UY28191A1 - Heterociclos biciclicos, medicamentos que contienen estos compuestos, su utilización y procedimientos para su preparación. - Google Patents
Heterociclos biciclicos, medicamentos que contienen estos compuestos, su utilización y procedimientos para su preparación.Info
- Publication number
- UY28191A1 UY28191A1 UY28191A UY28191A UY28191A1 UY 28191 A1 UY28191 A1 UY 28191A1 UY 28191 A UY28191 A UY 28191A UY 28191 A UY28191 A UY 28191A UY 28191 A1 UY28191 A1 UY 28191A1
- Authority
- UY
- Uruguay
- Prior art keywords
- preparation
- diseases
- bicyclic
- heterocicles
- procedures
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 abstract 1
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 abstract 1
- 125000002618 bicyclic heterocycle group Chemical group 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 210000004072 lung Anatomy 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 235000005985 organic acids Nutrition 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 210000002345 respiratory system Anatomy 0.000 abstract 1
- 230000019491 signal transduction Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Otolaryngology (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
La presente invención se refiere a heterociclos biciclicos de fórmula general en la que Ra, Rb, Rc, Rd, Re y X se definen como en la reivindicación 1, sus tautómeros, sus estereosiómeros, sus mezclas y sus sales, en particular sus sales fisiológicamente compatibles con ácidos inorgánicos u orgánicos, los cuales poseen valiosas propiedades farmacológicas, en particular un efecto inhibidor sobre la transducción de senal proporcionada por las tirosinaquinasas, su uso para el tratamiento de enfermedades, en particular de enfermedades tumorales, así como de la hiperplasia benigna de la próstata (BPH), de enfermedades de los pulmones y de las vías respiratorias y su preparación.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10307165A DE10307165A1 (de) | 2003-02-20 | 2003-02-20 | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, ihre Verwendung und Verfahren zu ihrer Herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UY28191A1 true UY28191A1 (es) | 2004-09-30 |
Family
ID=32797568
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UY28191A UY28191A1 (es) | 2003-02-20 | 2004-02-18 | Heterociclos biciclicos, medicamentos que contienen estos compuestos, su utilización y procedimientos para su preparación. |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP1597240B1 (es) |
| JP (1) | JP4468305B2 (es) |
| KR (1) | KR20050103230A (es) |
| CN (1) | CN1751033A (es) |
| AR (1) | AR043249A1 (es) |
| AT (1) | ATE407929T1 (es) |
| AU (1) | AU2004213129A1 (es) |
| BR (1) | BRPI0407709A (es) |
| CA (1) | CA2516426A1 (es) |
| CL (1) | CL2004000284A1 (es) |
| DE (2) | DE10307165A1 (es) |
| ES (1) | ES2314374T3 (es) |
| MX (1) | MXPA05008780A (es) |
| NZ (1) | NZ542402A (es) |
| PE (1) | PE20040953A1 (es) |
| RU (1) | RU2005128826A (es) |
| TW (1) | TW200505912A (es) |
| UY (1) | UY28191A1 (es) |
| WO (1) | WO2004074263A1 (es) |
| ZA (1) | ZA200506121B (es) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MEP45508A (en) | 1999-06-21 | 2011-02-10 | Boehringer Ingelheim Pharma | Bicyclic heterocycles, medicaments containing these compounds, their use and methods for the production thereof |
| US7019012B2 (en) | 2000-12-20 | 2006-03-28 | Boehringer Ingelheim International Pharma Gmbh & Co. Kg | Quinazoline derivatives and pharmaceutical compositions containing them |
| AU2006288716A1 (en) | 2005-09-06 | 2007-03-15 | T.K. Signal Ltd. | Polyalkylene glycol derivatives of 4- (phenylamino)quinazolines useful as irreversible inhibitors of epidermal growth factor receptor tyrosine kinase |
| DK1948180T3 (da) | 2005-11-11 | 2013-05-27 | Boehringer Ingelheim Int | Kombinationsbehandling af cancer omfattende EGFR/HER2 inhibitorer |
| WO2007054550A1 (en) | 2005-11-11 | 2007-05-18 | Boehringer Ingelheim International Gmbh | Quinazoline derivatives for the treatment of cancer diseases |
| EP1981863B1 (en) | 2006-01-26 | 2012-10-10 | Boehringer Ingelheim International GmbH | Process for preparing aminocrotonylamino-substituted quinazoline derivatives |
| NZ576065A (en) | 2006-09-18 | 2011-12-22 | Boehringer Ingelheim Int | Method for treating cancer harboring egfr mutations |
| RU2012103492A (ru) * | 2009-07-02 | 2013-08-10 | Ньюджен Терапьютикс, Инк. | Содержащие фосфор соединения хиназолина и способы применения |
| PT2451445T (pt) | 2009-07-06 | 2019-07-10 | Boehringer Ingelheim Int | Processo para secagem de bibw2992, dos seus sais e de formulações farmacêuticas sólidas compreendendo este ingrediente ativo |
| CN102020639A (zh) | 2009-09-14 | 2011-04-20 | 上海恒瑞医药有限公司 | 6-氨基喹唑啉或3-氰基喹啉类衍生物、其制备方法及其在医药上的应用 |
| NO2608792T3 (es) | 2010-08-26 | 2018-03-10 | ||
| CN102675287A (zh) * | 2011-03-11 | 2012-09-19 | 江苏恒瑞医药股份有限公司 | (e)-n-[4-[[3-氯-4-(2-吡啶基甲氧基)苯基]氨基]-3-氰基-7-乙氧基-6-喹啉基]-3-[(2r)-1-甲基吡咯烷-2-基]丙-2-烯酰胺的可药用的盐、其制备方法及其在医药上的应用 |
| US8828391B2 (en) | 2011-05-17 | 2014-09-09 | Boehringer Ingelheim International Gmbh | Method for EGFR directed combination treatment of non-small cell lung cancer |
| WO2013135176A1 (zh) * | 2012-03-16 | 2013-09-19 | 苏州迈泰生物技术有限公司 | 氨基喹唑啉衍生物及其在制备抗恶性肿瘤药物中的用途 |
| KR20140093223A (ko) * | 2011-10-12 | 2014-07-25 | 텔리진 엘티디. | 키나제 억제제로서의 퀴나졸린 유도체 및 이의 사용 방법 |
| US20150368230A1 (en) | 2013-02-01 | 2015-12-24 | Boehringer Ingelheim International Gmbh | Radiolabeled quinazoline derivatives |
| US9242965B2 (en) | 2013-12-31 | 2016-01-26 | Boehringer Ingelheim International Gmbh | Process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form and use thereof for synthesis of EGFR tyrosine kinase inhibitors |
| US10710968B2 (en) | 2016-01-13 | 2020-07-14 | Hadasit Medical Research Services And Development Ltd. | Radiolabeled erlotinib analogs and uses thereof |
| TWI808958B (zh) | 2017-01-25 | 2023-07-21 | 美商特普醫葯公司 | 涉及二芳基巨環化合物之組合療法 |
| TWI820414B (zh) * | 2020-04-17 | 2023-11-01 | 大陸商北京賽特明強醫藥科技有限公司 | 喹唑啉類化合物、製備方法及其應用 |
| CN115806548B (zh) * | 2021-09-15 | 2024-10-11 | 甫康（上海）健康科技有限责任公司 | 含有egfr抑制剂的药物组合物及其制备方法和应用 |
| CN115894383B (zh) * | 2021-09-30 | 2025-12-19 | 北京赛特明强医药科技有限公司 | 一种喹唑啉类化合物、组合物及其应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19911509A1 (de) * | 1999-03-15 | 2000-09-21 | Boehringer Ingelheim Pharma | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| DE10042060A1 (de) * | 2000-08-26 | 2002-03-07 | Boehringer Ingelheim Pharma | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| DE10063435A1 (de) * | 2000-12-20 | 2002-07-04 | Boehringer Ingelheim Pharma | Chinazolinderviate,diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
-
2003
- 2003-02-20 DE DE10307165A patent/DE10307165A1/de not_active Withdrawn
-
2004
- 2004-02-14 AU AU2004213129A patent/AU2004213129A1/en not_active Abandoned
- 2004-02-14 DE DE502004008024T patent/DE502004008024D1/de not_active Expired - Lifetime
- 2004-02-14 NZ NZ542402A patent/NZ542402A/en unknown
- 2004-02-14 EP EP04711303A patent/EP1597240B1/de not_active Expired - Lifetime
- 2004-02-14 RU RU2005128826/04A patent/RU2005128826A/ru not_active Application Discontinuation
- 2004-02-14 KR KR1020057015218A patent/KR20050103230A/ko not_active Withdrawn
- 2004-02-14 BR BRPI0407709-1A patent/BRPI0407709A/pt not_active IP Right Cessation
- 2004-02-14 CA CA002516426A patent/CA2516426A1/en not_active Abandoned
- 2004-02-14 JP JP2005518423A patent/JP4468305B2/ja not_active Expired - Fee Related
- 2004-02-14 CN CNA2004800047746A patent/CN1751033A/zh active Pending
- 2004-02-14 AT AT04711303T patent/ATE407929T1/de active
- 2004-02-14 ES ES04711303T patent/ES2314374T3/es not_active Expired - Lifetime
- 2004-02-14 MX MXPA05008780A patent/MXPA05008780A/es not_active Application Discontinuation
- 2004-02-14 WO PCT/EP2004/001398 patent/WO2004074263A1/de not_active Ceased
- 2004-02-18 UY UY28191A patent/UY28191A1/es not_active Application Discontinuation
- 2004-02-18 PE PE2004000166A patent/PE20040953A1/es not_active Application Discontinuation
- 2004-02-18 TW TW093103966A patent/TW200505912A/zh unknown
- 2004-02-18 CL CL200400284A patent/CL2004000284A1/es unknown
- 2004-02-20 AR ARP040100540A patent/AR043249A1/es unknown
-
2005
- 2005-08-01 ZA ZA200506121A patent/ZA200506121B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TW200505912A (en) | 2005-02-16 |
| MXPA05008780A (es) | 2005-10-18 |
| WO2004074263A1 (de) | 2004-09-02 |
| KR20050103230A (ko) | 2005-10-27 |
| ATE407929T1 (de) | 2008-09-15 |
| DE10307165A1 (de) | 2004-09-02 |
| EP1597240A1 (de) | 2005-11-23 |
| JP4468305B2 (ja) | 2010-05-26 |
| ZA200506121B (en) | 2006-11-29 |
| PE20040953A1 (es) | 2005-01-20 |
| ES2314374T3 (es) | 2009-03-16 |
| DE502004008024D1 (de) | 2008-10-23 |
| BRPI0407709A (pt) | 2006-02-14 |
| NZ542402A (en) | 2008-09-26 |
| CN1751033A (zh) | 2006-03-22 |
| EP1597240B1 (de) | 2008-09-10 |
| RU2005128826A (ru) | 2006-08-27 |
| AU2004213129A1 (en) | 2004-09-02 |
| CL2004000284A1 (es) | 2005-01-14 |
| JP2006515005A (ja) | 2006-05-18 |
| CA2516426A1 (en) | 2004-09-02 |
| AR043249A1 (es) | 2005-07-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 109 | Application deemed to be withdrawn |
Effective date: 20140407 |