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WO1992006992A3 - New process for biophosphorylating organic compounds - Google Patents

New process for biophosphorylating organic compounds Download PDF

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Publication number
WO1992006992A3
WO1992006992A3 PCT/US1991/006816 US9106816W WO9206992A3 WO 1992006992 A3 WO1992006992 A3 WO 1992006992A3 US 9106816 W US9106816 W US 9106816W WO 9206992 A3 WO9206992 A3 WO 9206992A3
Authority
WO
WIPO (PCT)
Prior art keywords
biophosphorylating
process include
organic compounds
new process
hydroxyl containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1991/006816
Other languages
French (fr)
Other versions
WO1992006992A2 (en
Inventor
Shieh-Shung Tom Chen
Brian R Petuch
Annjia T Hsu
Byron H Arison
Francis Dumont
Raymond F White
David J Mathre
Jane T Wu
Lydia T So
Robert A Reamer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/691,606 external-priority patent/US5198421A/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Priority to JP4501234A priority Critical patent/JPH06502536A/en
Publication of WO1992006992A2 publication Critical patent/WO1992006992A2/en
Publication of WO1992006992A3 publication Critical patent/WO1992006992A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P9/00—Preparation of organic compounds containing a metal or atom other than H, N, C, O, S or halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/117—Esters of phosphoric acids with cycloaliphatic alcohols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07F9/6533—Six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/65525—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a seven-(or more) membered ring
    • C07F9/65527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a seven-(or more) membered ring condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Described is a new microbial biophosphorylation process for regiospecifically phosphorylating the hydroxyl group, in a ''phosphate active'' hydroxyl containing organic compound, under biotransformation conditions utilizing the microorganism, Rhizopus oryzae ATCC No. 11145. The phosphorylated compounds produced by the process include e.g., macrolide FK-506 type immunosuppressants which are useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow, liver, kidney, lung and heart transplants. Other hydroxyl containing compounds, applicable in this process include rapamycin, echinocandins, HIV protease inhibitors, simvastatin and zearalenone.
PCT/US1991/006816 1990-10-09 1991-09-19 New process for biophosphorylating organic compounds Ceased WO1992006992A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP4501234A JPH06502536A (en) 1990-10-09 1991-09-19 Novel biological phosphorylation method for organic compounds

Applications Claiming Priority (14)

Application Number Priority Date Filing Date Title
US594,214 1975-07-09
US595,894 1984-04-02
US59421490A 1990-10-09 1990-10-09
US59450090A 1990-10-09 1990-10-09
US594,500 1990-10-09
US59589490A 1990-10-11 1990-10-11
US69160791A 1991-04-26 1991-04-26
US691,607 1991-04-26
US691,606 1991-04-26
US07/691,606 US5198421A (en) 1991-04-26 1991-04-26 Phosphorylated cyclic lipopeptide
US70138791A 1991-05-16 1991-05-16
US701,387 1991-05-16
US73596391A 1991-07-25 1991-07-25
US735,963 1991-07-25

Publications (2)

Publication Number Publication Date
WO1992006992A2 WO1992006992A2 (en) 1992-04-30
WO1992006992A3 true WO1992006992A3 (en) 1992-06-25

Family

ID=27569847

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1991/006816 Ceased WO1992006992A2 (en) 1990-10-09 1991-09-19 New process for biophosphorylating organic compounds

Country Status (4)

Country Link
EP (1) EP0552309A1 (en)
JP (1) JPH06502536A (en)
CA (1) CA2093429A1 (en)
WO (1) WO1992006992A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5493107A (en) * 1993-05-07 1996-02-20 Digicomp Research Corporation Shelf price label and product placement verification method and apparatus
ES2065290B1 (en) * 1993-07-29 1995-11-01 Consejo Superior Investigacion USE OF ENZYMATIC INHIBITORS FOR THE TREATMENT OF DISEASES CAUSED BY PARASITES.
ATE260983T1 (en) * 1997-03-11 2004-03-15 Aventis Pharma Inc METHOD FOR PRODUCING 4-(4-(4-(HYDROXYDIPHENYL)-1-PIPERIDINYL)-1-HYDROXYBUTYL - ALPHA,ALPHA-DIMENTHYLPHENYLACETIC ACID AND PHOSPHORYLATED DERIVATIVES
EP2407473A3 (en) 2002-02-01 2012-03-21 ARIAD Pharmaceuticals, Inc Method for producing phosphorus-containing compounds
AU2003901812A0 (en) * 2003-04-15 2003-05-01 Vital Health Sciences Pty Ltd Phosphates of secondary alcohols
DE102005056669A1 (en) 2005-11-28 2007-05-31 Basf Ag Fermentative preparation of organic compounds, useful for making, e.g. amino acids or enzymes, using a starch source from which non-starch solids have not been removed, hydrolyzed and enzymatically converted to monosaccharides
CN101583347A (en) 2006-11-14 2009-11-18 阿里亚德医药股份有限公司 Oral preparation
US9868682B2 (en) * 2013-08-19 2018-01-16 REG Life Sciences, LLC Production of partially refined waste glycerol

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0192091A2 (en) * 1985-01-29 1986-08-27 Asahi Denka Kogyo Kabushiki Kaisha Metal salts of organic phosphates and antihyperlipemic agents containing them
EP0337714A2 (en) * 1988-04-12 1989-10-18 Merck & Co. Inc. HIV protease inhibitors useful for the treatment of aids
EP0405997A1 (en) * 1989-06-30 1991-01-02 Merck & Co. Inc. Antibiotic agent
EP0434365A2 (en) * 1989-12-18 1991-06-26 Merck & Co. Inc. HIV protease inhibitors useful for the treatment of aids

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0192091A2 (en) * 1985-01-29 1986-08-27 Asahi Denka Kogyo Kabushiki Kaisha Metal salts of organic phosphates and antihyperlipemic agents containing them
EP0337714A2 (en) * 1988-04-12 1989-10-18 Merck & Co. Inc. HIV protease inhibitors useful for the treatment of aids
EP0405997A1 (en) * 1989-06-30 1991-01-02 Merck & Co. Inc. Antibiotic agent
EP0434365A2 (en) * 1989-12-18 1991-06-26 Merck & Co. Inc. HIV protease inhibitors useful for the treatment of aids

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Journal of Antibiotics, vol. 38, no. 3, March 1985, (Tokyo, JP), A. ENDO et al.: "Microbial phosphorylation of compactin (ML-236B) and related compounds", pages 328-332, see the whole document *
Patent Abstracts of Japan, vol. 9, no. 188 (C-295)[1911], 3 August 1985, & JP,A,60058084 (AKIRA ENDOU) 4 April 1985, see abstract *

Also Published As

Publication number Publication date
WO1992006992A2 (en) 1992-04-30
CA2093429A1 (en) 1992-04-10
JPH06502536A (en) 1994-03-24
EP0552309A1 (en) 1993-07-28

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