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WO1992009311A1 - Prothese vasculaire a double paroi synthetique et biocompatible contenant des cellules a secretion d'hormone - Google Patents

Prothese vasculaire a double paroi synthetique et biocompatible contenant des cellules a secretion d'hormone Download PDF

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Publication number
WO1992009311A1
WO1992009311A1 PCT/EP1991/002258 EP9102258W WO9209311A1 WO 1992009311 A1 WO1992009311 A1 WO 1992009311A1 EP 9102258 W EP9102258 W EP 9102258W WO 9209311 A1 WO9209311 A1 WO 9209311A1
Authority
WO
WIPO (PCT)
Prior art keywords
tubular element
tubular
web
prosthesis according
comprised
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP1991/002258
Other languages
English (en)
Inventor
Giovanni Brotzu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BIORICERCHE SNC DI CARLA ZEDDA
Original Assignee
BIORICERCHE SNC DI CARLA ZEDDA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BIORICERCHE SNC DI CARLA ZEDDA filed Critical BIORICERCHE SNC DI CARLA ZEDDA
Publication of WO1992009311A1 publication Critical patent/WO1992009311A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/507—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials for artificial blood vessels

Definitions

  • Microcapsules consisting of saccharide polymers and polyaminoacids, or other substances such as agarose polymers, suitable to contain hormone producing living cells are known.
  • Microcapsules of such a type are produced and commercialized for instance by the firm Damon Biotech of Boston under the Trade Mark
  • Encapcell The features of said microcapsules allow the cells to be protected from possible rejection events, and enable the necessary cell metabolic supply and the release of the hormones secreted by the same cells.
  • the microcapsules implanted in the body are surrounded by a connective reaction tissue which prevents both the cell metabolic supply and the release of the secreted hormones;
  • biocompatible synthetic double-wall vascular prostheses characterized in that they comprise an outer tubular element 1 made of low-porosity synthetic material and an internal tubular element 2 coaxial with the former and consisting of high porosity synthetic material imbued with polysaccharide material coated with, polyaminoacids, the space comprised between said element 1 and said element 2 being filled with hormone-secreting cells 3-
  • the process for preparing said prostheses is characterized in that it comprises the following stages: a) inside a tubular element 1 made of low-porosity synthetic material, a tubular web 2 of high-porosity synthetic material is placed; b) within said tubular web, a mandrel is introduced of such a diameter that the web adheres to it; c) the web is coated with a thin layer of saccharide polymer; d) the mandrel is removed; e) a further layer consisting of a polyaminoacid is sedimented upon said saccharide polymer layer ; f) the space comprised between the element 1 and the element 2 is filled with hormone-secreting cells.
  • prosthesis exhibits the property of being biocompatible and moreover the element 2 shows a controlled permeability-
  • the prosthesis is employed to make arteriovenous fistulae in which the feasibility of the metabolic exchange between blood and cells 3 and the release into the blood stream of the hormones secreted by the same cells is enabled.
  • FIG. 1 is a schematic illustration of a prosthesis according to the present invention. Reference is made to the numbers in said figure.
  • a tubular web 2 consisting of polyester fibres and including free spaces of size ranging from 10 to 100 ⁇ m within the fibres, is placed into a tubular element 1 consisting of PTFE or of low porosity tissue.
  • tubular web 2 Into the tubular web 2 there is located a mandrel of plastic material or glass having such a diameter that the web adheres to it.
  • the web is soaked with a polysaccharide gel, preferably sodium alginate, in order to fill up the free spaces within the fibres.
  • a polysaccharide gel preferably sodium alginate
  • the mandrel is thereafter removed and the thus obtained structure 2 is coated with a thin layer of a polyaminoacid, preferably polylysine or polyornithine.
  • a polyaminoacid preferably polylysine or polyornithine.
  • mandrel is intended to prevent the polysaccharide material, or any other, from flowing into the lumen of the element
  • the prosthesis manufactured according to the disclosed technique and making use of the described substances exhibits structural properties, biocompatibility and porosity such as to allow it to be successfully employed as prosthesis for arteriovenous fistulae.
  • the coating of the element 2 with polylysine (MW 15000) imparts a good permeability for dextrane having MW 40 000 while maintaining the element 2 actually proof against dextrane having MW higher than 60 000.
  • the permeability may be changed in either direction.
  • the permeability of the element 2 may be adjusted up to a MW of 70 000 thus allowing the transfer of metabolic products from the inside to the outside and vice versa, not however the exchange of immunoglobulins or any other high molecular weight substance.
  • the thickness of the element 2 needs in any case to be lower than 100 ⁇ m in order to allow the metabolic exchanges in both direction.
  • the inner diameter of the element 2 is comprised between 4 and 8 mm while the inner diameter of the element 1 is comprised between 10 and 14 mm.
  • the tubular element 2 consists of a small tube of PTFE having a lamellar structure including free spaces of 10 to 100 ⁇ m, which impart to the same a high porosity.
  • the impregnation with polysaccharide material is achieved by dipping the small tube into the same material and then by submitting it to the vacuum in order to facilitate the filling of the free spaces of the PTFE with the material itself .
  • the polyaminoacid is then sedimented on the thus obtained element.
  • Finally the space comprised between the tubular element 1 and the tubular element 2 is filled with hormone-secreting cells 3 t which may be either free or microincapsulated.
  • prostheses which are employed to make arteriovenous fistulae , allow the supply of oxygen and any other product necessary to the cellular metabolism from the blood stream to said cells and the release in opposite direction of the hormones secreted by the same cells .
  • the inner surface of element 2 may be coated by a monolayer similar to an endothelial one.
  • a specifically favourable application of the prostheses of the present invention is obtained when the microcapsules contain Langherans 1 islands cells which secret insulin.
  • the disclosed technique can be applied for manufacturing any surface of synthetic material coated with biocompatible substances .

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Prostheses (AREA)
  • Materials For Medical Uses (AREA)

Abstract

Prothèses vasculaires à double paroi, synthétiques et biocompatibles, comprenant un élément tubulaire externe (1) fabriqué à partir d'un matériau synthétique de faible viscosité et un élément tubulaire interne (2) coaxial avec le premier et composé d'un matériau synthétique de porosité élevée imprégné d'une matière de polysaccharide enduite d'acides polyaminés qui confèrent à l'élément (2) une caractéristique de perméabilité contrôlée, l'espace compris entre ledit élément (1) et ledit élément (2) étant rempli de cellules à sécrétion d'hormone (3).
PCT/EP1991/002258 1990-11-29 1991-11-27 Prothese vasculaire a double paroi synthetique et biocompatible contenant des cellules a secretion d'hormone Ceased WO1992009311A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT22228A/90 1990-11-29
IT02222890A IT1244808B (it) 1990-11-29 1990-11-29 Protesi vascolare sintetica biocompatibile a doppia parete contenente cellule ormonosecernenti

Publications (1)

Publication Number Publication Date
WO1992009311A1 true WO1992009311A1 (fr) 1992-06-11

Family

ID=11193359

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1991/002258 Ceased WO1992009311A1 (fr) 1990-11-29 1991-11-27 Prothese vasculaire a double paroi synthetique et biocompatible contenant des cellules a secretion d'hormone

Country Status (2)

Country Link
IT (1) IT1244808B (fr)
WO (1) WO1992009311A1 (fr)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0633032A1 (fr) * 1993-06-25 1995-01-11 Sumitomo Electric Industries, Ltd. Prothèse vasculaire et suture chirurgicale antibactérienne
US5527324A (en) * 1994-09-07 1996-06-18 Krantz; Kermit E. Surgical stent
US5679122A (en) * 1993-08-14 1997-10-21 Minnesota Mining & Manufacturing Company Filter for the filtration of a fluid flow
WO1998010804A1 (fr) * 1996-09-13 1998-03-19 Meadox Medicals, Inc. Materiaux d'etancheite a bioresorption ameliores pour greffons vasculaires poreux
US5854382A (en) * 1997-08-18 1998-12-29 Meadox Medicals, Inc. Bioresorbable compositions for implantable prostheses
US6316522B1 (en) 1997-08-18 2001-11-13 Scimed Life Systems, Inc. Bioresorbable hydrogel compositions for implantable prostheses
AT411328B (de) * 2000-07-12 2003-12-29 Universitaetsklinikum Freiburg Röhrensystem zur rekonstruktion einer harnröhre
EP3829603A4 (fr) * 2018-07-27 2022-04-27 Washington University Greffon vasculaire à cellules intégrées pour transplantation
US12053731B2 (en) 2017-04-11 2024-08-06 Cummins Filtration Ip, Inc. Panel filter element

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1982003764A1 (fr) * 1981-05-08 1982-11-11 Massachusetts Inst Technology Fabrication de vaisseaux sanguins et de tissus glandulaires vivants
EP0147939A2 (fr) * 1983-11-15 1985-07-10 JOHNSON & JOHNSON Module implantable pour la régulation de la glycémie
CA1215922A (fr) * 1984-05-25 1986-12-30 Connaught Laboratories Limited Microencapsulation de cellules et de tissus vivants
EP0406665A1 (fr) * 1989-07-04 1991-01-09 Giovanni Brotzu Prothèse vasculaire dont la paroi est chargée de microcapsules contenant des cellules productrices d'hormones
WO1991000119A1 (fr) * 1989-06-30 1991-01-10 Baxter International Inc. Dispositif implantable

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1982003764A1 (fr) * 1981-05-08 1982-11-11 Massachusetts Inst Technology Fabrication de vaisseaux sanguins et de tissus glandulaires vivants
EP0147939A2 (fr) * 1983-11-15 1985-07-10 JOHNSON & JOHNSON Module implantable pour la régulation de la glycémie
CA1215922A (fr) * 1984-05-25 1986-12-30 Connaught Laboratories Limited Microencapsulation de cellules et de tissus vivants
WO1991000119A1 (fr) * 1989-06-30 1991-01-10 Baxter International Inc. Dispositif implantable
EP0406665A1 (fr) * 1989-07-04 1991-01-09 Giovanni Brotzu Prothèse vasculaire dont la paroi est chargée de microcapsules contenant des cellules productrices d'hormones

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0633032A1 (fr) * 1993-06-25 1995-01-11 Sumitomo Electric Industries, Ltd. Prothèse vasculaire et suture chirurgicale antibactérienne
US5584877A (en) * 1993-06-25 1996-12-17 Sumitomo Electric Industries, Ltd. Antibacterial vascular prosthesis and surgical suture
US5679122A (en) * 1993-08-14 1997-10-21 Minnesota Mining & Manufacturing Company Filter for the filtration of a fluid flow
US5527324A (en) * 1994-09-07 1996-06-18 Krantz; Kermit E. Surgical stent
WO1998010804A1 (fr) * 1996-09-13 1998-03-19 Meadox Medicals, Inc. Materiaux d'etancheite a bioresorption ameliores pour greffons vasculaires poreux
US5851229A (en) * 1996-09-13 1998-12-22 Meadox Medicals, Inc. Bioresorbable sealants for porous vascular grafts
US6028164A (en) * 1997-08-18 2000-02-22 Meadox Medicals, Inc. Bioresorbable compositions for implantable prostheses
US6005020A (en) * 1997-08-18 1999-12-21 Meadox Medicals, Inc. Bioresorbable compositions for implantable prostheses
US5854382A (en) * 1997-08-18 1998-12-29 Meadox Medicals, Inc. Bioresorbable compositions for implantable prostheses
US6316522B1 (en) 1997-08-18 2001-11-13 Scimed Life Systems, Inc. Bioresorbable hydrogel compositions for implantable prostheses
US6403758B1 (en) 1997-08-18 2002-06-11 Scimed Life Systems, Inc. Bioresorbable compositions for implantable prostheses
US6660827B2 (en) 1997-08-18 2003-12-09 Scimed Life Systems, Inc. Bioresorbable hydrogel compositions for implantable prostheses
US6946499B2 (en) 1997-08-18 2005-09-20 Scimed Life Systems, Inc. Bioresorbable hydrogel compositions for implantable prostheses
US7109255B2 (en) 1997-08-18 2006-09-19 Scimed Life Systems, Inc. Bioresorbable hydrogel compositions for implantable prostheses
AT411328B (de) * 2000-07-12 2003-12-29 Universitaetsklinikum Freiburg Röhrensystem zur rekonstruktion einer harnröhre
US6939381B2 (en) 2000-07-12 2005-09-06 Universitatsklinikum Frieburg Tube system for reconstructing of hollow organs
US12053731B2 (en) 2017-04-11 2024-08-06 Cummins Filtration Ip, Inc. Panel filter element
EP3829603A4 (fr) * 2018-07-27 2022-04-27 Washington University Greffon vasculaire à cellules intégrées pour transplantation

Also Published As

Publication number Publication date
IT9022228A1 (it) 1992-05-30
IT9022228A0 (it) 1990-11-29
IT1244808B (it) 1994-09-05

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