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WO1992007830A3 - Antagonistes de peptide aux oxindoles - Google Patents

Antagonistes de peptide aux oxindoles Download PDF

Info

Publication number
WO1992007830A3
WO1992007830A3 PCT/US1991/004978 US9104978W WO9207830A3 WO 1992007830 A3 WO1992007830 A3 WO 1992007830A3 US 9104978 W US9104978 W US 9104978W WO 9207830 A3 WO9207830 A3 WO 9207830A3
Authority
WO
WIPO (PCT)
Prior art keywords
oxindole
peptide antagonists
formula
antagonists
peptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1991/004978
Other languages
English (en)
Other versions
WO1992007830A2 (fr
Inventor
Susumu Nakanishi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp Belgium
Pfizer Corp SRL
Original Assignee
Pfizer Corp Belgium
Pfizer Corp SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp Belgium, Pfizer Corp SRL filed Critical Pfizer Corp Belgium
Publication of WO1992007830A2 publication Critical patent/WO1992007830A2/fr
Publication of WO1992007830A3 publication Critical patent/WO1992007830A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne des antagonistes de peptide aux oxindoles représentés par la formule (I), dans laquelle R2 représente =CH-Ar ou spirohydantoïne, et R1, R3 et R4 ont la notation indiquée. Les composés de formule (I) sont utiles dans le traitement des petites cellules cancéreuses de mammifères.
PCT/US1991/004978 1990-10-29 1991-07-18 Antagonistes de peptide aux oxindoles Ceased WO1992007830A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60522090A 1990-10-29 1990-10-29
US605,220 1990-10-29

Publications (2)

Publication Number Publication Date
WO1992007830A2 WO1992007830A2 (fr) 1992-05-14
WO1992007830A3 true WO1992007830A3 (fr) 1992-06-25

Family

ID=24422724

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1991/004978 Ceased WO1992007830A2 (fr) 1990-10-29 1991-07-18 Antagonistes de peptide aux oxindoles

Country Status (3)

Country Link
IE (1) IE913732A1 (fr)
PT (1) PT99350A (fr)
WO (1) WO1992007830A2 (fr)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2694004B1 (fr) * 1992-07-21 1994-08-26 Adir Nouvelles 3-(Hydroxybenzylidényl)-indoline-2-ones et 3-(hydroxybenzylidényl)-indoline-2-thiones, leurs procédés de préparation, et les compositions pharmaceutiques qui les contiennent.
MY128102A (en) * 1993-02-17 2007-01-31 Chugai Pharmaceutical Co Ltd Indolin-2-one-derivatives
GB9313638D0 (en) * 1993-07-01 1993-08-18 Erba Carlo Spa Arylidene and heteroarylidene oxindole derivatives and process for their preparation
US5502072A (en) * 1993-11-26 1996-03-26 Pfizer Inc. Substituted oxindoles
US6906093B2 (en) 1995-06-07 2005-06-14 Sugen, Inc. Indolinone combinatorial libraries and related products and methods for the treatment of disease
US6316635B1 (en) 1995-06-07 2001-11-13 Sugen, Inc. 2-indolinone derivatives as modulators of protein kinase activity
US6147106A (en) 1997-08-20 2000-11-14 Sugen, Inc. Indolinone combinatorial libraries and related products and methods for the treatment of disease
US5880141A (en) 1995-06-07 1999-03-09 Sugen, Inc. Benzylidene-Z-indoline compounds for the treatment of disease
DE69722858T2 (de) * 1996-01-17 2004-05-13 Taiho Pharmaceutical Co. Ltd. Intimale verdickungsinhibitoren
US6486185B1 (en) 1997-05-07 2002-11-26 Sugen, Inc. 3-heteroarylidene-2-indolinone protein kinase inhibitors
US6316429B1 (en) 1997-05-07 2001-11-13 Sugen, Inc. Bicyclic protein kinase inhibitors
US6531502B1 (en) 1998-01-21 2003-03-11 Sugen, Inc. 3-Methylidenyl-2-indolinone modulators of protein kinase
AU3363599A (en) * 1998-03-26 1999-10-18 Max-Planck Institut Fur Biochemie Heterocyclic families of compounds for the modulation of tyrosine protein kinase
US6514981B1 (en) 1998-04-02 2003-02-04 Sugen, Inc. Methods of modulating tyrosine protein kinase function with indolinone compounds
US6569868B2 (en) 1998-04-16 2003-05-27 Sugen, Inc. 2-indolinone derivatives as modulators of protein kinase activity
DK2020408T3 (da) 1998-05-29 2013-09-30 Sugen Inc Pyrrol-substitueret 2-indolinon som proteinkinaseinhibitor
PT1157019E (pt) 1998-12-17 2003-06-30 Hoffmann La Roche 4-alcenil (e alcinil) oxindolos como inibidores dequinases dependentes de ciclina em particular cdk2
ATE387448T1 (de) 1998-12-17 2008-03-15 Hoffmann La Roche 4,5-pyrazinoxindole als proteinkinasehemmer
US6153634A (en) * 1998-12-17 2000-11-28 Hoffmann-La Roche Inc. 4,5-azolo-oxindoles
EP1149093A1 (fr) 1998-12-17 2001-10-31 F. Hoffmann-La Roche Ag 4-aryloxindoles utilises comme inhibiteurs de proteines kinases jnk
US6689806B1 (en) 1999-03-24 2004-02-10 Sugen, Inc. Indolinone compounds as kinase inhibitors
US6878733B1 (en) 1999-11-24 2005-04-12 Sugen, Inc. Formulations for pharmaceutical agents ionizable as free acids or free bases
US6313310B1 (en) 1999-12-15 2001-11-06 Hoffmann-La Roche Inc. 4-and 5-alkynyloxindoles and 4-and 5-alkenyloxindoles
KR100713960B1 (ko) 2000-02-15 2007-05-02 수젠, 인크. 피롤 치환 2-인돌리논 단백질 인산화 효소 저해제
MY128449A (en) 2000-05-24 2007-02-28 Sugen Inc Prodrugs of 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives
US6706709B2 (en) 2000-06-02 2004-03-16 Sugen, Inc. Indolinone derivatives as protein kinase/phosphatase inhibitors
US6504034B2 (en) 2001-01-23 2003-01-07 Hoffmann-La Roche Inc. Naphthostyrils
AR042586A1 (es) 2001-02-15 2005-06-29 Sugen Inc 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa
US6599902B2 (en) 2001-05-30 2003-07-29 Sugen, Inc. 5-aralkysufonyl-3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives as kinase inhibitors
US20070021366A1 (en) * 2004-11-19 2007-01-25 Srivastava Satish K Structural-based inhibitors of the glutathione binding site in aldose reductase, methods of screening therefor and methods of use
US7795385B2 (en) * 2004-12-17 2010-09-14 Bexar Global, Inc. Use of bombesin/gastrin-releasing peptide antagonists for the treatment of inflammatory conditions, acute lung injury and bipolar disorder
US8101580B2 (en) 2005-04-21 2012-01-24 Astellas Pharma Inc. Therapeutic agent for irritable bowel syndrome
AR059265A1 (es) 2006-02-07 2008-03-19 Astrazeneca Ab Compuestos espiro condensados con actividad inhibitoria en el receptor vaniloide1 (vr1)
CN103274988B (zh) * 2013-06-20 2016-04-13 河北大学 3-(氰基-p-硝基苯甲撑基)-2-吲哚酮衍生物及其合成方法和用途
CN115403566B (zh) * 2022-09-21 2024-01-30 山东大学 3-取代吲哚-2-酮化合物及其制备方法和应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0028906A1 (fr) * 1979-11-13 1981-05-20 Imperial Chemical Industries Plc Spiro(imidazolidine-4,3'-indoline)triones-2,2',5 substituées en position 1', procédés pour leur préparation et compositions pharmaceutiques les contenant
EP0304493A1 (fr) * 1987-03-11 1989-03-01 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Derives d'hydroxystyrene

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0028906A1 (fr) * 1979-11-13 1981-05-20 Imperial Chemical Industries Plc Spiro(imidazolidine-4,3'-indoline)triones-2,2',5 substituées en position 1', procédés pour leur préparation et compositions pharmaceutiques les contenant
EP0304493A1 (fr) * 1987-03-11 1989-03-01 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Derives d'hydroxystyrene

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
J.E. RIVIER et al.: "Peptides: Chemistry, Structure and Biology. Proceedings of the Eleventh American Peptide Symposium, La Jolla, California, 9-14 July 1989", D.C. HEIMBROOK et al.: "Design and evaluation of novel gastrin-releasing peptide antagonists for the treatment of small cell lung cancer", 1990, ESCOM, Leiden, NL, pages 56-59, see the whole document (cited in the application) *

Also Published As

Publication number Publication date
IE913732A1 (en) 1992-05-22
WO1992007830A2 (fr) 1992-05-14
PT99350A (pt) 1992-10-30

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