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WO1991005511A1 - Technique amelioree de prelevement sanguin - Google Patents

Technique amelioree de prelevement sanguin Download PDF

Info

Publication number
WO1991005511A1
WO1991005511A1 PCT/GB1990/001562 GB9001562W WO9105511A1 WO 1991005511 A1 WO1991005511 A1 WO 1991005511A1 GB 9001562 W GB9001562 W GB 9001562W WO 9105511 A1 WO9105511 A1 WO 9105511A1
Authority
WO
WIPO (PCT)
Prior art keywords
pad
blood
aperture
tube
capillary tube
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB1990/001562
Other languages
English (en)
Inventor
Gerrard Abdool Rayman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of WO1991005511A1 publication Critical patent/WO1991005511A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150748—Having means for aiding positioning of the piercing device at a location where the body is to be pierced
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150015—Source of blood
    • A61B5/150022—Source of blood for capillary blood or interstitial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150213—Venting means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150236—Pistons, i.e. cylindrical bodies that sit inside the syringe barrel, typically with an air tight seal, and slide in the barrel to create a vacuum or to expel blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150244—Rods for actuating or driving the piston, i.e. the cylindrical body that sits inside the syringe barrel, typically with an air tight seal, and slides in the barrel to create a vacuum or to expel blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150358—Strips for collecting blood, e.g. absorbent

Definitions

  • This invention relates generally to blood sampling and is particularly concerned with a method of and apparatus for taking a small sample of blood from a pin prick, for exampl e on a fi nger .
  • the finger is pricked and then the end of a capillary tube is held against the skin at the point of the prick in an endeavour to attract a small quantity of blood, say two or three drops, into the tube.
  • the finger may be massaged or squeezed.
  • the blood collecting step is very uncertain, because the blood, when it does appear, may not appear directly under the end of the tube and may quickly run away around the finger.
  • a method of taking a blood sample according to which an apertured adhesive pad is applied to the skin, and the skin is pricked through the aperture in the pad so that the escape of blood is
  • blood is collected from the aperture in the pad by a blood porous layer of the pad behind the adhesive layer.
  • the blood is collected from the aperture in the pad by a portable collecting device, such as a capillary tube.
  • a portable collecting device such as a capillary tube.
  • the invention also provides apparatus for carrying out the afore-described methods.
  • an adhesive pad having a generally central aperture, an impervious adhesive layer on one face and a thicker layer of blood-porous material behind the adhesive layer.
  • apparatus comprising an adhesive pad having a generally central blood- collecting aperture and an adhesive layer on one face, together with a portable collecting device having a forward end adapted to enter the aperture in the pad to withdraw blood therefrom.
  • the layer of pad behind the adhesive layer is preferably of low porosity to blood.
  • the pad aperture and the forward end of the capillary tube are mutually adapted to locate the
  • the capillary tube has a vent hole at an intermediate point in its length, together with a plunger inserted in the rear end of the tube.
  • the apertured pad is applied to the skin and a pricker, such as that made and sold by Owen Mumford Limited under the Registered Trade Mark AUTOLET, is used to prick the skin through the pad aperture at the point where the capillary tube end is to be located.
  • the forward end of the tube is then applied at this point, with the plunger withdrawn sufficiently to expose the vent hole.
  • the tube and its plunger need not be held during this time; the engagement of the forward end of the tube with the pad is sufficient to support the assembly. If necessary, the finger can be squeezed or massaged to assist the supply of blood.
  • the tube When the sample has been taken, the tube is removed and taken to wherever it is to be dispensed. This operation is done by the plunger, and as its end moves past the vent hole, air can no longer vent and so the sample is forced out of the tube.
  • the plunger may be provided with a stop that will eventually cooperate with the rear end of the tube and thus give a predetermined effective stroke for the plunger, resulting in a measured quantity of blood sample being dispensed, which is important for some blood tests.
  • the forward end of the tube ay be slightly tapered, enabling it to be pushed into the pad aperture more easily.
  • the preferred pad will be of a composite construction with a thin skin-sealing adhesive skin forming one face backed by a thicker layer, possibly of smaller area and possibly of closed cell foam with a slight resilience.
  • the aperture in the pad at which the blood collects may be slightly smaller than the main portion of the capillary tube, so that when the forward end of the tube is pressed in, the tube will be firmly gripped and retained, more especially to render the tube self-supporting.
  • Figure 1 is mostly a longitudinal section of one
  • Figure 2 is another longitudinal section of the device, to a smaller scale, containing a blood sample
  • Figure 3 is a longitudinal section of the device having just dispensed a sample
  • Figure 4 is a transverse cross-section through an
  • the exemplified blood sampling device comprises a capillary tube 1 with a plunger 2 inserted in one end and with an adhesive pad 3 for application to and sealing against the subject's skin.
  • the tube 1 which is
  • the plunger 2 is basically a straight rod, also of plastics material, with a close sliding fit in the tube 1, but with a finger pad 6 at its free end and a stop 7 in the form of a collar at an intermediate point.
  • the pad 3 consists of an adhesive film 8 with a generally non-porous and slightly resilient foam layer 9 on the side away from that which is to engage the skin.
  • a central aperture 10 extends through both the film 8 and layer 9, its diameter being slightly less than the external
  • the pad 3 is stuck to a finger, for example, and a prick is made through the aperture 10.
  • the plunger 2 With the plunger 2 in the withdrawn position as shown in Figure 1, the tapered end 4 of the capillary tube is inserted in the aperture 10 and urged in until its extremity is in contact with the skin around the pin prick.
  • a droplets of blood are
  • the sample is then dispensed, for example on a strip 12 as shown in Figure 3, by pressing the plunger 2. At first, there will simply be an escape of air through the hole 5 . But once this is closed off, the sample will be forced out through the tapered end 4 of the tube until the stop 7 meets the rear end of the tube 1. This will give an accurately measured quantity of blood.
  • Figure 4 shows an embodiment of the adhesive pad 3 in cross-section, using reference letters corresponding to those employed in Figure 1. More particularly, the dashed lines 13 indicate the flow of blood from the subject's finger 14 into the aperture 10 in the pad, where it collects and is retained in the aperture ready for collection, as indicated at 15.
  • the capillary tube described with reference to Figures 1 to 3 is a preferred but not essential means of collecting the blood. Any convenient portable collecting device having a forward end adapted to enter the pad aperture may be employed.
  • this layer 9 can itself be used to collect the blood. This is convenient when the subject has to take a blood sample personally and then forward it for analysis, as the entire pad incorporating the stored blood can be carefully stripped off and taken or sent to the

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Manufacturing & Machinery (AREA)
  • Vascular Medicine (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Technique de prélèvement sanguin consistant à coller un tampon adhésif (3) à ouverture sur la peau et à piquer la peau par l'ouverture du tampon pour que le sang y exsude et soit retenu dans l'ouverture (10) du tampon pour le prélèvement, soit au moyen d'un dispositif de prélèvement portable soit par une couche (9) poreuse située sur le tampon derrière la couche adhésive (8).
PCT/GB1990/001562 1989-10-14 1990-10-10 Technique amelioree de prelevement sanguin Ceased WO1991005511A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8923210.2 1989-10-14
GB898923210A GB8923210D0 (en) 1989-10-14 1989-10-14 Improvements relating to blood sampling devices

Publications (1)

Publication Number Publication Date
WO1991005511A1 true WO1991005511A1 (fr) 1991-05-02

Family

ID=10664613

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1990/001562 Ceased WO1991005511A1 (fr) 1989-10-14 1990-10-10 Technique amelioree de prelevement sanguin

Country Status (3)

Country Link
AU (1) AU6620890A (fr)
GB (2) GB8923210D0 (fr)
WO (1) WO1991005511A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1092390A1 (fr) * 1999-10-13 2001-04-18 ARKRAY, Inc. Indicateur de position pour prélèvement sanguin
WO2010103179A1 (fr) * 2009-03-09 2010-09-16 Thermo Fisher Scientific Oy Pointe de dilution
CN102252870A (zh) * 2010-04-14 2011-11-23 韩国电子通信研究院 样品收集装置

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE540613T1 (de) 2001-07-13 2012-01-15 Arkray Inc Analysevorrichtung und durchstechelement- integrierte verbindung für eine konzentrationsanalysevorrichtung

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2014735A1 (fr) * 1968-07-26 1970-04-17 Battelle Development Corp
US3741197A (en) * 1970-09-04 1973-06-26 Micromedia Syst Inc Percussion apparatus for blood sampling
EP0209705A2 (fr) * 1985-07-22 1987-01-28 Drummond Scientific Company Pipette capillaire jetable munie de moyens de présélection du volume de liquide et procédé de préparation d'un échantillon liquide pour d'essais
WO1988006427A1 (fr) * 1987-02-24 1988-09-07 Ken Heimreid Sparadrap destine a etre utilise lors du prelevement d'echantillons sanguins

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2014735A1 (fr) * 1968-07-26 1970-04-17 Battelle Development Corp
US3741197A (en) * 1970-09-04 1973-06-26 Micromedia Syst Inc Percussion apparatus for blood sampling
EP0209705A2 (fr) * 1985-07-22 1987-01-28 Drummond Scientific Company Pipette capillaire jetable munie de moyens de présélection du volume de liquide et procédé de préparation d'un échantillon liquide pour d'essais
WO1988006427A1 (fr) * 1987-02-24 1988-09-07 Ken Heimreid Sparadrap destine a etre utilise lors du prelevement d'echantillons sanguins

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1092390A1 (fr) * 1999-10-13 2001-04-18 ARKRAY, Inc. Indicateur de position pour prélèvement sanguin
US6503210B1 (en) 1999-10-13 2003-01-07 Arkray, Inc. Blood-collection position indicator
US6626851B2 (en) 1999-10-13 2003-09-30 Arkray, Inc. Blood-collection position indicator
WO2010103179A1 (fr) * 2009-03-09 2010-09-16 Thermo Fisher Scientific Oy Pointe de dilution
CN102252870A (zh) * 2010-04-14 2011-11-23 韩国电子通信研究院 样品收集装置

Also Published As

Publication number Publication date
AU6620890A (en) 1991-05-16
GB9021948D0 (en) 1990-11-21
GB2236680A (en) 1991-04-17
GB8923210D0 (en) 1989-11-29

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