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WO1984002892A1 - Multi-chamber container for reactive substances - Google Patents

Multi-chamber container for reactive substances Download PDF

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Publication number
WO1984002892A1
WO1984002892A1 PCT/CH1984/000009 CH8400009W WO8402892A1 WO 1984002892 A1 WO1984002892 A1 WO 1984002892A1 CH 8400009 W CH8400009 W CH 8400009W WO 8402892 A1 WO8402892 A1 WO 8402892A1
Authority
WO
WIPO (PCT)
Prior art keywords
chamber
cover film
container
container according
chamber container
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CH1984/000009
Other languages
German (de)
French (fr)
Inventor
Max A Staub
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SEDIA AG LA CORBAZ
SEDIA AG
Original Assignee
SEDIA AG LA CORBAZ
SEDIA AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SEDIA AG LA CORBAZ, SEDIA AG filed Critical SEDIA AG LA CORBAZ
Publication of WO1984002892A1 publication Critical patent/WO1984002892A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/32—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents for packaging two or more different materials which must be maintained separate prior to use in admixture
    • B65D81/3294—Thermoformed trays or the like with a plurality of recesses for different materials located in different recesses
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/32—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents for packaging two or more different materials which must be maintained separate prior to use in admixture
    • B65D81/3261—Flexible containers having several compartments
    • B65D81/3266—Flexible containers having several compartments separated by a common rupturable seal, a clip or other removable fastening device

Definitions

  • Multi-chamber container for reactive substances Multi-chamber container for reactive substances
  • the patient and the canned blood must be mixed with the corresponding test sera, the identity of the patient and canned blood being able to be assumed with the same reaction.
  • the blood and the test serum are applied and mixed on a carrier, this method being time-consuming, many auxiliaries being required and, moreover, conditional on the test serum being available in separate containers. There are also cards on which dried test sera are applied.
  • the test serum must be liquefied in order to carry out the tests. In most cases, moreover, the blood with additional liquid must ver ⁇ 'be thinned. In this method, many auxiliaries are also necessary, and there is also a risk of contamination of the test sera.
  • a plastic container with various chambers is known from German Offenlegungsschrift 29 21 136, in which the test serum is filled. The transfusion
  • flSO or patient blood is introduced into the chambers with a cannula, in which there is already test serum, but there is a risk of contamination of the cannula with one serum, since traces are also introduced when the cannula is introduced into a chamber which contains a second test serum of the first serum. Furthermore, the serum in the chambers is in contact with a relatively large volume of air, which can lead to a change in the serum during long storage times.
  • the object of the present invention to create a multi-chamber container for reactive substances with which the above-mentioned disadvantages can be avoided.
  • the serum introduced into a chamber of the container should not be able to be contaminated.
  • the test procedure should be able to be carried out quickly and without aids.
  • the multi-chamber container should furthermore be able to be used very generally for reaction tests in which a liquid, gaseous or pasty substance is only introduced into the reaction chamber at the moment when the reaction is desired. This is achieved according to the invention by the features of the characterizing part of patent claim 1.
  • the test material should also be able to be introduced by means of a pipette, dropping, etc. and not only by means of a cannula, as in known devices.
  • FIG. 1 shows a multi-chamber container with a lower container part and cover film in a perspective view
  • FIG. 2 shows a longitudinal section through the container according to FIG. 1
  • FIG. 3 shows a longitudinal section through the container according to FIG. 1, with the cover film over the intermediate
  • FIG. 4 shows a perspective view of a second exemplary embodiment of a lower container part with cover film.
  • 5 shows a section through the container according to FIG. 4 with glued-on plastic strips,
  • FIG. 6 shows a section through a third exemplary embodiment of a container
  • FIG. 7 is a perspective view of the lower part of the container of a fourth embodiment
  • FIG. 8 is a plan view of the lower container part according to FIG. 7,
  • FIG. 9 shows a longitudinal section through the lower part of the container with an applied cover film according to FIGS. 7 and 8.
  • FIG. 10 shows a fifth embodiment with three chambers.
  • 11 shows a sixth embodiment with three chambers.
  • a deep-drawn container lower part 1 made of plastic, preferably PVDC.
  • B. filled the test serum when using the container for blood tests.
  • a large chamber 3 serves to mix the blood to be tested with the serum.
  • a connecting channel 4 is provided between the small chamber 2 and the large chamber 3.
  • a cover film 5 is coated on its side opposite the lower part of the container with thermal lacquer and sealed to the lower part 1 of the container. If, during a reaction test, the liquid to be tested is introduced into the large chamber 3, for example with a cannula, as soon as the reaction is to take place, as indicated by the arrows in FIG. 2, the small chamber 2 can be compressed, the liquid 8 located in the small chamber reaches the large chamber 3. As can be seen in Fig. 3, the cover film 5 is raised in its area 6 over the connecting web 4, a passage channel 7 being created for the test serum. This ensures that the liquid 8 in the small chamber does not become contaminated before the reaction.
  • the lower container part 9 again has a small chamber 10 e.g. for the test serum and a large reaction chamber 11.
  • the cover film 12 has an area 13 with a strong thermal lacquer coating and an area 14 with a weak, preferably colored, thermal lacquer coating.
  • the rectangular part 15 of the weak coating comes to rest over the web 16 between the large and small chamber in the lower part of the container.
  • the circular part 17 with a weak coating has a circular punch 18 which is concentric with the coating.
  • the opening 18 lies over the middle of the large chamber 11.
  • the liquid to be tested can be poured directly into the reaction chamber 11 through the opening 18 or introduced with a dropper pipette.
  • the circular ring 17 serves as a marking for the opening.
  • the part 15 with a weak coating comes to rest over the web 16 between the small and large chamber and, when the small chamber is pressed together, allows the liquid in the small chamber 10 to be pushed over the web 16 into the large chamber 11.
  • This part 15 is only coated with thermal varnish to such an extent that the cover film in the area of the web 16 can be detached when the small chamber 10 is pressed together by hand.
  • FIG. 5 shows a longitudinal section through a further embodiment, which likewise comprises a lower container part 21 and a cover film 22.
  • the lower container part 21 has a small chamber 23 and a reaction chamber 24.
  • a connecting channel 25 is provided between the two chambers.
  • a porous material preferably an open-cell polyurethane foam, is filled, which absorbs the liquid. If the reaction is to be carried out, this porous material 26 is pressed together, the liquid flowing from the small chamber 23 into the reaction chamber 24.
  • 6 to 8 is a further embodiment of the invention in a perspective view, in
  • the container in turn comprises a lower container part 27 with a large chamber 28 and a small chamber 29.
  • the two chambers are connected by a channel 30 when the cover film is lifted off over the intermediate area between the chambers.
  • the reaction chamber 28 has, opposite the small chamber 29, a wall 31 which is almost perpendicular to the connecting duct 30.
  • the small chamber 29 is squeezed to bring the liquid therein into the large chamber 28, it splashes as it passes through the channel 30 onto the wall 31 and runs down the same onto the bottom of the chamber 28. This prevents the liquid collects by capillary effect on the upper edge of the large chamber between the cover film and the lower part of the container.
  • the cover film can preferably also be made from hydrophobic material in order to prevent the above-mentioned accumulation of the liquid from the small chamber between the cover film and the lower part of the container at the upper edge of the large chamber.
  • 10 shows a further exemplary embodiment in which the reaction chamber 32 is connected to two small chambers 33 and 34 for test sera. Perpendicular to the breakthrough points 35 and 36, two walls 37, 38 are provided in the reaction chamber in order to cause the test serum to accumulate at the bottom of the reaction chamber 32.
  • two small chambers 39 and 40 are connected in series with the reaction chamber 41. This makes it possible to first mix the two substances in the chambers 39 and 40 before they are brought together into the reaction chamber 41.

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Devices For Use In Laboratory Experiments (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

The container comprises a lower portion (9) and a cover sheet (12) to be sealed therewith. In the lower portion of the container there are provided a small chamber (10) and a large reaction chamber (11). Between those two chambers, a bridge (16) is provided. The cover sheet has a strong thermolacquer layer (13) as well as a weak thermolacquer layer. A rectangular shaped portion (15) of the weak thermolacquer layer is arranged on the bridge (16) of the lower portion of the container (9). The liquid to be tested is supplied to the reaction chamber through an opening (18) provided in the cover sheet. By compressing the small chamber (10), the portion (15) is lifted from the cover sheet of the bridge (16) and the liquid is passed from the small chamber to the reaction chamber. This container is particularly appropriate for comparative tests of patient blood and blood stored with testing serum. Contamination risks are avoided.

Description

Mehrkammerbehälter für reaktive Stoffe Multi-chamber container for reactive substances

Bei Bluttransfusionen stellt sich das Problem, das Patientenblut mit dem Konservenblut vor der Trans¬ fusion zu vergleichen, insbesondere den ABO Identitäts¬ test durchzuführen. Dabei muss jeweils das Patienten- und das Konservenblut mit entsprechenden Testseren ver¬ mischt werden, wobei bei gleicher Reaktion Identität des Patienten- und Konservenblutes angenommen werden kann. Bei bekannten Verfahren werden z.B. das Blut und das Testserum auf einen Träger aufgebracht und vermischt, wobei dieses Verfahren zeitraubend ist, viele Hilfsmit¬ tel benötigt werden und zudem bedingt, dass Testserum in separaten Behältern zur Verfügung steht. Im weiteren bestehen Karten, auf welchen angetrocknete Testseren aufgebracht sind. Zwecks Durchführung der Tests muss das Testserum verflüssigt werden. In den meisten Fällen muss zudem das Blut mit zusätzlicher Flüssigkeit ver¬ dünnt' werden. Bei diesem Verfahren sind ebenfalls vie¬ le Hilfsmittel notwendig, wobei auch eine Verunreini¬ gungsgefahr der Testseren besteht. Im weiteren ist aus der deutschen Offenlegungsschrift 29 21 136 ein Kunst¬ stoffbehälter mit verschiedenen Kammern bekannt, in denen das Testserum eingefüllt ist. Das Transfusions-In the case of blood transfusions, the problem arises of comparing the patient's blood with the canned blood before the trans fusion, in particular of carrying out the ABO identity test. In this case, the patient and the canned blood must be mixed with the corresponding test sera, the identity of the patient and canned blood being able to be assumed with the same reaction. In known methods, for example, the blood and the test serum are applied and mixed on a carrier, this method being time-consuming, many auxiliaries being required and, moreover, conditional on the test serum being available in separate containers. There are also cards on which dried test sera are applied. The test serum must be liquefied in order to carry out the tests. In most cases, moreover, the blood with additional liquid must ver¬ 'be thinned. In this method, many auxiliaries are also necessary, and there is also a risk of contamination of the test sera. Furthermore, a plastic container with various chambers is known from German Offenlegungsschrift 29 21 136, in which the test serum is filled. The transfusion

flSO oder Patientenblut wird mit einer Kanüle in die Kam¬ mern eingebracht, in denen sich bereits Testserum be— findet, wobei jedoch eine Verunreinigungsgefahr der Kanüle mit dem einen Serum besteht, da bei Einführen der Kanüle in eine Kammer, die ein zweites Testserum enthält auch Spuren des ersten Serums eingebracht werden. Im weiteren steht das Serum in den Kammern mit einem relativ grossen Luftvolumen in Kontakt, was zu ei¬ ner Veränderung des Serums während langer Lagerzeiten führen kann.flSO or patient blood is introduced into the chambers with a cannula, in which there is already test serum, but there is a risk of contamination of the cannula with one serum, since traces are also introduced when the cannula is introduced into a chamber which contains a second test serum of the first serum. Furthermore, the serum in the chambers is in contact with a relatively large volume of air, which can lead to a change in the serum during long storage times.

Es ist Aufgabe der vorliegenden Erfindung, ei¬ nen Mehrkammerbehälter für reaktive Stoffe zu schaffen, mit welchem die obgenannten Nachteile vermieden werden können. Das in eine Kammer des Behälters eingebrachte Serum soll nicht kontaminiert werden können. Im weiteren soll das Testverfahren schnell und ohne Hilfsmittel durchgeführt werden können. Der Mehrkammerbehälter soll im weiteren ganz allgemein für Reaktionstests verwendet werden können, bei welchen eine flüssige, gasförmige oder pastöse Substanz erst in dem Moment in die Reak¬ tionskammer verbracht wird, wenn die Reaktion erwünscht ist. Dies wird erfindungsgemäss erzielt durch die Merk¬ male des kennzeichnenden Teiles des Patentanspruches 1. Das Einbringen des Testgutes soll auch mittels Pipette, Eintropfen usw. erfolgen können und nicht nur mittels einer Kanüle, wie bei bekannten Vorrichtungen.It is the object of the present invention to create a multi-chamber container for reactive substances with which the above-mentioned disadvantages can be avoided. The serum introduced into a chamber of the container should not be able to be contaminated. Furthermore, the test procedure should be able to be carried out quickly and without aids. The multi-chamber container should furthermore be able to be used very generally for reaction tests in which a liquid, gaseous or pasty substance is only introduced into the reaction chamber at the moment when the reaction is desired. This is achieved according to the invention by the features of the characterizing part of patent claim 1. The test material should also be able to be introduced by means of a pipette, dropping, etc. and not only by means of a cannula, as in known devices.

Im folgenden werden Ausführungsbeispiele der Er- ' findung sowie deren Verwendung anhand der beiliegenden Zeichnungen näher erläutert. Es zeigenExemplary embodiments of the invention and their use are explained in more detail below with reference to the accompanying drawings. Show it

Fig. 1 einen Mehrkammerbehälter mit Behälterun¬ terteil und Deckfolie in perspektivischer Ansicht,1 shows a multi-chamber container with a lower container part and cover film in a perspective view,

Fig. 2 einen Längsschnitt durch den Behälter ge¬ mäss Fig. 1 , Fig. 3 einen Längsschnitt durch den Behälter ge¬ mäss Fig. 1, wobei die Deckfolie über den Zwischenbe-2 shows a longitudinal section through the container according to FIG. 1, FIG. 3 shows a longitudinal section through the container according to FIG. 1, with the cover film over the intermediate

OM reich abgehoben ist.OM is richly withdrawn.

Fig. 4 ein zweites Ausführungsbeispiel eines Be¬ hälterunterteils mit Deckfolie in perspektivischer An¬ sicht. Fig. 5 einen Schnitt durch den Behälter gemäss Fig. 4 mit aufgeklebtem Kunststoffstreifen,4 shows a perspective view of a second exemplary embodiment of a lower container part with cover film. 5 shows a section through the container according to FIG. 4 with glued-on plastic strips,

Fig. 6 einen Schnitt durch ein drittes Ausfüh¬ rungsbeispiel eines Behälters,6 shows a section through a third exemplary embodiment of a container,

Fig. 7 eine perspektivische Ansicht des Behäl- terunterteils eines vierten Ausführungsbeispiels,7 is a perspective view of the lower part of the container of a fourth embodiment,

Fig. 8 eine Draufsicht auf den Behälterunter¬ teil gemäss Fig. 7,8 is a plan view of the lower container part according to FIG. 7,

Fig. 9 einen Längsschnitt durch den Behälterun¬ terteil mit aufgebrachter Deckfolie gemäss Fig. 7 und 8. Fig. 10 ein fünftes Ausführungsbeispiel mit drei Kammern.9 shows a longitudinal section through the lower part of the container with an applied cover film according to FIGS. 7 and 8. FIG. 10 shows a fifth embodiment with three chambers.

Fig 11 ein sechstes Ausführungsbeispiel mit drei Kammern.11 shows a sixth embodiment with three chambers.

Der Behälter gemäss Fig. 1 umfasst einen tiefge- zogenen Behälterunterteil 1 aus Kunststoff, vorzugswei¬ se PVDC. In eine kleine Kammer 2 wird z. B. bei der Verwendung des Behälters für Bluttests das Testserum eingefüllt. Eine grosse Kammer 3 dient zur Vermi¬ schung des zu testenden Blutes mit dem Serum. Zwischen kleiner Kammer 2 und grosser Kammer 3 ist ein Verbin¬ dungskanal 4 vorgesehen. Eine Deckfolie 5 wird auf ihrer dem Behälterunterteil gegenüberliegenden Seite mit Ther- molack beschichtet und mit dem Behälterunterteil 1 ver¬ siegelt. Wird bei einem Reaktionstest die zu testende Flüs¬ sigkeit in die grosse Kammer 3 z.B. mit einer Kanüle eingebracht, so kann, sobald die Reaktion stattfinden soll, wie mit Pfeilen in Fig. 2 angedeutet, die klei¬ ne Kammer 2 zusammengedrückt werden, wobei die in der kleinen Kammer befindliche Flüssigkeit 8 in die grosse Kammer 3 gelangt. Wie in Fig. 3 ersichtlich ist, wird die Deckfolie 5 in ihrem Bereich 6 über den Verbindungs¬ steg 4 abgehoben, wobei ein Durchtrittskanal 7 für das Testserum entsteht. Es ist so gewährleistet, dass keine Verunreinigung der in der kleinen Kammer befindlichen Flüssigkeit 8 vor der Reaktion stattfindet.1 comprises a deep-drawn container lower part 1 made of plastic, preferably PVDC. In a small chamber 2 z. B. filled the test serum when using the container for blood tests. A large chamber 3 serves to mix the blood to be tested with the serum. A connecting channel 4 is provided between the small chamber 2 and the large chamber 3. A cover film 5 is coated on its side opposite the lower part of the container with thermal lacquer and sealed to the lower part 1 of the container. If, during a reaction test, the liquid to be tested is introduced into the large chamber 3, for example with a cannula, as soon as the reaction is to take place, as indicated by the arrows in FIG. 2, the small chamber 2 can be compressed, the liquid 8 located in the small chamber reaches the large chamber 3. As can be seen in Fig. 3, the cover film 5 is raised in its area 6 over the connecting web 4, a passage channel 7 being created for the test serum. This ensures that the liquid 8 in the small chamber does not become contaminated before the reaction.

In Fig. 3 ist ein zweites Ausführungsbeispiel der Erfindung dargestellt. Der Behälterunterteil 9 weist wiederum eine kleine Kammer 10 z.B. für das Testserum und eine grosse Reaktionskammer 11 auf. Die Deckfolie 12 weist einen Bereich 13 mit starker Thermolackbeschich¬ tung und einen Bereich 14 mit schwacher, vorzugsweise eingefärbter Thermolackbeschichtung auf. Der rechteck- förmige Teil 15 der schwachen Beschichtung kommt über den Steg 16 zwischen grosser und kleiner Kammer im Be- hälterunterteil zu liegen. Der kreisringförmige Teil 17 mit schwacher Beschichtung weist eine konzentrisch zu der Beschichtung liegende kreisförmige Ausstanzung 18 auf. Die Oeffnung 18 kommt beim Versiegeln der Deck- • folie mit dem Behälterunterteil über die Mitte der grossen Kammer 11 zu liegen. Bei dieser Ausführungs¬ variante kann die zu testende Flüssigkeit direkt durch die Oeffnung 18 in die Reaktionskammer 11 eingegossen oder mit einer Tropfpipette eingebracht werden. Der Kreisring 17 dient als Markierung für die Oeffnung. Der Teil 15 mit schwacher Beschichtung kommt über den Steg 16 zwischen kleiner und grosser Kammer zu liegen und ermöglicht beim Zusammendrükken der kleinen Kammer ein HinüberfHessen der in der kleinen Kammer 10 be¬ findlichen Flüssigkeit über den Steg 16 in die grosse Kammer 11. Dieser Teil 15 ist nur so stark mit Thermo- lack beschichtet, dass ein Ablösen der Deckfolie im Bereich des Steges 16 beim Zusammendrücken von Hand der kleinen Kammer 10 ermöglicht wird.3 shows a second exemplary embodiment of the invention. The lower container part 9 again has a small chamber 10 e.g. for the test serum and a large reaction chamber 11. The cover film 12 has an area 13 with a strong thermal lacquer coating and an area 14 with a weak, preferably colored, thermal lacquer coating. The rectangular part 15 of the weak coating comes to rest over the web 16 between the large and small chamber in the lower part of the container. The circular part 17 with a weak coating has a circular punch 18 which is concentric with the coating. When the cover film is sealed with the bottom part of the container, the opening 18 lies over the middle of the large chamber 11. In this embodiment variant, the liquid to be tested can be poured directly into the reaction chamber 11 through the opening 18 or introduced with a dropper pipette. The circular ring 17 serves as a marking for the opening. The part 15 with a weak coating comes to rest over the web 16 between the small and large chamber and, when the small chamber is pressed together, allows the liquid in the small chamber 10 to be pushed over the web 16 into the large chamber 11. This part 15 is only coated with thermal varnish to such an extent that the cover film in the area of the web 16 can be detached when the small chamber 10 is pressed together by hand.

In Fig. 4 ist ein Längsschnitt durch den mit der Deckfolie T2 versiegelten Behälterunterteil 9 darge¬ stellt. Nach dem Einbringen der zu prüfenden Flüssig- keit 19 in den Reaktionsraum 11 wird die Oeffnung 18 in der Deckfolie mit einem Klebestreifen 20 verschlossen. Der Behälter kann zwecks besserem Reagieren der beiden Flüssigkeiten geschüttelt werden, ohne dass die Flüs- sigkeit aus der Reaktionskammer 11 durch die Oeffnung 18 ausfliesst.4 shows a longitudinal section through the lower container part 9 sealed with the cover film T2. After introducing the liquid to be tested speed 19 in the reaction chamber 11, the opening 18 in the cover film is closed with an adhesive strip 20. For better reaction of the two liquids, the container can be shaken without the liquid flowing out of the reaction chamber 11 through the opening 18.

In Fig. 5 ist ein Längsschnitt durch eine weite¬ re Ausführungsform dargestellt, welche ebenfalls einen Behälteruntεrteil 21 sowie eine Deckfolie 22 umfasst. Der Behälterunterteil 21 weist eine kleine Kammer 23 sowie eine Reaktionskammer 24 auf. Zwischen den beiden Kammern ist ein Verbindungskanal 25 vorgesehen. In der kleinen Kammer 23 ist ein poröses Material, vorzugsweise ein offenzelliger Polyurethanschaum eingefüllt,, der die Flüssigkeit aufnimmt. Falls die Reaktion durchgeführt werden soll, so wird dieses poröse Material 26 zusammen- gepresst, wobei die Flüssigkeit von der kleinen Kammer 23 in die Reaktionskammer 24 fliesst.5 shows a longitudinal section through a further embodiment, which likewise comprises a lower container part 21 and a cover film 22. The lower container part 21 has a small chamber 23 and a reaction chamber 24. A connecting channel 25 is provided between the two chambers. In the small chamber 23, a porous material, preferably an open-cell polyurethane foam, is filled, which absorbs the liquid. If the reaction is to be carried out, this porous material 26 is pressed together, the liquid flowing from the small chamber 23 into the reaction chamber 24.

In den Fig. 6 bis 8 ist ein weiteres Ausführungs- beispiel der Erfindung in perspektivischer Ansicht, in6 to 8 is a further embodiment of the invention in a perspective view, in

Draufsicht sowie im Längsschnitt dargestellt. Der Behäl¬ ter umfasst wiederum einen Behälterunterteil 27 mit einer grossen Kammer 28 und einer kleinen Kammer 29. Die beiden Kammern sind beim Abheben der Deckfolie über dem Zwischenbereich zwischen den Kammern durch einen Kanal 30 verbunden. Die Reaktionskammer 28 weist der kleinen Kammer 29 gegenüberliegend eine zum Verbin¬ dungskanal 30 nahezu senkrechte Wand 31 auf. Beim Zu¬ sammendrücken der kleinen Kammer 29 zum Verbringen der darin befindlichen Flüssigkeit in die grosse Kammer 28 spritzt dieselbe beim Durchtreten durch den Kanal 30 an die Wand 31 und läuft an derselben hinunter auf den Bo¬ den der Kammer 28. Dadurch wird vermieden, dass sich die Flüssigkeit durch Kapillareffekt am oberen Rand der grossen Kammer zwischen Deckfolie und Behälterunter¬ teil ansammelt. Es ist wünschenswert, dass die zur Re- aktion zu bringenden beiden Flüssigkeiten am Boden der grossen Kammer 28 befindlich sind, um ein möglichst homo¬ genes Durchmischen der beiden Flüssigkeiten ermöglichen zu können. Vorzugsweise kann die Deckfolie auch aus hydro¬ phobem Materiel hergestellt werden, um das oben erwähnte Ansammeln der Flüssigkeit aus der kleinen Kammer zwi¬ schen Deckfolie und Behälterunterteil am oberen Rand der grossen Kammer zu verhindern. In Fig. 10 ist ein weiteres Ausführungsbeispiel dargestellt, bei welchem die Reaktionskammer 32 mit zwei kleinen Kammern 33 und 34 für Testseren verbunden ist. Senkrecht zu den Durchbruchstellen 35 und 36 sind 2 Wände 37,38 in der Reaktionskammer vorgesehen, um das Ansammeln des Testserums am Boden der Reaktionskammer 32 zu bewirken.Top view and shown in longitudinal section. The container in turn comprises a lower container part 27 with a large chamber 28 and a small chamber 29. The two chambers are connected by a channel 30 when the cover film is lifted off over the intermediate area between the chambers. The reaction chamber 28 has, opposite the small chamber 29, a wall 31 which is almost perpendicular to the connecting duct 30. When the small chamber 29 is squeezed to bring the liquid therein into the large chamber 28, it splashes as it passes through the channel 30 onto the wall 31 and runs down the same onto the bottom of the chamber 28. This prevents the liquid collects by capillary effect on the upper edge of the large chamber between the cover film and the lower part of the container. It is desirable that the action to be brought two liquids are at the bottom of the large chamber 28 in order to enable the most homogeneous possible mixing of the two liquids. The cover film can preferably also be made from hydrophobic material in order to prevent the above-mentioned accumulation of the liquid from the small chamber between the cover film and the lower part of the container at the upper edge of the large chamber. 10 shows a further exemplary embodiment in which the reaction chamber 32 is connected to two small chambers 33 and 34 for test sera. Perpendicular to the breakthrough points 35 and 36, two walls 37, 38 are provided in the reaction chamber in order to cause the test serum to accumulate at the bottom of the reaction chamber 32.

Beim Ausführungsbeispiel gemäss Fig. 11 sind zwei kleine Kammern 39 und 40 in Serie mit der Reaktionskam¬ mer 41 verbunden. Dies ermöglicht, zuerst die beiden in den Kammern 39 und 40 befindlichen Substanzen zu vermi¬ schen, bevor dieselben zusammen in die Reaktionskammer 41 verbracht werden. In the exemplary embodiment according to FIG. 11, two small chambers 39 and 40 are connected in series with the reaction chamber 41. This makes it possible to first mix the two substances in the chambers 39 and 40 before they are brought together into the reaction chamber 41.

Claims

Patentansprüche Claims 1. Mehrkammerbehälter für reaktive Stoffe, ge¬ kennzeichnet durch einen voneinander getrennt ausgebil-. dete Kammern enthaltenden Behälterunterteil und eine mit dem Behälterunterteil verbundene Deckfolie, wobei1. Multi-chamber container for reactive substances, characterized by a separately trained ge . Dete chambers containing the lower container part and a cover film connected to the lower container part, wherein 5 im Zwischenbereich zwischen mindestens zwei benachbarten Kammern ein Verbindungskanal oder eine Durchbruchstelle vorgesehen ist.5 a connecting channel or a breakthrough point is provided in the intermediate area between at least two adjacent chambers. 2. Mehrkammerbehälter nach Patentanspruch 1, da- durchgekennzeichnet, dass die Deckfolie im Zwischenbe-2. Multi-chamber container according to claim 1, characterized in that the cover film in the intermediate 10 reich lösbar mit dem Behälterunterteil verbunden ist.10 is releasably connected to the lower part of the container. 3. Mehrkammerbehälter nach Patentanspruch 1 oder 2, dadurch gekennzeichnet, dass die Deckfolie auf ihrer dem Behälterunterteil zugewandten Seite beschichtet ist.3. Multi-chamber container according to claim 1 or 2, characterized in that the cover film is coated on its side facing the lower container part. 4. Mehrkammerbehälter nach Patentanspruch 3, da- 5 durch gekennzeichnet, dass die Deckfolie mit Thermolack beschichtet ist.4. Multi-chamber container according to claim 3, characterized in that the cover film is coated with thermal lacquer. 5. Mehrkammerbehälter nach Patentanspruch 3 oder 4, dadurch gekennzeichnet, dass die Deckfolie im Zwi¬ schenbereich eine zweite Beschichtung aufweist.5. Multi-chamber container according to claim 3 or 4, characterized in that the cover film has a second coating in the intermediate region. 0 6. Mehrkammerbehälter nach einem der vorangehen¬ den Patentansprüche, dadurch gekennzeichnet, dass die Deckfolie im Mittelbereich mindestens einer Kammer eine Oeffnung aufweist.6. Multi-chamber container according to one of the preceding claims, characterized in that the cover film has an opening in the central region of at least one chamber. 7. Mehrkammerbehälter nach einem der vorangehen- 5 den Patentansprüche, dadurch gekennzeichnet dass die Deckfolie aus hydrophobem Matrial besteht. 7. Multi-chamber container according to one of the preceding claims 5, characterized in that the cover film consists of hydrophobic material. 8. Mehrkammerbehälter nach einem der vorangehen¬ den Patentansprüche, dadurch gekennzeichnet, dass min¬ destens eine Kammer eine in bezug auf den Verbindungs¬ kanal oder die Durchbruchstelle etwa rechtwinklig ange- ordnete Seitenwand aufweist.8. Multi-chamber container according to one of the preceding claims, characterized in that at least one chamber has a side wall arranged approximately at right angles with respect to the connecting channel or the breakthrough point. 9. Verwendung des Mehrkammerbehälters nach einem der vorangehenden Patentansprüche für die Durchführung von Bluttests.9. Use of the multi-chamber container according to one of the preceding claims for performing blood tests. 10. Verwendung des Mehrkammerbehälters nach Pa- tentanspruch 9 dadurch gekennzeichnet, dass eine Haupt¬ kammer als Reaktionskammer zur Aufnahme des Blutes dient, und in mindestens einer Nebenkammer Testserum vorhanden ist. 10. Use of the multi-chamber container according to claim 9, characterized in that a main chamber serves as a reaction chamber for receiving the blood, and test serum is present in at least one secondary chamber.
PCT/CH1984/000009 1983-01-21 1984-01-13 Multi-chamber container for reactive substances Ceased WO1984002892A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH36283 1983-01-21

Publications (1)

Publication Number Publication Date
WO1984002892A1 true WO1984002892A1 (en) 1984-08-02

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ID=4185289

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CH1984/000009 Ceased WO1984002892A1 (en) 1983-01-21 1984-01-13 Multi-chamber container for reactive substances

Country Status (3)

Country Link
EP (1) EP0143785A1 (en)
ES (1) ES277009Y (en)
WO (1) WO1984002892A1 (en)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2577898A1 (en) * 1985-02-22 1986-08-29 Triballat Laiteries Package for exudative product
DE3726876A1 (en) * 1986-08-12 1988-02-18 Oreal CONTAINER FOR SEPARATELY STORING AT LEAST TWO PRODUCTS
DE9000813U1 (en) * 1990-01-25 1990-03-01 Klocke Verpackungs-Service GmbH, 7504 Weingarten Packaging, especially multi-component bag packaging
EP0378183A1 (en) * 1989-01-12 1990-07-18 Karl H. Sengewald GmbH & Co. KG Sterile plastic package
WO2000009414A1 (en) * 1998-08-12 2000-02-24 Klocke Verpackungs-Service Gmbh Multi-chamber container
GB2351062A (en) * 2000-06-14 2000-12-20 Dalmian Frank Rapson Sealable multi-compartment container
USD983671S1 (en) 2021-06-30 2023-04-18 General Mills, Inc. Dual compartment food container
USD1021618S1 (en) 2022-05-13 2024-04-09 General Mills, Inc. Food packaging container

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB943498A (en) * 1958-12-22 1963-12-04 Minnesota Mining & Mfg Packages formed from heat sealable materials
GB1328539A (en) * 1970-11-10 1973-08-30 Inoue Japax Res Packaging dental filling and method of and apparatus for spatulating same
US3983994A (en) * 1975-01-29 1976-10-05 Ihor Wyslotsky Flexible package
DE2921136A1 (en) * 1979-05-25 1980-11-27 Geisen Hans Peter Bed-side test identification card - uses anti-bodies in liq. form in reaction chambers, hermetically closed by transparent foils

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB943498A (en) * 1958-12-22 1963-12-04 Minnesota Mining & Mfg Packages formed from heat sealable materials
GB1328539A (en) * 1970-11-10 1973-08-30 Inoue Japax Res Packaging dental filling and method of and apparatus for spatulating same
US3983994A (en) * 1975-01-29 1976-10-05 Ihor Wyslotsky Flexible package
DE2921136A1 (en) * 1979-05-25 1980-11-27 Geisen Hans Peter Bed-side test identification card - uses anti-bodies in liq. form in reaction chambers, hermetically closed by transparent foils

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2577898A1 (en) * 1985-02-22 1986-08-29 Triballat Laiteries Package for exudative product
DE3726876A1 (en) * 1986-08-12 1988-02-18 Oreal CONTAINER FOR SEPARATELY STORING AT LEAST TWO PRODUCTS
US4844251A (en) * 1986-08-12 1989-07-04 L'oreal Container means for separately storing at least two products to be brought into contact at the time of use
EP0378183A1 (en) * 1989-01-12 1990-07-18 Karl H. Sengewald GmbH & Co. KG Sterile plastic package
DE9000813U1 (en) * 1990-01-25 1990-03-01 Klocke Verpackungs-Service GmbH, 7504 Weingarten Packaging, especially multi-component bag packaging
WO2000009414A1 (en) * 1998-08-12 2000-02-24 Klocke Verpackungs-Service Gmbh Multi-chamber container
GB2351062A (en) * 2000-06-14 2000-12-20 Dalmian Frank Rapson Sealable multi-compartment container
GB2351062B (en) * 2000-06-14 2001-05-30 Dalmian Frank Rapson Sealable multicompartment container
US6354456B2 (en) 2000-06-14 2002-03-12 Dalmian Rapson Sealable multicompartment container
USD983671S1 (en) 2021-06-30 2023-04-18 General Mills, Inc. Dual compartment food container
USD1021618S1 (en) 2022-05-13 2024-04-09 General Mills, Inc. Food packaging container

Also Published As

Publication number Publication date
ES277009U (en) 1984-10-16
ES277009Y (en) 1985-04-16
EP0143785A1 (en) 1985-06-12

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