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WO1986000307A3 - Analogues pyrazole de la mevalonolactone et leurs derives, leurs procedes de preparation et leur utilisation - Google Patents

Analogues pyrazole de la mevalonolactone et leurs derives, leurs procedes de preparation et leur utilisation

Info

Publication number
WO1986000307A3
WO1986000307A3 PCT/EP1985/000293 EP8500293W WO8600307A3 WO 1986000307 A3 WO1986000307 A3 WO 1986000307A3 EP 8500293 W EP8500293 W EP 8500293W WO 8600307 A3 WO8600307 A3 WO 8600307A3
Authority
WO
WIPO (PCT)
Prior art keywords
3alkyl
phenoxy
fluoro
chloro
trifluoromethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP1985/000293
Other languages
English (en)
Other versions
WO1986000307A2 (fr
Inventor
James Richard Wareing
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Priority to FI860755A priority Critical patent/FI860755L/fi
Priority to AT85903248T priority patent/ATE62906T1/de
Priority to DE8585903248T priority patent/DE3582674D1/de
Priority to KR1019860700100A priority patent/KR890001651B1/ko
Priority to HU853053A priority patent/HU198711B/hu
Publication of WO1986000307A2 publication Critical patent/WO1986000307A2/fr
Priority to DK083886A priority patent/DK157543C/da
Publication of WO1986000307A3 publication Critical patent/WO1986000307A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F13/00—Interconnection of, or transfer of information or other signals between, memories, input/output devices or central processing units
    • G06F13/38—Information transfer, e.g. on bus
    • G06F13/382—Information transfer, e.g. on bus using universal interface adapter
    • G06F13/387—Information transfer, e.g. on bus using universal interface adapter for adaptation of different data processing systems to different peripheral devices, e.g. protocol converters for incompatible systems, open system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F13/00—Interconnection of, or transfer of information or other signals between, memories, input/output devices or central processing units
    • G06F13/38—Information transfer, e.g. on bus
    • G06F13/40—Bus structure
    • G06F13/4004—Coupling between buses
    • G06F13/4009—Coupling between buses with data restructuring
    • G06F13/4018—Coupling between buses with data restructuring with data-width conversion

Landscapes

  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Theoretical Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Computer Hardware Design (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Composés de formule (I) où R1 représente un alkyle comportant de 1 à 6 C; R2 et R5 représentent indépendamment un hydrogène, un alkyle de 1 à 4 C, un alkoxy de 1 à 4 C (t-butoxy excepté), un trifluorométhyle, un fluoro, un chloro, un phényle, un phénoxy ou un benzyloxy, R3 et R6 représentent indépendamment un hydrogène, un alkyle de 1 à 3 C, un alkoxy de 1 à 3 C, un trifluorométhyle, un fluoro, un chloro, un phénoxy ou un benzyloxy; R4 et R7 représentent un hydrogène, un alkyle de 1 à 3 C, un alkoxy de 1 ou 2 C, un fluoro ou un chloro; à condition qu'il ne puisse y avoir qu'un seul substituant trifluorométhyle, phénoxy ou benzyloxy dans chacun des cycles A et B; X représente -(CH2)m- ou -(CH2)qCH=CH(CH2)q- où m vaut 0, 1, 2 ou 3 et les deux q valent 0 ou l'un vaut 0 et l'autre 1, et Z représente (II) où R10 représente un hydrogène ou un alkyle de 1 à 3 C; à condition que le groupe -X-Z' se trouve en position 4 ou 5 du cycle pyrazole et qu'il soit ortho par rapport à R1; ces composés se trouvant sous une forme acide libre ou sous la forme d'un ester ou d'une delta-lactone, ou sous une forme de sel, indiqués pour une utilisation en tant qu'agents hypolipoprotéinémiques et anti-athérosclérotiques.
PCT/EP1985/000293 1984-06-22 1985-06-18 Analogues pyrazole de la mevalonolactone et leurs derives, leurs procedes de preparation et leur utilisation Ceased WO1986000307A2 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
FI860755A FI860755L (fi) 1984-06-22 1985-06-18 Pyrazolanaloger av mevolonolakton och deras derivat, foerfaranden foer deras framstaellning samt deras andvaendning.
AT85903248T ATE62906T1 (de) 1984-06-22 1985-06-18 Pyrazolanaloge von mevalonolakton und abkoemmlinge davon, verfahren zu deren herstellung und deren verwendung.
DE8585903248T DE3582674D1 (de) 1984-06-22 1985-06-18 Pyrazolanaloge von mevalonolakton und abkoemmlinge davon, verfahren zu deren herstellung und deren verwendung.
KR1019860700100A KR890001651B1 (ko) 1984-06-22 1985-06-18 메발로노락톤의 피라졸 동족체 및 이의 유도체의 제조방법
HU853053A HU198711B (en) 1984-06-22 1985-06-18 Process for producing mevalolacton, derivatives and pyrazol analogues and pharmaceutical composition containing them
DK083886A DK157543C (da) 1984-06-22 1986-02-21 Pyrazolanaloge af mevalonolacton og derivater deraf samt deres anvendelse

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62339384A 1984-06-22 1984-06-22
US623,393 1984-06-22

Publications (2)

Publication Number Publication Date
WO1986000307A2 WO1986000307A2 (fr) 1986-01-16
WO1986000307A3 true WO1986000307A3 (fr) 1986-04-10

Family

ID=24497918

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1985/000293 Ceased WO1986000307A2 (fr) 1984-06-22 1985-06-18 Analogues pyrazole de la mevalonolactone et leurs derives, leurs procedes de preparation et leur utilisation

Country Status (19)

Country Link
EP (1) EP0200736B1 (fr)
JP (1) JPS61502467A (fr)
KR (1) KR890001651B1 (fr)
AT (1) ATE62906T1 (fr)
AU (1) AU573368B2 (fr)
CA (1) CA1249283A (fr)
DE (1) DE3582674D1 (fr)
DK (1) DK157543C (fr)
ES (1) ES8703842A1 (fr)
FI (1) FI860755L (fr)
GR (1) GR851510B (fr)
HU (1) HU198711B (fr)
IL (1) IL75583A (fr)
MY (1) MY101903A (fr)
NZ (1) NZ212501A (fr)
PL (1) PL151016B1 (fr)
PT (1) PT80674B (fr)
WO (1) WO1986000307A2 (fr)
ZA (1) ZA854719B (fr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4668794A (en) * 1985-05-22 1987-05-26 Sandoz Pharm. Corp. Intermediate imidazole acrolein analogs
EP0221025A1 (fr) * 1985-10-25 1987-05-06 Sandoz Ag Analogues hétérocycliques de la mévalonolactone et dérivés de ceux-ci, leur procédé de préparation et leur application comme médicaments
JPS6322056A (ja) * 1986-04-30 1988-01-29 サンド・アクチエンゲゼルシヤフト オレフイン性化合物の製造法
US4808621A (en) * 1986-07-07 1989-02-28 Warner-Lambert Company Trans-6-[2-(N-heteroaryl-3,5-disubstituted)pyrazol-4-yl)-ethyl]- or ethenyl]tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis
NZ221717A (en) * 1986-09-10 1990-08-28 Sandoz Ltd Azaindole and indolizine derivatives and pharmaceutical compositions
US4751235A (en) * 1986-12-23 1988-06-14 Sandoz Pharm. Corp. Anti-atherosclerotic indolizine derivatives
US4735958A (en) * 1986-12-22 1988-04-05 Warner-Lambert Company Trans-6-[2-[2-(substituted-phenyl)-3- (or 4-) heteroaryl-5-substituted-1H-pyrrol-1-yl]-ethyl]tetrahydro-4-hydroxy-2H-pyran-2-one inhibitors of cholesterol biosynthesis
US4898949A (en) * 1987-02-25 1990-02-06 Bristol-Myers Company Intermediates for the preparation of antihypercholesterolemic tetrazole compounds
AT401518B (de) * 1987-02-25 1996-09-25 Bristol Myers Squibb Co Neue tetrazol-verbindungen und verfahren zu ihrer herstellung
US4897490A (en) * 1987-02-25 1990-01-30 Bristol-Meyers Company Antihypercholesterolemic tetrazole compounds
JP2569746B2 (ja) * 1987-08-20 1997-01-08 日産化学工業株式会社 キノリン系メバロノラクトン類
CA1336714C (fr) * 1987-08-20 1995-08-15 Yoshihiro Fujikawa Mevalonolactone de type quinoleine utilisee comme inhibiteurs de la biosynthese du cholesterol
US4997837A (en) * 1987-09-08 1991-03-05 Warner-Lambert Company 6-(((substituted)pyridin-3-yl)alkyl)-and alkenyl)-tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis
US4906624A (en) * 1987-09-08 1990-03-06 Warner-Lambert Company 6-(((Substituted)pyridin-3-yl)alkyl)-and alkenyl)-tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis
DE3800785A1 (de) * 1988-01-09 1989-07-20 Hoechst Ag Substituierte 7-(pyridazin-5-yl)-3,5-dihydroxyheptan(en)- saeuren, ihre entsprechenden (delta)-lactone bzw. derivate, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel, pharmazeutische praeparate und zwischenprodukte
US4822799A (en) * 1988-01-27 1989-04-18 Sandoz Pharm. Corp. Pyrazolopyridine analogs of mevalonolactone and derivatives thereof useful for inhibiting cholesterol biosynthesis in mammals
NO890522L (no) * 1988-02-25 1989-08-28 Bayer Ag Substituerte imidazolinoner og imidazolinthioner.
US5024999A (en) * 1988-04-26 1991-06-18 Nissan Chemical Industries Ltd. Pyrazolopyridine type mevalonolactones useful as pharmaeuticals
JP2890448B2 (ja) * 1988-04-26 1999-05-17 日産化学工業株式会社 ピラゾロピリジン系メバロノラクトン類
ES2060712T3 (es) * 1988-10-13 1994-12-01 Sandoz Ag Proceso para la preparacion de acidos 7-sustituido-hept-6-enoicos y -heptanoicos y derivados y compuestos intermedios de los mismos.
JPH04270285A (ja) * 1988-11-14 1992-09-25 Nissan Chem Ind Ltd ピラゾロピリミジン系メバロノラクトン類
IT1237793B (it) * 1989-12-21 1993-06-17 Zambon Spa Composti attivi come inibitori dell'enzima hmg-coa reduttasi
US5134155A (en) * 1991-08-08 1992-07-28 Ortho Pharmaceutical Corporation Tetrahydroindazole, tetrahydrocyclopentapyrazole, and hexahydrocycloheptapyrazole compounds and their use as HMG-coA reductase inhibitors
JPH07507200A (ja) * 1991-09-20 1995-08-10 ゼネカ　リミテッド ピラノン
US5335293A (en) * 1992-06-16 1994-08-02 Key Technology, Inc. Product inspection method and apparatus
CA2504511A1 (fr) 2002-11-01 2004-05-13 Takeda Pharmaceutical Company Limited Agent pour la prevention ou le traitement de neuropathie
EP1819681B1 (fr) 2004-11-23 2009-08-12 Warner-Lambert Company LLC Derives d'acide 7-(2h-pyrazol-3-yl)-3, 5-dihyroxy-heptanoique comme inhibiteurs de hmg co-a reductase pour le traitement de l'hyperlipidemie
WO2006087630A2 (fr) * 2005-02-16 2006-08-24 Warner-Lambert Company Llc Inhibiteurs oxypyrazole de l'enzyme hmg co-a reductase
EP1775299A1 (fr) 2005-10-05 2007-04-18 LEK Pharmaceuticals D.D. Procédé de préparation de inhibiteurs de la HMG-CoA réductase
JP5113531B2 (ja) * 2006-01-16 2013-01-09 三井化学アグロ株式会社 （３−硫黄原子置換フェニル）ピラゾール誘導体

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3254093A (en) * 1961-09-22 1966-05-31 Hoechst Ag Process for preparing pyrazoles
EP0019760A1 (fr) * 1979-05-23 1980-12-10 BASF Aktiengesellschaft Esters de l'acide 3-aryl-5-méthyl-pyrazole-4-carboxyliques, herbicides les contenant, procédé pour leur production et leur utilisation
US4245106A (en) * 1979-07-05 1981-01-13 Monsanto Company Process for the preparation of 1-alkyl-3-aryl-4-pyrazolecarboxylates

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3254093A (en) * 1961-09-22 1966-05-31 Hoechst Ag Process for preparing pyrazoles
EP0019760A1 (fr) * 1979-05-23 1980-12-10 BASF Aktiengesellschaft Esters de l'acide 3-aryl-5-méthyl-pyrazole-4-carboxyliques, herbicides les contenant, procédé pour leur production et leur utilisation
US4245106A (en) * 1979-07-05 1981-01-13 Monsanto Company Process for the preparation of 1-alkyl-3-aryl-4-pyrazolecarboxylates

Also Published As

Publication number Publication date
PL151016B1 (en) 1990-07-31
EP0200736A1 (fr) 1986-11-12
KR890001651B1 (ko) 1989-05-12
IL75583A0 (en) 1985-10-31
ES8703842A1 (es) 1987-03-01
ZA854719B (en) 1987-02-25
KR860700253A (ko) 1986-08-01
HU198711B (en) 1989-11-28
ATE62906T1 (de) 1991-05-15
EP0200736B1 (fr) 1991-04-24
ES544407A0 (es) 1987-03-01
DK83886D0 (da) 1986-02-21
FI860755A7 (fi) 1986-02-20
GR851510B (fr) 1985-11-25
PT80674B (en) 1987-03-17
IL75583A (en) 1989-09-10
PL254121A1 (en) 1988-07-21
WO1986000307A2 (fr) 1986-01-16
NZ212501A (en) 1988-06-30
HUT39178A (en) 1986-08-28
DK83886A (da) 1986-02-21
DK157543B (da) 1990-01-22
DK157543C (da) 1990-06-11
FI860755A0 (fi) 1986-02-20
PT80674A (en) 1985-07-01
CA1249283A (fr) 1989-01-24
AU573368B2 (en) 1988-06-02
DE3582674D1 (de) 1991-05-29
FI860755L (fi) 1986-02-20
JPS61502467A (ja) 1986-10-30
AU4546685A (en) 1986-01-24
MY101903A (en) 1992-02-15

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