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WO1993007885A1 - Compositions pharmaceutiques anti-psoriasiques et leur procede de preparation - Google Patents

Compositions pharmaceutiques anti-psoriasiques et leur procede de preparation Download PDF

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Publication number
WO1993007885A1
WO1993007885A1 PCT/HU1992/000040 HU9200040W WO9307885A1 WO 1993007885 A1 WO1993007885 A1 WO 1993007885A1 HU 9200040 W HU9200040 W HU 9200040W WO 9307885 A1 WO9307885 A1 WO 9307885A1
Authority
WO
WIPO (PCT)
Prior art keywords
active agent
grist
heating
psoriasis
pharmaceutical composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/HU1992/000040
Other languages
English (en)
Inventor
Margit ÁRKOSI
Lajos MOLNÁR
Antal MOLNÁR
Zsigmond PAJTÁS
János VARGA
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Florin Vegyipari Szovetkezet
Original Assignee
Florin Vegyipari Szovetkezet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Florin Vegyipari Szovetkezet filed Critical Florin Vegyipari Szovetkezet
Priority to FI941800A priority Critical patent/FI941800A7/fi
Priority to EP92922168A priority patent/EP0610306A1/fr
Publication of WO1993007885A1 publication Critical patent/WO1993007885A1/fr
Priority to NO941426A priority patent/NO941426D0/no
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane

Definitions

  • This invention relates to novel antipsoriatic pharmaceutical compositions, particularly to novel pharmaceutical compositions useful for healing psoriasis.
  • the invention furthermore relates to a process for preparing these compositions.
  • Psoriasis is a worldwide occurring disease being particularly frequent in the moderate zone. Both men and women of various ages suffer from this disease. More than 1 % and in Europe 2 - 5 % of the entire population are psoriatic.
  • Characteristics of psoriasis are: silvery squamae, desquamation of high grade and a well-circumscribed, round, usually lens-size skin tuber. This tuber occurs most frequently in the knee, elbow and scalp. At present it is recognized that psoriasis is hereditable, which is characteristic of families in some geographical areas. The most characteristic types of psoriasis are: gyrate psoriasis, palm-and-sole psoriasis as well as psoriasis of the scalp.
  • the salt-water bathes can be considered to be an important supplementary treatment, chiefly due to the removal of squamae and relieving of the inflammations.
  • the present invention is aimed to develop a pharmaceutical composition being useful for healing psoriasis, by which the psoriasis can entirely be ceased without any adverse side effects and the original condition and colour of skin surface can be restored. It has been observed in the course of our experi ⁇ ments that, on carrying out the extraction of wheat grain and/or the grist thereof by pressing and heating, a complex active agent is obtained which, after being formulated to a pharmaceutical composition and used for treatment of the ill psoriatic skin, firstly results in the diminution of the psoriatic skin surface within a short period, then entirely heals it, depending on the severity of the disease and size of the skin surface, within 1-3 month(s) .
  • the skin surface has the same consistency and colour as those of the healthy skin and the psoriasis ceases once for all.
  • the present invention relates to an anti- psoriatic pharmaceutical composition (being useful for healing psoriasis) , which comprises as active ingredient a complex active agent extract obtained by heating and subsequently pressing wheat grain and/or a grist thereof.
  • the novel antipsoriatic compositions are prepared by heating and then pressing wheat grain and/or a grist thereof and subsequently, formulating the thus-obtained complex active agent extract to a therapeutically useful composition, suitably cream, emulsion, gel, tonic or solution.
  • a therapeutically useful composition suitably cream, emulsion, gel, tonic or solution.
  • the complex active agent is obtained by placing wheat and/or a grist thereof onto a metal plate and pressing it at a temperature between 200 and 800 °C. After mixing with one or more solid and/or liquid carrier(s) and/or additiv (s) , the complex active agent extract is transformed to a cream, emulsion, gel, tonic or solution.
  • the composition according to the invention does not contain any other therapeutically active substance in addition to the complex active agent.
  • compositions according to the invention known substances such as talc, wheat, maize or potato starch may be employed as solid carriers and one or more therapeutically acceptable liquid solvent(s) , e.g. water, ethanol, and oils of plant or animal origin causing no skin irritation as liquid carrier(s) may be used.
  • liquid solvent(s) e.g. water, ethanol, and oils of plant or animal origin causing no skin irritation as liquid carrier(s)
  • oleic acid stearic acid or lanolin fatty acid may also be used as liquid carriers.
  • Oils or their mixtures commonly used in the cosmetical industry may also be employed as liquid carriers in the compositions according to the invention.
  • Menthol and camphor are suitable tonicizing agents.
  • distilled or deionized water may be used in an amount of 15 - 70 % calculated for the total weight of the compo ⁇ sition.
  • the water amount of creams or ointments is 50-70 %, whereas tonics and solutions preferably contain water in an amount of 30 - 80 %.
  • Example 1 The invention is illustrated in detail by the following non-limiting Examples.
  • Example 1 The invention is illustrated in detail by the following non-limiting Examples.
  • Example 1 The process described in Example 1 is followed.
  • the complex active agent extract obtained is dissolved off by 40 % ethanol and further diluted to a solution of 60 %.
  • This composition is used for painting.
  • the effect of the compositions according to the invention has been proven by the experiments described hereinafter.
  • the therapeutically active solution prepared was tested on 20 patients (5 children of 12 - 14 years, 7 women of 18 - 56 years and 8 men of 25 - 72 years) .
  • the patients had been psoriatic for seven years in average.
  • the patients were treated once daily or every two or three days.
  • the ill skin surface healed beginning from the outer edge towards its inside; a ring-like clear streak developed on the skin, which became similar to the colour of skin after 3-5 days. Subsequently, the extension of the ill skin surface was further diminished, the psoriatic part was contracted to a pinhead size and finally, it completely disappeared from the formerly ill skin.
  • the duration of treatment is 1-3 month(s) in average; this depends on the size of the ill skin surface, on the interval passed from the beginning of the disase and age of the patients.
  • the degree of psoriasis was severe in all cases. The longest period of treatment was three months. After treatment, the psoriasis ceased on all patients (20 persons) , the skin surface became smooth and identical to other skin surfaces of the body.

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

Composition pharmaceutique utilisée pour guérir le psoriasis. Elle comporte, à titre d'ingrédient actif, un extrait d'agent actif complexe obtenu par le chauffage puis le pressage de grains de blé et/ou d'une mouture de ceux-ci mélangés/mélangée à des excipients et/ou additifs utilisés couramment dans l'industrie pharmaceutique. On prépare ladite composition de telle sorte que lesdits grains de blé et/ou ladite mouture soi(en)t chauffés/chauffée par des plaques métalliques, et que l'extrait d'agent actif complexe ainsi obtenu soit par la suite transformé de façon connue en crème, en émulsion, en gel, en tonique ou en solution par mélange avec des excipients et/ou additifs utilisés couramment dans l'industrie pharmaceutique.
PCT/HU1992/000040 1991-10-21 1992-10-21 Compositions pharmaceutiques anti-psoriasiques et leur procede de preparation Ceased WO1993007885A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
FI941800A FI941800A7 (fi) 1991-10-21 1992-10-21 Psoriasiksen vastaiset lääkeainekoostumukset ja menetelmä niiden valmi stamiseksi
EP92922168A EP0610306A1 (fr) 1991-10-21 1992-10-21 Compositions pharmaceutiques anti-psoriasiques et leur procede de preparation
NO941426A NO941426D0 (no) 1991-10-21 1994-04-20 Antisporiatiske farmasöytiske preparater og fremgangsmåte for fremstilling av slike

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU3310/91 1991-10-21
HU913310A HU207801B (en) 1991-10-21 1991-10-21 Process for producing pharmaceutical composition for treating psoriasis

Publications (1)

Publication Number Publication Date
WO1993007885A1 true WO1993007885A1 (fr) 1993-04-29

Family

ID=10963524

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/HU1992/000040 Ceased WO1993007885A1 (fr) 1991-10-21 1992-10-21 Compositions pharmaceutiques anti-psoriasiques et leur procede de preparation

Country Status (6)

Country Link
EP (1) EP0610306A1 (fr)
CA (1) CA2121783A1 (fr)
FI (1) FI941800A7 (fr)
HU (1) HU207801B (fr)
PL (1) PL307859A1 (fr)
WO (1) WO1993007885A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996027019A1 (fr) * 1995-02-25 1996-09-06 Imperial Cancer Research Technology Limited Animaux transgeniques utilises comme modele du psoriasis
ES2110921A1 (es) * 1996-08-08 1998-02-16 Ternum S C C L Composicion anti-psoriasica y procedimiento para la preparacion de la misma.

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0242794A2 (fr) * 1986-04-22 1987-10-28 ALLRUTAN BIO-PRODUKTE GmbH Composition stable et sa méthode de préparation
EP0279984A2 (fr) * 1986-12-03 1988-08-31 David Rudov Utilisation pharmaceutique des extraits de graminées

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0242794A2 (fr) * 1986-04-22 1987-10-28 ALLRUTAN BIO-PRODUKTE GmbH Composition stable et sa méthode de préparation
EP0279984A2 (fr) * 1986-12-03 1988-08-31 David Rudov Utilisation pharmaceutique des extraits de graminées

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996027019A1 (fr) * 1995-02-25 1996-09-06 Imperial Cancer Research Technology Limited Animaux transgeniques utilises comme modele du psoriasis
AU698317B2 (en) * 1995-02-25 1998-10-29 Cancer Research Technology Limited Transgenic animals as model of psoriasis
US6187993B1 (en) 1995-02-25 2001-02-13 Imperial Cancer Research Technology Limited Transgenic animals as model of psoriasis
ES2110921A1 (es) * 1996-08-08 1998-02-16 Ternum S C C L Composicion anti-psoriasica y procedimiento para la preparacion de la misma.

Also Published As

Publication number Publication date
EP0610306A1 (fr) 1994-08-17
CA2121783A1 (fr) 1993-04-29
FI941800L (fi) 1994-04-19
FI941800A0 (fi) 1994-04-19
HU913310D0 (en) 1992-01-28
PL307859A1 (en) 1995-06-26
FI941800A7 (fi) 1994-04-19
HU207801B (en) 1993-06-28

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