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UY31773A1 - SPECIFIC ANTIBODIES FOR THE PROTEFIBRILL FORM OF THE BETA-AMILOID PROTEIN - Google Patents

SPECIFIC ANTIBODIES FOR THE PROTEFIBRILL FORM OF THE BETA-AMILOID PROTEIN

Info

Publication number
UY31773A1
UY31773A1 UY31773A UY31773A UY31773A1 UY 31773 A1 UY31773 A1 UY 31773A1 UY 31773 A UY31773 A UY 31773A UY 31773 A UY31773 A UY 31773A UY 31773 A1 UY31773 A1 UY 31773A1
Authority
UY
Uruguay
Prior art keywords
beta
aminoid
peptide
isolated antibodies
protefibrill
Prior art date
Application number
UY31773A
Other languages
Spanish (es)
Inventor
Hidehiro Fukuyama
Jeffrey V Ravetch
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority to UY31773A priority Critical patent/UY31773A1/en
Publication of UY31773A1 publication Critical patent/UY31773A1/en

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Se han caracterizado anticuerpos aislados que presentan una afinidad específica para el epítope conformacional repetido de una forma de protofibrilla del péptido B(Beta)-amiloide humano comparada con formas de bajo peso molecular del péptido B(Beta)-amiloide. Estos anticuerpos aislados y composiciones farmacéuticamente eficaces relacionadas pueden ser utiles en el tratamiento terapéutico y/o profiláctico de la enfermedad de Alzheimer bloqueando eficazmente la capacidad de la forma de protofibrilla del péptido B(Beta)-amiloide de formar formas de fibrillas vinculadas a complicaciones asociadas con la enfermedad de Alzheimer.Los anticuerpos aislados de la presente invencion también son utiles en diferentes ensayos de diagnostico y estuches asociados.Isolated antibodies have been characterized that have a specific affinity for the repeated conformational epitope of a protofibril form of the human B (Beta) -aminoid peptide compared to low molecular weight forms of the B (Beta) -aminoid peptide. These isolated antibodies and related pharmaceutically effective compositions may be useful in the therapeutic and / or prophylactic treatment of Alzheimer's disease by effectively blocking the ability of the protofibril form of peptide B (Beta) -aminoid to form fibril forms linked to associated complications. with Alzheimer's disease. The isolated antibodies of the present invention are also useful in different diagnostic assays and associated kits.

UY31773A 2009-04-17 2009-04-17 SPECIFIC ANTIBODIES FOR THE PROTEFIBRILL FORM OF THE BETA-AMILOID PROTEIN UY31773A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
UY31773A UY31773A1 (en) 2009-04-17 2009-04-17 SPECIFIC ANTIBODIES FOR THE PROTEFIBRILL FORM OF THE BETA-AMILOID PROTEIN

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
UY31773A UY31773A1 (en) 2009-04-17 2009-04-17 SPECIFIC ANTIBODIES FOR THE PROTEFIBRILL FORM OF THE BETA-AMILOID PROTEIN

Publications (1)

Publication Number Publication Date
UY31773A1 true UY31773A1 (en) 2009-05-29

Family

ID=40732198

Family Applications (1)

Application Number Title Priority Date Filing Date
UY31773A UY31773A1 (en) 2009-04-17 2009-04-17 SPECIFIC ANTIBODIES FOR THE PROTEFIBRILL FORM OF THE BETA-AMILOID PROTEIN

Country Status (1)

Country Link
UY (1) UY31773A1 (en)

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Legal Events

Date Code Title Description
109 Application deemed to be withdrawn

Effective date: 20200730