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WO1992010504A3 - Acides phosphoniques derives utiles comme agents antiinflammatoires - Google Patents

Acides phosphoniques derives utiles comme agents antiinflammatoires Download PDF

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Publication number
WO1992010504A3
WO1992010504A3 PCT/US1991/008817 US9108817W WO9210504A3 WO 1992010504 A3 WO1992010504 A3 WO 1992010504A3 US 9108817 W US9108817 W US 9108817W WO 9210504 A3 WO9210504 A3 WO 9210504A3
Authority
WO
WIPO (PCT)
Prior art keywords
bisphosphonic acid
methylene
bis
tetramethyl ester
acid tetramethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1991/008817
Other languages
English (en)
Other versions
WO1992010504A2 (fr
Inventor
Roy Allen Johnson
Herman Walden Smith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Priority to EP92901352A priority Critical patent/EP0561948B1/fr
Priority to JP4501562A priority patent/JPH06503329A/ja
Priority to DE69108739T priority patent/DE69108739T2/de
Publication of WO1992010504A2 publication Critical patent/WO1992010504A2/fr
Publication of WO1992010504A3 publication Critical patent/WO1992010504A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/650952—Six-membered rings having the nitrogen atoms in the positions 1 and 4
    • C07F9/650994—Six-membered rings having the nitrogen atoms in the positions 1 and 4 condensed with carbocyclic rings or carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4025—Esters of poly(thio)phosphonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/657163—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom
    • C07F9/657181—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom the ring phosphorus atom and, at least, one ring oxygen atom being part of a (thio)phosphonic acid derivative

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Filtration Of Liquid (AREA)

Abstract

De nouveaux acides, esters, et sels d'acides biphosphoniques de phényle, naphthyle, quinoxalinyle, de biphényle, et des nouvelles 1,2-oxaphosphépines sont décrits. Ces composés sont utiles comme agents anti-inflammatoires et anti-arthritiques. L'invention concerne également des composés connus des classes de bisphosphonates de phényle, naphthyle, quinoxalinyle, et biphényle, qui sont également utiles comme agents anti-inflammatoires et anti-arthritiques. Dans les composés représentatifs de cette invention sont compris l'ester de tétraméthyle d'acide [1,2-phénylediyl]-bis(méthylène)bisphosphonique, l'ester de tétraméthyle d'acide [2,3-quinoxalinediyl]bis(méthylène)bisphosphonique, l'ester de tétraméthyle d'acide [[3-(propyl)-4-(méthoxy)-1,8-naphthalènediyl]bis(méthylène)]bisphosphonique, l'ester de tétraéthyle d'acide [2,6-naphthalènediylbis(méthylène)bisphosphonique, et l'ester de tétraméthyle d'acide [2,2'-biphénylènebis(méthyl)]bisphosphonique. Des oxaphosphépines représentatives de l'invention comprennent le 3,4-dihydro-3-méthoxy-7-(phénylméthoxy)-1H-naphth[1,8de][1,2]oxaphosphépine-3-oxyde préféré.
PCT/US1991/008817 1990-12-07 1991-12-03 Acides phosphoniques derives utiles comme agents antiinflammatoires Ceased WO1992010504A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP92901352A EP0561948B1 (fr) 1990-12-07 1991-12-03 Acides phosphoniques derives utiles comme agents antiinflammatoires
JP4501562A JPH06503329A (ja) 1990-12-07 1991-12-03 抗炎症剤として有用なホスホン酸誘導体
DE69108739T DE69108739T2 (de) 1990-12-07 1991-12-03 Phosphonsäurederivate als entzündungshemmende mittel.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62411990A 1990-12-07 1990-12-07
US924,119 1990-12-07

Publications (2)

Publication Number Publication Date
WO1992010504A2 WO1992010504A2 (fr) 1992-06-25
WO1992010504A3 true WO1992010504A3 (fr) 1992-09-17

Family

ID=24500731

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1991/008817 Ceased WO1992010504A2 (fr) 1990-12-07 1991-12-03 Acides phosphoniques derives utiles comme agents antiinflammatoires

Country Status (8)

Country Link
US (2) US5298498A (fr)
EP (2) EP0561948B1 (fr)
JP (1) JPH06503329A (fr)
AU (1) AU9097791A (fr)
CA (1) CA2094123A1 (fr)
DE (1) DE69108739T2 (fr)
DK (1) DK0561948T3 (fr)
WO (1) WO1992010504A2 (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0561948B1 (fr) * 1990-12-07 1995-04-05 The Upjohn Company Acides phosphoniques derives utiles comme agents antiinflammatoires
WO1994007501A1 (fr) * 1992-09-23 1994-04-14 The Upjohn Company Arylmethylphosphonates et acides phosphoniques utiles en tant qu'agents anti-inflammatoires
JP3951367B2 (ja) * 1996-11-28 2007-08-01 住友化学株式会社 ５価のリン系化合物を有効成分とする熱可塑性樹脂用安定剤、その製造方法およびその用途
GB2326369B (en) * 1997-06-20 2001-06-27 Aea Technology Plc Double lid system
US6096730A (en) * 1997-07-24 2000-08-01 University Of Kentucky Research Foundation Phosphonated agents and their antiangiogenic and antitumorigenic use
US5932563A (en) * 1998-10-23 1999-08-03 Ohio State Research Foundation Methods for treating spinal cord injury
US6627215B1 (en) * 1998-12-30 2003-09-30 Oligos Etc. Inc. Devices for improved wound management
US7868162B2 (en) * 1998-12-30 2011-01-11 Lakewood-Amedex, Inc. Antimicrobial and antiviral compounds and methods for their use
US20020032164A1 (en) * 1998-12-30 2002-03-14 Dale Roderic M. K. Antimicrobial compounds and methods for their use
AU777770C (en) 1999-05-04 2005-11-10 Strakan International Limited Androgen glycosides and androgenic activity thereof
JP4164718B2 (ja) * 1999-10-06 2008-10-15 ソニー株式会社 ビス（アミノスチリル）ナフタレン化合物及びその合成中間体、これらの製造方法、並びに有機電界発光素子
CA2450073C (fr) 2001-07-25 2017-08-29 Biomarin Pharmaceutical Inc. Compositions et procedes de modulation du transport a travers la barriere hematho-encephalique
JP2008539047A (ja) 2005-04-28 2008-11-13 プロテウス バイオメディカル インコーポレイテッド ファーマインフォーマティックスシステム
EP1962586B1 (fr) * 2005-12-22 2017-07-12 Oakwood Laboratories L.L.C. Systeme a liberation lente sublimable et son procede de fabrication
CN101594878A (zh) 2006-09-18 2009-12-02 雷普特药品公司 通过给予受体相关蛋白（rap）-缀合物对肝病症的治疗
EP2060639B1 (fr) 2007-11-14 2019-01-30 Fresenius Kabi Austria GmbH Procédé continu pour la préparation de lactulose cristallisé
EP3395372B1 (fr) 2009-02-20 2022-04-06 EnhanX Biopharm Inc. Système d'administration de médicament à base de glutathion
SG10201402069PA (en) 2009-05-06 2014-07-30 Lab Skin Care Inc Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Citations (3)

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Publication number Priority date Publication date Assignee Title
DE1124949B (de) * 1960-03-04 1962-03-08 Basf Ag Verfahren zur Herstellung von Verbindungen der 1,2-Bis-(vinyl)-benzolreihe
EP0085321A2 (fr) * 1982-01-27 1983-08-10 Schering Aktiengesellschaft Dérivés d'acides diphosphoniques et préparations pharmaceutiques les contenant
EP0149802A2 (fr) * 1983-12-21 1985-07-31 Hoechst Aktiengesellschaft 2,3-Bis(arylethényl)-quinoxalines, procédé pour leur préparation et leur usage comme composés photoconducteurs

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FR1541025A (fr) * 1967-08-01 1968-10-04 Prec Mecanique Labinal Perfectionnements apportés aux filtres, notamment du type remplaçable, et plus spécialement en matière plastique
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JPS5038861A (fr) * 1973-08-11 1975-04-10
JPS53105716A (en) * 1977-02-25 1978-09-14 Daicel Chem Ind Ltd Hose or tube for solvent
JPS5677474A (en) * 1979-11-28 1981-06-25 Ishikawajima Harima Heavy Ind Method of constructing multiple shell tank
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Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1124949B (de) * 1960-03-04 1962-03-08 Basf Ag Verfahren zur Herstellung von Verbindungen der 1,2-Bis-(vinyl)-benzolreihe
EP0085321A2 (fr) * 1982-01-27 1983-08-10 Schering Aktiengesellschaft Dérivés d'acides diphosphoniques et préparations pharmaceutiques les contenant
EP0149802A2 (fr) * 1983-12-21 1985-07-31 Hoechst Aktiengesellschaft 2,3-Bis(arylethényl)-quinoxalines, procédé pour leur préparation et leur usage comme composés photoconducteurs

Non-Patent Citations (3)

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Title
Chemical Abstracts, vol. 68, no. 19, 6 May 1968, (Columbus, Ohio, US), V.S. ABRAMOV et al.: "Effect of some dihalo derivatives on sodium salts of dialkylphosphonic acids and phosphites", see page 8428, abstract no. 87351r, & ZH. OBSHCH. KHIM. 37(10), 2243-7(1967), see the abstract *
Chemical Abstracts, vol. 90, no. 13, 26 March 1979, (Columbus, Ohio, US), L. MAIER et al.: "Organic phosphorus compounds. 70. Preparation and properties of new phosphorus containing chelating agents for calcium and magnesium ions", see page 605, abstract no. 104063x, & PHOSPHORUS SULFUR 1978, 5(1), 45-51, see the abstract *
Journal of the American Chemical Society, vol. 93, no. 3, 10 February 1971, J. MEINWALD et al.: "Photochemical reactions of 1,8-divinylnaphthalene and 1,8-distyrylnaphthalene", pages 725-731, see page 726, compound 13; page 729, column 2, middle *

Also Published As

Publication number Publication date
DE69108739T2 (de) 1995-09-14
WO1992010504A2 (fr) 1992-06-25
EP0561948B1 (fr) 1995-04-05
DE69108739D1 (de) 1995-05-11
EP0561948A1 (fr) 1993-09-29
US5298498A (en) 1994-03-29
DK0561948T3 (da) 1995-08-21
US5360797A (en) 1994-11-01
CA2094123A1 (fr) 1992-06-08
AU9097791A (en) 1992-07-08
JPH06503329A (ja) 1994-04-14
EP0622373A1 (fr) 1994-11-02

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