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WO1990009779A1 - Procede et composition de traitement de maladie periodontique - Google Patents

Procede et composition de traitement de maladie periodontique Download PDF

Info

Publication number
WO1990009779A1
WO1990009779A1 PCT/US1990/001041 US9001041W WO9009779A1 WO 1990009779 A1 WO1990009779 A1 WO 1990009779A1 US 9001041 W US9001041 W US 9001041W WO 9009779 A1 WO9009779 A1 WO 9009779A1
Authority
WO
WIPO (PCT)
Prior art keywords
composition
periodontal disease
chlorhexidine gluconate
allantoin
sodium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1990/001041
Other languages
English (en)
Inventor
Marc N. Benhuri
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of WO1990009779A1 publication Critical patent/WO1990009779A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/43—Guanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles

Definitions

  • the present invention relates to a method and composition for treatment of periodontal disease and, more particularly, to a composition suitable for topical application to prevent and treat periodontitis.
  • Periodontal disease is the major cause of tooth loss in adults.
  • the periodontium is subject to inflammation for many reasons, primary among them being the accumulation of plaque deposits under and above the gumline.
  • These calcareous deposits of organic and mineral matter consist of microbial colonies growing in carbohydrate residues (from food) , attach themselves to tooth surfaces and can, over time, calcify into tartar. This hard, mineralized substance adheres tenaciously to the teeth and, when under the gumline, causes inflammation of the periodontium.
  • Other causes of periodontitis can include malocclusion, food impaction and mouth breathing.
  • Periodontitis outside of taking preventive measures to keep it from developing in the first place, was surgery.
  • the accepted surgical procedure involves removing the inflamed gum tissue, which is expensive and requires a long and painful recovery.
  • a composition suitable for treating periodontitis comprises an aqueous solution of an antimicrobial agent with bacteriacidal activity, an agent with therapeutic action against skin ulcers, an analgesic, a stain remover and, if desired, suitable wetting agents, emulsifiers, dispersants, buffers stabilizers, preservatives, flavoring and coloring.
  • the composition is used in a treatment method which comprises the steps of topically applying the composition to inflamed periodontium.
  • the various components of the composition of the present invention are present in an aqueous carrier of sterile distilled water, glycerine and ethanol.
  • the glycerine provides the composition with the desired feel and texture and the ethanol acts as an antiseptic.
  • chlorhexidine gluconate (0.12% solution), C 3 H 5 Cl 2 N 10 O 14 (Merck Index 2057) , as an antimicrobial agent with bacteriacidal action, (2) allantoin, or (2,5-dioxo-4- imidazolidinyl)urea (Merck Index 242) as an agent that exhibits therapeutic action against skin ulcers, (3) sodium salicylate, or 2-hydroxybenzoic acid monosodium salt (Merck Index 8515) , as an analgesic, and (4) sodium bicarbonate (Merck Index 8414) as a stain remover, along with wetting agents, preservatives, emulsifiers, dispersants, buffers stabilizers, flavoring and coloring, as desired. (All references herein to the Merck Index refer to the 1983 edition.)
  • the above ingredients are provided in the following proportions:
  • Ethanol (MI 212) 7.50% Polysorbate 80 (as an emulsifier and dispersant; MI 7455) 4.20% Chlorhexidine gluconate (0.12% sol.) (MI 2057) 3.50% Sodium bicarbonate (as a stain remover; MI 8414) 0.50% Sodium lauryl sulfate (as a wetting agent; MI 8474) 0.50%
  • MI 8413 0.10% Xanthan gum (as a stabilizer and e ulsifier; MI 9868) 0.10%
  • the above composition is prepared by first measuring an appropriate quantity of sterile distilled water; for example, lOOOcc of the composition is to be prepared, 101 . lc . of water are used. The remaining ingredients are added in the order listed in Table 1, with each ingredient being thoroughly mixed by gently stirring the composition before the next ingredient is added.
  • a clinical test involving 30 people was performed using a composition similar to that set out above, except for using 72.77% sterile water, 8.00% ethanol, 1.50% chlorhexidine gluconate (0.12% solution) and 0.138% allantoin.
  • the subjects were chosen because all exhibited, periodontal pockets up to 8mm or 9mm deep.
  • Prior to beginning the treatment regimen all 30 subjects agreed not to brush or floss their teeth for one week.
  • 15 of the subjects rinsed their mouths three times a day with 1.0 cc of the above composition 30 seconds before brushing and 15 rinsed their mouths three times a day with an equal amount of a colored sugar-water placebo 30 seconds before brushing.
  • the subjects did not know whether they were using the inventive composition or the placebo.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cosmetics (AREA)

Abstract

Une composition de traitement de maladie périodontique comprend un support aqueux d'eau stérile, de glycérine et d'éthanol, dans lequel sont présents gluconate de chlorhexidine, allantoïne, salicylate de sodium et bicarbonate de sodium. Un procédé de traitement préféré consiste en l'application locale au périoste alvéolaire de l'homme dans un bain de bouche.
PCT/US1990/001041 1989-02-28 1990-02-28 Procede et composition de traitement de maladie periodontique Ceased WO1990009779A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31727189A 1989-02-28 1989-02-28
US317,271 1989-02-28

Publications (1)

Publication Number Publication Date
WO1990009779A1 true WO1990009779A1 (fr) 1990-09-07

Family

ID=23232900

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1990/001041 Ceased WO1990009779A1 (fr) 1989-02-28 1990-02-28 Procede et composition de traitement de maladie periodontique

Country Status (4)

Country Link
EP (1) EP0423266A4 (fr)
AU (1) AU5287090A (fr)
CA (1) CA2028136A1 (fr)
WO (1) WO1990009779A1 (fr)

Cited By (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0572963A2 (fr) 1992-06-02 1993-12-08 Sergio Capurro Solution sclérosante très efficace ne produisant pas de lésions iatrogènes et procédé pour obtenir cette solution
US6281236B1 (en) 1999-07-23 2001-08-28 Alwyn Company, Inc. Oil-in-water emulsion with improved stability
US6329413B1 (en) 1999-07-23 2001-12-11 Alwyn Company, Inc. Allantoin-containing skin cream
WO2001041753A3 (fr) * 1999-12-07 2002-09-12 Univ Rutgers Compositions et methodes therapeutiques
US6468519B1 (en) 1997-09-10 2002-10-22 Rutgers, The State University Of New Jersey Polyanhydrides with biologically active degradation products
US6531500B2 (en) 1999-07-23 2003-03-11 Alwyn Company, Inc. Methods for treatment of inflammatory diseases
US6613807B2 (en) 2000-07-27 2003-09-02 Rutgers, The State University Of New Jersey Therapeutic polyanhydride compounds for drug delivery
US6673826B2 (en) 1999-07-23 2004-01-06 Alwyn Company, Inc. Methods for treatment of inflammatory diseases
US6685928B2 (en) 1999-12-07 2004-02-03 Rutgers, The State University Of New Jersey Therapeutic compositions and methods
US6864274B2 (en) 1999-07-23 2005-03-08 Alwyn Company, Inc. Allantoin-containing skin cream
US6896897B2 (en) 1999-07-23 2005-05-24 Alwyn Company, Inc. Flexible applicator for applying oil-in-water emulsion with improved stability
WO2011006263A1 (fr) * 2009-07-17 2011-01-20 Klox Technologies Inc. Composition orale antibactérienne
US8088405B2 (en) 1999-12-07 2012-01-03 Rutgers, The State University of New Jersery Therapeutic compositions and methods
US8632822B2 (en) 2008-11-07 2014-01-21 Klox Technologies Inc. Combination of an oxidant and a photoactivator for the healing of wounds
CN103893026A (zh) * 2014-03-31 2014-07-02 陈光健 一种用于口腔清洁和保健的漱口水
US8877790B2 (en) 1999-07-23 2014-11-04 Scioderm, Inc. Allantoin-containing skin cream
US8986719B2 (en) 2005-11-09 2015-03-24 Klox Technologies Inc. Teeth whitening compositions and methods
US9095574B2 (en) 2010-02-02 2015-08-04 Scioderm, Inc. Methods of treating psoriasis using allantoin
US9108070B2 (en) 2006-09-13 2015-08-18 Polymerix Corporation Active agents and their oligomers and polymers
US9144579B2 (en) 2012-08-17 2015-09-29 Rutgers, The State University Of New Jersey Polyesters and methods of use thereof
US9345648B2 (en) 2006-11-09 2016-05-24 Klox Technologies Inc. Photoactivatable oxygen-evolving compositions and methods for teeth whitening
US9387250B2 (en) 2013-03-15 2016-07-12 Rutgers, The State University Of New Jersey Therapeutic compositions for bone repair
US9655829B2 (en) 2012-09-14 2017-05-23 Valeant Pharmaceuticals International, Inc. Compositions and methods for teeth whitening
US9782432B2 (en) 2012-10-25 2017-10-10 Rutgers, The State University Of New Jersey Polymers and methods thereof for wound healing
US9862672B2 (en) 2013-05-29 2018-01-09 Rutgers, The State University Of New Jersey Antioxidant-based poly(anhydride-esters)
US10023521B2 (en) 2014-06-13 2018-07-17 Rutgers, The State University Of New Jersey Process and intermediates for preparing poly(anhydride-esters)
US10130706B2 (en) 2013-03-14 2018-11-20 Klox Technologies Inc. Biophotonic materials and uses thereof
US10207029B2 (en) 2014-04-01 2019-02-19 Klox Technologies Inc. Tissue filler compositions and methods of use
US10213373B2 (en) 2012-04-20 2019-02-26 Klox Technologies, Inc. Chromophore combinations for biophotonic uses
US10543162B2 (en) 2015-04-10 2020-01-28 Rutgers, The State University Of New Jersey Kojic acid polymers
US10881736B2 (en) 2013-07-03 2021-01-05 Klox Technologies Inc. Biophotonic compositions comprising a chromophore and a gelling agent for treating wounds
US11116841B2 (en) 2012-04-20 2021-09-14 Klox Technologies Inc. Biophotonic compositions, kits and methods
US11421349B2 (en) 2014-10-31 2022-08-23 Klox Technologies Inc. Photoactivatable fibers and fabric media

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4370314A (en) * 1975-12-08 1983-01-25 Colgate-Palmolive Company Oral composition containing antibacterial agent
US4454110A (en) * 1982-05-24 1984-06-12 Forsyth Dental Infirmary For Children Self-gelling liquid composition for topical application in the oral cavity
EP0130690A2 (fr) * 1983-06-01 1985-01-09 Teijin Limited Préparation pharmaceutique pour guérir les maladies du périoste dentaire et procédé de sa fabrication
US4512968A (en) * 1982-11-30 1985-04-23 Lion Corporation Oral compositions
WO1987005501A1 (fr) * 1986-03-17 1987-09-24 Oral Research Laboratories, Inc. Traitement des surfaces dentaires a l'aide d'agents retardant la plaque

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2529271C3 (de) * 1975-07-01 1979-05-03 Erich 2400 Luebeck Hofacker Verwendung von Chlorhexidin und Allantoin
IT1150603B (it) * 1982-01-26 1986-12-17 Ugo Baldacci Composizione per la pulizia e l'igiene dentaria

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4370314A (en) * 1975-12-08 1983-01-25 Colgate-Palmolive Company Oral composition containing antibacterial agent
US4454110A (en) * 1982-05-24 1984-06-12 Forsyth Dental Infirmary For Children Self-gelling liquid composition for topical application in the oral cavity
US4512968A (en) * 1982-11-30 1985-04-23 Lion Corporation Oral compositions
EP0130690A2 (fr) * 1983-06-01 1985-01-09 Teijin Limited Préparation pharmaceutique pour guérir les maladies du périoste dentaire et procédé de sa fabrication
WO1987005501A1 (fr) * 1986-03-17 1987-09-24 Oral Research Laboratories, Inc. Traitement des surfaces dentaires a l'aide d'agents retardant la plaque

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP0423266A4 *

Cited By (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0572963A3 (fr) * 1992-06-02 1994-03-23 Sergio Capurro
EP0572963A2 (fr) 1992-06-02 1993-12-08 Sergio Capurro Solution sclérosante très efficace ne produisant pas de lésions iatrogènes et procédé pour obtenir cette solution
US6468519B1 (en) 1997-09-10 2002-10-22 Rutgers, The State University Of New Jersey Polyanhydrides with biologically active degradation products
US8877789B2 (en) 1999-07-23 2014-11-04 Scioderm, Inc. Allantoin-containing skin cream
US6281236B1 (en) 1999-07-23 2001-08-28 Alwyn Company, Inc. Oil-in-water emulsion with improved stability
US6329413B1 (en) 1999-07-23 2001-12-11 Alwyn Company, Inc. Allantoin-containing skin cream
US6531500B2 (en) 1999-07-23 2003-03-11 Alwyn Company, Inc. Methods for treatment of inflammatory diseases
US8877788B2 (en) 1999-07-23 2014-11-04 Scioderm, Inc. Allantoin-containing skin cream
US8877790B2 (en) 1999-07-23 2014-11-04 Scioderm, Inc. Allantoin-containing skin cream
US6673826B2 (en) 1999-07-23 2004-01-06 Alwyn Company, Inc. Methods for treatment of inflammatory diseases
US9084780B2 (en) 1999-07-23 2015-07-21 Scioderm, Inc. Allantoin-containing skin cream
US6864274B2 (en) 1999-07-23 2005-03-08 Alwyn Company, Inc. Allantoin-containing skin cream
US6896897B2 (en) 1999-07-23 2005-05-24 Alwyn Company, Inc. Flexible applicator for applying oil-in-water emulsion with improved stability
JP2003528044A (ja) * 1999-12-07 2003-09-24 ラトガーズ， ザ ステイト ユニバーシティ オブ ニュー ジャージー 治療組成物および治療方法
US8088405B2 (en) 1999-12-07 2012-01-03 Rutgers, The State University of New Jersery Therapeutic compositions and methods
US6685928B2 (en) 1999-12-07 2004-02-03 Rutgers, The State University Of New Jersey Therapeutic compositions and methods
WO2001041753A3 (fr) * 1999-12-07 2002-09-12 Univ Rutgers Compositions et methodes therapeutiques
US6613807B2 (en) 2000-07-27 2003-09-02 Rutgers, The State University Of New Jersey Therapeutic polyanhydride compounds for drug delivery
US8986719B2 (en) 2005-11-09 2015-03-24 Klox Technologies Inc. Teeth whitening compositions and methods
US9108070B2 (en) 2006-09-13 2015-08-18 Polymerix Corporation Active agents and their oligomers and polymers
US10092578B2 (en) 2006-09-13 2018-10-09 Polymerix Corporation Active agents and their oligomers and polymers
US9345648B2 (en) 2006-11-09 2016-05-24 Klox Technologies Inc. Photoactivatable oxygen-evolving compositions and methods for teeth whitening
US8974833B2 (en) 2008-11-07 2015-03-10 Klox Technologies Inc. Combination of an oxidant and a photoactivator for the healing of wounds
US10485986B2 (en) 2008-11-07 2019-11-26 Klox Technologies Inc. Methods and compositions for treatment of pigmented lesions
US10149985B2 (en) 2008-11-07 2018-12-11 Klox Technologies Inc. Methods and compositions for treating rosacea
US8911791B2 (en) 2008-11-07 2014-12-16 Klox Technologies Inc. Method for acne treatment using an oxidative-photoactivated composition
US10384072B2 (en) 2008-11-07 2019-08-20 Klox Technologies Inc. Combination of an oxidant and a photoactivator for the healing of wounds
US8986745B2 (en) 2008-11-07 2015-03-24 Klox Technologies Inc. Oxidatitive photoactivated skin rejeuvenation composition comprising hyaluronic acid, glucosamine, or allantoin
US8658219B2 (en) 2008-11-07 2014-02-25 Klox Technologies Inc. Oxidatitive photoactivated skin rejeuvenation composition comprising hyaluronic acid, glucosamine, or allantoin
US9597349B2 (en) 2008-11-07 2017-03-21 Klox Technologies Inc. Combination of an oxidant and a photoactivator for the healing of wounds
US8637086B2 (en) 2008-11-07 2014-01-28 Klox Technologies Inc. Method for acne treatment using an oxidative-photoactivated composition
US11020609B2 (en) 2008-11-07 2021-06-01 Klox Technologies Inc. Methods and compositions for treatment of pigmented lesions
US8632822B2 (en) 2008-11-07 2014-01-21 Klox Technologies Inc. Combination of an oxidant and a photoactivator for the healing of wounds
US11691025B2 (en) 2008-11-07 2023-07-04 Klox Technologies Inc. Methods and compositions for reversing or mitigating skin aging
US9375446B2 (en) 2008-11-07 2016-06-28 Klox Technologies Inc. Oxidatitive photoactivated skin rejeuvenation composition comprising hyaluronic acid, glucosamine, or allantoin
US10758744B2 (en) 2008-11-07 2020-09-01 Klox Technologies Inc. Combination of an oxidant and a photoactivator for the wounds
WO2011006263A1 (fr) * 2009-07-17 2011-01-20 Klox Technologies Inc. Composition orale antibactérienne
EA025022B1 (ru) * 2009-07-17 2016-11-30 Клокс Текнолоджиз Инк. Антибактериальная композиция для ротовой полости
US9603929B2 (en) 2009-07-17 2017-03-28 Klox Technologies Inc. Combination of an oxidant, a photosensitizer and a wound healing agent for oral disinfecton and treatment of oral disease
US11141482B2 (en) 2009-07-17 2021-10-12 Klox Technologies Inc. Combination of an oxidant, a photosensitizer and a wound healing agent for oral disinfection and treatment of oral disease
US10471147B2 (en) 2009-07-17 2019-11-12 Klox Technologies Inc. Combination of an oxidant, a photosensitizer and a wound healing agent for oral disinfection and treatment of oral disease
US8986746B2 (en) 2009-07-17 2015-03-24 Klox Technologies Inc. Combination of an oxidant, a photosensitizer and a wound healing agent for oral disinfection and treatment of oral disease
US10322179B2 (en) 2009-07-17 2019-06-18 Klox Technologies Inc. Combination of an oxidant, a photosensitizer and a wound healing agent for oral disinfection and treatment of oral disease
US8685466B2 (en) 2009-07-17 2014-04-01 Klox Technologies Inc. Combination of an oxidant, a photosensitizer and a wound healing agent for oral disinfection and treatment of oral disease
US9339492B1 (en) 2010-02-02 2016-05-17 Scioderm, Inc. Methods of treating psoriasis using allantoin
US9095574B2 (en) 2010-02-02 2015-08-04 Scioderm, Inc. Methods of treating psoriasis using allantoin
US10376455B2 (en) 2012-04-20 2019-08-13 Klox Technologies Inc. Biophotonic compositions and methods for providing biophotonic treatment
US11116841B2 (en) 2012-04-20 2021-09-14 Klox Technologies Inc. Biophotonic compositions, kits and methods
US10213373B2 (en) 2012-04-20 2019-02-26 Klox Technologies, Inc. Chromophore combinations for biophotonic uses
US11723854B2 (en) 2012-04-20 2023-08-15 Fle International S.R.L. Biophotonic compositions and methods for providing biophotonic treatment
US11331257B2 (en) 2012-04-20 2022-05-17 Klox Technologies Inc. Biophotonic compositions and methods for providing biophotonic treatment
US9144579B2 (en) 2012-08-17 2015-09-29 Rutgers, The State University Of New Jersey Polyesters and methods of use thereof
US9655829B2 (en) 2012-09-14 2017-05-23 Valeant Pharmaceuticals International, Inc. Compositions and methods for teeth whitening
US9782432B2 (en) 2012-10-25 2017-10-10 Rutgers, The State University Of New Jersey Polymers and methods thereof for wound healing
US10130706B2 (en) 2013-03-14 2018-11-20 Klox Technologies Inc. Biophotonic materials and uses thereof
US11324823B2 (en) 2013-03-14 2022-05-10 Klox Technologies Inc. Biophotonic materials and uses thereof
US9387250B2 (en) 2013-03-15 2016-07-12 Rutgers, The State University Of New Jersey Therapeutic compositions for bone repair
US9862672B2 (en) 2013-05-29 2018-01-09 Rutgers, The State University Of New Jersey Antioxidant-based poly(anhydride-esters)
US10881736B2 (en) 2013-07-03 2021-01-05 Klox Technologies Inc. Biophotonic compositions comprising a chromophore and a gelling agent for treating wounds
CN103893026A (zh) * 2014-03-31 2014-07-02 陈光健 一种用于口腔清洁和保健的漱口水
CN103893026B (zh) * 2014-03-31 2018-04-06 陈光健 一种用于口腔清洁和保健的漱口水
US10772990B2 (en) 2014-04-01 2020-09-15 Klox Technologies Inc. Tissue filler compositions and methods of use
US10207029B2 (en) 2014-04-01 2019-02-19 Klox Technologies Inc. Tissue filler compositions and methods of use
US10023521B2 (en) 2014-06-13 2018-07-17 Rutgers, The State University Of New Jersey Process and intermediates for preparing poly(anhydride-esters)
US11421349B2 (en) 2014-10-31 2022-08-23 Klox Technologies Inc. Photoactivatable fibers and fabric media
US10543162B2 (en) 2015-04-10 2020-01-28 Rutgers, The State University Of New Jersey Kojic acid polymers

Also Published As

Publication number Publication date
AU5287090A (en) 1990-09-26
CA2028136A1 (fr) 1990-09-29
EP0423266A1 (fr) 1991-04-24
EP0423266A4 (en) 1991-09-25

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