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WO1988007351A1 - Tube collecteur et appareil servant a faire le vide au prealable - Google Patents

Tube collecteur et appareil servant a faire le vide au prealable Download PDF

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Publication number
WO1988007351A1
WO1988007351A1 PCT/AU1988/000081 AU8800081W WO8807351A1 WO 1988007351 A1 WO1988007351 A1 WO 1988007351A1 AU 8800081 W AU8800081 W AU 8800081W WO 8807351 A1 WO8807351 A1 WO 8807351A1
Authority
WO
WIPO (PCT)
Prior art keywords
tube
vacuum
evacuation
fluid
communication
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/AU1988/000081
Other languages
English (en)
Inventor
Joseph R. B. Parsons
Joanna Mary Parsons
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Joseph Parsons Nominees Pty Ltd
Original Assignee
Joseph Parsons Nominees Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Joseph Parsons Nominees Pty Ltd filed Critical Joseph Parsons Nominees Pty Ltd
Publication of WO1988007351A1 publication Critical patent/WO1988007351A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/153—Devices specially adapted for taking samples of venous or arterial blood, e.g. with syringes
    • A61B5/154—Devices using pre-evacuated means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150015—Source of blood
    • A61B5/15003—Source of blood for venous or arterial blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150274—Manufacture or production processes or steps for blood sampling devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150381—Design of piercing elements
    • A61B5/150389—Hollow piercing elements, e.g. canulas, needles, for piercing the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150381—Design of piercing elements
    • A61B5/150473—Double-ended needles, e.g. used with pre-evacuated sampling tubes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/10—Devices for withdrawing samples in the liquid or fluent state
    • G01N1/14—Suction devices, e.g. pumps; Ejector devices

Definitions

  • the present invention relates to an apparatus and method(s) for drawing fluid using evacuation of an enclosed c space or a chamber.
  • the present invention may be used or adapted for use in the medical field or environment, although the present invention may equally be adapted to many other fields (such as veterinary or chemical) where evacuation is required.
  • the present invention deals with an apparatus and method for collecting, transferring and/or handling of body fluid or any other suitable fluid.
  • Background Art m syringes have commonly been used for the collection of blood or other body fluid samples.
  • a syringe needle can be used to pierce a blood filled vein or other organ from which body fluids are to be sampled.
  • the syringe plunger can then be retracted, such that, a vacuum is created in the syringe body. Blood flows or is drawn 0 into the syringe body by this vacuum. Once a prescribed or desired sample has been taken, the syringe can be withdrawn from the vein.
  • the sample In order for analysis to be carried out on the blood sample taken, the sample must first be transferred into another more suitable vessel. This transfer involves 5 exposing the sample, such that spillage or contamination of the sample, the people handling the sample and the working environment may occur. Most often, the blood sample is transferred to more than one other vessel, each transfer 0 accentuating the possibility of spillage or contamination of the sample.
  • Pre-evacuated tubes have also been herebefore used.
  • the tubes commonly used have been made only of glass, since plastic tubes do not reliably retain a vacuum for an extended period of time.
  • These pre-evacuated tubes are expensive and also have a preset vacuum therein which is used to draw a measured or preset amount of blood sample.
  • the present vacuum is susceptible to leakage due to the glass containers imperfect sealing especially where there is an extended period between the time of the manufacture and sealing of the evacuated tube and the time of its intended use. Accordingly, amounts of fluid drawn by the pre-evacuated tubes can vary from tube to tube. Often, in use, a large blood sample is drawn, then smaller samples are obtained, via transfer and handling, with the dangers as described above.
  • the sample is taken by means of a syringe body having an external needle fitted to the inlet thereof for insertion into a vein of a patient and internal needle projecting into the syringe body.
  • an evacuated glass sample tube sealed as described above is depressed into the syringe body.
  • the internal needle pierces the plug and on passing fully through the plug permits blood from the patient to be drawn into the sample tube by the vacuum therein. Withdrawal of the plunger/sample tube once full, results in withdrawal of the internal of the needle from the plug.
  • the material of the plug is such that the orifice formed by the needle is effectively resealed when the needle is withdrawn.
  • An alternative tube comprises a glass tubular body having a screw threaded open end and an appropriate screw cap with an orifice in the end or top thereof. The tube is sealed by way of an appropriate rubber (or other material) disc inserted between the tube and the cap which provides the plug through which the needle is passed.
  • These sample tubes are normally evacuated or subject to a certain reduced pressure to withdraw a set volume (e.g. 5 ml), 10 ml) blood sample.
  • the sample tube may be used at some long and indefinite time after manufacture and evacuation, the degree of evacuation of the tube may be uncertain and thus a blood sample, of insufficient volume for a particular test, may be withdrawn from a patient. Thus additional samples must be taken from the patient, resulting in a waste of time and materials and perhaps removal of too much blood from a patient.
  • the stopper is then attached to the connector by jaws.
  • the connector when used is in communication with a fluid reservoir.
  • the fluid is drawn into the barrel by retracting the barrel from the connector causing fluid to be drawn into the void left by the stopper.
  • the barrel is full, it
  • ____b can be detached from the connector, whereupon the stopper is released by the connector and forms a plug for the barrel.
  • This apparatus has the disadvantage of using the same connector (needle means) for piercing the vein of a patient for each sample taken. This increases the risk of disease _ n transfer. If, the connector is only used once and dispensed, then the disclosed apparatus is very expensive to use. Furthermore, withdrawl of sample is preset in volume and dependent on the reliability of the stopper. Barrels containing anti-coagulant are not contemplated, since complete depressing of the stopper into the barrel upon fitting the barrel to the connector is not possible.
  • U.S. Patent Specification No. 3,965,889 granted 29th June, 1976 discloses a vein piercing device comprising a double ended needle, one for piercing the vein and the other end for piercing a tube adapted to fit within the device, for communication of fluid from the vein to the tube.
  • the tube has therein a sack which is expandable by means of a vacuum supplied by a pump to the tube. As the vacuum is applied to the tube, the sack expands, drawing fluid from the vein.
  • This apparatus is high in cost, most cumbersome in use as a pump is not always readily available for use and, again, the same neeedle is used to pierce the vein for each sample, thereby increasing considerably the risk of contamination.
  • the device for evacuating a tube just prior to taking a fluid sample from a vein.
  • the device is adapted to receive a tube having a pierceable stopper therein.
  • the device pierces the stopper, thus providing communication between the tubes interior and a chamber within the device.
  • the tube causes a piston within, the chamber to retract, thus causing a vacuum in the chamber and also in the tube.
  • the tube is disconnected from the chamber just prior to having the tube again pierced by a needle having its other end in a fluid reservoir or vein, thus allowing fluid to be drawn into the tube under vacuum.
  • the device suffers from several disadvantages, namely, the device is only adapted to receive one size of tube and can only draw a fluid sample of one size.
  • the needle of the device can be re-used, thereby risking contamination of the sample or communicating disease.
  • the device is difficult to operate. In use, the needle is inserted into a vein, and while the needle is situated in the vein, the evacuated tube is pushed onto the other end of the needle.
  • 'tube' throughout the specification should be read, unless otherwise specified, as including reference to a tube, a test tube, a resealable tube, closed c tube, an enclosed space of any form or chamber.
  • the 'tube' may be made of glass, plastic or any other suitable material. The type of material used is dependent upon the application.
  • the present invention seeks to alleviate or overcome some or all of the disadvantages of the prior art by providing a method and apparatus for collecting fluid samples in which the sample is collected in a substantially Q . synthetic plastics material tube which has been evacuated just prior to use.
  • the present invention provides, in one form, a closed fluid sample collection tube evacuating apparatus for evacuation of a closed fluid sample collection tube just 5 prior to collection of a fluid sample of predetermined volume in relation to the volume of the sample tube, said apparatus comprising : evacuation means mounted in or on a housing, said evacuation means being adapted to evacuate a closed sample Q tube to a required vacuum being derived from a predetermined degree of vacuum or to one of a series of predetermined degrees of vacuum, and communication means for connection of said evacuation means to the sample collection tube to enable evacuation of said tube to the required vacuum.
  • a system for collecting a fluid sample comprising a tube adapted to receive and retain for a predetermined amount of time, a vacuum, the tube being pierceable or needle penetrable so as to provide fluid communication between a fluid reservoir and the interior of said tube and for evacuating the tube, such that the sample drawn is of a predetermined volume in relation to the volume of the tube, just prior to collection of said sample, said tube being adapted to substantially reseal after piercing so as to hold said vacuum for said time or to hold said sample, evacuation means mounted in or on a housing and being adapted to evacuate the tube to a predetermined degree of vacuum or to one of a series of predetermined degrees of vacuum, and communication means adapted to connect said evacuation means to said tube to enable evacuation of said tube to the predetermined degree of vacuum or to one of the series of predetermined degrees of vacuum.
  • a method of sampling a predetermined volume of fluid comprising the steps of : providing a fluid path means in communication with a fluid reservoir, selecting the predetermined volume of fluid required to be sampled from the reservoir, selecting a resealable tube having an enclosed space adapted for evacuation and retaining a prescribed vacuum for a predetermined amount of time, providing the tube with the vacuum by allowing the tube to be pierced such that communication is provided between a source of vacuum and the interior of the tube until the prescribed vacuum is instilled in the tube, and then disconnecting the tube from the vacuum source, whereby the tube reseals in order to retain the prescribed vacuum, mating the tube with the fluid path means, piercing the evacuated tube and allowing the predetermined volume of fluid into the tube.
  • a method of collecting a fluid sample from a patient comprising : attaching " a syringe body to a first hollow needle permanently or temporarily inserted in a vein of the patient, said syringe body having a second internal hollow needle extending axially into the tubular internal cavity of the syringe body; evacuating or partially evacuating a plastics c material sample tube having a needle-penetrable stopper therein by piercing said stopper with a needle attached to a vacuum device, operating said vacuum device to evacuate or partially evacuate said sample tube, disengaging said evacuated or partially evacuated sample tube from said Q needle; inserting the evacuated or partially evacuated sample tube into the internal cavity of the syringe body to cause the second internal hollow needle to pierce said stopper and enter said sample tube to allow the vacuum or 5 partial vacuum to permit blood from the patient to flow into the sample tube; and disconnecting said sample tube and said first needle, as desired, when desired volume or volumes of blood have been collected.
  • the syringe body may be connected to what is conventionally known as a "butterfly needle" which allows repeated access to the vein of a patient via a flexible tube and appropriate connector such as a Luer connector.
  • a flexible tube and appropriate connector such as a Luer connector.
  • Such arrangement permits the use of a clamp on the flexible tube 5 to control the flow of blood into the evacuated sample tube. Too rapid a flow of blood, in young and elderly patients, can result in collapse of the vein.
  • a method of providing a resealable tube with a predetermined vacuum including the steps of : Q providing the resealable or needle penetrable tube having an enclosed space adapted for evacuation and retaining a prescribed vacuum for a predetermined amount of time, mating the tube with communication means adapted to 5 connect an evacuation means to said tube to enable evacuation of the tube to the vacuum, the evacuation means being mounted in or on a housing and being adapted to evacuate the tube to the vacuum, allowing the tube to be evacuated by said evacuation means, withdrawing ' the tube from the communication means whereby the tube reseals so as to hold the vacuum for the c predetermined amount of time.
  • a method of inter-tube transfer of fluid including the steps of : providing a tube having the fluid therein, connecting the fluid tube to a transfer means
  • Figure 1 shows one embodiment of the present invention in the form of a simple hand operated tube evacuator.
  • FIGS 2 to 4 show in block diagram form various 30 embodiments of the present invention.
  • Figures 5 and 6 show preferred embodiment realisations of Figures 2 and 3, respectively.
  • Figure 7 shows a device for use in inter-tube transfer of fluid. 35 Note, in the Figures and description, like numerals denote similar integers or devices. Best Mode of Carrying Out Invention
  • the device 10 comprises a base 11 with front 12 and rear 13 brackets mounted thereon.
  • the brackets 12 and 13 have mounted thereon cylinder 14 ,. having piston 15 disposed therein and front 16 and rear 17 ends.
  • a socket member 18 Disposed in front end 16 is a socket member 18 having a bore therethrough and adapted to receive hollow needle 19 such that there is communication between the interior of the cylinder and the outside so that air or fluid may be drawn, by operation of the piston, through the needle into the 0 cylinder.
  • the needle 19 may be releasably attached to the socket by standard tapered friction fit or a standard Luer fitting.
  • Housing 20 is adapted to be releasably fitted via screw 21 to the front cover plate 12 to protect a user from 5 accidental impalement on the needle 19.
  • the socket 18 may include a ball or other valve means to permit passage of air only from needle 19 to cylinder 14. When the piston is operated (as will be later described), a vacuum can be generated by movement towards the right or rear of the 0 device.
  • the cylinder may also include non return- valve 22 to permit easy expulsion of air from the cylinder 14 when the piston is operated towards the left or front of the device.
  • the rear end 17 of the cylinder may include, as is customary, bleed hole 23.
  • a cover 24 including rear plate 5 25 is provided to enclose the piston 15 and cylinder 14 and includes a slot 26 adapted to engage slide member 27 connected to an end member 28 of piston rod 29.
  • Slide member 27 is adapted to slide in slot 26 and is connected at pivot 30 to linkage 31.
  • Linkage 31 extends 0 and is pivotally connected at pivot 34 to handle 33 at a point between base pivot point 35 and hand grip 33a.
  • the sample tube may be of synthetic plastics material in place of the presently used glass tube which is liable to shatter if dropped either prior to or after filling with the associated dangers.
  • the synthetic plastics material tube whilst not able to retain a partial vacuum indefinitely, retains sufficient vacuum for the intended purpose as it is 5 partially evacuated just prior to use.
  • any suitable synthetic plastics material may be used for the moulding of the tube provided that.the material is chemically inert to the samples to be retained therein.
  • the material of construction of the evacuation 0 device or pump 10 may be of any suitable metal or synthetic plastics material. It will be seen also that by appropriate callibration, variation of the stroke of the piston in the cylinder will produce a partial vacuum which will draw a blood sample of the desired volume (e.g. 5 ml or 10 ml or 5 any other convenient volume) into the sample tube.
  • a blood sample of the desired volume e.g. 5 ml or 10 ml or 5 any other convenient volume
  • FIG. 1 An alternative embodiment to that of Figure 1 can be realised by actuating the piston 15 by use of an electrical solenoid and spring mechanism (not shown) attached to rod 29, in place of the handle 31, level 31 and slide 27.
  • the solenoid can be housed within cover 24 and arranged for axial operation so as to draw the piston 'to the right or rear when actuated, and, when released, the spring mechanism serves to return the piston to a base position to
  • an ultra-violet light can be disposed about needle 19 so as to provide a radiation source which will substantially eliminate contamination occurring between tubes to be evacuated when they are pierced by needle 19.
  • a pump 62 driven by motor 61 and mounted on a housing 60 is a primary source of vacuum.
  • the pump 62 can be continuously operated or selectively or discontinuously operated.
  • the pump 62 should provide, as an output, a vacuum greater than that required in the sample tube 40 for ⁇ n the drawing of the prescribed amount of fluid as a sample so as to overcome any losses in the device 70 and to ensure a rapid tube evacuation.
  • the pump 62 is connected to a manifold 65 which provides a means of selecting or adjusting the primary 5 vacuum to the required vacuum.
  • the required vacuum is an amount sufficient to draw the required or predetermined fluid sample into the evacuated tube.
  • the volume of fluid drawn into the tube is dependent on the tube volume, for example, if the required vacuum draws, say, 5 ml into an 8 0 ml tube, then the same amount of vacuum will draw 10 ml into a 16 ml tube, and so on.
  • the manifold 65 can have a rotatory selector therein or attached thereto, for adjusting the primary vacuum input to the required vacuum output.
  • the 5 selector can be in the form of a 'loss' unit, involving a number of selectable holes which provide for a loss in vacuum. The larger the hole, the more vacuum lost.
  • the manifold can be manufactured such that a number of holes can be incorporated into the manifold, each hole being of 0 sufficient size to enable a required vacuum to enter a particular tube size. Other holes can correspond, respectively, to other tube .sizes in order to draw a sufficiently sized fluid sample.
  • the manifold can, alternatively, or additionally, incorporate a slideable hole 5 selector or any other suitable means for obtaining from the manifold the required vacuum for each tube size, and/or, fluid sample size.
  • the manifold 65 preferably, includes a calibration means 59 and a measurement means 58.
  • the calibration means 59 is used to stabilise and regulate the vacuum from the pump 62 to the manifold 65.
  • the calibration means also sets c a 'base line' vacuum, a vacuum from which, or relative to which, the required vacuum is determined.
  • the calibration means 59 preferably, is in the form of a preset or calibrateable hole to set vacuum loss or a regulator of conventional form.
  • 1Q suitable locations may be used as a means of ensuring correct vacuum(s) are maintained in or delivered by the device 70.
  • tube sensor means 67 may be used to detect the presence or absence of a tube to be evacuated.
  • the sensor 67 is preferably located adjacent the needle 68, such that, upon actuation of the sensor 67 by a tube, the pump 62 and manifold 65 attain the required vacuum just prior to the
  • a motorised needle injector 73 to which the needle and its assembly are attached is also preferably used to move the needle into and out of communication with the
  • the required vacuum is attained as described above.
  • the sensor 67 can activate the needle injector 73 to move the needle toward the area where the tube is inserted or places in the device 70. The operator can hold the tube in place, on and allow the injector 73 to push the needle 68 through stopper 41 and so allow the required vacuum to be applied to the interior space-of the tube 40. After a few moments or at such time as the tube has been evacuated as required, the injector 73 can withdraw the needle from the tube and
  • the stopper 41 is to be made of a resilient material so as to reseal the tube and substantially maintain the evacuation of the tube for a limited period of time.
  • the injector 73 can withdraw or move the needle 68 to such a position that, accidental insertion of an operator's finger into the device will not make contact with the needle.
  • the sensor 67 can be made or placed such a way that it will not activate unless a tube of particular size c or constitution is inserted into the device 70, in order to b avoid accidental operator contact with the needle 68, for example, the sensor can be a photo electric cell set to detect an empty tube only and not activate if a finger, no tube or tube with serum or fluid is placed into the device
  • An ultra-violet (uv) light 9 may also be disposed in the device 73 so as to radiate the needle in its resting or 'home' position. This will allow the needle to be substantially sterilised between tube insertions in order to
  • Figure 3 shows an alternative to the device d.escribed above, in that the manifold does not incorporate a 0 vacuum selector. Rather, a pressure measurement sensor 78 monitors the vacuum being delivered to a tube inserted into the device 70, the measurement being fed to a control means 77.
  • the control means 77 monitors the pressure measurement and when the required vacuum in the tube in the device is 5 detected by sensor 78, the control means 77 can activate the value to close the vacuum to the tube.
  • the control means 77 can also be used to switch on or off the pump after a predetermined amount of time so as to reduce wear on the 0 parts of the device.
  • Figure 4 shows an alternative to Figure 3.
  • a pressure sensor 79 can monitor the pressure (vacuum) delivered to a tube 40.
  • the tube sensor 67 can activate the pump 62 and, when sufficient vacuum has been applied to the 5 tube, the pressure sensor 79 can de-activate the pump 62, until the next tube is detected.
  • Figure 5 shows one preferred form of the present invention, generally denoted as device 70.
  • Motor 61 drives pump 62 which develops a primary vacuum.
  • Tube 63 communicates this vacuum to manifold 65, which utilises a
  • the 'lossy' selector in " order to provide the required vacuum to the tube 40.
  • the 'lossy' selector utilises hole 64, or a series of holes, in order to reduce the primary vacuum to the required vacuum.
  • the connection means can induce -50 KPa into a 15 ml tube via needle 68.
  • the evacuated tube can then draw 10 ml + 0.25 ml of fluid or blood.
  • Selection of the hole(s) is arranged via a rotatory selector switch 66.
  • Switch 66 can also be arranged in a mechanism arm assembly so that the appropriate hole 64 can be selected via a slidable sleeve having a hole therein and being moved over a tube having holes therein so that alignment of holes occurs.
  • the needle 68 is stationary and has a resilient means 69, preferably a spring disposed adjacent thereto.
  • Tube 40 is inserted or pushed by an operator into device 70 via an access orifice, actuator switch or sensor 67 which activates motor 61 and pump 62 to produce vacuum.
  • the seal or stopper of the tube is pierced by needle 68 while compressing resilient means 69.
  • the required vacuum is then installed in the tube. After a predetermined amount of time, preferably about 2 or 3 seconds, the operator can stop holding the tube in the device 70.
  • the resilient means 69 effectively pushes the tube away from needle 68 and the operator can withdraw the tube for fluid sampling.
  • the needle assembly can alternatively or additionally be mounted on an injector assembly (73) as hereinbefore described.
  • Figure 6 shows another preferred form of the present invention wherein required or selected tube vacuum can be obtained by pump and/or motor control.
  • a regulator 72 can be used to control the motor 61 which operates pump 62 such that a speed or time control affects the device 70 to provide the required vacuum to tube 40.
  • a vent or bleed hole(s) 64 is or are optional, and may provide additional vacuum control.
  • a reserve power supply means 75, 12V battery for example, may be provided to facilitate the device's portability.
  • a selector 66 may be a
  • An injector assembly 73 can be used to move the needle 68 to an injecting position (communication with a
  • the injector 73 can comprise a motor having an arm mounted thereon in an off-set cam arrangement. Needle 68 can be attached to the end of the arm.
  • 1 c end of the arm can be slidably nestled in a guide means to ensure the needle is correctly positioned for insertion into a tube.
  • the motor can be arranged in a 'one-shot' type operation, such that only one revolution per tube detection is performed.
  • An ultra-violet light 74 can also be disposed about needle 68 to reduce contamination between tubes. The uv light serves to substantially sterilise the needle.
  • a tube holder 71 may be provided to assist operators. If a tube is small in size, it may be placed in c the tube holder such that handling of the tube is made less difficult. The tube holder may be adapted to position the small tube such that communication with the needle 68 is possible when the tube holder is placed in the device 70.
  • sample tube 40 0 has been (partially evacuated)
  • inner needle 53 can pierce the stopper 41 and provide fluid access to the tube thus allowing, fluid to be drawn into the tube by 5 way of the partial evacuation.
  • the sample tubes may contain chemicals for initial reaction with a fluid sample as is known. This method can also be used for inter-tube transfer whereby, the needle 52 is inserted into a tube having a fluid reservoir therein.
  • needle 52 may also include another tube of suitable size which can act as a r breather tube'. This will allow a larger sample to be drawn into the evacuated tube.
  • a method of obtaining a predetermined volume of blood may include the steps of : i) providing a communicating means with a blood reservoir; ii) selecting the predetermined volume of blood required to be drawn from the reservoir; iii) selecting a suitable tube; iv) providing the tube with an appropriate vacuum to affect drawing of the predetermined volume of blood using the apparatus of the invention; and v) mating the tube and communicating means such that blood is drawn from the reservoir.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Manufacturing & Machinery (AREA)
  • Hydrology & Water Resources (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

Un appareil à faire le vide (70) dans un tube fermé collecteur d'échantillons fluides sert à faire le vide dans un tube fermé (40) collecteur d'échantillons fluides juste avant que celui-ci recoive un échantillon fluide de volume prédéterminé par rapport au volume du tube (40) pour échantillons. L'appareil (70) comprend: des organes (62, 61) servant à faire le vide qui sont montés dans ou sur un logement (60) et qui sont destinés à faire le vide dans un tube fermé (40) pour échantillons à un niveau de vide requis obtenu à partir d'un degré de vide prédéterminé ou à un degré de vide à l'intérieur d'une série de degrés de vide prédéterminés; et un organe de communication (68) destiné à relier les organes (61, 62) servant à faire le vide au tube (40) collecteur d'échantillons, de façon à permettre de faire le vide dans ledit tube (40) au niveau de vide requis. La spécification décrit également différents procédés permettant de faire le vide dans un tube (40), permettant le transfert inter-tube de fluide ainsi qu'un système permettant de recueillir un échantillon fluide. Un procédé permettant de recueillir un échantillon de fluide biologique, tel que notamment un échantillon de sang, est également décrit.
PCT/AU1988/000081 1987-03-23 1988-03-21 Tube collecteur et appareil servant a faire le vide au prealable Ceased WO1988007351A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
AUPI1016 1987-03-23
AU101687 1987-03-23
AU355087 1987-08-05
AUPI3550 1987-08-05

Publications (1)

Publication Number Publication Date
WO1988007351A1 true WO1988007351A1 (fr) 1988-10-06

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PCT/AU1988/000081 Ceased WO1988007351A1 (fr) 1987-03-23 1988-03-21 Tube collecteur et appareil servant a faire le vide au prealable

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EP (1) EP0383756A4 (fr)
WO (1) WO1988007351A1 (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0479047A3 (en) * 1990-10-02 1992-07-01 Daiichi Kogyo Kabushiki Kaisha Apparatus and method for evacuating blood aspiration tubes
EP0533989A1 (fr) * 1991-09-25 1993-03-31 Sekisui Chemical Co., Ltd. Dispositif et procédé pour la préparation de tubes sous vide pour le prélèvement du sang
AT397610B (de) * 1990-06-01 1994-05-25 Avl Verbrennungskraft Messtech Vorrichtung zur entnahme von körperflüssigkeiten
FR2762092A1 (fr) * 1997-04-15 1998-10-16 Bio Merieux Procede et dispositif de remplissage avec un milieu liquide d'une carte d'analyse
EP1300114A3 (fr) * 2001-10-06 2003-05-28 Sarstedt AG & Co. Dispositif pour évacuer des tubes de prélèvement de sang
EP1470781A3 (fr) * 2003-04-23 2005-01-05 Matsushita Electric Industrial Co., Ltd. Lancette et boitier correspondant

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US3433216A (en) * 1966-12-22 1969-03-18 Roger P Mattson Self-evacuating fluid sampling device
US3633566A (en) * 1969-05-15 1972-01-11 Systematics Blood collecting method and device
US3776218A (en) * 1971-12-27 1973-12-04 J Svensson Apparatus for drawing liquid such as blood
US4192320A (en) * 1977-07-28 1980-03-11 Becton, Dickinson And Company Adapter for syringe
GB1564009A (en) * 1975-08-28 1980-04-02 Svensson J A Apparatus for collecting fluid samples in containers sealed by a resilient stopper
US4317456A (en) * 1980-03-10 1982-03-02 Becton, Dickinson And Company Multiple sample needle with anti-backflow valve

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FR2409040A1 (fr) * 1977-11-17 1979-06-15 Rebillard Jean Louis Appareil de prelevement et de stockage d'un liquide
GB8401754D0 (en) * 1984-01-24 1984-02-29 Bilbate Ltd Fluid sampling device

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3433216A (en) * 1966-12-22 1969-03-18 Roger P Mattson Self-evacuating fluid sampling device
US3633566A (en) * 1969-05-15 1972-01-11 Systematics Blood collecting method and device
US3776218A (en) * 1971-12-27 1973-12-04 J Svensson Apparatus for drawing liquid such as blood
GB1564009A (en) * 1975-08-28 1980-04-02 Svensson J A Apparatus for collecting fluid samples in containers sealed by a resilient stopper
US4192320A (en) * 1977-07-28 1980-03-11 Becton, Dickinson And Company Adapter for syringe
US4317456A (en) * 1980-03-10 1982-03-02 Becton, Dickinson And Company Multiple sample needle with anti-backflow valve

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See also references of EP0383756A4 *

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT397610B (de) * 1990-06-01 1994-05-25 Avl Verbrennungskraft Messtech Vorrichtung zur entnahme von körperflüssigkeiten
EP0479047A3 (en) * 1990-10-02 1992-07-01 Daiichi Kogyo Kabushiki Kaisha Apparatus and method for evacuating blood aspiration tubes
EP0533989A1 (fr) * 1991-09-25 1993-03-31 Sekisui Chemical Co., Ltd. Dispositif et procédé pour la préparation de tubes sous vide pour le prélèvement du sang
FR2762092A1 (fr) * 1997-04-15 1998-10-16 Bio Merieux Procede et dispositif de remplissage avec un milieu liquide d'une carte d'analyse
WO1998046977A1 (fr) * 1997-04-15 1998-10-22 Bio Merieux Procede et dispositif de remplissage avec un milieu liquide d'une carte d'analyse
JP2000512765A (ja) * 1997-04-15 2000-09-26 ベーイーオー メリュー 分析カードに液状媒体を充填する方法およびその装置
AU726363B2 (en) * 1997-04-15 2000-11-02 Bio Merieux Method and device for filling an analysis card with a liquid medium
US6589790B1 (en) 1997-04-15 2003-07-08 Bio Merieux Method and device for filling an analysis card with a liquid medium
EP1300114A3 (fr) * 2001-10-06 2003-05-28 Sarstedt AG & Co. Dispositif pour évacuer des tubes de prélèvement de sang
EP1470781A3 (fr) * 2003-04-23 2005-01-05 Matsushita Electric Industrial Co., Ltd. Lancette et boitier correspondant

Also Published As

Publication number Publication date
EP0383756A4 (en) 1991-01-09
EP0383756A1 (fr) 1990-08-29

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