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WO1993013779A3 - Utilisation de diphosphoglucose d'uridine en tant qu'antidote electif dans le traitement therapeutique de cancers - Google Patents

Utilisation de diphosphoglucose d'uridine en tant qu'antidote electif dans le traitement therapeutique de cancers Download PDF

Info

Publication number
WO1993013779A3
WO1993013779A3 PCT/US1991/007613 US9107613W WO9313779A3 WO 1993013779 A3 WO1993013779 A3 WO 1993013779A3 US 9107613 W US9107613 W US 9107613W WO 9313779 A3 WO9313779 A3 WO 9313779A3
Authority
WO
WIPO (PCT)
Prior art keywords
udpg
cancer therapy
rescue agent
therapy rescue
antipyrimidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1991/007613
Other languages
English (en)
Other versions
WO1993013779A2 (fr
Inventor
Robert L Stolfi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics SpA
Original Assignee
Boehringer Mannheim Italia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Italia SpA filed Critical Boehringer Mannheim Italia SpA
Priority to AU41001/93A priority Critical patent/AU4100193A/en
Priority to PCT/US1991/007613 priority patent/WO1993013779A2/fr
Priority to EP93910550A priority patent/EP0617625A1/fr
Priority to JP5510416A priority patent/JPH07501810A/ja
Publication of WO1993013779A2 publication Critical patent/WO1993013779A2/fr
Publication of WO1993013779A3 publication Critical patent/WO1993013779A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Procédé permettant de sauver les cellules saines d'un patient atteint d'un cancer qui est traité avec des composés antitumoraux d'antipyrimidine, ou avec des composés apparentés. On sauve ces cellules en administrant du diphosphoglucose d'uridine (UDPG) après avoir administré le composé antitumoral d'antipyrimidine associé préférablement à l'administration de 5-benzylacyclouridine (BAU).
PCT/US1991/007613 1991-12-16 1991-12-16 Utilisation de diphosphoglucose d'uridine en tant qu'antidote electif dans le traitement therapeutique de cancers Ceased WO1993013779A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU41001/93A AU4100193A (en) 1991-12-16 1991-12-16 Use of udpg as cancer therapy rescue agent
PCT/US1991/007613 WO1993013779A2 (fr) 1991-12-16 1991-12-16 Utilisation de diphosphoglucose d'uridine en tant qu'antidote electif dans le traitement therapeutique de cancers
EP93910550A EP0617625A1 (fr) 1991-12-16 1991-12-16 Utilisation de diphosphoglucose d'uridine en tant qu'antidote electif dans le traitement therapeutique de cancers
JP5510416A JPH07501810A (ja) 1991-12-16 1991-12-16 癌治療のレスキュー剤としてのｕｄｐｇの利用

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1991/007613 WO1993013779A2 (fr) 1991-12-16 1991-12-16 Utilisation de diphosphoglucose d'uridine en tant qu'antidote electif dans le traitement therapeutique de cancers

Publications (2)

Publication Number Publication Date
WO1993013779A2 WO1993013779A2 (fr) 1993-07-22
WO1993013779A3 true WO1993013779A3 (fr) 1993-08-19

Family

ID=22225879

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1991/007613 Ceased WO1993013779A2 (fr) 1991-12-16 1991-12-16 Utilisation de diphosphoglucose d'uridine en tant qu'antidote electif dans le traitement therapeutique de cancers

Country Status (4)

Country Link
EP (1) EP0617625A1 (fr)
JP (1) JPH07501810A (fr)
AU (1) AU4100193A (fr)
WO (1) WO1993013779A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPR951101A0 (en) * 2001-12-13 2002-01-24 Centre For Molecular Biology And Medicine Method of treatment

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986003678A1 (fr) * 1984-12-20 1986-07-03 Memorial Hospital For Cancer And Allied Diseases Composition et procede de traitement de tumeurs avec de l'udpg

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986003678A1 (fr) * 1984-12-20 1986-07-03 Memorial Hospital For Cancer And Allied Diseases Composition et procede de traitement de tumeurs avec de l'udpg

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BIOCHEM. PHARMACOL. vol. 36, no. 5, 1987, pages 633 - 637 L.C. YIP ET AL 'Effects of uridine diphosphoglucose (udpg) infusion on 5-phosphoribosyl pyrophosphate (prpp) levels of mouse tissues.' *
PHARM. RES. vol. 6, no. 10, 1989, pages 863 - 866 J.R. COLOFIORE ET AL 'Effect of uridine diphosphoglucose on levels of 5-phosphoribosyl pyrophosphate and uridine triphosphate in murine tissues.' *

Also Published As

Publication number Publication date
JPH07501810A (ja) 1995-02-23
WO1993013779A2 (fr) 1993-07-22
EP0617625A1 (fr) 1994-10-05
AU4100193A (en) 1993-08-03

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