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WO1992006603A1 - Fibres medicamenteuses au gout deguise - Google Patents

Fibres medicamenteuses au gout deguise Download PDF

Info

Publication number
WO1992006603A1
WO1992006603A1 PCT/US1990/005859 US9005859W WO9206603A1 WO 1992006603 A1 WO1992006603 A1 WO 1992006603A1 US 9005859 W US9005859 W US 9005859W WO 9206603 A1 WO9206603 A1 WO 9206603A1
Authority
WO
WIPO (PCT)
Prior art keywords
dosage unit
unit according
pharmaceutic
medicament
pharmaceutic dosage
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1990/005859
Other languages
English (en)
Inventor
Richard C. Fuisz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fuisz Pharmaceutical Ltd
Biovail Technologies Ltd
Original Assignee
Fuisz Pharmaceutical Ltd
Fuisz Technologies Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fuisz Pharmaceutical Ltd, Fuisz Technologies Ltd filed Critical Fuisz Pharmaceutical Ltd
Priority to AU67118/90A priority Critical patent/AU6711890A/en
Priority to PCT/US1990/005859 priority patent/WO1992006603A1/fr
Priority to CA002027360A priority patent/CA2027360C/fr
Publication of WO1992006603A1 publication Critical patent/WO1992006603A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/20—Synthetic spices, flavouring agents or condiments
    • A23L27/204—Aromatic compounds

Definitions

  • TITLE TASTE MASKED MEDICATED FLOSS
  • Serial No. 07/325,643 is also a continuation-in-part of said application Serial No. 07/169,838 and of application Serial No. 07/169,914, filed March 18, 1988, which is another continuation-in-part of application Serial No. 07/040,371.
  • the disclosure in application Serial No. 07/283,742 deals with oleaginous substances such as vegetable oil, baby oil, olive oil, margarine, lanolin, cocoa butter and the like, and how their lack of affinity for water is altered by mixing the oleaginous substance with sugar and melt spinning the mixture in a cotton candy spinning machine or the equivalent. As so modified the products disperse autogenously in water forming a colloidal or colloidal-like dispersion.
  • a spun product from a combination of a saccharide and a hydrophobic ingredient is hydrophillic with low concentrations of such ingredient but becomes increasingly hydrophobic as the concentration of the hydrophobic ingredient is increased, although the end product nevertheless acts hydrophilically when the water temperature is elevated. Larger ratios of hydrophobic substance-to-saccharide yields a spun fibrous product that has increased stability. Similar stabilization can be attained by adding either beeswax or a petrolatum to the saccharide either in the presence of or absence of a separate active ingredient. Control with beeswax can also provide a time release tablet or the like when swallowed.
  • Example VIII beeswax granules were mixed with sucrose in the ratio of 1:16, and in Example IX the ratio was increased to 1:12.
  • Example XV where "MAALOX" antacid suspension was the medicament, 1/4 tsp.
  • ground beeswax USP was blended with 1:6 parts "MAALOX” to sucrose.
  • the resulting floss when placed as a wad on the tongue, sat on the tongue for about 2 seconds and then was gone within an additional 3 seconds. No aftertaste of the "MAALOX" antacid could be detected.
  • an object of the present invention to provide a floss type oral dosage unit that includes a taste masking substance other than the saccharide.
  • Another object of the invention is to provide a dosage unit containing an effective amount of an ingredient that functions to inhibit undesirable taste stimulation by an unpalatable or distasteful medicament.
  • a pharmaceutic dosage unit comprising compacted spun fibers of a spinnable, readily water-soluble material, an effective amount of a medicament, and an effective amount of an ingredient other than said medicament and said material which ingredient, when the dosage unit is taken orally, functions to inhibit undesirable taste stimulation by said medicament.
  • Co-pending application Serial No. 07/169,838 describes methods for combining a medicament with any one or more of the water soluble melt spinnable sugars and spinning the combination to produce a readily soluble floss form of the medicament.
  • the disclosure of such application is incorporated herein by reference.
  • Co-pending application Serial No. 07/283,742 discloses that any oleaginous substance that can be mixed with a melt-spinnable sugar, when spun in a cotton candy spinning machine, produces a product which, when added to water or has water added to it, forms, virtually autogenously, a uniform dispersion having all the appearances of a colloidal dispersion.
  • the disclosure of such application is incorporated herein by reference.
  • Co-pending application Serial No. 07/325,643 discloses that if the ratio of oleaginous material to sugar (saccharide) exceeds a certain value, the precise crossover point being a function of the particular oleaginous material and sugar, the floss product will no longer disperse rapidly in water at normal room temperature. However, rapid dispersal as an apparent colloidal system does take place at elevated water temperatures. Similar results can be obtained by admixing with the sugar, with or without other ingredients, suitable quantities of certain semi-solid substances that individually are practically insoluble in water, such as beeswax or petrolatum. In general, the fibrous products produced by the examples set forth in that application give the appearance when added to water at normal room temperature of being hydrophobic.
  • the fibrous product actually float on the surface of the water. But as soon as the water temperature is raised above some critical level for the particular fiber product, the fibrous product disperses rapidly throughout the body of water forming what appears to be a colloidal dispersion.
  • the present invention can best be described and understood from a consideration of certain examples.
  • the floss spinning machine used was: Econo floss Model 3017 manufactured by Gold Medal Products Co. of Cincinnati, Ohio. Unless otherwise stated, reference to sucrose in the examples is to "Gold Medal" flossugar, lime flavor. Unless otherwise indicated, the temperature of the grid in the spinning machine was about 180°F. (82.2°C.) while the operating speed was about 3800 R.P.M.
  • Each lozenge contains as the active ingredients 32.5 mg phenol and sodium phenolate, with inactive ingredients comprising coloring agent, corn syrup, flavor and sucrose.
  • the chopper was operated for about 1 minute until materials were blended into fine powder.
  • the powder was transferred to a mixing vessel to which was added 3 tsp. aspirin USP from Valley Biomedical of Winchester, Virginia, 1/5 tsp. "Crisco" vegetable oil for binding, and 1/2 cup (24 tsps.) lime flosssugar.
  • the ingredients were mixed thoroughly with a spoon for about 4 minutes, and the resulting mixture spun using the floss spinning machine. A nice floss resulted.
  • the floss was observed to float.
  • the floss dispersed immediately while a quantity of telltale white material appeared at the surface. It was concluded that the white material was the aspirin content.
  • a quantity of the floss produced in Example II about the size of a quarter dollar and about 1/4" thick, was placed on the tongue of the experimenter. It dispersed in about 4 to 5 seconds leaving a bitter aftertaste characteristic of aspirin. About 1 hour later, having cleared the palate, the experimenter repeated the test this time using a wad, the same size, of the floss produced in Example I. Again, it took about 4 to 5 seconds to disperse on the tongue. But this time the phenol content apparently numbed slightly the taste buds such that absolutely no aspirin taste could be detected either during the dispersion or by way of aftertaste.
  • the ratio of the "chlorseptic" lozenge to the aspirin medicament in Example I is believed to be about 1:9.
  • the actual phenol content is less than that relative to the medicament and has been estimated as in the ratio of about 1:40.
  • the test described in Example II revealed that the beeswax plus sucrose content by itself was ineffective to cause the sucrose content to mask the taste of the aspirin.
  • the small quantity of phenol in the ratio of 1 part phenol to 40 parts aspirin to 320 parts sucrose was completely effective.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

L'addition d'une quantité infime d'un agent anesthésiant, tel que du phénol, à des fibres de saccharide contenant une dose de médicament engourdit suffisamment les papilles gustatives pour que le médicament ne puisse pas les stimuler de manière désagréable au goût.
PCT/US1990/005859 1990-10-10 1990-10-10 Fibres medicamenteuses au gout deguise Ceased WO1992006603A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU67118/90A AU6711890A (en) 1990-10-10 1990-10-10 Taste masked medicated floss
PCT/US1990/005859 WO1992006603A1 (fr) 1990-10-10 1990-10-10 Fibres medicamenteuses au gout deguise
CA002027360A CA2027360C (fr) 1990-10-10 1990-10-11 Soie medicamentee au gout masque

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU67118/90A AU6711890A (en) 1990-10-10 1990-10-10 Taste masked medicated floss
PCT/US1990/005859 WO1992006603A1 (fr) 1990-10-10 1990-10-10 Fibres medicamenteuses au gout deguise
CA002027360A CA2027360C (fr) 1990-10-10 1990-10-11 Soie medicamentee au gout masque

Publications (1)

Publication Number Publication Date
WO1992006603A1 true WO1992006603A1 (fr) 1992-04-30

Family

ID=27155683

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1990/005859 Ceased WO1992006603A1 (fr) 1990-10-10 1990-10-10 Fibres medicamenteuses au gout deguise

Country Status (3)

Country Link
AU (1) AU6711890A (fr)
CA (1) CA2027360C (fr)
WO (1) WO1992006603A1 (fr)

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5843922A (en) * 1994-07-29 1998-12-01 Fuisz Technologies Ltd. Preparation of oligosaccharides and products therefrom
US8785361B2 (en) 2010-07-02 2014-07-22 The Procter & Gamble Company Detergent product and method for making same
US9074305B2 (en) 2010-07-02 2015-07-07 The Procter & Gamble Company Method for delivering an active agent
US9163205B2 (en) 2010-07-02 2015-10-20 The Procter & Gamble Company Process for making films from nonwoven webs
US9801830B2 (en) 2010-07-02 2017-10-31 The Procter & Gamble Company Methods of delivering a health care active by administering personal health care articles comprising a filmament
US10982176B2 (en) 2018-07-27 2021-04-20 The Procter & Gamble Company Process of laundering fabrics using a water-soluble unit dose article
US11053466B2 (en) 2018-01-26 2021-07-06 The Procter & Gamble Company Water-soluble unit dose articles comprising perfume
US11142730B2 (en) 2018-01-26 2021-10-12 The Procter & Gamble Company Water-soluble articles and related processes
US11193097B2 (en) 2018-01-26 2021-12-07 The Procter & Gamble Company Water-soluble unit dose articles comprising enzyme
US11434586B2 (en) 2010-07-02 2022-09-06 The Procter & Gamble Company Filaments comprising an active agent nonwoven webs and methods for making same
US11505379B2 (en) 2018-02-27 2022-11-22 The Procter & Gamble Company Consumer product comprising a flat package containing unit dose articles
US11679066B2 (en) 2019-06-28 2023-06-20 The Procter & Gamble Company Dissolvable solid fibrous articles containing anionic surfactants
US11753608B2 (en) 2018-01-26 2023-09-12 The Procter & Gamble Company Water-soluble unit dose articles comprising perfume
US11859338B2 (en) 2019-01-28 2024-01-02 The Procter & Gamble Company Recyclable, renewable, or biodegradable package
US11878077B2 (en) 2019-03-19 2024-01-23 The Procter & Gamble Company Fibrous water-soluble unit dose articles comprising water-soluble fibrous structures
US11925698B2 (en) 2020-07-31 2024-03-12 The Procter & Gamble Company Water-soluble fibrous pouch containing prills for hair care
US12031254B2 (en) 2019-03-19 2024-07-09 The Procter & Gamble Company Process of reducing malodors on fabrics
US12234431B2 (en) 2018-10-03 2025-02-25 The Procter & Gamble Company Water-soluble unit dose articles comprising water-soluble fibrous structures and particles
US12364651B2 (en) 2020-08-19 2025-07-22 The Procter & Gamble Company Flexible, porous, dissolvable solid sheet article containing direct-added microcapsules and process for making the same
US12403083B2 (en) 2021-08-30 2025-09-02 The Procter & Gamble Company Dissolvable solid structure comprising first and second polymeric structurants

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6123982A (en) * 1998-09-01 2000-09-26 Colgate-Palmolive Company Dental floss

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4855326A (en) * 1987-04-20 1989-08-08 Fuisz Pharmaceutical Ltd. Rapidly dissoluble medicinal dosage unit and method of manufacture
US4873085A (en) * 1987-04-20 1989-10-10 Fuisz Pharmaceutical Ltd. Spun fibrous cosmetic and method of use

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4855326A (en) * 1987-04-20 1989-08-08 Fuisz Pharmaceutical Ltd. Rapidly dissoluble medicinal dosage unit and method of manufacture
US4873085A (en) * 1987-04-20 1989-10-10 Fuisz Pharmaceutical Ltd. Spun fibrous cosmetic and method of use

Cited By (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5843922A (en) * 1994-07-29 1998-12-01 Fuisz Technologies Ltd. Preparation of oligosaccharides and products therefrom
US10517836B2 (en) 2010-07-02 2019-12-31 The Procter & Gamble Company Methods of delivering a health care active by administering personal health care articles comprising a filmament
US10646413B2 (en) 2010-07-02 2020-05-12 The Procter & Gamble Company Web material and method for making same
US9163205B2 (en) 2010-07-02 2015-10-20 The Procter & Gamble Company Process for making films from nonwoven webs
US11944693B2 (en) 2010-07-02 2024-04-02 The Procter & Gamble Company Method for delivering an active agent
US9421153B2 (en) 2010-07-02 2016-08-23 The Procter & Gamble Company Detergent product and method for making same
US9480628B2 (en) 2010-07-02 2016-11-01 The Procer & Gamble Company Web material and method for making same
US9801830B2 (en) 2010-07-02 2017-10-31 The Procter & Gamble Company Methods of delivering a health care active by administering personal health care articles comprising a filmament
US10045915B2 (en) 2010-07-02 2018-08-14 The Procter & Gamble Company Method for delivering an active agent
US9074305B2 (en) 2010-07-02 2015-07-07 The Procter & Gamble Company Method for delivering an active agent
US10449163B2 (en) 2010-07-02 2019-10-22 The Procter & Gamble Company Methods of delivering a health care active by administering personal health care articles comprising a filament
US9175250B2 (en) 2010-07-02 2015-11-03 The Procter & Gamble Company Fibrous structure and method for making same
US10894005B2 (en) 2010-07-02 2021-01-19 The Procter & Gamble Company Detergent product and method for making same
US10912738B2 (en) 2010-07-02 2021-02-09 The Procter & Gamble Company Methods of delivering an oral care active by administering oral care articles comprising a filament
US12194118B2 (en) 2010-07-02 2025-01-14 The Procter & Gamble Company Detergent product and method for making same
US11970789B2 (en) 2010-07-02 2024-04-30 The Procter & Gamble Company Filaments comprising an active agent nonwoven webs and methods for making same
US8785361B2 (en) 2010-07-02 2014-07-22 The Procter & Gamble Company Detergent product and method for making same
US11964059B2 (en) 2010-07-02 2024-04-23 The Procter & Gamble Company Methods of delivering an oral care active by administering oral care articles comprising a filament
US11434586B2 (en) 2010-07-02 2022-09-06 The Procter & Gamble Company Filaments comprising an active agent nonwoven webs and methods for making same
US11944696B2 (en) 2010-07-02 2024-04-02 The Procter & Gamble Company Detergent product and method for making same
US11142730B2 (en) 2018-01-26 2021-10-12 The Procter & Gamble Company Water-soluble articles and related processes
US11753608B2 (en) 2018-01-26 2023-09-12 The Procter & Gamble Company Water-soluble unit dose articles comprising perfume
US11053466B2 (en) 2018-01-26 2021-07-06 The Procter & Gamble Company Water-soluble unit dose articles comprising perfume
US11193097B2 (en) 2018-01-26 2021-12-07 The Procter & Gamble Company Water-soluble unit dose articles comprising enzyme
US11505379B2 (en) 2018-02-27 2022-11-22 The Procter & Gamble Company Consumer product comprising a flat package containing unit dose articles
US10982176B2 (en) 2018-07-27 2021-04-20 The Procter & Gamble Company Process of laundering fabrics using a water-soluble unit dose article
US12234431B2 (en) 2018-10-03 2025-02-25 The Procter & Gamble Company Water-soluble unit dose articles comprising water-soluble fibrous structures and particles
US11859338B2 (en) 2019-01-28 2024-01-02 The Procter & Gamble Company Recyclable, renewable, or biodegradable package
US11878077B2 (en) 2019-03-19 2024-01-23 The Procter & Gamble Company Fibrous water-soluble unit dose articles comprising water-soluble fibrous structures
US12031254B2 (en) 2019-03-19 2024-07-09 The Procter & Gamble Company Process of reducing malodors on fabrics
US11679066B2 (en) 2019-06-28 2023-06-20 The Procter & Gamble Company Dissolvable solid fibrous articles containing anionic surfactants
US11925698B2 (en) 2020-07-31 2024-03-12 The Procter & Gamble Company Water-soluble fibrous pouch containing prills for hair care
US12364651B2 (en) 2020-08-19 2025-07-22 The Procter & Gamble Company Flexible, porous, dissolvable solid sheet article containing direct-added microcapsules and process for making the same
US12403083B2 (en) 2021-08-30 2025-09-02 The Procter & Gamble Company Dissolvable solid structure comprising first and second polymeric structurants

Also Published As

Publication number Publication date
CA2027360C (fr) 1998-02-03
CA2027360A1 (fr) 1992-04-12
AU6711890A (en) 1992-05-20

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