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UY31597A1 - Nuevos derivados de insulina con perfil tiempo/accion extremadamente retardado - Google Patents

Nuevos derivados de insulina con perfil tiempo/accion extremadamente retardado

Info

Publication number
UY31597A1
UY31597A1 UY031597A UY31597A UY31597A1 UY 31597 A1 UY31597 A1 UY 31597A1 UY 031597 A UY031597 A UY 031597A UY 31597 A UY31597 A UY 31597A UY 31597 A1 UY31597 A1 UY 31597A1
Authority
UY
Uruguay
Prior art keywords
action profile
delayed time
insulin derivatives
new insulin
extremely delayed
Prior art date
Application number
UY031597A
Other languages
English (en)
Inventor
Urlich Wernwr
Tschank Georg
Tennagels Norbert
Sommerfeld Mark
Seipke Gerhard
Gunter Muller
Roland Kurrle
Paul Habermann
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE102008003566A external-priority patent/DE102008003566A1/de
Priority claimed from DE200810025007 external-priority patent/DE102008025007A1/de
Application filed filed Critical
Publication of UY31597A1 publication Critical patent/UY31597A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102—Mutagenizing nucleic acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La invención se refiere a nuevos análogos de insulina con pefil basal de tiempo/acción, que se caracterizan por la adición y/o sustitución de residuos aminoácidos cargados negativa y positivamente, y una amidación del grupo carboxi C-terminal de la cadena B e histidina en la posición 8 de la cadena A de la insulina, a su preparación y uso.
UY031597A 2008-01-09 2009-01-07 Nuevos derivados de insulina con perfil tiempo/accion extremadamente retardado UY31597A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102008003566A DE102008003566A1 (de) 2008-01-09 2008-01-09 Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil
DE200810025007 DE102008025007A1 (de) 2008-05-24 2008-05-24 Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil

Publications (1)

Publication Number Publication Date
UY31597A1 true UY31597A1 (es) 2009-08-31

Family

ID=40473425

Family Applications (1)

Application Number Title Priority Date Filing Date
UY031597A UY31597A1 (es) 2008-01-09 2009-01-07 Nuevos derivados de insulina con perfil tiempo/accion extremadamente retardado

Country Status (20)

Country Link
US (1) US8633156B2 (es)
EP (1) EP2229406B1 (es)
JP (1) JP5695909B2 (es)
KR (1) KR20100111683A (es)
CN (1) CN101970476B (es)
AR (1) AR070119A1 (es)
AU (1) AU2009203810B2 (es)
BR (1) BRPI0907119A2 (es)
CA (1) CA2711752A1 (es)
CL (1) CL2009000018A1 (es)
CO (1) CO6290770A2 (es)
IL (1) IL206843A0 (es)
MA (1) MA31997B1 (es)
NZ (1) NZ586589A (es)
PA (1) PA8811501A1 (es)
PE (1) PE20091305A1 (es)
TW (1) TWI433681B (es)
UY (1) UY31597A1 (es)
WO (1) WO2009087082A2 (es)
ZA (1) ZA201003927B (es)

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AU2008365555B2 (en) 2008-12-15 2016-01-14 Zealand Pharma A/S Glucagon analogues
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AP3329A (en) 2009-07-13 2015-06-30 Zealand Pharma As Acylated glucagon analogues
WO2011058083A1 (de) 2009-11-13 2011-05-19 Sanofi-Aventis Deutschland Gmbh Pharmazeutische zusammensetzung umfassend einen glp-1-agonisten, ein insulin und methionin
SG10201500871TA (en) 2009-11-13 2015-04-29 Sanofi Aventis Deutschland Pharmaceutical composition comprising a glp-1 agonist and methionine
AR081975A1 (es) 2010-06-23 2012-10-31 Zealand Pharma As Analogos de glucagon
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KR20220025926A (ko) 2010-06-24 2022-03-03 베링거 인겔하임 인터내셔날 게엠베하 당뇨병 요법
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US20120283169A1 (en) 2010-11-08 2012-11-08 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof
WO2012098462A1 (en) 2011-01-20 2012-07-26 Zealand Pharma A/S Combination of acylated glucagon analogues with insulin analogues
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
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HRP20151068T1 (hr) 2011-08-29 2016-01-01 Sanofi-Aventis Deutschland Gmbh Farmaceutska kombinacija za upotrebu za glikemijsku kontrolu kod pacijenata s dijabetesom tipa 2
AR087744A1 (es) 2011-09-01 2014-04-16 Sanofi Aventis Deutschland Composicion farmaceutica para uso en el tratamiento de una enfermedad neurodegenerativa
WO2013164483A1 (en) 2012-05-03 2013-11-07 Zealand Pharma A/S Gip-glp-1 dual agonist compounds and methods
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TWI608013B (zh) 2012-09-17 2017-12-11 西蘭製藥公司 升糖素類似物
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US9988429B2 (en) 2013-10-17 2018-06-05 Zealand Pharma A/S Glucagon analogues
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US10131702B2 (en) 2013-11-06 2018-11-20 Zealand Pharma A/S Glucagon-GLP-1-GIP triple agonist compounds
EP3065767B1 (en) 2013-11-06 2020-12-30 Zealand Pharma A/S Gip-glp-1 dual agonist compounds and methods
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RU2016132340A (ru) 2014-01-09 2018-02-14 Санофи Стабилизированные фармацевтические составы на основе инсулина аспарта
MA43289B1 (fr) * 2014-01-20 2019-12-31 Hanmi Pharm Ind Co Ltd Insuline à action prolongée et utilisation associée
AR100639A1 (es) 2014-05-29 2016-10-19 Hanmi Pharm Ind Co Ltd Composición para tratar diabetes que comprende conjugados de análogos de insulina de acción prolongada y conjugados de péptidos insulinotrópicos de acción prolongada
TWI684458B (zh) 2014-05-30 2020-02-11 南韓商韓美藥品股份有限公司 包含胰島素及ｇｌｐ-１/昇糖素雙重促效劑之治療糖尿病之組成物
US10253078B2 (en) 2014-10-29 2019-04-09 Zealand Pharma A/S GIP agonist compounds and methods
TWI758239B (zh) 2014-12-12 2022-03-21 德商賽諾菲阿凡提斯德意志有限公司 甘精胰島素/利司那肽固定比率配製劑
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患之治療
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UY36870A (es) 2015-08-28 2017-03-31 Hanmi Pharm Ind Co Ltd Análogos de insulina novedosos
BR112019005637A2 (pt) * 2016-09-23 2019-07-30 Hanmi Pharm Ind Co Ltd análogos da insulina com afinidade reduzida para o receptor de insulina e seu uso
TWI798209B (zh) 2017-03-23 2023-04-11 南韓商韓美藥品股份有限公司 對胰島素受體有降低親和性之胰島素類似物之接合物及其用途
CN110615836B (zh) * 2018-06-20 2022-09-13 鲁南制药集团股份有限公司 一种利拉鲁肽的固相合成方法
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Also Published As

Publication number Publication date
CO6290770A2 (es) 2011-06-20
CA2711752A1 (en) 2009-07-16
HK1148542A1 (en) 2011-09-09
TWI433681B (zh) 2014-04-11
PE20091305A1 (es) 2009-09-26
NZ586589A (en) 2012-04-27
CN101970476B (zh) 2014-08-27
ZA201003927B (en) 2011-04-28
AU2009203810A1 (en) 2009-07-16
AR070119A1 (es) 2010-03-17
US8633156B2 (en) 2014-01-21
MA31997B1 (fr) 2011-01-03
EP2229406A2 (de) 2010-09-22
PA8811501A1 (es) 2009-09-17
CL2009000018A1 (es) 2009-06-05
EP2229406B1 (de) 2015-04-22
TW200942257A (en) 2009-10-16
KR20100111683A (ko) 2010-10-15
CN101970476A (zh) 2011-02-09
US20110173722A1 (en) 2011-07-14
AU2009203810B2 (en) 2013-07-25
JP2011509269A (ja) 2011-03-24
IL206843A0 (en) 2010-12-30
WO2009087082A3 (de) 2009-09-24
BRPI0907119A2 (pt) 2015-07-14
JP5695909B2 (ja) 2015-04-08
WO2009087082A2 (de) 2009-07-16

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