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WO1990011322A3 - Procede et agent de reaction pour la sulfuration de composants organophosphoreux - Google Patents

Procede et agent de reaction pour la sulfuration de composants organophosphoreux Download PDF

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Publication number
WO1990011322A3
WO1990011322A3 PCT/US1990/000970 US9000970W WO9011322A3 WO 1990011322 A3 WO1990011322 A3 WO 1990011322A3 US 9000970 W US9000970 W US 9000970W WO 9011322 A3 WO9011322 A3 WO 9011322A3
Authority
WO
WIPO (PCT)
Prior art keywords
reagent
sulfurization
tertiary amine
organophosphorous compounds
amine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1990/000970
Other languages
English (en)
Other versions
WO1990011322A2 (fr
Inventor
Ram S Bhatt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gen Probe Inc
Original Assignee
Gen Probe Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gen Probe Inc filed Critical Gen Probe Inc
Publication of WO1990011322A2 publication Critical patent/WO1990011322A2/fr
Publication of WO1990011322A3 publication Critical patent/WO1990011322A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/16—Esters of thiophosphoric acids or thiophosphorous acids
    • C07F9/165—Esters of thiophosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

L'invention concerne une composition appropriée à la sulfuration d'un organophosphite. L'agent de réaction consiste en une solution de soufre et une amine tertiaire, dans un solvant approprié tel que du soufre de carbone. L'amine tertiaire est de préférence une amine trialkyle éventuellement substituée, par exemple une triéthylamine ou une diisopropylamine. L'invention concerne également un procédé de sulfuration de phosphites ou d'esters phosphoneux en leurs phosphorothioates ou phosphonothioates correspondants, respectivement, en utilisant les compositions de la présente invention. Ce procédé s'applique en particulier à la production de liaisons de phosphorothioate ou phosphonothioate internucléotide dans un multimère nucléotide.
PCT/US1990/000970 1989-03-06 1990-03-02 Procede et agent de reaction pour la sulfuration de composants organophosphoreux Ceased WO1990011322A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/319,570 US5449769A (en) 1989-03-06 1989-03-06 Method and reagent for sulfurization of organophosphorous compounds
US319,570 1989-03-06

Publications (2)

Publication Number Publication Date
WO1990011322A2 WO1990011322A2 (fr) 1990-10-04
WO1990011322A3 true WO1990011322A3 (fr) 1991-04-04

Family

ID=23242812

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1990/000970 Ceased WO1990011322A2 (fr) 1989-03-06 1990-03-02 Procede et agent de reaction pour la sulfuration de composants organophosphoreux

Country Status (9)

Country Link
US (2) US5449769A (fr)
EP (1) EP0386987B1 (fr)
JP (1) JP2898750B2 (fr)
AT (1) ATE153343T1 (fr)
CA (1) CA2011430C (fr)
DE (1) DE69030745T2 (fr)
DK (1) DK0386987T3 (fr)
ES (1) ES2101689T3 (fr)
WO (1) WO1990011322A2 (fr)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5714380A (en) 1986-10-23 1998-02-03 Amoco Corporation Closed vessel for isolating target molecules and for performing amplification
WO1992018522A1 (fr) * 1991-04-18 1992-10-29 The Salk Institute For Biological Studies Oligodesoxynucleotides et oligonucleotides utiles en tant que pieges pour des proteines qui se lient selectivement a des sequences definies d'adn
IT1249732B (it) * 1991-11-26 1995-03-09 Angeletti P Ist Richerche Bio Oligonucleotidi antisenso.
WO1994002499A1 (fr) * 1992-07-27 1994-02-03 Hybridon, Inc. Alkylphosphonothioates oligonucleotidiques
US6087491A (en) 1993-01-08 2000-07-11 Hybridon, Inc. Extremely high purity oligonucleotides and methods of synthesizing them using dimer blocks
ATE150464T1 (de) * 1993-01-08 1997-04-15 Hybridon Inc Synthese von dimer-blöcken und ihre verwendung bei der zusammensetzung von oligonukleotiden
FI953541A7 (fi) * 1993-01-25 1995-08-31 Hybridon Inc Oligonukleotidialkyylifosfonaatteja ja -alkyylifosfonotioaatteja
US5739309A (en) * 1993-07-19 1998-04-14 Gen-Probe Incorporated Enhancement of oligonucleotide inhibition of protein production, cell proliferation and / or multiplication of infectious disease pathogens
US5733781A (en) 1994-07-19 1998-03-31 Gen-Probe Incorporated Oligonucleotides and methods for inhibiting propagation of human immunodeficiency virus
US5514551A (en) * 1994-10-14 1996-05-07 Gen-Probe Incorporated Compositions for the detection of Chlamydia trachomatis
JP3124036B2 (ja) * 1995-01-19 2001-01-15 ジェン−プローブ・インコーポレーテッド ライム病関連ボレリアに対する核酸増幅オリゴヌクレオチドおよびプローブ
US5747470A (en) * 1995-06-07 1998-05-05 Gen-Probe Incorporated Method for inhibiting cellular proliferation using antisense oligonucleotides to gp130 mRNA
US5674995A (en) * 1995-06-07 1997-10-07 Gen-Probe Incorporated Oligonucleotides specific for cytokine signal transducer gp130 mRNA
US5716846A (en) * 1995-06-07 1998-02-10 Gen-Probe Incorporated Method for inhibiting cellular proliferation using antisense oligonucleotides to interleukin-6 receptor mRNA
US6172217B1 (en) 1996-12-27 2001-01-09 Isis Pharmaceuticals Inc. Method of synthesizing phosphorothioate oligonucleotides
US6025133A (en) * 1996-12-30 2000-02-15 Gen-Probe Incorporated Promoter-sequestered oligonucleoside and method of use
US5760209A (en) * 1997-03-03 1998-06-02 Isis Pharmaceuticals, Inc. Protecting group for synthesizing oligonucleotide analogs
US5902881A (en) * 1997-03-03 1999-05-11 Isis Pharmaceuticals, Inc. Reagent useful for synthesizing sulfurized oligonucleotide analogs
EP0975807B1 (fr) * 1997-05-02 2006-09-27 Gen-Probe Incorporated Hybridation en deux temps et capture d'un polynucleotide
US6534273B2 (en) 1997-05-02 2003-03-18 Gen-Probe Incorporated Two-step hybridization and capture of a polynucleotide
US6995259B1 (en) * 1998-10-23 2006-02-07 Sirna Therapeutics, Inc. Method for the chemical synthesis of oligonucleotides
ATE289610T1 (de) * 2000-09-07 2005-03-15 Avecia Biotechnology Inc Synthone zur herstellung von oligonukleotiden
US7205399B1 (en) * 2001-07-06 2007-04-17 Sirna Therapeutics, Inc. Methods and reagents for oligonucleotide synthesis
WO2005031005A2 (fr) 2003-05-19 2005-04-07 Gen-Probe Incorporated Compositions, methodes et kits de detection de la presence de trichomonas vaginalis dans un echantillon d'essai
WO2008016988A1 (fr) 2006-08-01 2008-02-07 Gen-Probe Incorporated Procédés de capture de cible non spécifique d'acides nucléiques
US8309710B2 (en) 2009-06-29 2012-11-13 Agilent Technologies, Inc. Use of N-alkyl imidazole for sulfurization of oligonucleotides with an acetyl disulfide
CN110612354B (zh) 2017-05-11 2025-02-11 简·探针公司 用于分离靶核酸的组合物和方法
EP3841223A1 (fr) 2018-08-08 2021-06-30 Gen-Probe Incorporated Compositions, procédés et kits pour la détection de mycoplasma genitalium
US20220298548A1 (en) 2019-08-23 2022-09-22 Gen-Probe Incorporated Compositions, methods and kits for detecting treponema pallidum
AU2020343334A1 (en) 2019-09-05 2022-04-07 Gen-Probe Incorporated Detection of Chlamydia trachomatis nucleic acid variants
US20220396786A1 (en) 2019-11-14 2022-12-15 Gen-Probe Incorporated Compositions and Methods for Capturing Target Nucleic Acids
US20240218469A1 (en) 2021-05-14 2024-07-04 Gen-Probe Incorporated Compositions and methods for detecting human adenovirus nucleic acid
EP4382620A3 (fr) 2021-07-27 2024-08-07 Gen-Probe Incorporated Compositions et procédés de détection de c. jejuni et au moins l'un de salmonella, c. coli, shigella et stec.
WO2024137379A2 (fr) 2022-12-19 2024-06-27 Gen-Probe Incorporated Compositions et procédés de détection d'agents pathogènes gastro-intestinaux
WO2024192338A1 (fr) 2023-03-16 2024-09-19 Gen-Probe Incorporated Compositions et procédés de détection de parasites gastro-intestinaux

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2647140A (en) * 1949-04-16 1953-07-28 Bayer Ag Process for the production of dialkylthiophosphates
DE1210834B (de) * 1964-07-01 1966-02-17 Bayer Ag Verfahren zur Herstellung von Thiophosphorverbindungen
US3687808A (en) * 1969-08-14 1972-08-29 Univ Leland Stanford Junior Synthetic polynucleotides
SU410021A1 (fr) * 1972-05-30 1974-01-05

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA661668A (en) * 1963-04-23 H. Ford-Moore Arthur Manufacture of organic phosphorus compounds
US2536647A (en) * 1948-03-06 1951-01-02 Monsanto Chemicals Process of preparing bis (beta-chlorethyl)-para-nitrophenyl thiophosphate
US2907787A (en) * 1957-11-13 1959-10-06 Friedrich W Hoffmann Preparation of phosphono-thiono esters of 2-hydroxyethyl sulfides
DE1126382B (de) * 1960-08-17 1962-03-29 Bayer Ag Verfahren zur Herstellung von Thiophosphorsaeureestern
NL136286C (fr) * 1962-01-24
US3162570A (en) * 1962-05-21 1964-12-22 Socony Mobil Oil Co Inc Organophosphorus compounds as insecticides and nematocides
GB1346409A (en) * 1962-06-21 1974-02-13 Secr Defence Manufacture of organic phosphorous compounds containing sulphur
US3296221A (en) * 1963-05-13 1967-01-03 Phillips Petroleum Co Mercapto-substituted thio-phosphites and phosphates and polysulfide polymers thereof
US4197209A (en) * 1977-03-10 1980-04-08 Ciba-Geigy Corporation Lubricant compositions containing sulfur-containing esters of phosphoric acid
US4625677A (en) * 1985-05-23 1986-12-02 Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V. Apparatus for coating and polishing a micropipette

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2647140A (en) * 1949-04-16 1953-07-28 Bayer Ag Process for the production of dialkylthiophosphates
DE1210834B (de) * 1964-07-01 1966-02-17 Bayer Ag Verfahren zur Herstellung von Thiophosphorverbindungen
US3687808A (en) * 1969-08-14 1972-08-29 Univ Leland Stanford Junior Synthetic polynucleotides
SU410021A1 (fr) * 1972-05-30 1974-01-05

Also Published As

Publication number Publication date
ATE153343T1 (de) 1997-06-15
ES2101689T3 (es) 1997-07-16
DE69030745T2 (de) 1997-09-11
CA2011430A1 (fr) 1990-09-06
DK0386987T3 (da) 1997-10-13
JPH04503956A (ja) 1992-07-16
US5252723A (en) 1993-10-12
US5449769A (en) 1995-09-12
JP2898750B2 (ja) 1999-06-02
EP0386987A1 (fr) 1990-09-12
CA2011430C (fr) 2000-06-20
DE69030745D1 (de) 1997-06-26
EP0386987B1 (fr) 1997-05-21
WO1990011322A2 (fr) 1990-10-04

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