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WO1990000594A3 - Vehicules d'expression mycobacteriens de recombinaison et leur utilisation - Google Patents

Vehicules d'expression mycobacteriens de recombinaison et leur utilisation Download PDF

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Publication number
WO1990000594A3
WO1990000594A3 PCT/US1989/002962 US8902962W WO9000594A3 WO 1990000594 A3 WO1990000594 A3 WO 1990000594A3 US 8902962 W US8902962 W US 8902962W WO 9000594 A3 WO9000594 A3 WO 9000594A3
Authority
WO
WIPO (PCT)
Prior art keywords
mycobacteria
recombinant
dna
interest
coli
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1989/002962
Other languages
English (en)
Other versions
WO1990000594A2 (fr
Inventor
Barry R Bloom
Ronald W Davis
William R Jacobs Jr
Richard A Young
Robert N Husson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Albert Einstein College of Medicine
Leland Stanford Junior University
Whitehead Institute for Biomedical Research
Original Assignee
Albert Einstein College of Medicine
Leland Stanford Junior University
Whitehead Institute for Biomedical Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Albert Einstein College of Medicine, Leland Stanford Junior University, Whitehead Institute for Biomedical Research filed Critical Albert Einstein College of Medicine
Priority to DE68929507T priority Critical patent/DE68929507T2/de
Priority to AT89908028T priority patent/ATE256730T1/de
Priority to EP89908028A priority patent/EP0424437B1/fr
Publication of WO1990000594A2 publication Critical patent/WO1990000594A2/fr
Publication of WO1990000594A3 publication Critical patent/WO1990000594A3/fr
Anticipated expiration legal-status Critical
Priority to US08/096,027 priority patent/US5591632A/en
Priority to US08/095,734 priority patent/US5807723A/en
Priority to US08/444,623 priority patent/US5866403A/en
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/08—Antibacterial agents for leprosy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/10011—Details dsDNA Bacteriophages
    • C12N2795/10022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/32—Mycobacterium
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pulmonology (AREA)
  • Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • AIDS & HIV (AREA)
  • Toxicology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

L'invention concerne des mycobactéries cultivables de recombinaison capables d'exprimer de l'ADN d'intérêt codant au moins un antigène protéique contre lequel on veut obtenir une réponse immune, ainsi que des procédés d'introduction d'ADN d'intérêt dans les mycobactéries. Dans les mycobactéries de recombinaison l'ADN d'intérêt est maintenu stable extrachromosomiquement ou est intégré de manière stable dans de l'ADN génomique. De telles mycobactéries de recombinaison sont utiles comme véhicules servant de vaccins pour assurer l'immunité contre un gène pathogène, de ''vaccins'' anti-fécondité, et pour augmenter non spécifiquement des réponses immunitaires à des antigènes étrangers exprimés par BCG ou pour traiter des cancers chez l'homme. L'invention concerne également des vecteurs de recombinaison utiles pour introduire de l'ADN d'intérêt dans des mycobactéries, où il est exprimé. Un type de vecteur est un plasmide de recombinaison capable de réplication en tant que plasmide dans E. coli, et de lysogérer un hôte mycobactérien. Un second type de vecteur est un plasmide de recombinaison que l'on peut introduire dans des mycobactéries, où il est maintenu stable extrachromosomiquement. Un troisième type de vecteur de recombinaison est du type à réplication dans E. coli mais pas dans des mycobactéries. Il comprend: 1) un gène ou des sections de gène mycobactérien, requis pour la recombinaison avec des séquences homologues dans le génome des mycobactéries transformées à l'aide du plasmide de recombinaison; 2) tout ou une partie d'un gène en codant un polypeptide ou une protéine dont on veut obtenir l'expression dans des mycobactéries transformées à l'aide du plasmide de recombinaison; 3) des séquences d'ADN nécessaires à la réplication et à la sélection dans E. coli et 4) des séquences d'ADN nécessaires à la sélection dans des mycobactéries (par exemple, résistance aux médicaments).
PCT/US1989/002962 1987-03-02 1989-07-07 Vehicules d'expression mycobacteriens de recombinaison et leur utilisation Ceased WO1990000594A2 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
DE68929507T DE68929507T2 (de) 1988-07-07 1989-07-07 Rekombinante mykobakterielle expressions-träger sowie deren verwendung
AT89908028T ATE256730T1 (de) 1988-07-07 1989-07-07 Rekombinante mykobakterielle expressions-träger sowie deren verwendung
EP89908028A EP0424437B1 (fr) 1988-07-07 1989-07-07 Vehicules d'expression mycobacteriens de recombinaison et leur utilisation
US08/096,027 US5591632A (en) 1987-03-02 1993-07-22 Recombinant BCG
US08/095,734 US5807723A (en) 1987-03-02 1993-07-22 Homologously recombinant slow growing mycobacteria and uses therefor
US08/444,623 US5866403A (en) 1987-03-02 1995-05-19 Homologously recombinant slow growing mycobacteria and uses therefor

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US21639088A 1988-07-07 1988-07-07
US216,390 1988-07-07
US22308988A 1988-07-22 1988-07-22
US223,089 1988-07-22
US07/361,944 US5504005A (en) 1987-03-02 1989-06-05 Recombinant mycobacterial vaccine
US361,944 1989-06-05

Publications (2)

Publication Number Publication Date
WO1990000594A2 WO1990000594A2 (fr) 1990-01-25
WO1990000594A3 true WO1990000594A3 (fr) 1990-05-03

Family

ID=27396269

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1989/002962 Ceased WO1990000594A2 (fr) 1987-03-02 1989-07-07 Vehicules d'expression mycobacteriens de recombinaison et leur utilisation

Country Status (8)

Country Link
US (5) US5504005A (fr)
EP (1) EP0424437B1 (fr)
JP (2) JP3485916B2 (fr)
AT (1) ATE256730T1 (fr)
AU (1) AU3867789A (fr)
CA (1) CA1339526C (fr)
DE (1) DE68929507T2 (fr)
WO (1) WO1990000594A2 (fr)

Families Citing this family (120)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5807723A (en) * 1987-03-02 1998-09-15 Whitehead Institute For Biomedical Research Homologously recombinant slow growing mycobacteria and uses therefor
WO1994029459A1 (fr) * 1993-06-04 1994-12-22 Whitehead Institute For Biomedical Research Proteines du stress et leurs utilisations
EP0400973B1 (fr) * 1989-05-31 1996-07-31 Ajinomoto Co., Inc. Vecteurs d'expression et de sécrétion pour mycobacterium et les transformants
JP2903414B2 (ja) * 1989-05-31 1999-06-07 味の素株式会社 抗酸菌分泌発現ベクター及び抗酸菌
DE69034100T2 (de) * 1989-06-19 2004-06-09 Whitehead Institute For Biomedical Research, Cambridge Verktorvermittelte genominsertion und expression von dna in bcg
JPH05504067A (ja) * 1990-02-26 1993-07-01 コモンウェルス　サイエンティフィック　アンド　インダストリアル　リサーチ　オーガナイゼイション 大腸菌及びマイコバクテリアのためのシャトルプラスミド
CA2045842A1 (fr) * 1990-07-16 1992-01-17 William R. Jacobs Adn capable de s'integrer dans un site particulier de mycobacteries
GB9015888D0 (en) * 1990-07-19 1990-09-05 Smithkline Biolog Vectors
AU643842B2 (en) * 1990-10-25 1993-11-25 Commonwealth Scientific And Industrial Research Organisation Corynebacteria and related organisms as vaccine vectors
JPH06501847A (ja) * 1990-10-25 1994-03-03 コモンウェルス　サイエンティフィク　アンド　インダストリアルリサーチ　オーガナイゼイション ワクチンベクターとしてのコリネバクテリウム及び関連する生物
US5637303A (en) * 1990-10-25 1997-06-10 Commonwealth Scientific And Industrial Research Organisation Use of a phospholipase D mutant of Corynebacterium pseudotuberculosis for vaccination
EP0587775A4 (fr) * 1991-06-06 1994-11-02 Medimmune Inc Induction de reponses de lymphocytes t cytotoxiques a des antigenes etrangers exprimes dans des mycobacteries.
WO1992021374A1 (fr) * 1991-06-06 1992-12-10 Medimmune, Inc. Induction d'une reaction immunitaire a la toxine du tetanos par administration de mycobacteries exprimant la toxine du tetanos ou des fragments de celle-ci
US6566121B1 (en) * 1991-06-13 2003-05-20 Albert Einstein College Of Medicine Of Yeshiva University Insertional mutations in mycobacteria
WO1992022326A1 (fr) * 1991-06-13 1992-12-23 Albert Einstein College Of Medicine, A Division Of Yeshiva University Mutations par insertion dans des mycobacteries
EP0521220A1 (fr) * 1991-06-14 1993-01-07 Institut Pasteur Actinomycétale immunogène recombinant
US6300061B1 (en) 1992-02-07 2001-10-09 Albert Einstein College Of Medicine Of Yeshiva University Mycobacterial species-specific reporter mycobacteriophages
US5750384A (en) * 1992-02-07 1998-05-12 Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University L5 shuttle phasmids
US5330754A (en) * 1992-06-29 1994-07-19 Archana Kapoor Membrane-associated immunogens of mycobacteria
US6238676B1 (en) 1992-12-10 2001-05-29 Brigham And Women's Hospital Presentation of hydrophobic antigens to T-cells by CD1 molecules
US7063844B2 (en) 1992-12-10 2006-06-20 The Brigham And Women's Hospital, Inc. Presentation of hydrophobic antigens to T-cells by CD1 molecules
US6752993B1 (en) 1993-11-23 2004-06-22 The Regents Of The University Of California Abundant extracellular product vaccines and methods for their production and use
ATE407945T1 (de) 1993-11-23 2008-09-15 Univ California Reichlich vorhandene extrazelluläre produkte und methoden zu ihrer herstellung sowie ihre verwendung
US7300660B2 (en) 1993-11-23 2007-11-27 The Regents Of The University Of California Abundant extracellular products and methods for their production and use
FR2720076B1 (fr) 1994-05-20 1996-08-02 Inst Nat Sante Rech Med Vecteurs navettes pour l'introduction d'ADN dans des mycobactéries et utilisation de ces bactéries comme vaccins.
US6458366B1 (en) 1995-09-01 2002-10-01 Corixa Corporation Compounds and methods for diagnosis of tuberculosis
US6592877B1 (en) 1995-09-01 2003-07-15 Corixa Corporation Compounds and methods for immunotherapy and diagnosis of tuberculosis
US6290969B1 (en) * 1995-09-01 2001-09-18 Corixa Corporation Compounds and methods for immunotherapy and diagnosis of tuberculosis
AU774535B2 (en) * 1995-10-20 2004-07-01 Actogenix Nv Delivery of biologically active polypeptides
GB9521568D0 (en) * 1995-10-20 1995-12-20 Lynxvale Ltd Delivery of biologically active polypeptides
US6013660A (en) * 1996-10-02 2000-01-11 The Regents Of The University Of California Externally targeted prophylactic and chemotherapeutic method and agents
US6221364B1 (en) * 1996-11-12 2001-04-24 Albert Einstein College Of Medicine Of Yeshiva University Recombinant mycobacteria auxotrophic for diaminopimelate
US7157089B1 (en) 1996-11-26 2007-01-02 Stressgen Biotechnologies Corporation Immune responses using compositions containing stress proteins
WO1998031388A1 (fr) * 1997-01-21 1998-07-23 Regents Of The University Of California Produits extracellulaires abondants et leurs procedes de production et d'utilisation
CA2282426A1 (fr) * 1997-02-18 1998-08-20 The Whitehead Institute For Biomedical Research Utilisation de proteines de choc thermique pour introduire des fractions dans des cellules
CN1915425A (zh) 1997-08-05 2007-02-21 斯特思吉生物技术公司 包含hpv抗原和应激蛋白或者其表达载体的组合物激发的抗hpv抗原免疫应答
EP0934421A1 (fr) 1997-08-06 1999-08-11 Laboratorio Medinfar-Produtos Farmaceuticos LDA. INTEGRATION D'ADN DANS LE GENOME "MYCOBACTERIUM spp" PAR TRANS-COMPLEMENTATION A L'AIDE D'UN SYSTEME D'INTEGRATION DIRIGE
CA2245408A1 (fr) * 1997-08-21 1999-02-21 York University Systeme de criblage a haut rendement pour les inhibiteurs d'enzymes
EP0902086A1 (fr) * 1997-08-22 1999-03-17 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Vaccin contre la tubercolose
US5972700A (en) * 1997-09-26 1999-10-26 Albert Einstein College Of Medicine Of Yeshiva University TM4 conditional shuttle phasmids and uses thereof
US6387694B1 (en) 1998-04-03 2002-05-14 Albert Einstein College Of Medicine Of Yeshiva University Mycobacterial isocitrate lyase gene and uses thereof
US6693087B1 (en) 1998-08-20 2004-02-17 Aventis Pasteur Limited Nucleic acid molecules encoding POMP91A protein of Chlamydia
EP1105490A1 (fr) 1998-08-20 2001-06-13 Aventis Pasteur Limited Molecules d'acide nucleique codant la proteine membrane d'inclusion c de chlamydia
US6686339B1 (en) 1998-08-20 2004-02-03 Aventis Pasteur Limited Nucleic acid molecules encoding inclusion membrane protein C of Chlamydia
US6497880B1 (en) * 1998-12-08 2002-12-24 Stressgen Biotechnologies Corporation Heat shock genes and proteins from Neisseria meningitidis, Candida glabrata and Aspergillus fumigatus
US7022320B1 (en) * 1999-02-09 2006-04-04 Powderject Vaccines, Inc. Mycobacterium tuberculosis immunization
US8143386B2 (en) * 1999-04-07 2012-03-27 Corixa Corporation Fusion proteins of mycobacterium tuberculosis antigens and their uses
CN1367875A (zh) 1999-07-08 2002-09-04 斯特思吉生物技术公司 活体外th1一样反应的诱导方法
CA2386841A1 (fr) * 1999-10-07 2001-04-12 Corixa Corporation Proteines hybrides de mycobacterium tuberculosis
JP2003512829A (ja) 1999-10-22 2003-04-08 アヴェンティス パストゥール リミテッド 改変型ｇｐ１００およびその使用
DE60042704D1 (de) 2000-01-14 2009-09-17 Whitehead Biomedical Inst Induktion zytotoxischer lymphozyten durch hitzeschockprotein-fusionsproteine hängt von der atp-bindungsdomäne in hsp ab und is cd4+ unabhängig
WO2001062893A2 (fr) * 2000-02-25 2001-08-30 Corixa Corporation Composes et methodes de diagnostic et d'immunotherapie de la tuberculose
US6924118B2 (en) * 2000-04-17 2005-08-02 The Regents Of The University Of California Recombinant intracellular pathogen immunogenic compositions and methods for use
US6471967B1 (en) 2000-04-17 2002-10-29 The Regents Of The University Of California Recombinant intracellular pathogen vaccines and methods for use
EP1792995A3 (fr) 2000-05-08 2007-06-13 Sanofi Pasteur Limited Antigènes de chlamydia et fragments d'adn correspondants, et utilisations de ceux-ci
EP1741782B1 (fr) * 2000-05-10 2011-06-22 Sanofi Pasteur Limited Polypeptides immunogéniques codés par des minigènes mage et leurs utilisations
PT2133100E (pt) * 2000-06-20 2012-01-11 Corixa Corp Antigénio mtb32a de mycobacterium tuberculosis com um local activo inactivado e suas proteínas de fusão
CZ20024154A3 (cs) * 2000-06-26 2003-08-13 Stressgen Biotechnologies Corporation Použití prostředku obsahujícího napojený protein pro výrobu farmaceutického přípravku pro léčení bradavic a chorob a stavů souvisejících s papiloma virem
JP2004506086A (ja) 2000-08-25 2004-02-26 アベンティス、パストゥール、リミテッド インフルエンザ菌感染症の予防用ワクチンとしてのインフルエンザ菌リポ多糖内部コアオリゴ糖エピトープ
EP1343894A4 (fr) 2000-11-02 2005-05-04 Univ Singapore Gene aopb, proteine, homologues, fragments et variants de celui-ci, ainsi que l'utilisation de ces derniers pour presentation a la surface cellulaire
MXPA03006971A (es) * 2001-02-05 2004-05-05 Stressgen Biotechnologies Corp Tratamiento del virus de hepatitis b.
US7780961B2 (en) * 2001-05-03 2010-08-24 Actogenix N.V. Self-containing Lactococcus strain
US20030194798A1 (en) 2001-05-24 2003-10-16 Surber Mark W. Minicell compositions and methods
US7396822B2 (en) 2001-05-24 2008-07-08 Vaxiion Therapeutics, Inc. Immunogenic minicells and methods of use
UA79952C2 (en) * 2001-12-10 2007-08-10 Kabulesh Mafatlal Khamar MYCOBACTERIUM w APPLICATIONS FOR CANCER TREATMENT
US7026465B2 (en) 2002-02-15 2006-04-11 Corixa Corporation Fusion proteins of Mycobacterium tuberculosis
US7758874B2 (en) * 2002-02-19 2010-07-20 Albert Einstein College Of Medicine Of Yeshiva University Attenuated Mycobacterium tuberculosis vaccines
AU2003209345A1 (en) * 2002-02-19 2003-09-09 Albert Einstein College Of Medicine Of Yeshiva University Attenuated mycobacterium tuberculosis vaccines
US7074559B2 (en) * 2002-03-06 2006-07-11 Refents of the University of Minnesota Mycobacterial diagnostics
DE60315628T2 (de) 2002-04-09 2008-06-05 Sanofi Pasteur Ltd., Toronto Modifizierte cea nucleinsäure und expressionsvektoren
CA2481108C (fr) * 2002-04-16 2013-05-28 Jun Liu Souches recombinees de bacille de calmette-guerin exprimant l'alanine deshydrogenase, serine deshydratase et/ou glutamine synthetase en tant que vaccins contre la tuberculose
EP1513545B1 (fr) * 2002-06-19 2008-03-19 Actogenix N.V. Procedes et moyens permettant de favoriser l'absorption intestinale
EP1535627B1 (fr) * 2002-08-16 2008-07-09 Japan Science and Technology Agency Vaccin contre le bcg recombine
CA2506031A1 (fr) * 2002-11-15 2004-06-03 Vib Vzw Souche de lactobacillus automone comprenant une mutation du gene thya et applications therapeutiques associees
DE60333228D1 (de) * 2002-12-02 2010-08-12 Amgen Fremont Inc Gegen den tumor nekrose faktor gerichtete antikörper und deren verwendungen
US8084041B2 (en) * 2003-01-24 2011-12-27 Albert Einstein College Of Medicine Of Yeshiva University Use of mycrobacterial vaccines in CD4+ or CD8+ lymphocyte-deficient mammals
KR101162970B1 (ko) * 2003-10-08 2012-07-12 테리온 바이오로직스, 인크. 변형된 ｃｅａ/ｂ7 벡터
WO2007121194A1 (fr) * 2006-04-10 2007-10-25 The Regents Of The University Of California Compositions immunogènes à agents pathogènes intracellulaires recombinés immunostimulants, et procédés d'utilisation
WO2005037222A2 (fr) 2003-10-16 2005-04-28 The Regents Of The University Of California Compositions immunogenes de pathogenes intracellulaires recombinants et procedes d'utilisation de celles-ci
US8163294B2 (en) * 2003-10-16 2012-04-24 The Regents Of The University Of California Growth regulatable recombinant BCG compositions
US8383132B2 (en) * 2003-10-16 2013-02-26 The Regents Of The University Of California Immunostimulatory recombinant intracellular pathogen immunogenic compositions and methods of use
US7842289B2 (en) * 2003-12-24 2010-11-30 Aduro Biotech Recombinant nucleic acid molecules, expression cassettes, and bacteria, and methods of use thereof
US20060002956A1 (en) * 2004-04-05 2006-01-05 Surber Mark W Minicells as vaccines
EP1846024B1 (fr) * 2005-01-12 2016-03-23 Albert Einstein College of Medicine, Inc. Mutants mycobacteriens afectant l'apoptose chez l'hôte
US7998471B2 (en) * 2005-01-12 2011-08-16 Albert Einstein College Of Medicine Of Yeshiva University Mycobacteria expressing HIV-1 and malaria antigens
EP1841860A2 (fr) 2005-01-18 2007-10-10 Vereniging voor christelijk hoger onderwijs, wetenschappelijk onderzoek en patiëntenzorg Mycobacteries presentant un lipoarabinomannane deficient en coiffes de mannose
US20090123561A1 (en) * 2005-07-14 2009-05-14 Basf Aktiengeselllschaft Fungicide mixtures based on 1-methyl-pyrazol-4-ylcarboxanilides
AU2006319216B2 (en) 2005-11-29 2012-09-13 Intrexon Actobiotics Nv Induction of mucosal tolerance to antigens
WO2007067729A2 (fr) 2005-12-09 2007-06-14 University Of Georgia Research Foundation, Inc. Vaccin microbien et vecteur de vaccin
WO2007084353A2 (fr) * 2006-01-12 2007-07-26 Albert Einstein College Of Medicine Of Yeshiva University Seca2 mutants mycobacteriens
ES2492468T3 (es) 2007-01-25 2014-09-09 Actogenix N.V. Tratamiento de enfermedad inmunitaria por administración a través de la mucosa de antígenos usando Lactobacillus genéticamente modificado
US8591918B2 (en) 2007-03-19 2013-11-26 Albert Einstein College Of Medicine Of Yeshiva University Mycobacterial mutants inducing IL-12
WO2008136790A1 (fr) 2007-05-02 2008-11-13 Merial Limited Plasmides à adn à expression et stabilité améliorées
US7670609B2 (en) * 2007-11-27 2010-03-02 Aeras Global Tb Vaccine Foundation Recombinant BCG tuberculosis vaccine designed to elicit immune responses to Mycobacterium tuberculosis in all physiological stages of infection and disease
US8361482B2 (en) * 2007-11-27 2013-01-29 Aeras Global Tb Vaccine Foundation Recombinant BCG tuberculosis vaccine designed to elicit immune responses to mycobacterium tuberculosis in all physiological stages of infection and disease
RU2392002C2 (ru) * 2008-04-02 2010-06-20 ФГОУ ВПО Курская государственная сельскохозяйственная академия им. профессора И.И. Иванова Способ получения туберкулезного анатоксина
RU2372936C1 (ru) * 2008-05-19 2009-11-20 Закрытое акционерное общество "Томские клеточные технологии" (ЗАО "Томские клеточные технологии") Способ получения аутологичной вакцины для лечения туберкулеза
CA2748149C (fr) 2008-12-24 2018-03-06 Netherlands Vaccine Institute Polypeptides de pneumolysine de streptococcus pneumoniae modifies
US20140093556A1 (en) 2011-01-28 2014-04-03 Sanofi Pasteur Sa Immunological Compositions Against HIV
JP6199746B2 (ja) 2011-02-15 2017-09-20 バキシオン セラピューティクス，リミテッド ライアビリティ カンパニー 抗体およびＦｃ含有標的化分子に基づく生理活性分子の標的送達のための細菌ミニ細胞による治療用組成物および方法
CN103889440A (zh) 2011-08-08 2014-06-25 Cl昂科莱吉有限公司 用于癌症治疗和预防的涉及p62的方法和组合物
WO2013059616A1 (fr) * 2011-10-21 2013-04-25 Albert Einstein College Of Medicine Of Yeshiva University Mycobactériophages recombinants permettant d'administrer des acides nucléiques d'intérêt dans des mycobactéries
BR102012003790A2 (pt) 2012-02-17 2014-04-22 Fundacao Butantan Cepa de mycobacterium recombinante, composição imunogênica e uso
WO2014032835A1 (fr) 2012-08-31 2014-03-06 Laboratorios Del Dr. Esteve, S.A. Mycobactérie comprenant un vecteur d'expression doté de deux marqueurs de sélection auxotrophiques et son utilisation comme vaccin
EP2895501B1 (fr) 2012-09-17 2017-01-18 Novartis Tiergesundheit AG Alphavirus des salmonids et leurs utilisations
EP2914618B1 (fr) 2012-11-02 2017-07-26 Novartis Tiergesundheit AG Flavivirus associés à la maladie de theiler
WO2014140938A2 (fr) 2013-03-14 2014-09-18 Centre Hospitalier Universitaire Vaudois Méthodes immunologiques
CA2935232A1 (fr) 2013-12-29 2015-07-02 Curelab Oncology, Inc. Methodes et compositions relatives a p62/sqstm1 pour traiter et prevenir les maladies associees a une inflammation
US9982053B2 (en) 2014-08-05 2018-05-29 MabQuest, SA Immunological reagents
JP2019509046A (ja) 2015-12-05 2019-04-04 サントル オスピタリエ ユニヴェルシテール ヴォドアＣｅｎｔｒｅ Ｈｏｓｐｉｔａｌｉｅｒ Ｕｎｉｖｅｒｓｉｔａｉｒｅ Ｖａｕｄｏｉｓ Ｈｉｖ結合剤
AU2017208819B2 (en) 2016-01-22 2023-10-19 MabQuest SA PD1 specific antibodies
EP3436603B1 (fr) * 2016-03-31 2025-11-26 University Of The Witwatersrand, Johannesburg Souches génétiquement modifiées de mycobacterium smegmatis
US11419908B2 (en) * 2016-06-30 2022-08-23 Technology Innovation Momentum Fund (Israel) Limited Partnership Bacteriophage variants having extended host-range, methods for preparation and uses thereof in transducing nucleic acids into hosts of interest
EP3596202A4 (fr) 2017-03-14 2021-01-27 The Regents of the University of California Identification à l'échelle du génome de fonctions d'évasion immunitaire dans un virus
CN109825497A (zh) * 2019-01-25 2019-05-31 石河子大学 一种新型结核杆菌融合菌株的制备方法及其应用
WO2021009697A2 (fr) 2019-07-15 2021-01-21 Lausanne University Hospital Agents de liaison au vih
TWI884296B (zh) 2020-08-11 2025-05-21 美商碩騰服務公司 抗冠狀病毒疫苗
CN114315985A (zh) 2020-09-29 2022-04-12 硕腾服务有限责任公司 减毒猪流行性腹泻病毒
EP4317441A4 (fr) * 2021-03-22 2025-09-17 Clipsbnc Co Ltd Nouvelle souche recombinée de mycobacterium smegmatis et son utilisation
US20240390476A1 (en) 2021-08-31 2024-11-28 Zoetis Services Llc Attenuated alphavirus

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0127328A2 (fr) * 1983-04-28 1984-12-05 Genex Corporation L'emploi d'une intégration dans des chromosomes pour stabiliser des gènes hétérologues
EP0191643A2 (fr) * 1985-02-13 1986-08-20 Biotechnica International, Inc. Intégration d'un gène dans un chromosome et découpage contrôlé de celui-ci
WO1988000974A2 (fr) * 1986-07-31 1988-02-11 Whitehead Institute For Biomedical Research Genes de codage d'antigenes de m. leprae
WO1988006626A1 (fr) * 1987-03-02 1988-09-07 Whitehead Institute For Biomedical Research Vaccin mycobacterien recombinant

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8314645D0 (en) * 1983-05-26 1983-06-29 Wellcome Found Bivalent vaccines

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0127328A2 (fr) * 1983-04-28 1984-12-05 Genex Corporation L'emploi d'une intégration dans des chromosomes pour stabiliser des gènes hétérologues
EP0191643A2 (fr) * 1985-02-13 1986-08-20 Biotechnica International, Inc. Intégration d'un gène dans un chromosome et découpage contrôlé de celui-ci
WO1988000974A2 (fr) * 1986-07-31 1988-02-11 Whitehead Institute For Biomedical Research Genes de codage d'antigenes de m. leprae
WO1988006626A1 (fr) * 1987-03-02 1988-09-07 Whitehead Institute For Biomedical Research Vaccin mycobacterien recombinant

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTACTS, Vol. 96, No. 19, 10 May 1982, (Columbus, Ohio, US), S. BRENNER et al.: "Phasmids: Hybrids Between Co1E1 Plasmids and E. Coli Bacteriophage Lambda", page 187* Abstact No. 156476C, & Gene 1982, 17(1), 27-44* *
Infection and Immunity, Vol. 52, No. 1, April 1986, American Society for Microbiology, W.R. JACOBS et al.: "in Vivo Repack-Aging of Recombinant Cosmid Molecules for Analyses of Salmonella Typhimurium, Streptococcus Mutants, and Mycobacterial Genomic Libraries", pages 101-109 *
Nature, Vol. 327, No. 6122, 11-17 June 1987, (Basingstoke, Hampshire, GB), W.R. Jacobs, Jr. et al.: "Introduction of Foreign DNA into Mycobacteria Using a Shuttle Phasmid", pages 532-535 *
Proc. Natl. Acac. Sci. USA, Vol. 85, September 1988, S.B. SNAPPER et al.: "Lysogeny and Transformation in Mycobacteria: Stable Expression of Foreign Genes", pages 6987-6991, *
Reviews of Infectious Diseases, Vol. II, Supplement 2, March-April 1989, The University of Chicago, W.R. JACOBS, JR. et al.: "Mycobacteriophage Vector Systems", pages 404-410 *

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US6372478B1 (en) 2002-04-16
JP2000350578A (ja) 2000-12-19
AU3867789A (en) 1990-02-05
US5854055A (en) 1998-12-29
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WO1990000594A2 (fr) 1990-01-25
US5504005A (en) 1996-04-02
US5968733A (en) 1999-10-19
EP0424437A1 (fr) 1991-05-02
ATE256730T1 (de) 2004-01-15
US6270776B1 (en) 2001-08-07
EP0424437B1 (fr) 2003-12-17
DE68929507D1 (de) 2004-01-29

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