[go: up one dir, main page]

WO1991012339A3 - Association allelomorphe du gene recepteur de dopamine (d2) humaine dans des troubles compulsifs tels que l'alcoolisme - Google Patents

Association allelomorphe du gene recepteur de dopamine (d2) humaine dans des troubles compulsifs tels que l'alcoolisme Download PDF

Info

Publication number
WO1991012339A3
WO1991012339A3 PCT/US1991/000855 US9100855W WO9112339A3 WO 1991012339 A3 WO1991012339 A3 WO 1991012339A3 US 9100855 W US9100855 W US 9100855W WO 9112339 A3 WO9112339 A3 WO 9112339A3
Authority
WO
WIPO (PCT)
Prior art keywords
receptor gene
alcoholism
allele
sample
compulsive disorders
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1991/000855
Other languages
English (en)
Other versions
WO1991012339A2 (fr
Inventor
E P Noble
Kenneth L Blum
Peter J Sheridan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Texas System
University of Texas at Austin
University of California Berkeley
University of California San Diego UCSD
Original Assignee
University of Texas System
University of Texas at Austin
University of California Berkeley
University of California San Diego UCSD
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Texas System, University of Texas at Austin, University of California Berkeley, University of California San Diego UCSD filed Critical University of Texas System
Priority to CA002074519A priority Critical patent/CA2074519C/fr
Priority to DE69120526T priority patent/DE69120526T2/de
Priority to JP91505069A priority patent/JPH05508072A/ja
Priority to EP91905230A priority patent/EP0514490B1/fr
Publication of WO1991012339A2 publication Critical patent/WO1991012339A2/fr
Publication of WO1991012339A3 publication Critical patent/WO1991012339A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Dans un mode de réalisation important, l'invention concerne un procédé de diagnostic de la prédisposition d'un individu à des maladies compulsives. Le procédé consiste initialement à prélever un échantillon d'ADN sur ledit individu, puis à déterminer la présence ou l'absence, dans ledit échantillon, d'un gène allèle récepteur de D2 humaine particulier. La détection dudit allèle dans l'échantillon indique la prédisposition à des maladies compulsives. Un mode de réalisation particulièrement préféré consiste à détecter la susceptibilité de devenir alcoolique, notamment puisque l'on a découvert la présence dudit allèle chez une majorité d'alcooliques présentant des symptômes cliniques. On détecte, de préférence dans ledit échantillon, le gène A1 allèle récepteur de D2 humaine.
PCT/US1991/000855 1990-02-07 1991-02-07 Association allelomorphe du gene recepteur de dopamine (d2) humaine dans des troubles compulsifs tels que l'alcoolisme Ceased WO1991012339A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002074519A CA2074519C (fr) 1990-02-07 1991-02-07 Association allelique du gene du recepteur de la dopamine (d2) dans les troubles associes a un comportement compulsif tels que l'alcoolisme
DE69120526T DE69120526T2 (de) 1990-02-07 1991-02-07 Allelische verbindung des humanen dopamin-(d2)rezeptor-gens in kompulsionsstörungen wie alkoholismus
JP91505069A JPH05508072A (ja) 1990-02-07 1991-02-07 アルコール中毒症様の強迫的不全症におけるヒトド―パミン（ｄ２）受容体遺伝子の対立遺伝子関連
EP91905230A EP0514490B1 (fr) 1990-02-07 1991-02-07 Association allomorphe du gene recepteur de dopamine (d2) humaine dans des troubles compulsifs tels que l'alcoolisme

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47705790A 1990-02-07 1990-02-07
US477,057 1990-02-07

Publications (2)

Publication Number Publication Date
WO1991012339A2 WO1991012339A2 (fr) 1991-08-22
WO1991012339A3 true WO1991012339A3 (fr) 1991-10-03

Family

ID=23894338

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1991/000855 Ceased WO1991012339A2 (fr) 1990-02-07 1991-02-07 Association allelomorphe du gene recepteur de dopamine (d2) humaine dans des troubles compulsifs tels que l'alcoolisme

Country Status (7)

Country Link
EP (1) EP0514490B1 (fr)
JP (1) JPH05508072A (fr)
AT (1) ATE139803T1 (fr)
CA (1) CA2074519C (fr)
DE (1) DE69120526T2 (fr)
DK (1) DK0514490T3 (fr)
WO (1) WO1991012339A2 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6277591B1 (en) 1988-11-18 2001-08-21 Oregon Health Science University Dopamine receptors and genes
US5569601A (en) 1990-12-07 1996-10-29 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University Human dopamine receptor and its uses
DE69518526T2 (de) 1995-10-31 2001-06-13 Agfa-Gevaert N.V., Mortsel Auf der Druckpressentwicklung von lithographischen Druckplatten bestehend aus lichtempfindlichem Schichten mit Aryldiazosulphonatharzen
EP0773112B1 (fr) 1995-11-09 2001-05-30 Agfa-Gevaert N.V. Elément d'enregistrement thermosensible et méthode pour la fabrication d'un cliché pour l'imprimerie utilisant cet élément
EP0773113B1 (fr) 1995-11-09 2000-05-24 Agfa-Gevaert N.V. Elément d'enregistrement thermosensible et méthode pour la fabrication d'un cliché lithographique utilisant cet élément
EP0800928B1 (fr) 1996-04-09 1999-07-28 Agfa-Gevaert N.V. Elément d'enregistrement thermosensible et procédé pour la fabrication de plaques lithographiques utilisant cet élément
EP0845709B1 (fr) 1996-11-29 2006-01-18 Agfa-Gevaert Elément d'enregistrement thermosensible et méthode pour la fabrication d'un cliché pour l'imprimerie utilisant cet élément
EP0849091B1 (fr) 1996-12-19 2001-03-21 Agfa-Gevaert N.V. Elément sensible à la chaleur formateur d'image pour la fabrication de plaques d'impression lithographiques comprenant des particules de polymère avec une dimension de particule spécifique
EP0849090A3 (fr) 1996-12-19 1998-07-01 Agfa-Gevaert N.V. Elément thermosensible formateur d'image pour la préparation de plaques d'impression lithographiques présentant des propriétés améliorées de transport
DE69901642T3 (de) 1998-03-14 2019-03-21 Agfa Nv Verfahren zur Herstellung einer positiv arbeitenden Druckplatte aus einem wärmeempfindlichem Bildaufzeichnungsmaterial

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990005780A1 (fr) * 1988-11-18 1990-05-31 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University Recepteurs de dopamine et genes

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990005780A1 (fr) * 1988-11-18 1990-05-31 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University Recepteurs de dopamine et genes

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
The American Journal of Human Genetics, volume 45, no. 5, November 1989, University of Chicago Press (Illinois, US), D.K. Grady et al.: "The human dopamine D2 receptor gene is located on chromosome II at q22-q23 and identifies a TaqI RFLP", pages 778-785 *
The Journal of the American Medical Association, volume 263, no. 15, 18 April 1990, K. Blum et al.: "Allelic association of human dopamine D2 receptor gene in alcoholism", pages 2055-2060 *
The Journal of the American Medical Association, volume 264, no. 24, 26 December 1990, A.M. Bolos et al.: "Population and pedigree studies reveal a lack of association between the dopamine D2 receptor gene and alcoholism", pages 3156-3160 *

Also Published As

Publication number Publication date
CA2074519A1 (fr) 1991-08-08
DE69120526T2 (de) 1997-02-13
DK0514490T3 (da) 1996-11-04
EP0514490A1 (fr) 1992-11-25
CA2074519C (fr) 2003-10-28
DE69120526D1 (de) 1996-08-01
ATE139803T1 (de) 1996-07-15
WO1991012339A2 (fr) 1991-08-22
JPH05508072A (ja) 1993-11-18
EP0514490B1 (fr) 1996-06-26

Similar Documents

Publication Publication Date Title
CA2230372A1 (fr) Quantification de p97 pour diagnostiquer et surveiller la maladie d'alzheimer
EP0769560A3 (fr) Détection d'une prédisposition génétique d'affections périodontiques
WO2000004187A3 (fr) Necessaires de diagnostic et d'evaluation des predispositions pour certaines affections, et procede correspondant
CA2282746A1 (fr) Prediction de la coronaropathie
CA2275865A1 (fr) Procede de detection de dereglements proliferatifs cellulaires
EP1256797A3 (fr) Mesure optique de la concentration dans les dispositifs de détection d'analyte
WO2000040749A3 (fr) Technique de detection de transcrits geniques dans le sang et leur utilisation
CA2226223A1 (fr) Detection de la predisposition genetique a l'osteoporose
AU2849300A (en) Methods and assay kits for detecting mononuclear cell phenotype
WO1991012339A3 (fr) Association allelomorphe du gene recepteur de dopamine (d2) humaine dans des troubles compulsifs tels que l'alcoolisme
US20090011452A1 (en) Method of Prognosis of Mental Diseases, E.G. Autism and Cerebral Palsy
MX9804305A (es) Analisis sanguineo de proporcion del factor v paradeterminar la susceptibilidad a la tromboembolia.
CA2125787A1 (fr) Depistage de la maladie d'alzheimer et d'autres maladies par une methode de marquage a photoaffinite
WO1998014611A3 (fr) Detection et identification d'enterovirus non poliovirus
EP1159614A4 (fr) Methodes diagnostiques de l'asthme
CA2009813A1 (fr) Methode de diagnostic des affections parodontales par la detection de l'alanine aminotransferase
Osuna et al. Vitreous humor carbohydrate-deficient transferrin concentrations in the postmortem diagnosis of alcoholism
CZ228898A3 (cs) Způsob určení stavu jaterních funkcí jedince, včetně u příjemce jaterního štěpu
ES2082881T3 (es) Procedimiento para la deteccion y determinacion cuantitativa de cepas de nitrosomonas en aguas residuales o suelos.
EP1052511A4 (fr) Procede de depistage de la maladie de crohn et kit d'analyse prevu a cet effet
WO2000050629A3 (fr) Procede de diagnostic et de criblage
WO1999027366A3 (fr) Detection de l'antigene prostate-specifique
AU2997597A (en) Method and reagent for monitoring blood levels of antiplatelet compounds
DE59808639D1 (de) Verfahren zur bestimmung von schilddrüsen-autoantikörpern
Bradley Sublethal bioassay for environmental quality

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): CA JP US

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FR GB GR IT LU NL SE

AK Designated states

Kind code of ref document: A3

Designated state(s): CA JP US

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): AT BE CH DE DK ES FR GB GR IT LU NL SE

WWE Wipo information: entry into national phase

Ref document number: 2074519

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 1991905230

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 1991905230

Country of ref document: EP

WWG Wipo information: grant in national office

Ref document number: 1991905230

Country of ref document: EP