[go: up one dir, main page]

WO1992017200A3 - Formulations stables a base d'ion metal et d'hormone de croissance - Google Patents

Formulations stables a base d'ion metal et d'hormone de croissance Download PDF

Info

Publication number
WO1992017200A3
WO1992017200A3 PCT/US1992/002365 US9202365W WO9217200A3 WO 1992017200 A3 WO1992017200 A3 WO 1992017200A3 US 9202365 W US9202365 W US 9202365W WO 9217200 A3 WO9217200 A3 WO 9217200A3
Authority
WO
WIPO (PCT)
Prior art keywords
metal ion
growth hormone
stable growth
hgh
formulations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1992/002365
Other languages
English (en)
Other versions
WO1992017200A2 (fr
Inventor
Brian C Cunningham
Michael G Mulkerrin
James A Wells
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of WO1992017200A2 publication Critical patent/WO1992017200A2/fr
Publication of WO1992017200A3 publication Critical patent/WO1992017200A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/27—Growth hormone [GH], i.e. somatotropin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Cette invention concerne des complexes stables d'hormone de croissance humaine (hGH) et d'ion métal bivalent permettant d'obtenir des formulations stabilisées de hGH par formation de dimères ion métal-hGH. Les dimères stables sont caractérisés et les formulations thérapeutiques de zinc et hGH sont également décrites.
PCT/US1992/002365 1991-03-28 1992-03-25 Formulations stables a base d'ion metal et d'hormone de croissance Ceased WO1992017200A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67664591A 1991-03-28 1991-03-28
US676,645 1991-03-28

Publications (2)

Publication Number Publication Date
WO1992017200A2 WO1992017200A2 (fr) 1992-10-15
WO1992017200A3 true WO1992017200A3 (fr) 1992-12-23

Family

ID=24715358

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1992/002365 Ceased WO1992017200A2 (fr) 1991-03-28 1992-03-25 Formulations stables a base d'ion metal et d'hormone de croissance

Country Status (2)

Country Link
AU (1) AU1757092A (fr)
WO (1) WO1992017200A2 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5763394A (en) * 1988-04-15 1998-06-09 Genentech, Inc. Human growth hormone aqueous formulation
US5981485A (en) 1997-07-14 1999-11-09 Genentech, Inc. Human growth hormone aqueous formulation
US6022858A (en) * 1991-12-20 2000-02-08 Novo Nordisk A/S Pharmaceutical formulation of human-growth hormone pretreated with zinc salt
SE9201073D0 (sv) * 1992-04-03 1992-04-03 Kabi Pharmacia Ab Protein formulation
US6087324A (en) * 1993-06-24 2000-07-11 Takeda Chemical Industries, Ltd. Sustained-release preparation
ZA965368B (en) * 1995-07-14 1997-01-14 Novo Nordisk As A pharmaceutical formulation
AU7871298A (en) 1996-12-20 1998-07-17 Takeda Chemical Industries Ltd. Method of producing a sustained-release preparation
ZA9711731B (en) * 1996-12-31 1998-07-01 Monsanto Co Aqueous glycerol formulations of somatotropin
US6191107B1 (en) 1997-09-26 2001-02-20 Takeda Chemical Industries, Ltd. Complex of human growth hormone and zinc
JP2001521897A (ja) * 1997-10-31 2001-11-13 スミスクライン・ビーチャム・コーポレイション 新規な金属錯体
AU738473B2 (en) * 1997-10-31 2001-09-20 Glaxosmithkline Llc Novel metal complexes
KR100674528B1 (ko) 1999-06-28 2007-01-29 제넨테크, 인크. 2가 금속 이온을 사용한 Ａｐｏ-2 리간드 제조 방법
JP4361710B2 (ja) * 2000-04-19 2009-11-11 ジェネンテック・インコーポレーテッド 徐放製剤
WO2002011695A2 (fr) 2000-08-07 2002-02-14 Inhale Therapeutic Systems, Inc. Poudres a inhaler de proteines en faisceau a quatre helices sechees par atomisation presentant une agregation reduite au minimum
DE60231862D1 (de) 2001-02-23 2009-05-20 Genentech Inc Erodierbare polymere zur injektion
WO2003000282A1 (fr) 2001-06-21 2003-01-03 Genentech, Inc. Formulation a liberation lente
JP2005508162A (ja) 2001-10-02 2005-03-31 ジェネンテック・インコーポレーテッド Ａｐｏ−２リガンド変異体とその使用法
CA2489348A1 (fr) 2002-06-24 2003-12-31 Genentech, Inc. Variants du ligand apo-2/trail et utilisations de ceux-ci

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB885798A (en) * 1958-12-06 1961-12-28 Organon Labor Ltd Preparations of the growth hormone
EP0216485A1 (fr) * 1985-08-12 1987-04-01 International Minerals And Chemical Corporation Libération prolongée d'hormones stimulantes de croissance
WO1989009614A1 (fr) * 1988-04-15 1989-10-19 Genentech, Inc. Formulation d'hormones de croissance humaine
EP0343696A2 (fr) * 1984-10-04 1989-11-29 Monsanto Company Zinc-somatotropines

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB885798A (en) * 1958-12-06 1961-12-28 Organon Labor Ltd Preparations of the growth hormone
EP0343696A2 (fr) * 1984-10-04 1989-11-29 Monsanto Company Zinc-somatotropines
EP0216485A1 (fr) * 1985-08-12 1987-04-01 International Minerals And Chemical Corporation Libération prolongée d'hormones stimulantes de croissance
WO1989009614A1 (fr) * 1988-04-15 1989-10-19 Genentech, Inc. Formulation d'hormones de croissance humaine

Also Published As

Publication number Publication date
WO1992017200A2 (fr) 1992-10-15
AU1757092A (en) 1992-11-02

Similar Documents

Publication Publication Date Title
WO1992017200A3 (fr) Formulations stables a base d'ion metal et d'hormone de croissance
AU563665B2 (en) Pest control in animals
AU1962088A (en) Urinary follicle stimulating hormone
HUP9802287A3 (en) A stabilized pharmaceutical formulation comprising a growth hormone pre-treated with zinc and optionally lysine or calcium ions
EP0591688A3 (en) Self-propelled combine
AU1508688A (en) Stabilised metallic oxides
AU1868595A (en) Human growth hormone
AU2179788A (en) Combine harvester
AU4288293A (en) Fungicidal 1,3,4-oxadiazines and 1,3,4-thiadiazines
AU579358B2 (en) Fish growth hormone
AU4628993A (en) Physiologically active peptide composition
AU5743194A (en) Treatment of dermatological malignancies with biologically active peptides
AU5271893A (en) Release-controlled implantable somatotropin composition
AU1929888A (en) Grass edger
AU1283988A (en) Phenoxyphenylthioureas, phenoxyphenylisothioureas and phenoxyphenylcarbodiimides and use thereof for controlling pests
AU1543488A (en) Fungicidal aminotriazoles and aminoimidazoles
AU1967288A (en) Growth hormone related peptide
EP0663834A4 (fr) Peptides liberant l'hormone de croissance.
AU2050688A (en) Stabilised pesticidal composition
AU587708B2 (en) Zoysia grass plant
AU633018B2 (en) Stabilized thiocarbonate solutions and the use thereof for controlling soil pests
AU7209394A (en) Gallium complexes for the treatment of free radical-induced diseases
AU3402289A (en) 3-pyrrolidinylthio-1-azabicyclo (3.2.0)hept-2-ene-2- carboxylic acid derivatives and their preparation
AU4701893A (en) 2-arylhydrazono-3-ketonic acid piperidides as pest control agents
NZ268125A (en) Growth hormone pharmaceutical composition

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AU CA FI HU JP NO

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH DE DK ES FR GB GR IT LU MC NL SE

AK Designated states

Kind code of ref document: A3

Designated state(s): AU CA FI HU JP NO

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): AT BE CH DE DK ES FR GB GR IT LU MC NL SE

NENP Non-entry into the national phase

Ref country code: CA

122 Ep: pct application non-entry in european phase