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WO1993003841A1 - Ion exchanger, production thereof, and process for separating biopolymer by using same - Google Patents

Ion exchanger, production thereof, and process for separating biopolymer by using same Download PDF

Info

Publication number
WO1993003841A1
WO1993003841A1 PCT/JP1992/001061 JP9201061W WO9303841A1 WO 1993003841 A1 WO1993003841 A1 WO 1993003841A1 JP 9201061 W JP9201061 W JP 9201061W WO 9303841 A1 WO9303841 A1 WO 9303841A1
Authority
WO
WIPO (PCT)
Prior art keywords
cross
linked
ion exchanger
production
pores
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP1992/001061
Other languages
French (fr)
Japanese (ja)
Inventor
Keiko Kudo
Hideaki Kiniwa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Chemical Corp
Original Assignee
Mitsubishi Kasei Corp
Mitsubishi Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Kasei Corp, Mitsubishi Chemical Industries Ltd filed Critical Mitsubishi Kasei Corp
Publication of WO1993003841A1 publication Critical patent/WO1993003841A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/26—Cation exchangers for chromatographic processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/08—Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/16—Organic material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J47/00—Ion-exchange processes in general; Apparatus therefor
    • B01J47/014—Ion-exchange processes in general; Apparatus therefor in which the adsorbent properties of the ion-exchanger are involved, e.g. recovery of proteins or other high-molecular compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)

Abstract

An ion exchanger comprising a composite having a degree of swelling in water of 2 to 7 ml/g of resin, said composite being prepared by holding a cross-linked gel, which comprises a hydrophilic natural macromolecule having a three-dimensional cross-linked network structure and has ion-exchange groups, in the pores of a porous particle of a hydrophilic cross-linked copolymer having pores with a diameter of 0.01 to less than 1 νm, a pore volume of 30 to 70 % of the resin volume and preferably a particle diameter of 5 to 500 νm; a process for the production thereof; and a process for separating biopolymers such as proteins by using the ion exchanger. This exchanger undergoes little volume change, serves to remedy the shortcomings of conventional cross-linked gels in passing various liquids, and has merits of being free from nonspecific adsorption and having high adsoprtion and desorption rates in the separation of biopolymers such as proteins.
PCT/JP1992/001061 1991-08-23 1992-08-24 Ion exchanger, production thereof, and process for separating biopolymer by using same Ceased WO1993003841A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP21229691 1991-08-23
JP3/212296 1991-08-23

Publications (1)

Publication Number Publication Date
WO1993003841A1 true WO1993003841A1 (en) 1993-03-04

Family

ID=16620234

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1992/001061 Ceased WO1993003841A1 (en) 1991-08-23 1992-08-24 Ion exchanger, production thereof, and process for separating biopolymer by using same

Country Status (1)

Country Link
WO (1) WO1993003841A1 (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013011632A (en) * 2012-10-19 2013-01-17 Sekisui Chem Co Ltd Measurement method of hemoglobin a1c
JP2013515258A (en) * 2009-12-22 2013-05-02 ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ Method for dry-packing chromatography columns
JP2017125796A (en) * 2016-01-15 2017-07-20 日立化成株式会社 Separation material and column
JP2017125814A (en) * 2016-01-15 2017-07-20 日立化成株式会社 Separation material and column
JP2019177509A (en) * 2018-03-30 2019-10-17 株式会社リコー Hydrogel structure, production method and organ model
JP2021069991A (en) * 2019-10-31 2021-05-06 昭和電工株式会社 Method for producing filler for glycosylated hemoglobin analysis column
WO2025177962A1 (en) * 2024-02-22 2025-08-28 三菱ケミカル株式会社 Method for producing ion exchange resin, method for separating compound, and cation exchange resin

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01254247A (en) * 1988-04-01 1989-10-11 Mitsubishi Kasei Corp Composite separation agent and its manufacturing method

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01254247A (en) * 1988-04-01 1989-10-11 Mitsubishi Kasei Corp Composite separation agent and its manufacturing method

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013515258A (en) * 2009-12-22 2013-05-02 ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ Method for dry-packing chromatography columns
US9958421B2 (en) 2009-12-22 2018-05-01 Ge Healthcare Bioprocess R&D Ab Method for dry packing chromatography columns
JP2013011632A (en) * 2012-10-19 2013-01-17 Sekisui Chem Co Ltd Measurement method of hemoglobin a1c
JP2017125796A (en) * 2016-01-15 2017-07-20 日立化成株式会社 Separation material and column
JP2017125814A (en) * 2016-01-15 2017-07-20 日立化成株式会社 Separation material and column
JP2019177509A (en) * 2018-03-30 2019-10-17 株式会社リコー Hydrogel structure, production method and organ model
JP2021069991A (en) * 2019-10-31 2021-05-06 昭和電工株式会社 Method for producing filler for glycosylated hemoglobin analysis column
WO2025177962A1 (en) * 2024-02-22 2025-08-28 三菱ケミカル株式会社 Method for producing ion exchange resin, method for separating compound, and cation exchange resin

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