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WO1993005052A1 - Methanediphosphonic acid derivative, production thereof and medicinal use thereof - Google Patents

Methanediphosphonic acid derivative, production thereof and medicinal use thereof Download PDF

Info

Publication number
WO1993005052A1
WO1993005052A1 PCT/JP1992/001140 JP9201140W WO9305052A1 WO 1993005052 A1 WO1993005052 A1 WO 1993005052A1 JP 9201140 W JP9201140 W JP 9201140W WO 9305052 A1 WO9305052 A1 WO 9305052A1
Authority
WO
WIPO (PCT)
Prior art keywords
alkyl
acid derivative
medicinal use
production
methanediphosphonic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP1992/001140
Other languages
English (en)
French (fr)
Inventor
Norio Kawabe
Hiromi Uchiro
Teruo Nakadate
Masahiko Tanahashi
Masatoshi Ito
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toray Industries Inc
Original Assignee
Toray Industries Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries Inc filed Critical Toray Industries Inc
Priority to DE69225325T priority Critical patent/DE69225325T2/de
Priority to DK92918702T priority patent/DK0594857T3/da
Priority to EP92918702A priority patent/EP0594857B1/en
Publication of WO1993005052A1 publication Critical patent/WO1993005052A1/ja
Anticipated expiration legal-status Critical
Priority to US08/340,819 priority patent/US5527940A/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/386—Polyphosphonic acids containing hydroxy substituents in the hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3865—Polyphosphonic acids containing sulfur substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4025—Esters of poly(thio)phosphonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4025—Esters of poly(thio)phosphonic acids
    • C07F9/404—Esters of poly(thio)phosphonic acids containing hydroxy substituents in the hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4025—Esters of poly(thio)phosphonic acids
    • C07F9/405—Esters of poly(thio)phosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
PCT/JP1992/001140 1991-09-05 1992-09-07 Methanediphosphonic acid derivative, production thereof and medicinal use thereof Ceased WO1993005052A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
DE69225325T DE69225325T2 (de) 1991-09-05 1992-09-07 Methandiphosphonsäurederivat, herstellung davon und verwendung davon als arzneimittel
DK92918702T DK0594857T3 (da) 1991-09-05 1992-09-07 Methandiphosphonsyrederivat, fremstilling deraf ogmedicinsk anvendelse deraf
EP92918702A EP0594857B1 (en) 1991-09-05 1992-09-07 Methanediphosphonic acid derivative, production thereof and medicinal use thereof
US08/340,819 US5527940A (en) 1991-09-05 1994-11-17 Methanediphosphonate derivative, its manufacturing process and its pharmaceutical applications

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP22617591 1991-09-05
JP3/226175 1991-09-05
JP4/179802 1992-07-07
JP17980292 1992-07-07

Publications (1)

Publication Number Publication Date
WO1993005052A1 true WO1993005052A1 (en) 1993-03-18

Family

ID=26499539

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1992/001140 Ceased WO1993005052A1 (en) 1991-09-05 1992-09-07 Methanediphosphonic acid derivative, production thereof and medicinal use thereof

Country Status (9)

Country Link
US (2) US5527940A (ja)
EP (1) EP0594857B1 (ja)
JP (1) JPH0826048B2 (ja)
AT (1) ATE165603T1 (ja)
CA (1) CA2095128C (ja)
DE (1) DE69225325T2 (ja)
DK (1) DK0594857T3 (ja)
ES (1) ES2114946T3 (ja)
WO (1) WO1993005052A1 (ja)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993024496A1 (en) * 1992-05-29 1993-12-09 Procter & Gamble Pharmaceuticals, Inc. Sulfur-containing phosponate compounds for treating abnormal calcium and phosphate metabolism
EP0627438A4 (en) * 1992-10-30 1995-02-01 Toray Industries METHANDIPHOSPHONIC ACID DERIVATIVE, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL USE THEREOF.
WO2001005403A1 (en) * 1999-07-19 2001-01-25 Toray Industries, Inc. Drugs for periodontal diseases
JP2001181191A (ja) * 1999-12-24 2001-07-03 Cci Corp 慢性関節リウマチ疾患予防および治療剤
WO2010026701A1 (ja) * 2008-09-03 2010-03-11 国立大学法人東北大学 ［４－（メチルチオ）フェニルチオ］メタンビスホスホン酸又は薬学的に許容され得るその塩を有効成分とする骨形成促進剤

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0747350B1 (en) * 1994-12-22 2003-03-19 Toray Industries, Inc. Process for producing bis(4-alkylthiophenyl) disulfide
CA2281937A1 (en) * 1997-12-25 1999-07-08 Toray Industries, Inc. Drug for treating abnormalities in bone marrow
DE19828450A1 (de) * 1998-06-26 1999-12-30 Hassan Jomaa Bisphosphonsäuren und deren Derivate enthaltende Arzneimittel zur Prophylaxe und zur Behandlung von Autoimmunkrankheiten sowie von Allergien
WO2000038693A1 (en) * 1998-12-25 2000-07-06 Toray Industries, Inc. Interleukin-6 production inhibitors
US6692758B1 (en) * 1999-08-02 2004-02-17 Toray Industries, Inc. Insertion stabilizers for implants
US6548042B2 (en) 2000-08-07 2003-04-15 Arstad Erik Bis-phosphonate compounds
US20060040899A1 (en) * 2000-12-15 2006-02-23 Hassan Jomaa Medicaments containing bisphosphonic acids and derivatives thereof for preventing and treating diseases and allergies
AU2003232108A1 (en) * 2002-05-11 2003-11-11 Ilex Products, Inc. 1,1- and 1,2-bisphosphonates as apoliprotein e modulators
CN119097698A (zh) * 2015-09-09 2024-12-10 清华大学 作为高效的疫苗佐剂的甲羟戊酸通路的抑制剂
JP2024169831A (ja) * 2023-05-26 2024-12-06 公立大学法人福島県立医科大学 抗酸化剤

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0344328A (ja) * 1989-07-07 1991-02-26 Ciba Geigy Ag 経皮投与用医薬製剤
JPH03106893A (ja) * 1989-09-06 1991-05-07 Merck & Co Inc 骨吸収阻害剤としてのビスホスホン酸類のアシルオキシメチルエステル

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3609075A (en) * 1968-06-25 1971-09-28 Procter & Gamble Cleaning and softening detergent compositions
EP0085321B1 (de) * 1982-01-27 1986-08-27 Schering Aktiengesellschaft Diphosphonsäure-Derivate und diese enthaltende pharmazeutische Präparate
FR2531088B1 (fr) * 1982-07-29 1987-08-28 Sanofi Sa Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation
FR2558837B1 (fr) * 1984-01-26 1986-06-27 Sanofi Sa Derives de l'acide methylenediphosphonique, procede d'obtention et medicaments antirhumatismaux les contenant
US4902679A (en) * 1985-12-13 1990-02-20 Norwich Eaton Pharmaceuticals, Inc. Methods of treating diseases with certain geminal diphosphonates
ES2039237T3 (es) * 1986-04-24 1993-09-16 Fujisawa Pharmaceutical Co., Ltd. Procedimiento para preparar nuevos compuestos de acido difosfonico.
CH675422A5 (ja) * 1988-03-31 1990-09-28 Symphar Sa
JPH0377894A (ja) * 1989-08-18 1991-04-03 Toray Ind Inc メチレンジホスホン酸化合物
US5157027A (en) * 1991-05-13 1992-10-20 E. R. Squibb & Sons, Inc. Bisphosphonate squalene synthetase inhibitors and method
US5256808A (en) * 1992-12-04 1993-10-26 The University Of Tennessee Research Corp. Synthesis of tetraalkyl vinylidene diphosphonate monomer

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0344328A (ja) * 1989-07-07 1991-02-26 Ciba Geigy Ag 経皮投与用医薬製剤
JPH03106893A (ja) * 1989-09-06 1991-05-07 Merck & Co Inc 骨吸収阻害剤としてのビスホスホン酸類のアシルオキシメチルエステル

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993024496A1 (en) * 1992-05-29 1993-12-09 Procter & Gamble Pharmaceuticals, Inc. Sulfur-containing phosponate compounds for treating abnormal calcium and phosphate metabolism
AU669372B2 (en) * 1992-05-29 1996-06-06 Procter & Gamble Pharmaceuticals, Inc. Sulfur-containing phosponate compounds for treating abnormal calcium and phosphate metabolism
CN1061049C (zh) * 1992-05-29 2001-01-24 普罗格特甘布尔药品有限公司 含硫的膦酸化合物，药物组合物及其在制药方面的用途
EP0627438A4 (en) * 1992-10-30 1995-02-01 Toray Industries METHANDIPHOSPHONIC ACID DERIVATIVE, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL USE THEREOF.
US5565440A (en) * 1992-10-30 1996-10-15 Toray Industries, Inc. Methane diphosphonic acid derivative, its production process and its pharmaceutical applications
WO2001005403A1 (en) * 1999-07-19 2001-01-25 Toray Industries, Inc. Drugs for periodontal diseases
CN100349574C (zh) * 1999-07-19 2007-11-21 东丽株式会社 牙周疾病用剂
JP2001181191A (ja) * 1999-12-24 2001-07-03 Cci Corp 慢性関節リウマチ疾患予防および治療剤
WO2010026701A1 (ja) * 2008-09-03 2010-03-11 国立大学法人東北大学 ［４－（メチルチオ）フェニルチオ］メタンビスホスホン酸又は薬学的に許容され得るその塩を有効成分とする骨形成促進剤
JP5655179B2 (ja) * 2008-09-03 2015-01-21 国立大学法人東北大学 ［４−（メチルチオ）フェニルチオ］メタンビスホスホン酸又は薬学的に許容され得るその塩を有効成分とする骨形成促進剤

Also Published As

Publication number Publication date
DE69225325D1 (de) 1998-06-04
JPH0826048B2 (ja) 1996-03-13
US5683992A (en) 1997-11-04
CA2095128A1 (en) 1993-03-06
EP0594857A1 (en) 1994-05-04
DK0594857T3 (da) 1998-10-07
ES2114946T3 (es) 1998-06-16
CA2095128C (en) 1998-01-06
ATE165603T1 (de) 1998-05-15
EP0594857A4 (en) 1994-05-18
US5527940A (en) 1996-06-18
JPH06500489A (ja) 1994-01-20
EP0594857B1 (en) 1998-04-29
DE69225325T2 (de) 1998-08-27

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