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UY31322A1 - HETEROCYCLIC AMIDAS AND ITS METHODS OF USE-975 - Google Patents

HETEROCYCLIC AMIDAS AND ITS METHODS OF USE-975

Info

Publication number
UY31322A1
UY31322A1 UY31322A UY31322A UY31322A1 UY 31322 A1 UY31322 A1 UY 31322A1 UY 31322 A UY31322 A UY 31322A UY 31322 A UY31322 A UY 31322A UY 31322 A1 UY31322 A1 UY 31322A1
Authority
UY
Uruguay
Prior art keywords
methods
heterocyclic
compounds
amidas
diseases
Prior art date
Application number
UY31322A
Other languages
Spanish (es)
Inventor
Bin Yang
Daniel John Russell
Benjamin Fauber
Hird Alexander
James Janetka
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of UY31322A1 publication Critical patent/UY31322A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente divulgación se refiere a compuestos de amida heterocíclica que son útiles para inhibir la ruta de Hedgehog y a su uso en el tratamiento de enfermedades o trastornos médicos mediados de manera exclusiva o parcial por la inhibición de la ruta de Hedgehog. También se divulgan métodos para la fabricación de esos compuestos, composiciones farmacéuticas de esos compuestos, composiciones farmacéuticas de sos compuestos y el uso de éstos en la fabricación de medicamentos para el tratamiento de las enfermedades y los trastonos médicos en un sujeto.The present disclosure relates to heterocyclic amide compounds that are useful for inhibiting the Hedgehog pathway and its use in the treatment of diseases or medical disorders mediated exclusively or partially by the inhibition of the Hedgehog pathway. Methods for the manufacture of those compounds, pharmaceutical compositions of those compounds, pharmaceutical compositions of these compounds and their use in the manufacture of medicaments for the treatment of diseases and medical disorders in a subject are also disclosed.

UY31322A 2007-09-05 2008-09-04 HETEROCYCLIC AMIDAS AND ITS METHODS OF USE-975 UY31322A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97010707P 2007-09-05 2007-09-05
US3666108P 2008-03-14 2008-03-14

Publications (1)

Publication Number Publication Date
UY31322A1 true UY31322A1 (en) 2009-04-30

Family

ID=39938463

Family Applications (1)

Application Number Title Priority Date Filing Date
UY31322A UY31322A1 (en) 2007-09-05 2008-09-04 HETEROCYCLIC AMIDAS AND ITS METHODS OF USE-975

Country Status (5)

Country Link
AR (1) AR068376A1 (en)
PE (1) PE20091092A1 (en)
TW (1) TW200916458A (en)
UY (1) UY31322A1 (en)
WO (1) WO2009030952A2 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010144586A1 (en) * 2009-06-09 2010-12-16 Abraxis Bioscience, Llc Isoquinoline, quinoline, and quinazoline derivatives as inhibitors of hedgehog signaling
CN102802419A (en) * 2010-01-07 2012-11-28 西莱瑟根治疗公司 HEDGEHOG inhibitors
WO2011095807A1 (en) * 2010-02-07 2011-08-11 Astrazeneca Ab Combinations of mek and hh inhibitors
CN101993415B (en) * 2010-09-15 2013-08-14 北京韩美药品有限公司 Compound as Hedgehog path inhibitor, medicine composition containing same and application thereof
CN103570625A (en) * 2012-07-19 2014-02-12 南京英派药业有限公司 N-(3-aryl-heteroaryl)-4-aryl-aryl carboxamide and analog as hedgehog pathway inhibitors and application thereof
US9242969B2 (en) 2013-03-14 2016-01-26 Novartis Ag Biaryl amide compounds as kinase inhibitors
UY36294A (en) 2014-09-12 2016-04-29 Novartis Ag COMPOUNDS AND COMPOSITIONS AS QUINASA INHIBITORS
AU2017329090B9 (en) 2016-09-19 2019-09-05 Novartis Ag Therapeutic combinations comprising a RAF inhibitor and a ERK inhibitor
US20190255042A1 (en) * 2016-11-04 2019-08-22 Impact Therapeutics, Inc Application of hedgehog pathway inhibitor in treating fibrosis diseases
TWI798218B (en) 2017-05-02 2023-04-11 瑞士商諾華公司 Combination therapy
CN107281214A (en) * 2017-06-06 2017-10-24 北京工业大学 Hydrogen molecule liquid/gas is preparing the application in suppressing tumor stem cell medicine
CN109369634B (en) * 2018-12-19 2021-07-27 陕西国际商贸学院 Preparation method and use of 2-methoxynicotinamide derivatives with antitumor activity
MX2021013817A (en) 2019-05-13 2021-12-14 Novartis Ag NEW CRYSTALLINE FORMS OF N-(3-(2-(2-HYDROXYETOXY)-6-MORPHOLINOP IRIDIN-4-IL)-4-METHYLPHENYL)-2-(TRIFLUOROMETHYL)SONICOTINAMIDE AS RAF INHIBITORS FOR THE TREATMENT OF CANCER.
BR112023026747A2 (en) 2021-06-18 2024-03-12 Aligos Therapeutics Inc METHODS AND COMPOSITIONS FOR TARGETING PD-L1
US12428427B2 (en) 2021-12-16 2025-09-30 Aligos Therapeutics, Inc. Methods and compositions for targeting PD-L1

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2258687B1 (en) * 2002-02-12 2012-12-26 Glaxosmithkline LLC Nicotinamide derivates useful as P38 inhibitors
US7655674B2 (en) * 2002-04-22 2010-02-02 The Johns Hopkins University Modulators of hedgehog signaling pathways, compositions and uses related thereto
AU2005325267B2 (en) * 2004-04-30 2010-11-04 Curis Inc. Quinoxaline inhibitors of the hedgehog signalling pathway
CN102964294A (en) * 2004-09-02 2013-03-13 遗传技术研究公司 Pyridyl inhibitors of hedgehog signalling
AU2005301962B2 (en) * 2004-11-03 2011-10-20 Curis, Inc. Mediators of hedgehog signaling pathways, compositions and uses related thereto
JP2009511559A (en) * 2005-10-12 2009-03-19 バイオリポックス エービー Benzoxazoles useful for the treatment of inflammation
PE20080948A1 (en) * 2006-07-25 2008-09-10 Irm Llc IMIDAZOLE DERIVATIVES AS MODULATORS OF THE HEDGEHOG PATH

Also Published As

Publication number Publication date
AR068376A1 (en) 2009-11-11
TW200916458A (en) 2009-04-16
PE20091092A1 (en) 2009-08-27
WO2009030952A2 (en) 2009-03-12
WO2009030952A3 (en) 2009-05-07

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Effective date: 20120613