WO1993018769A3 - A new use of quinazoline derivative - Google Patents
A new use of quinazoline derivative Download PDFInfo
- Publication number
- WO1993018769A3 WO1993018769A3 PCT/JP1993/000307 JP9300307W WO9318769A3 WO 1993018769 A3 WO1993018769 A3 WO 1993018769A3 JP 9300307 W JP9300307 W JP 9300307W WO 9318769 A3 WO9318769 A3 WO 9318769A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- alkyl
- hydroxy
- protected
- prolactin
- optionally substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
A use of a compound of formula (I) in which R?1 and R2¿ are each hydrogen, halogen, nitro, amino, protected amino, hydroxyamino, lower alkyl, hydroxy, protected hydroxy, sulfamoyl, carboxy, protected carboxy, mercapto, optionally substituted heterocyclic-carbonyl, optionally substituted heterocyclic-(lower)alkyl, lower alkylthio, hydroxy(lower)alkyl or protected hydroxy(lower)alkyl, R3 is aryl which may have suitable substituent(s), and A is lower alkylene, or a pharmaceutically acceptable salt thereof, for the treatment of various diseases selected from the group consisting of cardiac hypertrophy, nephropacy such as nephritis or renal failure, arteriosclerosis, obliterans, obstructive thrombus, arterial embolus, Bürger-Grütz syndrome, acrocyanosis, chilblain, frostbite, prolactin-producing ovulation disorder, prolactin-producing pituitary tumor, puerperal galactoschesia, galactorrhea, distal hypertrophy, pituitary gigantism, mental illness, cerebrovascular diseases, tachycardia accompanied by sympathetic hypertonia, hyperaldosteronism, and diabetic complication.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB929205702A GB9205702D0 (en) | 1992-03-16 | 1992-03-16 | A new use of a quinazoline derivative |
| GB9205702.5 | 1992-03-16 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO1993018769A2 WO1993018769A2 (en) | 1993-09-30 |
| WO1993018769A3 true WO1993018769A3 (en) | 1993-11-25 |
Family
ID=10712228
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/JP1993/000307 Ceased WO1993018769A2 (en) | 1992-03-16 | 1993-03-15 | A new use of quinazoline derivative |
Country Status (2)
| Country | Link |
|---|---|
| GB (1) | GB9205702D0 (en) |
| WO (1) | WO1993018769A2 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2157208C2 (en) * | 1997-07-10 | 2000-10-10 | Институт органической и физической химии им. А.Е.Арбузова Казанского научного центра РАН | Preparation for treatment of freezing patients |
| ES2896400T3 (en) | 2014-08-01 | 2022-02-24 | Nuevolution As | Active compounds against bromdomains |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0436157A1 (en) * | 1990-01-02 | 1991-07-10 | Fujisawa Pharmaceutical Co., Ltd. | Quinazoline derivatives and their preparation |
| WO1993005035A1 (en) * | 1991-09-06 | 1993-03-18 | Fujisawa Pharmaceutical Co., Ltd. | Quinazoline derivatives and their preparation |
-
1992
- 1992-03-16 GB GB929205702A patent/GB9205702D0/en active Pending
-
1993
- 1993-03-15 WO PCT/JP1993/000307 patent/WO1993018769A2/en not_active Ceased
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0436157A1 (en) * | 1990-01-02 | 1991-07-10 | Fujisawa Pharmaceutical Co., Ltd. | Quinazoline derivatives and their preparation |
| WO1993005035A1 (en) * | 1991-09-06 | 1993-03-18 | Fujisawa Pharmaceutical Co., Ltd. | Quinazoline derivatives and their preparation |
Non-Patent Citations (3)
| Title |
|---|
| CARDIOVASCULAR DRUGS AND THERAPY vol. 4, no. S1, 1990, pages 73 - 84 C. COBO ET AL. ,V. COTO ET AL. , G.P. VYSSOULIS ET AL. 'EFFECTS OF KETANSERIN ON LEFT VENTRICULAR HYPERTROPHY IN HYPERTENSIVE PATIENTS, REGRESSION OF LEFT VENTRICULAR HYPERTROPHY AND SYSTOLIC FUNCTION IN HYPERTENSIVE PATIENTS DURING LONG-TERM TREATMENT WITH KETANSERIN, LEFT VENTRICULAR HYPERTROPHY REGRESSION AND FUNCTION CHANGES WITH KETANSERIN ...' * |
| GENERAL PHARMACOLOGY vol. 20, no. 6, 1989, pages 755 - 758 M. MIDOL-MONNET ET AL. 'STUDY ON THE MECHANISM OF 5-HT-INDUCED TACHYCARDIA IN THE PITHED RAT' * |
| JOURNAL OF CARDIOVASCULAR PHARMACOLOGY vol. 7, no. S7, 1985, pages S70 - S75 S. SAMAN ET AL. 'SEROTONIN AND THE HEART: EFFECTS OF KETANSERIN ON MYOCARDIAL FUNCTION, HEART RATE, AND ARRHYTHMIAS' * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO1993018769A2 (en) | 1993-09-30 |
| GB9205702D0 (en) | 1992-04-29 |
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| 122 | Ep: pct application non-entry in european phase |