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WO1992011367A3 - Lipid receptors for microorganisms and corresponding adhesins, dna sequences encoding adhesins, and use thereof - Google Patents

Lipid receptors for microorganisms and corresponding adhesins, dna sequences encoding adhesins, and use thereof Download PDF

Info

Publication number
WO1992011367A3
WO1992011367A3 PCT/US1991/009810 US9109810W WO9211367A3 WO 1992011367 A3 WO1992011367 A3 WO 1992011367A3 US 9109810 W US9109810 W US 9109810W WO 9211367 A3 WO9211367 A3 WO 9211367A3
Authority
WO
WIPO (PCT)
Prior art keywords
adhesins
microorganisms
dna sequences
sequences encoding
receptors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1991/009810
Other languages
French (fr)
Other versions
WO1992011367A2 (en
Inventor
Howard C Krivan
Bo Nilsson
Clifford A Lingwood
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
HSC Research and Development LP
Emergent Product Development Gaithersburg Inc
Original Assignee
HSC Research and Development LP
Microcarb Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by HSC Research and Development LP, Microcarb Inc filed Critical HSC Research and Development LP
Priority to JP4502887A priority Critical patent/JPH06504670A/en
Publication of WO1992011367A2 publication Critical patent/WO1992011367A2/en
Publication of WO1992011367A3 publication Critical patent/WO1992011367A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/205—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Campylobacter (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/295—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Chlamydiales (O)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Host cell lipid molecules (''receptors'') which permit binding of microorganisms are provided. Pharmaceutical compositions are formed from receptors in combination with a pharmaceutically acceptable carrier or diluent. The present invention also provides microbial proteins (''adhesins''), which mediate binding of microorganisms to host cells, and DNA sequences encoding adhesin proteins. Vaccines are formed from an adhesin protein in combination with a pharmaceutically acceptable carrier or diluent.
PCT/US1991/009810 1990-12-21 1991-12-20 Lipid receptors for microorganisms and corresponding adhesins, dna sequences encoding adhesins, and use thereof Ceased WO1992011367A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP4502887A JPH06504670A (en) 1990-12-21 1991-12-20 Lipid receptors and corresponding adhesins for microorganisms, DNA sequences encoding adhesins, and methods for their use

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63237190A 1990-12-21 1990-12-21
US632,371 1990-12-21

Publications (2)

Publication Number Publication Date
WO1992011367A2 WO1992011367A2 (en) 1992-07-09
WO1992011367A3 true WO1992011367A3 (en) 1992-10-15

Family

ID=24535261

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1991/009810 Ceased WO1992011367A2 (en) 1990-12-21 1991-12-20 Lipid receptors for microorganisms and corresponding adhesins, dna sequences encoding adhesins, and use thereof

Country Status (4)

Country Link
EP (1) EP0563240A1 (en)
JP (1) JPH06504670A (en)
CA (1) CA2098733A1 (en)
WO (1) WO1992011367A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5939297A (en) * 1994-07-21 1999-08-17 Connaught Laboratories Limited Analog of haemophilus HIN47 with reduced protease activity
US5506139A (en) * 1994-07-21 1996-04-09 Connaught Laboratories Limited Analog of haemophilus Hin47 with reduced protease activity
US5981503A (en) * 1994-06-07 1999-11-09 Connaught Laboratories Limited Analog of Haemophilus Hin47 with reduced protease activity
US6147057A (en) * 1994-07-21 2000-11-14 Connaught Laboratories Limited Analog of Haemophilus Hin47 with reduced protease activity
BR9506272B8 (en) * 1994-07-21 2014-08-05 Connaught Lab ISOLATED AND PURIFIED MUTANT PROTEIN Haemophilus influenzae Hin47, CHEMERIC MOLECULE, NUCLEIC ACID MOLECULA, RECOMBINED PROFESSIONAL FOR PROHIBA, PROFESSIONALLY PROCEDURE, PROFESSIONAL, PROCEDURAL COMPOSITION THE PRESENCE OF HIN47 PROTEIN IN A SAMPLE AND DIAGNOSTIC KIT TO DETERMINE THE PRESENCE OF ANTIBODIES IN A SPECIFICALLY REACTIVE SAMPLE WITH THE HIN47 PROTEIN.
CN1186516A (en) * 1995-06-07 1998-07-01 阿斯特拉公司 Nucleic acid and amino acid sequences relating to helicobacter pylori for diagnostics and therapeutics
AUPR512401A0 (en) * 2001-05-18 2001-06-14 Queensland University Of Technology Adherent entities and uses therefor

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1985005037A1 (en) * 1984-05-02 1985-11-21 Syn-Tek Ab Adhesin antigens, antibodies and dna fragment encoding the antigen, methods and means for diagnosis and immunization etc.
EP0293079A2 (en) * 1987-04-24 1988-11-30 368800 Alberta Ltd Chlamydia vaccine

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1985005037A1 (en) * 1984-05-02 1985-11-21 Syn-Tek Ab Adhesin antigens, antibodies and dna fragment encoding the antigen, methods and means for diagnosis and immunization etc.
EP0293079A2 (en) * 1987-04-24 1988-11-30 368800 Alberta Ltd Chlamydia vaccine

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Infection and Immunity, volume 55, no. 2, February 1987, Washington DC, US; G. Hinson et al.: "Adherence to human colonocytes of an Escherichia coli strain isolated from severe infantile enteritis: molecular and ultrastructural studies of a fibrillar adhesin", pages 393-402, see the whole article *
Infection and Immunity, volume 58, no. 4, April 1990, Washington, DC, US Hua Sue et al.: "Chlamydia trachomatis host cell interactions: role of the chlamydial major outer membrane protein as an adhesin", pages 1017-1025, see the wole article *
Journal of Bacteriology, volume 169, no. 11, November 1987, Baltimore, MD, US, R. Kaul et al.: "Cloning, expression and primary structure of a chlamydia trachomatis binding protein", pages 5152-5156, see the abstract and figure 3 *

Also Published As

Publication number Publication date
EP0563240A1 (en) 1993-10-06
WO1992011367A2 (en) 1992-07-09
CA2098733A1 (en) 1992-06-22
JPH06504670A (en) 1994-06-02

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