[go: up one dir, main page]

WO1993017651A3 - Antiviral nucleoside analogues, their production and use - Google Patents

Antiviral nucleoside analogues, their production and use Download PDF

Info

Publication number
WO1993017651A3
WO1993017651A3 PCT/DE1993/000213 DE9300213W WO9317651A3 WO 1993017651 A3 WO1993017651 A3 WO 1993017651A3 DE 9300213 W DE9300213 W DE 9300213W WO 9317651 A3 WO9317651 A3 WO 9317651A3
Authority
WO
WIPO (PCT)
Prior art keywords
production
nucleoside analogues
antiviral nucleoside
antiviral
disclosed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/DE1993/000213
Other languages
German (de)
French (fr)
Other versions
WO1993017651A2 (en
Inventor
Eckart Matthes
Janta-Lipinski Martin Von
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Max Delbrueck Centrum fuer Molekulare in der Helmholtz Gemeinschaft
Original Assignee
Max Delbrueck Centrum fuer Molekulare in der Helmholtz Gemeinschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max Delbrueck Centrum fuer Molekulare in der Helmholtz Gemeinschaft filed Critical Max Delbrueck Centrum fuer Molekulare in der Helmholtz Gemeinschaft
Publication of WO1993017651A2 publication Critical patent/WO1993017651A2/en
Publication of WO1993017651A3 publication Critical patent/WO1993017651A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

New and known nucleoside analogues particularly effective against hepatitis B and HIV infections are disclosed, as well as their production and use.
PCT/DE1993/000213 1992-03-04 1993-03-03 Antiviral nucleoside analogues, their production and use Ceased WO1993017651A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19924207363 DE4207363A1 (en) 1992-03-04 1992-03-04 ANTIVIRAL NUCLEOSIDE ANALOGS, THEIR PRODUCTION AND THEIR PHARMACEUTICAL USE
DEP4207363.4 1992-03-04

Publications (2)

Publication Number Publication Date
WO1993017651A2 WO1993017651A2 (en) 1993-09-16
WO1993017651A3 true WO1993017651A3 (en) 1993-11-25

Family

ID=6453548

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE1993/000213 Ceased WO1993017651A2 (en) 1992-03-04 1993-03-03 Antiviral nucleoside analogues, their production and use

Country Status (2)

Country Link
DE (1) DE4207363A1 (en)
WO (1) WO1993017651A2 (en)

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9109001B2 (en) 2012-05-22 2015-08-18 Idenix Pharmaceuticals, Inc. 3′,5′-cyclic phosphoramidate prodrugs for HCV infection
US9187515B2 (en) 2013-04-01 2015-11-17 Idenix Pharmaceuticals Llc 2′,4′-fluoro nucleosides for the treatment of HCV
US9192621B2 (en) 2012-09-27 2015-11-24 Idenix Pharmaceuticals Llc Esters and malonates of SATE prodrugs
US9211300B2 (en) 2012-12-19 2015-12-15 Idenix Pharmaceuticals Llc 4′-fluoro nucleosides for the treatment of HCV
US9243025B2 (en) 2011-03-31 2016-01-26 Idenix Pharmaceuticals, Llc Compounds and pharmaceutical compositions for the treatment of viral infections
US9296778B2 (en) 2012-05-22 2016-03-29 Idenix Pharmaceuticals, Inc. 3′,5′-cyclic phosphate prodrugs for HCV infection
US9309275B2 (en) 2013-03-04 2016-04-12 Idenix Pharmaceuticals Llc 3′-deoxy nucleosides for the treatment of HCV
US9403863B2 (en) 2011-09-12 2016-08-02 Idenix Pharmaceuticals Llc Substituted carbonyloxymethylphosphoramidate compounds and pharmaceutical compositions for the treatment of viral infections
US10005779B2 (en) 2013-06-05 2018-06-26 Idenix Pharmaceuticals Llc 1′,4′-thio nucleosides for the treatment of HCV
US10202411B2 (en) 2014-04-16 2019-02-12 Idenix Pharmaceuticals Llc 3′-substituted methyl or alkynyl nucleosides nucleotides for the treatment of HCV
US10231986B2 (en) 2013-03-13 2019-03-19 Idenix Pharmaceuticals Llc Amino acid phosphoramidate pronucleotides of 2′-cyano, azido and amino nucleosides for the treatment of HCV
US10238680B2 (en) 2013-08-01 2019-03-26 Idenix Pharmaceuticals Llc D-amino acid phosphoramidate pronucleotides of halogeno pyrimidine compounds for liver disease
US10513534B2 (en) 2012-10-08 2019-12-24 Idenix Pharmaceuticals Llc 2′-chloro nucleoside analogs for HCV infection
US10717758B2 (en) 2012-05-22 2020-07-21 Idenix Pharmaceuticals Llc D-amino acid compounds for liver disease

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995022330A1 (en) * 1994-02-17 1995-08-24 Commonwealth Scientific And Industrial Research Organisation Antiviral agents
BR0111196A (en) 2000-05-26 2004-04-06 Idenix Cayman Ltd Compositions and use thereof for treatment of flaviviruses and pestiviruses
GB0114286D0 (en) 2001-06-12 2001-08-01 Hoffmann La Roche Nucleoside Derivatives
HUE033832T2 (en) 2002-11-15 2018-01-29 Idenix Pharmaceuticals Llc 2'-methyl nucleosides in combination with interferon and flaviviridae mutation
CN100351264C (en) * 2002-11-19 2007-11-28 霍夫曼-拉罗奇有限公司 Antiviral nucleoside derivatives
TWI332507B (en) * 2002-11-19 2010-11-01 Hoffmann La Roche Antiviral nucleoside derivatives
EP1937825B1 (en) * 2005-09-26 2016-12-21 Gilead Pharmasset LLC Modified 4'-nucleosides as antiviral agents
US7951789B2 (en) 2006-12-28 2011-05-31 Idenix Pharmaceuticals, Inc. Compounds and pharmaceutical compositions for the treatment of viral infections
JP6138118B2 (en) * 2011-07-29 2017-05-31 ケンブリッジ エピジェネティクス リミテッド Method for detecting nucleotide modification
PL2861611T3 (en) 2012-05-25 2017-08-31 Janssen Sciences Ireland Uc Uracyl spirooxetane nucleosides
WO2014137930A1 (en) 2013-03-04 2014-09-12 Idenix Pharmaceuticals, Inc. Thiophosphate nucleosides for the treatment of hcv
CN104193801A (en) * 2014-08-12 2014-12-10 苏州维泰生物技术有限公司 Guanine peptide nucleic acid monomer and synthetic method thereof
JP7371931B2 (en) * 2018-03-07 2023-10-31 エモリー ユニバーシティー 4'-Halogen-containing nucleotide and nucleoside therapeutic compositions and uses related thereto

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0277599A2 (en) * 1987-01-30 1988-08-10 Asahi Glass Company Ltd. Fluorine containing cyclopentane derivatives and processes for their production
EP0322384A1 (en) * 1987-11-03 1989-06-28 Medivir Aktiebolag Nucleosides for use in therapy
EP0375183A1 (en) * 1988-12-05 1990-06-27 Schering Corporation Antiviral dimers and trimers
WO1991019727A1 (en) * 1990-06-19 1991-12-26 Sloan-Kettering Institute For Cancer Research 5'-hydrogenphosphonates and 5'-methylphosphonates of sugar modified nucleosides, compositions and uses thereof
EP0464642A1 (en) * 1990-07-02 1992-01-08 Hoechst Aktiengesellschaft Pyrimidine derivatives, their preparation and use as well as medicaments containing them
EP0302760B1 (en) * 1987-08-07 1992-07-29 The Governors of the University of Alberta Antiviral therapy for hepatitis b using 2',3'-dideoxynucleosides

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0277599A2 (en) * 1987-01-30 1988-08-10 Asahi Glass Company Ltd. Fluorine containing cyclopentane derivatives and processes for their production
EP0302760B1 (en) * 1987-08-07 1992-07-29 The Governors of the University of Alberta Antiviral therapy for hepatitis b using 2',3'-dideoxynucleosides
EP0322384A1 (en) * 1987-11-03 1989-06-28 Medivir Aktiebolag Nucleosides for use in therapy
EP0375183A1 (en) * 1988-12-05 1990-06-27 Schering Corporation Antiviral dimers and trimers
WO1991019727A1 (en) * 1990-06-19 1991-12-26 Sloan-Kettering Institute For Cancer Research 5'-hydrogenphosphonates and 5'-methylphosphonates of sugar modified nucleosides, compositions and uses thereof
EP0464642A1 (en) * 1990-07-02 1992-01-08 Hoechst Aktiengesellschaft Pyrimidine derivatives, their preparation and use as well as medicaments containing them

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JOURNAL OF ORGANIC CHEMISTRY. Bd. 41, Nr. 18, 3. September 1976, EASTON US Seiten 3010 - 3017 G.R.OWEN ET AL. '4'-Substituted Nucleosides. 3.Synthesis of Some 4'-Fluorouridine Derivatives.' *
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. Bd. 98, Nr. 11, 26. Mai 1976, GASTON, PA US Seiten 3346 - 3357 I.D.JENKINS ET AL. '4'-Substituted Nucleosides. 2. Synthesis of the Nucleoside Antibiotic Nucleocidin.' *

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9243025B2 (en) 2011-03-31 2016-01-26 Idenix Pharmaceuticals, Llc Compounds and pharmaceutical compositions for the treatment of viral infections
US9403863B2 (en) 2011-09-12 2016-08-02 Idenix Pharmaceuticals Llc Substituted carbonyloxymethylphosphoramidate compounds and pharmaceutical compositions for the treatment of viral infections
US10717758B2 (en) 2012-05-22 2020-07-21 Idenix Pharmaceuticals Llc D-amino acid compounds for liver disease
US9296778B2 (en) 2012-05-22 2016-03-29 Idenix Pharmaceuticals, Inc. 3′,5′-cyclic phosphate prodrugs for HCV infection
US9109001B2 (en) 2012-05-22 2015-08-18 Idenix Pharmaceuticals, Inc. 3′,5′-cyclic phosphoramidate prodrugs for HCV infection
US9192621B2 (en) 2012-09-27 2015-11-24 Idenix Pharmaceuticals Llc Esters and malonates of SATE prodrugs
US10513534B2 (en) 2012-10-08 2019-12-24 Idenix Pharmaceuticals Llc 2′-chloro nucleoside analogs for HCV infection
US9211300B2 (en) 2012-12-19 2015-12-15 Idenix Pharmaceuticals Llc 4′-fluoro nucleosides for the treatment of HCV
US9309275B2 (en) 2013-03-04 2016-04-12 Idenix Pharmaceuticals Llc 3′-deoxy nucleosides for the treatment of HCV
US10231986B2 (en) 2013-03-13 2019-03-19 Idenix Pharmaceuticals Llc Amino acid phosphoramidate pronucleotides of 2′-cyano, azido and amino nucleosides for the treatment of HCV
US9187515B2 (en) 2013-04-01 2015-11-17 Idenix Pharmaceuticals Llc 2′,4′-fluoro nucleosides for the treatment of HCV
US10005779B2 (en) 2013-06-05 2018-06-26 Idenix Pharmaceuticals Llc 1′,4′-thio nucleosides for the treatment of HCV
US10238680B2 (en) 2013-08-01 2019-03-26 Idenix Pharmaceuticals Llc D-amino acid phosphoramidate pronucleotides of halogeno pyrimidine compounds for liver disease
US10202411B2 (en) 2014-04-16 2019-02-12 Idenix Pharmaceuticals Llc 3′-substituted methyl or alkynyl nucleosides nucleotides for the treatment of HCV

Also Published As

Publication number Publication date
WO1993017651A2 (en) 1993-09-16
DE4207363A1 (en) 1993-09-09

Similar Documents

Publication Publication Date Title
WO1993017651A3 (en) Antiviral nucleoside analogues, their production and use
CA2068943A1 (en) 1,3-oxathiolanes useful in the treatment of hepatitis
NL960025I1 (en) Substituted 1,3-oxathiolanes with antiviral activity.
AU6924796A (en) 1,3-oxathiolane nucleoside analogues in the treatment of hepatitis c
AU3453993A (en) New liponucleotides, their preparation and their use as antiviral medicaments
FI942106L (en) Concentrated, water-based, surfactant-containing formulations
FI891716L (en) HIV PROTEASINHIBITORER, SOM AER ANVAENDBARA VID BEHANDLING AV AIDS.
EP0334368A3 (en) Production of 2',3'-dideoxy-2',3'-didehydronucleosides
ZA913293B (en) 1,3-oxathiolane nucleoside analogues
AU1437292A (en) Antiviral 1,3-dioxolane nucleosides and synthesis thereof
AU2001248331A1 (en) Medicaments against viral diseases
SG68541A1 (en) 1,3-oxathiolane nucleoside analogues
FI893962L (en) VID VAORD AV AIDS ANVAENDBARA HIV PROTEAS INHIBITORER.
EP1164133A3 (en) Enantiomerically pure Beta-D-(-)-dioxolane-nucleosides
AU7855191A (en) 2',3'-dideoxy-4'-thioribonucleosides as antiviral agents
CA2143204A1 (en) Use of Dideoxy Nucleoside Analogues in the Treatment of Viral Infections
DE69000743D1 (en) ANTIVIRAL TETRAHYDROIMIDAZO (1,4) BENZODIAZEPINE-2-THIONE.
FI912376A7 (en) ANTIVIRAL AEMNEN.
ZA949151B (en) 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents.
FI893948A0 (en) ANTIVIRAL BEHANDLINGSFOERFARANDE.
CA2120743A1 (en) Antiviral acyclic phosphonomethoxyalkyl substituted, alkenyl and alkynyl purine and pyrimidine derivatives
HUP0100087A3 (en) Nucleosides analogues, the use thereof for producing medicaments useful against retroviral infections and hepatitis b virus and the same medicaments
DE68918215D1 (en) 2'-halomethylidene, 2'-ethenylidene and 2'-ethynyl adenosine derivatives.
AU642751B2 (en) New embodiments of the HIV principal neutralizing determinant
AU3170193A (en) Therapeutic nucleosides

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): JP US

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE

AK Designated states

Kind code of ref document: A3

Designated state(s): JP US

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
122 Ep: pct application non-entry in european phase