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WO1990011688A1 - Microbes avirulents et leurs emplois - Google Patents

Microbes avirulents et leurs emplois Download PDF

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Publication number
WO1990011688A1
WO1990011688A1 PCT/US1990/001603 US9001603W WO9011688A1 WO 1990011688 A1 WO1990011688 A1 WO 1990011688A1 US 9001603 W US9001603 W US 9001603W WO 9011688 A1 WO9011688 A1 WO 9011688A1
Authority
WO
WIPO (PCT)
Prior art keywords
choleraesuis
crp
gene
avirulent
strain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1990/001603
Other languages
English (en)
Inventor
Roy Curtiss Iii
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Washington
Washington University in St Louis WUSTL
Original Assignee
University of Washington
Washington University in St Louis WUSTL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Washington, Washington University in St Louis WUSTL filed Critical University of Washington
Publication of WO1990011688A1 publication Critical patent/WO1990011688A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A61K39/0275—Salmonella
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/42—Salmonella
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Definitions

  • S. choleraesuis strains used in this Example are listed in Table 1. Bacterial strains were grown at 37°C in L broth and on L agar (Lennox, Virology 1: 190-206

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Amplifiers (AREA)
  • Stereophonic System (AREA)
  • Electronic Switches (AREA)

Abstract

L'invention concerne un vaccin d'immunisation d'un vertébré ou d'un invertébré, comprenant un dérivé avirulent de S. choleraesuis. Lesdits dérivés sont incapables de produire une cyclase d'adénylate fonctionnelle et/ou une protéine réceptrice d'AMP cyclique. L'invention concerne également un vaccin d'immunisation d'un vertébré et d'un invertébré, comprenant un dérivé virulent d'un microbe pathogène, ledit dérivé étant incapable de produire une cyclase d'adénylate fonctionnelle et/ ou une protéine réceptrice d'AMP cyclique, tout en étant capable d'exprimer un gène de recombinaison dérivé d'un germe pathogène dudit vertébré, afin de produire un antigène capable de provoquer une réponse immune chez ledit vertébré contre ledit germe pathogène.
PCT/US1990/001603 1989-03-31 1990-03-26 Microbes avirulents et leurs emplois Ceased WO1990011688A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33228589A 1989-03-31 1989-03-31
US332,285 1989-03-31

Publications (1)

Publication Number Publication Date
WO1990011688A1 true WO1990011688A1 (fr) 1990-10-18

Family

ID=23297569

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1990/001603 Ceased WO1990011688A1 (fr) 1989-03-31 1990-03-26 Microbes avirulents et leurs emplois

Country Status (6)

Country Link
EP (1) EP0465561A4 (fr)
JP (1) JPH04506000A (fr)
CN (1) CN1046463A (fr)
AU (1) AU5355990A (fr)
CA (1) CA2013572A1 (fr)
WO (1) WO1990011688A1 (fr)

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992019720A1 (fr) * 1991-05-02 1992-11-12 Institut Pasteur Souches recombinantes immunogenes de b. anthracis - compositions immunogenes les contenant
US5840312A (en) * 1991-05-02 1998-11-24 Institut Pasteur Recombinant Bacillus anthracis strains unable to produce the lethal factor protein or edema factor protein
US5922583A (en) * 1995-10-17 1999-07-13 Biostar Inc. Methods for production of recombinant plasmids
US8445254B2 (en) 2007-05-10 2013-05-21 The Arizona Board Of Regents For And On Behalf Of Arizona State University Regulated expression of antigen and/or regulated attentuation to enhance vaccine immunogenicity and/or safety
US8465755B2 (en) 2007-10-05 2013-06-18 The Arizona Board Of Regents For And On Behalf Of Arizona State University Recombinant bacterium capable of eliciting an immune response against enteric pathogens
US8889121B2 (en) 2010-01-22 2014-11-18 The Arizona Board Of Regents For An On Behalf Of Arizona State University Bacterium comprising a regulated rfaH nucleic acid
US9045742B2 (en) 2009-05-29 2015-06-02 The Arizona Board Of Regents For And On Behalf Of Arizona State University Recombinant Edwardsiella bacterium
US9050285B2 (en) 2008-10-17 2015-06-09 The United States of America National Institutes of Health (NH), U.S. Dept. of Health and Human Services (DHHS) Recombinant bacterium capable of eliciting an immune response against Streptococcus pneumoniae
US9062297B2 (en) 2010-01-13 2015-06-23 The Arizona Board Of Regents For And On Behalf Of Arizona State University Yersinia pestis vaccine
US9163219B2 (en) 2009-04-14 2015-10-20 Arizona Board Of Regents On Behalf Of Arizona State University Single expression vector for generation of a virus with a segmented genome
US9303264B2 (en) 2012-05-18 2016-04-05 The Arizona Board Of Regents For And On Behalf Of Arizona State University Photosynthetic microorganisms expressing thermostable lipase
US9481888B2 (en) 2009-05-22 2016-11-01 The Arizona Board Of Regents For And On Behalf Of Arizona State University Recombinant bacterium and methods of antigen and nucleic acid delivery
US9580718B2 (en) 2013-06-17 2017-02-28 Arizona Board Of Regents On Behalf Of Arizona State University Attenuated live bacteria with increased acid resistance and methods of use thereof
US9598697B2 (en) 2010-05-28 2017-03-21 The Arizona Board Of Regents For And On Behalf Of Arizona State University Recombinant bacterium to decrease tumor growth

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992008486A1 (fr) * 1990-11-09 1992-05-29 Washington University Microbes avirulents et leurs applications: salmonella typhi
US6713073B1 (en) * 1998-07-24 2004-03-30 Megan Health, Inc. Method of vaccination of newly hatched poultry

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
Immunological Investigations, Volume 18, pages 583-596. April 1989. R. CURTISS et al. Recombinant Avirulent Salmonella Vaccine Strains with stable maintenance and high level expression of cloned genes in vivo. See Abstract. *
Infection and Immunity, Volume 55(12), pages 3035-3043. R. CURTISS et al. December 1987. Salmonella typhimurium Deletion Mutants Lacking Adenylate Cyclase and Cyclic AMP Receptor Protein are Avirulent and Immunogenic. See Abstract. *
Infection and Immunity, Volume 55(4), pages 955-962. N.A. NNALUE et al. April 1987. "Tests of the Virulence and Live-Vaccine Efficacy of Auxotrophic and gal E Derivatives of Salmonella choleraesuis. See Abstract. *
Japan Journal of Veternary Science, Volume 50, pages 706-713. July 1988. N'AKAMURA, et al. Virulence and Immunogenicity of Plasimid-cured Salmonella serovar Enteritidis AL1192 against Cattle. See Abstract. *
Microbial Pathogenesis, Volume 7, pages 299-310. December 1989. N.A. NNALUE et al. Vaccination Route, infectivity and thioglycollate broth administration: effects on live vaccine efficacy of auxotrophic derivatives of Salmonella Choleraesuis. See Abstract. *
See also references of EP0465561A4 *

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5840312A (en) * 1991-05-02 1998-11-24 Institut Pasteur Recombinant Bacillus anthracis strains unable to produce the lethal factor protein or edema factor protein
WO1992019720A1 (fr) * 1991-05-02 1992-11-12 Institut Pasteur Souches recombinantes immunogenes de b. anthracis - compositions immunogenes les contenant
US5922583A (en) * 1995-10-17 1999-07-13 Biostar Inc. Methods for production of recombinant plasmids
US9297015B2 (en) 2007-05-10 2016-03-29 Arizona Board Of Regents For And On Behalf Of Arizona State University Regulated expression of antigen and/or regulated attentuation to enhance vaccine immunogenicity and/or safety
US8445254B2 (en) 2007-05-10 2013-05-21 The Arizona Board Of Regents For And On Behalf Of Arizona State University Regulated expression of antigen and/or regulated attentuation to enhance vaccine immunogenicity and/or safety
US11920139B2 (en) 2007-05-10 2024-03-05 The Washington University Regulated expression of antigen and/or regulated attenuation to enhance vaccine immunogenicity and/or safety
US11180765B2 (en) 2007-05-10 2021-11-23 The Arizona Board Of Regents For And On Behalf Of Arizona State University Regulated expression of antigen and/or regulated attenuation to enhance vaccine immunogenicity and/or safety
US10774334B2 (en) 2007-05-10 2020-09-15 Arizona Broad of Regents on Behalf of Arizona State University Regulated expression of antigen and/or regulated attenuation to enhance vaccine immunogenicity and/or safety
US8465755B2 (en) 2007-10-05 2013-06-18 The Arizona Board Of Regents For And On Behalf Of Arizona State University Recombinant bacterium capable of eliciting an immune response against enteric pathogens
US9040059B2 (en) 2007-10-05 2015-05-26 The Arizona Board Of Regents For And On Behalf Of Arizona State University Recombinant bacterium capable of eliciting a protective immune response against C. perfringens
US9050285B2 (en) 2008-10-17 2015-06-09 The United States of America National Institutes of Health (NH), U.S. Dept. of Health and Human Services (DHHS) Recombinant bacterium capable of eliciting an immune response against Streptococcus pneumoniae
US9163219B2 (en) 2009-04-14 2015-10-20 Arizona Board Of Regents On Behalf Of Arizona State University Single expression vector for generation of a virus with a segmented genome
US9481888B2 (en) 2009-05-22 2016-11-01 The Arizona Board Of Regents For And On Behalf Of Arizona State University Recombinant bacterium and methods of antigen and nucleic acid delivery
US9045742B2 (en) 2009-05-29 2015-06-02 The Arizona Board Of Regents For And On Behalf Of Arizona State University Recombinant Edwardsiella bacterium
US9062297B2 (en) 2010-01-13 2015-06-23 The Arizona Board Of Regents For And On Behalf Of Arizona State University Yersinia pestis vaccine
US8889121B2 (en) 2010-01-22 2014-11-18 The Arizona Board Of Regents For An On Behalf Of Arizona State University Bacterium comprising a regulated rfaH nucleic acid
US9598697B2 (en) 2010-05-28 2017-03-21 The Arizona Board Of Regents For And On Behalf Of Arizona State University Recombinant bacterium to decrease tumor growth
US9303264B2 (en) 2012-05-18 2016-04-05 The Arizona Board Of Regents For And On Behalf Of Arizona State University Photosynthetic microorganisms expressing thermostable lipase
US9580718B2 (en) 2013-06-17 2017-02-28 Arizona Board Of Regents On Behalf Of Arizona State University Attenuated live bacteria with increased acid resistance and methods of use thereof

Also Published As

Publication number Publication date
AU5355990A (en) 1990-11-05
CN1046463A (zh) 1990-10-31
EP0465561A1 (fr) 1992-01-15
CA2013572A1 (fr) 1990-09-30
JPH04506000A (ja) 1992-10-22
EP0465561A4 (en) 1992-04-08

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