 Rhone-Poulenc Chimie Silice pour compositions dentifrices compatible notamment avec la chlorhexidine
EP0317378A1 (fr) * 1987-11-04 1989-05-24 Rhone-Poulenc Chimie Silice pour compositions dentifrices compatible notamment avec le zinc

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP0641191A4 *

Cited By (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998003153A1 (fr) * 1996-07-23 1998-01-29 Rhodia Chimie Silice compatible avec les aromes, son procede de preparation et compositions dentifrices la contenant
FR2751635A1 (fr) * 1996-07-23 1998-01-30 Rhone Poulenc Chimie Silice compatible avec les aromes, son procede de preparation et compositions dentifrices la contenant
US5989524A (en) * 1996-07-23 1999-11-23 Rhodia Chimie Silica compatible with flavors, process for its preparation and dentifrice compositions containing it
US6946119B2 (en) * 2003-02-14 2005-09-20 J.M. Huber Corporation Precipitated silica product with low surface area, dentifrices containing same, and processes
US7255852B2 (en) * 2003-02-14 2007-08-14 J.M. Huber Corporation Precipitated silica product, dentifrices containing same, and processes
EP2995351A1 (fr) 2008-11-25 2016-03-16 The Procter and Gamble Company Compositions de soin buccal anti-sensibilité contenant de la silice fondue
WO2010068474A2 (fr) 2008-11-25 2010-06-17 The Procter & Gamble Company Compositions d'hygiène bucco-dentaire contenant de la silice fondue
US8211406B2 (en) 2008-11-25 2012-07-03 The Procter & Gamble Company Oral care compositions with fused silica
US8211408B2 (en) 2008-11-25 2012-07-03 The Proctor & Gamble Company Low pH oral care compositions with fused silica
US8211407B2 (en) 2008-11-25 2012-07-03 The Procter & Gamble Company Method of making oral care compositions with fused silica slurries
US8211410B2 (en) 2008-11-25 2012-07-03 The Procter & Gamble Company Oral care compositions with chelants and fused silica
US8211411B2 (en) 2008-11-25 2012-07-03 The Procter & Gamble Company Oral care compositions comprising fused silica
US8211409B2 (en) 2008-11-25 2012-07-03 The Procter & Gamble Company Whitening composition with fused silica
US8216552B2 (en) 2008-11-25 2012-07-10 The Procter & Gamble Company Oral care compositions containing gel networks and fused silica
US8216553B2 (en) 2008-11-25 2012-07-10 The Procter & Gamble Company Oral care compositions with improved aesthetics and fused silica
US8221725B2 (en) 2008-11-25 2012-07-17 The Procter & Gamble Company Oral care compositions comprising spherical fused silica
US8221726B2 (en) 2008-11-25 2012-07-17 The Procter & Gamble Company Sensitivity oral care compositions
US8221724B2 (en) 2008-11-25 2012-07-17 The Procter & Gamble Company Mild oral care compositions
US8221723B2 (en) 2008-11-25 2012-07-17 The Procter & Gamble Company Oral care compositions with abrasive combinations
US8221722B2 (en) 2008-11-25 2012-07-17 The Procter & Gamble Company Antibacterial oral care compositions with fused silica
US8226932B2 (en) 2008-11-25 2012-07-24 The Procter & Gamble Company Prophy paste and weekly oral care compositions
US8293216B2 (en) 2008-11-25 2012-10-23 The Procter & Gamble Company Cleaning oral care compositions
US8551457B2 (en) 2008-11-25 2013-10-08 The Procter & Gamble Company Oral care compositions comprising spherical fused silica
US8795637B2 (en) 2008-11-25 2014-08-05 The Procter & Gamble Company Oral care compositions with fused silica
AU2009324933B2 (en) * 2008-11-25 2015-01-22 The Procter & Gamble Company Antibacterial oral care compositions with fused silica
AU2009324944B2 (en) * 2008-11-25 2014-10-16 The Procter & Gamble Company Improved cleaning oral care compositions
US11052029B2 (en) 2009-06-16 2021-07-06 W. R. Grace & Co.-Conn. Cation compatible metal oxides and oral care compositions containing the metal oxides
EP2442872A4 (fr) * 2009-06-16 2015-05-20 Grace W R & Co Oxydes métalliques compatibles avec les cations, et compositions pour les soins de la bouche contenant les oxydes métalliques
WO2011150004A2 (fr) 2010-05-25 2011-12-01 The Procter & Gamble Company Compositions pour soins d'hygiène buccodentaire et procédés de fabrication de compositions pour soins d'hygiène buccodentaire contenant de la silice à partir de matériaux végétaux
WO2014071284A2 (fr) 2012-11-05 2014-05-08 The Procter & Gamble Company Silice précipitée traitée thermiquement
US9918914B2 (en) 2012-11-05 2018-03-20 The Procter & Gamble Company Heat treated precipitated silica
WO2014071284A3 (fr) * 2012-11-05 2014-09-12 The Procter & Gamble Company Silice précipitée traitée thermiquement
CN104768520A (zh) * 2012-11-05 2015-07-08 宝洁公司 热处理的沉淀二氧化硅
AU2013337356B2 (en) * 2012-11-05 2016-12-08 The Procter & Gamble Company Heat treated precipitated silica
RU2608129C2 (ru) * 2012-11-05 2017-01-13 Дзе Проктер Энд Гэмбл Компани Термически обработанная осажденная двуокись кремния
CN104768520B (zh) * 2012-11-05 2017-06-13 宝洁公司 热处理的沉淀二氧化硅
US20140140938A1 (en) * 2012-11-19 2014-05-22 JM Huber Corporation Treated silicas and metal silicates for improved cleaning in dentifrice
KR20150084787A (ko) * 2012-11-19 2015-07-22 제이. 엠. 후버 코포레이션 치약의 개선된 세정을 위한 처리된 실리카 및 금속 실리케이트
CN104781189B (zh) * 2012-11-19 2017-02-22 J.M.休伯有限公司 用于洁牙剂中的改进的清洁的处理过的二氧化硅和金属硅酸盐
RU2613924C2 (ru) * 2012-11-19 2017-03-22 Джей.Эм. ХЬЮБЕР КОРПОРЕЙШН Обработанные оксиды кремния и силикаты металлов для улучшения чистки в средстве для ухода за зубами
CN104781189A (zh) * 2012-11-19 2015-07-15 J.M.休伯有限公司 用于洁牙剂中的改进的清洁的处理过的二氧化硅和金属硅酸盐
WO2014078066A3 (fr) * 2012-11-19 2014-09-25 J.M. Huber Corporation Silices traitées et silicates métalliques pour le nettoyage amélioré dans un dentifrice
TWI630918B (zh) * 2012-11-19 2018-08-01 美商邱博集團 用於牙膏中提升清潔之經處理的矽石及金屬矽酸鹽
KR102126825B1 (ko) * 2012-11-19 2020-06-25 에보니크 오퍼레이션즈 게엠베하 치약의 개선된 세정을 위한 처리된 실리카 및 금속 실리케이트
US9186307B2 (en) 2012-11-19 2015-11-17 J.M. Huber Corporation Treated silicas and metal silicates for improved cleaning in dentifrice
EP3960705A1 (fr) * 2012-11-19 2022-03-02 Evonik Operations GmbH Silices traitées pour le nettoyage amélioré dans un dentifrice
US20140271900A1 (en) * 2013-03-15 2014-09-18 J.M. Huber Corporation High Cleaning Silica with Low Abrasion and Method for Making Same
WO2025021570A1 (fr) 2023-07-24 2025-01-30 Evonik Operations Gmbh Silice compatible avec le peroxyde
WO2025131994A1 (fr) 2023-12-22 2025-06-26 Evonik Operations Gmbh Silice calcinée par pulvérisation dans un réacteur à flamme

Also Published As

Publication number Publication date
AU4251693A (en) 1993-12-13
JPH08502034A (ja) 1996-03-05
EP0641191A4 (fr) 1996-08-21
EP0641191A1 (fr) 1995-03-08

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