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WO1986000811A1 - Preparations therapeutiques pour le traitement de certaines maladies d'origine virale ou autre et leur production - Google Patents

Preparations therapeutiques pour le traitement de certaines maladies d'origine virale ou autre et leur production Download PDF

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Publication number
WO1986000811A1
WO1986000811A1 PCT/HU1985/000048 HU8500048W WO8600811A1 WO 1986000811 A1 WO1986000811 A1 WO 1986000811A1 HU 8500048 W HU8500048 W HU 8500048W WO 8600811 A1 WO8600811 A1 WO 8600811A1
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WO
WIPO (PCT)
Prior art keywords
virus
diseases
preparations
treatment
avian
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/HU1985/000048
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English (en)
Inventor
László CSATÁRY
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Individual
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Filing date
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Application filed by Individual filed Critical Individual
Publication of WO1986000811A1 publication Critical patent/WO1986000811A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
    • A61K39/17—Newcastle disease virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/215—Coronaviridae, e.g. avian infectious bronchitis virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/245—Herpetoviridae, e.g. herpes simplex virus
    • A61K39/255—Marek's disease virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
    • A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16311—Mardivirus, e.g. Gallid herpesvirus 2, Marek-like viruses, turkey HV
    • C12N2710/16334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18111—Avulavirus, e.g. Newcastle disease virus
    • C12N2760/18134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/20011—Coronaviridae
    • C12N2770/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
    • C12N2770/24134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Definitions

  • the present invention relates to a set of therapeutic preparations (further on Preparation (s ) ) for the treatment of certain viral and other diseases , together with the complete technics of their production , including all materials and methods used.
  • the Preparations are effective against various pathological conditions caused by the Herpes group of viruses , and against certain malignant and benign tumours and collagen diseases as well.
  • Attenuated viral vaccines pre pared against some viral diseases of animals (Newcastle disease , Marek 's disease , avian bronchitis , avian encephalitis ) had a distinct therapeutic effect against various human diseases of known viral or unknown etiology.
  • the ob ject of the present invention is a set of preparations containing attenuated (or killed)
  • Newcastle disease virus Marek's disease virus , avian bronchitis virus or avian encephalitis virus , mixed in a carrier which is acceptable for use in humans.
  • the present invention relates also to all materials and methods used in the production of all preparations. The Preparations have already been used with very good result in the conditions listed below:
  • the Preparation containing attenuated Newcastle disease virus was active against the followin g conditions : a) Infections caused by viruses of the Herpes group , such as Herpex simplex I and II , Herpes zooster, Cytomegalovirus , infectious monon ⁇ cleoses (EpsteinBarr virus ) b) Aphthostomatitis c) Verruca vulgaris d) Infantile pharyngeal papilloma e) Human aden oca rein omas f ) Collagen diseases (e. g. nodous polyarteritis) g) Rheumatic arthritis
  • the Prepa ration containing attenuated avian bronchitis virus was active against the following conditions : a) Various human cancers b) Infections caused by the above listed (1.a) viruses of the Herpes goup.
  • the Preparations are produced by suspending live attenuated or inactivated , purified or highly purified and concentrated viruses in one of the carrier substances generally used in human pharmacology.
  • the Preparations may be supplemented with potentiating drugs (e.g. tranquilizers).
  • the optimal form of delivery of the Preparations is in a freeze-dried form , in sealed ampoules , with the diluent supplied in a separate vial.
  • the Preparations can be stored at room temperature for a practically unlimited time, toother forms of delivery are in solution , suppository , capsule , emulsion , suspension , ointment , etc. These should be stored in cold , for their activity may decay repidly at room temperature.
  • the dosage of the Preparations depends of their actual composition and form , on the patient 's general condition , and on stage (severity) of the disease actually treated.
  • the Preparations are non-toxic , and have no side effect whatever.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Préparations thérapeutiques contre certaines maladies d'origine virale ou autre chez l'homme. Ces préparations sont spécifiées en tant que formules contenant le virus atténué de la maladie de Newcastle, le virus de la maladie de Marek, le virus de la bronchite chez les aviens ou le virus de l'encéphalite chez les aviens, mélangés dans une substance-véhicule utilisée généralement en pharmacologie humaine, éventuellement avec une ou plusieurs préparations de renforcement. Un autre objet de l'invention est l'utilisation de ces virus dans le traitement de maladies d'origine virale, ainsi que de tumeurs bénignes et malignes et de maladies du collagène.
PCT/HU1985/000048 1984-07-30 1985-07-29 Preparations therapeutiques pour le traitement de certaines maladies d'origine virale ou autre et leur production Ceased WO1986000811A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU842919A HU197517B (en) 1984-07-30 1984-07-30 Process for production of terapeutical composition applicable against virus infection
HU2919/84 1984-07-30

Publications (1)

Publication Number Publication Date
WO1986000811A1 true WO1986000811A1 (fr) 1986-02-13

Family

ID=10961677

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/HU1985/000048 Ceased WO1986000811A1 (fr) 1984-07-30 1985-07-29 Preparations therapeutiques pour le traitement de certaines maladies d'origine virale ou autre et leur production

Country Status (4)

Country Link
EP (1) EP0188590A1 (fr)
AU (1) AU4638085A (fr)
HU (1) HU197517B (fr)
WO (1) WO1986000811A1 (fr)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0260779A3 (fr) * 1986-09-15 1989-06-07 Pitts, Ferris N., jr. Utilisation d'un médicament immunostimulant
EP0331102A1 (fr) * 1988-03-01 1989-09-06 Volker Prof. Dr. Schirrmacher Vaccin tumoral modifié avec des virus pour l'immunothérapie des métastases tumorales
EP0292293A3 (en) * 1987-05-19 1990-01-24 Yissum Research Development Company Of The Hebrew University Of Jerusalem Newcastle disease virus vaccine and method for the applicaton thereof
EP0312839A3 (en) * 1987-10-17 1990-03-14 Bayer Ag Method for the preparation of an inducer of non-specific immunity
US5602023A (en) * 1992-03-24 1997-02-11 Csatary; Laszlo K. Pharmaceutical product containing live, stabilized virus for the therapy of viral and malignant diseases and process for preparing the same
US7056689B1 (en) 1993-04-30 2006-06-06 Wellstat Biologics Corporation Methods of treating and detecting cancer using viruses
US7470426B1 (en) 1997-10-09 2008-12-30 Wellstat Biologics Corporation Treatment of neoplasms with viruses
US7780962B2 (en) 1997-10-09 2010-08-24 Wellstat Biologics Corporation Treatment of neoplasms with RNA viruses
US8043612B2 (en) 1997-10-09 2011-10-25 Wellstat Biologics Corporation Infection and treatment of neoplasms with vesicular stomatitis virus
US8105578B2 (en) 1997-10-09 2012-01-31 Wellstat Biologics Corporation Treatment of neoplasms with viruses
US8147822B1 (en) 1999-09-17 2012-04-03 Wellstat Biologics Corporation Oncolytic virus
US8377450B2 (en) 2009-11-30 2013-02-19 United Cancer Research Institute Clone of Newcastle disease virus, its manufacture and its application in the medical treatment of cancer

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2188593T3 (es) * 1992-03-24 2003-07-01 United Cancer Res Inst Vacuna que contiene un virus vivo.

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1492083A1 (de) * 1962-02-01 1969-08-07 Philips Roxane Verfahren zum Auswaehlen eines Virus oder sonstigen Organismus mit der Faehigkeit,in einem Tier Schutzwiderstand gegen einen mit dem Virus oder Organismus immunologisch nicht verwandten Krankheitserreger hervorzurufen
US3548054A (en) * 1969-06-06 1970-12-15 Lilly Co Eli Method for improving weight gains and reducing gross lesions in chickens exposed to marek's disease
DE2120929A1 (de) * 1970-04-29 1971-11-18 Merck & Co. Inc., Rahway, N.J. (V.StA.) Impfstoff für Geflügel gegen die Mareksche Hühnerlähme und Verfahren zu seiner Herstellung
GB1274820A (en) * 1969-11-29 1972-05-17 Takeda Chemical Industries Ltd Highly attenuated newcastle disease virus vaccine and production thereof
US3674861A (en) * 1968-11-18 1972-07-04 Anthony Edward Churchill Live attenuated marek{40 s disease virus vaccine for poultry
US4049794A (en) * 1974-06-24 1977-09-20 Bayer Aktiengesellschaft Treatment of infections in animals
AT343797B (de) * 1974-08-01 1978-06-12 Stickl Helmut Verfahren zur herstellung eines praparates zur behandlung interferonsensibler infektionskrankheiten
AT346476B (de) * 1973-07-19 1978-11-10 Sevoian Martin Verfahren zur herstellung einer vakzine zur immunisierung von gefluegel gegen die marek'schekrankheit
FR2444467A1 (fr) * 1978-12-20 1980-07-18 Gist Brocades Nv Vaccins contre des maladies provoquees par des reovirus et procede de preparation de ces vaccins
US4357320A (en) * 1980-11-24 1982-11-02 Gist-Brocades N. V. Infectious bronchitis vaccine for poultry
JPS58116422A (ja) * 1981-12-28 1983-07-11 Green Cross Corp:The 抗腫瘍剤
EP0086025A1 (fr) * 1982-02-05 1983-08-17 Akzo N.V. Vaccins contre la bronchite infectieuse

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1492083A1 (de) * 1962-02-01 1969-08-07 Philips Roxane Verfahren zum Auswaehlen eines Virus oder sonstigen Organismus mit der Faehigkeit,in einem Tier Schutzwiderstand gegen einen mit dem Virus oder Organismus immunologisch nicht verwandten Krankheitserreger hervorzurufen
US3674861A (en) * 1968-11-18 1972-07-04 Anthony Edward Churchill Live attenuated marek{40 s disease virus vaccine for poultry
US3548054A (en) * 1969-06-06 1970-12-15 Lilly Co Eli Method for improving weight gains and reducing gross lesions in chickens exposed to marek's disease
GB1274820A (en) * 1969-11-29 1972-05-17 Takeda Chemical Industries Ltd Highly attenuated newcastle disease virus vaccine and production thereof
DE2120929A1 (de) * 1970-04-29 1971-11-18 Merck & Co. Inc., Rahway, N.J. (V.StA.) Impfstoff für Geflügel gegen die Mareksche Hühnerlähme und Verfahren zu seiner Herstellung
AT346476B (de) * 1973-07-19 1978-11-10 Sevoian Martin Verfahren zur herstellung einer vakzine zur immunisierung von gefluegel gegen die marek'schekrankheit
US4049794A (en) * 1974-06-24 1977-09-20 Bayer Aktiengesellschaft Treatment of infections in animals
AT343797B (de) * 1974-08-01 1978-06-12 Stickl Helmut Verfahren zur herstellung eines praparates zur behandlung interferonsensibler infektionskrankheiten
FR2444467A1 (fr) * 1978-12-20 1980-07-18 Gist Brocades Nv Vaccins contre des maladies provoquees par des reovirus et procede de preparation de ces vaccins
US4357320A (en) * 1980-11-24 1982-11-02 Gist-Brocades N. V. Infectious bronchitis vaccine for poultry
JPS58116422A (ja) * 1981-12-28 1983-07-11 Green Cross Corp:The 抗腫瘍剤
EP0086025A1 (fr) * 1982-02-05 1983-08-17 Akzo N.V. Vaccins contre la bronchite infectieuse

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Patent Abstracts of Japan, unexamined applications, section C, vol. 7, no. 219, issued 30 March 1983, The Patent Office Japanese Government, page 76 C 188, see Kokai-no. 58-116 422 (Midori Juji K.K.). *

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0260779A3 (fr) * 1986-09-15 1989-06-07 Pitts, Ferris N., jr. Utilisation d'un médicament immunostimulant
EP0292293A3 (en) * 1987-05-19 1990-01-24 Yissum Research Development Company Of The Hebrew University Of Jerusalem Newcastle disease virus vaccine and method for the applicaton thereof
US5152981A (en) * 1987-05-19 1992-10-06 Yissum Research Development Company Of The Hebrew University Of Jerusalem Newcastle disease virus vaccine and method for the application thereof
EP0312839A3 (en) * 1987-10-17 1990-03-14 Bayer Ag Method for the preparation of an inducer of non-specific immunity
US5094850A (en) * 1987-10-17 1992-03-10 Bayer Aktiengesellschaft Process for the preparation of inducers of non-specific immunity and product produced
EP0331102A1 (fr) * 1988-03-01 1989-09-06 Volker Prof. Dr. Schirrmacher Vaccin tumoral modifié avec des virus pour l'immunothérapie des métastases tumorales
WO1989007946A1 (fr) * 1988-03-01 1989-09-08 Deutsches Krebsforschungszentrum Vaccins tumoraux modifies viralement pour immunotherapie de metastases tumorales
US5602023A (en) * 1992-03-24 1997-02-11 Csatary; Laszlo K. Pharmaceutical product containing live, stabilized virus for the therapy of viral and malignant diseases and process for preparing the same
US7056689B1 (en) 1993-04-30 2006-06-06 Wellstat Biologics Corporation Methods of treating and detecting cancer using viruses
US7736640B2 (en) 1993-04-30 2010-06-15 Wellstat Biologics Corporation Methods of treating and detecting cancer using viruses
US7470426B1 (en) 1997-10-09 2008-12-30 Wellstat Biologics Corporation Treatment of neoplasms with viruses
US7780962B2 (en) 1997-10-09 2010-08-24 Wellstat Biologics Corporation Treatment of neoplasms with RNA viruses
US8043612B2 (en) 1997-10-09 2011-10-25 Wellstat Biologics Corporation Infection and treatment of neoplasms with vesicular stomatitis virus
US8105578B2 (en) 1997-10-09 2012-01-31 Wellstat Biologics Corporation Treatment of neoplasms with viruses
US8147822B1 (en) 1999-09-17 2012-04-03 Wellstat Biologics Corporation Oncolytic virus
US8377450B2 (en) 2009-11-30 2013-02-19 United Cancer Research Institute Clone of Newcastle disease virus, its manufacture and its application in the medical treatment of cancer

Also Published As

Publication number Publication date
EP0188590A1 (fr) 1986-07-30
HU197517B (en) 1989-04-28
HUT40572A (en) 1987-01-28
AU4638085A (en) 1986-02-25

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