UY28484A1 - Compuestos para el tratamiento de trastornos neurodegenerativos - Google Patents
Compuestos para el tratamiento de trastornos neurodegenerativosInfo
- Publication number
- UY28484A1 UY28484A1 UY28484A UY28484A UY28484A1 UY 28484 A1 UY28484 A1 UY 28484A1 UY 28484 A UY28484 A UY 28484A UY 28484 A UY28484 A UY 28484A UY 28484 A1 UY28484 A1 UY 28484A1
- Authority
- UY
- Uruguay
- Prior art keywords
- compounds
- treatment
- neurodegenerative disorders
- formula
- relates
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 208000015122 neurodegenerative disease Diseases 0.000 title abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
- C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
- C07D285/135—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invención se relaciona con compuestos de Fórmula I en donde R3, R5, R7, U, X, Y y Z son como se definen. Los compuestos de Fórmula I presentn actividad inhibitoria de la producción de AB-péptidos. Esta invención también se relaciona con composiciones farmacéuticas y métodos para el tratamiento de enfermedades, por ejemplo, enfermedades neurodegenerativas como la enfermedad de Alzheimer, en un mamífero que comprende compuestos de Fórmula I.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49673503P | 2003-08-21 | 2003-08-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UY28484A1 true UY28484A1 (es) | 2005-03-31 |
Family
ID=34272502
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UY28484A UY28484A1 (es) | 2003-08-21 | 2004-08-20 | Compuestos para el tratamiento de trastornos neurodegenerativos |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US7253195B2 (es) |
| EP (1) | EP1658072A4 (es) |
| JP (1) | JP2007502828A (es) |
| AR (1) | AR045474A1 (es) |
| BR (1) | BRPI0413709A (es) |
| CA (1) | CA2534532A1 (es) |
| MX (1) | MXPA06001845A (es) |
| PA (1) | PA8609801A1 (es) |
| TW (1) | TW200526610A (es) |
| UY (1) | UY28484A1 (es) |
| WO (1) | WO2005020991A1 (es) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007502828A (ja) * | 2003-08-21 | 2007-02-15 | ファイザー・プロダクツ・インク | 神経変性性疾患の治療のための化合物 |
| US7763609B2 (en) | 2003-12-15 | 2010-07-27 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
| ATE399155T1 (de) * | 2004-03-23 | 2008-07-15 | Pfizer Prod Inc | Imidazolverbindungen zur behandlung von neurodegenerativen erkrankungen |
| US7232820B2 (en) | 2004-04-01 | 2007-06-19 | Pfizer Inc | Thiadiazole-amine compounds for the treatment of neurodegenerative disorders |
| ES2400689T3 (es) * | 2004-10-18 | 2013-04-11 | Amgen, Inc | Compuestos de tiadiazol y métodos de uso |
| EA200800659A1 (ru) * | 2005-09-22 | 2008-08-29 | Пфайзер Продактс Инк. | Соединения имидазола для лечения неврологических нарушений |
| GB0602335D0 (en) * | 2006-02-07 | 2006-03-15 | Remynd Nv | Thiadiazole Derivatives For The Treatment Of Neurodegenerative Diseases |
| US8541406B2 (en) | 2006-02-07 | 2013-09-24 | Nv Remynd | Thiadiazole derivatives for the treatment of neurodegenerative diseases |
| GB0623258D0 (en) | 2006-11-22 | 2007-01-03 | Remynd Nv | Thiadiazole derivatives for the treatment of neuro-degenerative diseases |
| GB0704394D0 (en) * | 2007-03-07 | 2007-04-11 | Senexis Ltd | Compounds |
| CA2692713A1 (en) | 2007-07-17 | 2009-01-22 | Amgen Inc. | Heterocyclic modulators of pkb |
| WO2009011871A2 (en) * | 2007-07-17 | 2009-01-22 | Amgen Inc. | Thiadiazole modulators of pkb |
| WO2010096371A2 (en) | 2009-02-18 | 2010-08-26 | Boehringer Ingelheim International Gmbh | Heterocyclic compounds which modulate the cb2 receptor |
| US8299103B2 (en) * | 2009-06-15 | 2012-10-30 | Boehringer Ingelheim International Gmbh | Compounds which selectively modulate the CB2 receptor |
| EP2523936A1 (en) | 2010-01-15 | 2012-11-21 | Boehringer Ingelheim International GmbH | Compounds which modulate the cb2 receptor |
| WO2012012307A1 (en) | 2010-07-22 | 2012-01-26 | Boehringer Ingelheim International Gmbh | Sulfonyl compounds which modulate the cb2 rece |
| UA110688C2 (uk) | 2012-09-21 | 2016-01-25 | Пфайзер Інк. | Біциклічні піридинони |
| WO2014122152A1 (en) | 2013-02-05 | 2014-08-14 | Basf Se | Process for preparing a titanium-containing zeolitic material having an mww framework structure |
| EP2803668A1 (en) | 2013-05-17 | 2014-11-19 | Boehringer Ingelheim International Gmbh | Novel (cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles |
| DK3253755T3 (da) | 2015-02-03 | 2020-09-28 | Pfizer | Hidtil ukendte cyclopropabenzofuranyl-pyridopyrazindioner |
| CN110869011B (zh) * | 2017-05-15 | 2024-01-05 | 考格尼申治疗股份有限公司 | 用于治疗神经退行性疾病的组合物 |
| CA3159633A1 (en) * | 2019-11-05 | 2021-05-14 | Dermira, Inc. | Mrgprx2 antagonists and uses thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE233251T1 (de) * | 1996-06-21 | 2003-03-15 | Upjohn Co | Mmp-hemmende thiadiazolylamide |
| US6323315B1 (en) * | 1999-09-10 | 2001-11-27 | Basf Aktiengesellschaft | Dolastatin peptides |
| DE10019755A1 (de) * | 2000-04-20 | 2001-11-08 | Bayer Ag | Neue Aminoaryl/cycloalkylcarbonsäuren als Integrinantagonisten |
| JP2007502828A (ja) * | 2003-08-21 | 2007-02-15 | ファイザー・プロダクツ・インク | 神経変性性疾患の治療のための化合物 |
-
2004
- 2004-08-18 JP JP2006524019A patent/JP2007502828A/ja not_active Withdrawn
- 2004-08-18 BR BRPI0413709-4A patent/BRPI0413709A/pt not_active IP Right Cessation
- 2004-08-18 WO PCT/US2004/026854 patent/WO2005020991A1/en not_active Ceased
- 2004-08-18 MX MXPA06001845A patent/MXPA06001845A/es active IP Right Grant
- 2004-08-18 CA CA002534532A patent/CA2534532A1/en not_active Abandoned
- 2004-08-18 EP EP04781522A patent/EP1658072A4/en not_active Withdrawn
- 2004-08-20 UY UY28484A patent/UY28484A1/es not_active Application Discontinuation
- 2004-08-20 TW TW093125231A patent/TW200526610A/zh unknown
- 2004-08-20 PA PA20048609801A patent/PA8609801A1/es unknown
- 2004-08-20 US US10/922,425 patent/US7253195B2/en not_active Expired - Fee Related
- 2004-08-23 AR ARP040103015A patent/AR045474A1/es unknown
-
2007
- 2007-07-17 US US11/778,773 patent/US7408068B2/en not_active Expired - Fee Related
-
2008
- 2008-06-18 US US12/141,212 patent/US20080249094A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US7253195B2 (en) | 2007-08-07 |
| EP1658072A4 (en) | 2009-03-25 |
| TW200526610A (en) | 2005-08-16 |
| US20070270426A1 (en) | 2007-11-22 |
| AR045474A1 (es) | 2005-10-26 |
| US20080249094A1 (en) | 2008-10-09 |
| PA8609801A1 (es) | 2005-05-24 |
| BRPI0413709A (pt) | 2006-10-17 |
| JP2007502828A (ja) | 2007-02-15 |
| CA2534532A1 (en) | 2005-03-10 |
| MXPA06001845A (es) | 2006-05-04 |
| WO2005020991A1 (en) | 2005-03-10 |
| US7408068B2 (en) | 2008-08-05 |
| US20050043372A1 (en) | 2005-02-24 |
| EP1658072A1 (en) | 2006-05-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 109 | Application deemed to be withdrawn |
Effective date: 20150608 |