[go: up one dir, main page]

UY26908A1 - PROCESS FOR THE MANUFACTURE OF N - ARYL - ANTHRANILIC ACIDS AND THEIR DERIVATIVES - Google Patents

PROCESS FOR THE MANUFACTURE OF N - ARYL - ANTHRANILIC ACIDS AND THEIR DERIVATIVES

Info

Publication number
UY26908A1
UY26908A1 UY26908A UY26908A UY26908A1 UY 26908 A1 UY26908 A1 UY 26908A1 UY 26908 A UY26908 A UY 26908A UY 26908 A UY26908 A UY 26908A UY 26908 A1 UY26908 A1 UY 26908A1
Authority
UY
Uruguay
Prior art keywords
aryl
derivatives
manufacture
anthranilic acids
preparation
Prior art date
Application number
UY26908A
Other languages
Spanish (es)
Inventor
Edward Mark Davis
Javier Magano
Thomas Norman Nanninga
Derick Winkle
Michael Huai Gu Chen
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of UY26908A1 publication Critical patent/UY26908A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/10—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04—Formation of amino groups in compounds containing carboxyl groups
    • C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
    • C07C227/08—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid by reaction of ammonia or amines with acids containing functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyridine Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

La presente invención se relaciona con un proceso para la preparación de ácidos N-arilantranílicos, y con un proceso para la preparación de esteres N-antranílicos, amidas, y esteres hidroxamicos.The present invention relates to a process for the preparation of N-arylanthranilic acids, and to a process for the preparation of N-anthranilyl esters, amides, and hydroxamic esters.

UY26908A 2000-08-25 2001-08-24 PROCESS FOR THE MANUFACTURE OF N - ARYL - ANTHRANILIC ACIDS AND THEIR DERIVATIVES UY26908A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US22820600P 2000-08-25 2000-08-25

Publications (1)

Publication Number Publication Date
UY26908A1 true UY26908A1 (en) 2001-11-30

Family

ID=22856235

Family Applications (1)

Application Number Title Priority Date Filing Date
UY26908A UY26908A1 (en) 2000-08-25 2001-08-24 PROCESS FOR THE MANUFACTURE OF N - ARYL - ANTHRANILIC ACIDS AND THEIR DERIVATIVES

Country Status (31)

Country Link
EP (1) EP1313694A1 (en)
JP (1) JP2004507518A (en)
KR (1) KR20030059115A (en)
CN (1) CN1458921A (en)
AP (1) AP2001002249A0 (en)
AR (1) AR032175A1 (en)
AU (1) AU2001277044A1 (en)
BG (1) BG107635A (en)
BR (1) BR0113520A (en)
CA (1) CA2420003A1 (en)
CZ (1) CZ2003477A3 (en)
DO (1) DOP2001000238A (en)
EA (1) EA200300187A1 (en)
GT (1) GT200100174A (en)
HN (1) HN2001000216A (en)
HU (1) HUP0300828A2 (en)
IL (1) IL154507A0 (en)
IS (1) IS6724A (en)
MA (1) MA26949A1 (en)
MX (1) MXPA03001654A (en)
NO (1) NO20030844L (en)
PA (1) PA8526501A1 (en)
PE (1) PE20020393A1 (en)
PL (1) PL360699A1 (en)
SK (1) SK2072003A3 (en)
SV (1) SV2002000601A (en)
TN (1) TNSN01127A1 (en)
UY (1) UY26908A1 (en)
WO (1) WO2002018319A1 (en)
YU (1) YU14303A (en)
ZA (1) ZA200301182B (en)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2275102T1 (en) 2002-03-13 2015-12-31 Array Biopharma, Inc. N3 alkylated benzimidazole derivatives as MEK inhibitors
US7235537B2 (en) 2002-03-13 2007-06-26 Array Biopharma, Inc. N3 alkylated benzimidazole derivatives as MEK inhibitors
US7538120B2 (en) 2003-09-03 2009-05-26 Array Biopharma Inc. Method of treating inflammatory diseases
US7144907B2 (en) 2003-09-03 2006-12-05 Array Biopharma Inc. Heterocyclic inhibitors of MEK and methods of use thereof
NZ546011A (en) 2003-10-21 2009-09-25 Warner Lambert Co Polymorphic form of N-[(R)-2,3-dihydroxy-propoxy]-3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-benzamide
EP2251327B1 (en) 2003-11-19 2014-02-12 Array Biopharma, Inc. Heterocyclic inhibitors of mek
US7732616B2 (en) 2003-11-19 2010-06-08 Array Biopharma Inc. Dihydropyridine and dihydropyridazine derivatives as inhibitors of MEK and methods of use thereof
US7517994B2 (en) 2003-11-19 2009-04-14 Array Biopharma Inc. Heterocyclic inhibitors of MEK and methods of use thereof
US20050130954A1 (en) 2003-11-21 2005-06-16 Mitchell Ian S. AKT protein kinase inhibitors
UA89035C2 (en) * 2003-12-03 2009-12-25 Лео Фарма А/С Hydroxamic acid esters and pharmaceutical use thereof
WO2006109075A2 (en) 2005-04-13 2006-10-19 Astex Therapeutics Limited Hydroxybenzamide derivatives and their use as inhibitors of hsp90
EP2361905B1 (en) 2005-05-18 2013-03-06 Array Biopharma Inc. Heterocyclic Inhibitors of MEK and methods of use thereof
US7754725B2 (en) 2006-03-01 2010-07-13 Astex Therapeutics Ltd. Dihydroxyphenyl isoindolymethanones
WO2008006039A1 (en) 2006-07-06 2008-01-10 Array Biopharma Inc. Dihydrothieno pyrimidines as akt protein kinase inhibitors
ES2372955T3 (en) 2006-07-06 2012-01-30 Array Biopharma, Inc. CICLOPENTA [D] PYRIMIDINS AS INHIBITORS OF THE PROTEIN CINASA AKT.
CA2656566C (en) 2006-07-06 2014-06-17 Array Biopharma Inc. Dihydrofuro pyrimidines as akt protein kinase inhibitors
US8063050B2 (en) 2006-07-06 2011-11-22 Array Biopharma Inc. Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
GB0620259D0 (en) 2006-10-12 2006-11-22 Astex Therapeutics Ltd Pharmaceutical compounds
WO2008044029A1 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Pharmaceutical combinations
EP2073804B1 (en) 2006-10-12 2017-09-13 Astex Therapeutics Limited Hydroxy-substituted benzoic acid amide compounds for use in the treatment of pain
WO2008044045A1 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Pharmaceutical combinations
EP2073803B1 (en) 2006-10-12 2018-09-19 Astex Therapeutics Limited Pharmaceutical combinations
JP5410285B2 (en) 2006-10-12 2014-02-05 アステックス、セラピューティックス、リミテッド Pharmaceutical compounds
US9409886B2 (en) 2007-07-05 2016-08-09 Array Biopharma Inc. Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
KR20150089099A (en) 2007-07-05 2015-08-04 어레이 바이오파마 인크. Pyrimidyl cyclopentanes as akt protein kinase inhibitors
US8846683B2 (en) 2007-07-05 2014-09-30 Array Biopharma, Inc. Pyrimidyl cyclopentanes as Akt protein kinase inhibitors
JP5542282B2 (en) 2007-07-05 2014-07-09 アレイ バイオファーマ、インコーポレイテッド Pyrimidylcyclopentane as an AKT protein kinase inhibitor
US8835434B2 (en) 2008-01-09 2014-09-16 Array Biopharma, Inc. Hydroxylated pyrimidyl cyclopentanes as akt protein kinase inhibitors
JP5539225B2 (en) 2008-01-09 2014-07-02 アレイ バイオファーマ、インコーポレイテッド Hydroxylated pyrimidylcyclopentane as an AKT protein kinase inhibitor
GB0806527D0 (en) 2008-04-11 2008-05-14 Astex Therapeutics Ltd Pharmaceutical compounds
CN101985428B (en) * 2009-07-29 2014-02-12 杭州民生药业有限公司 O-anilino benzoic acid derivatives or pharmaceutically acceptable salts thereof as well as preparation method and application thereof
CN102985399A (en) * 2010-02-19 2013-03-20 国家科学研究中心 Method for preparing chemical compounds of interest by nucleophilic aromatic substitution of aromatic carboxylic acid derivatives supporting at least one electro-attractive group
EP2536683A1 (en) * 2010-02-19 2012-12-26 Centre National De La Recherche Scientifique Method for preparing chemical compounds of interest by aromatic nucleophilic substitution
RU2013148817A (en) 2011-04-01 2015-05-10 Дженентек, Инк. COMBINATIONS OF ACT AND MEK INHIBITOR COMPOUNDS AND WAYS OF THEIR APPLICATION
WO2012135753A1 (en) 2011-04-01 2012-10-04 Genentech, Inc. Combinations of akt inhibitor compounds and erlotinib, and methods of use
BR112015008113B1 (en) * 2012-10-12 2022-05-24 Exelixis, Inc. New process to prepare compounds for use in cancer treatment
CN112745237B (en) * 2019-10-29 2023-06-20 中国科学院上海药物研究所 2-arylamine compound and its preparation method and application
CN119948008A (en) * 2022-07-15 2025-05-06 南方科技大学 A method for preparing condensed ring aromatic amines using isonitrile and cyclopropene as raw materials

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3138636A (en) * 1960-06-23 1964-06-23 Parke Davis & Co Anthranilic acid derivatives
US6251943B1 (en) * 1997-02-28 2001-06-26 Warner-Lambert Company Method of treating or preventing septic shock by administering a MEK inhibitor
AU756586C (en) * 1997-07-01 2004-01-29 Warner-Lambert Company 2-(4-bromo or 4-iodo phenylamino) benzoic acid derivatives and their use as MEK inhibitors
IL132840A (en) * 1997-07-01 2004-12-15 Warner Lambert Co 4-bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and pharmaceutical compositions comprising them for use as mek inhibitors
CA2348236A1 (en) * 1999-01-13 2000-07-20 Stephen Douglas Barrett 4-arylamino, 4-aryloxy, and 4-arylthio diarylamines and derivatives thereof as selective mek inhibitors
KR20010108521A (en) * 1999-04-21 2001-12-07 로즈 암스트롱, 크리스틴 에이. 트러트웨인 Method for Making 2-(N-phenylamino)benzoic Acids

Also Published As

Publication number Publication date
JP2004507518A (en) 2004-03-11
BR0113520A (en) 2003-06-24
YU14303A (en) 2006-08-17
SK2072003A3 (en) 2004-01-08
WO2002018319A1 (en) 2002-03-07
IL154507A0 (en) 2003-09-17
HUP0300828A2 (en) 2003-09-29
BG107635A (en) 2004-09-30
PL360699A1 (en) 2004-09-20
HN2001000216A (en) 2002-05-22
AP2001002249A0 (en) 2001-09-30
CZ2003477A3 (en) 2003-10-15
NO20030844D0 (en) 2003-02-24
IS6724A (en) 2003-02-20
PE20020393A1 (en) 2002-05-09
AU2001277044A1 (en) 2002-03-13
TNSN01127A1 (en) 2005-11-10
EP1313694A1 (en) 2003-05-28
DOP2001000238A (en) 2003-01-31
SV2002000601A (en) 2002-04-03
MXPA03001654A (en) 2004-09-10
EA200300187A1 (en) 2003-08-28
CN1458921A (en) 2003-11-26
ZA200301182B (en) 2004-05-12
KR20030059115A (en) 2003-07-07
GT200100174A (en) 2002-07-18
AR032175A1 (en) 2003-10-29
PA8526501A1 (en) 2002-07-30
NO20030844L (en) 2003-02-25
CA2420003A1 (en) 2002-03-07
MA26949A1 (en) 2004-12-20

Similar Documents

Publication Publication Date Title
UY26908A1 (en) PROCESS FOR THE MANUFACTURE OF N - ARYL - ANTHRANILIC ACIDS AND THEIR DERIVATIVES
ECSP095220A (en) DERIVATIVES OF N-FENIL-2-PIRIMIDIN-AMINA
HN1999000072A (en) STABILIZED PHARMACEUTICAL PREPARATIONS FOR GABA PENTINA AND PROCESS FOR PREPARING IT.
HN1998000020A (en) ARILSULFONYL HYDROXAMIC ACID DERIVATIVES.
BR0112584A (en) oxygenated esters of 4-iodophenylamino benzhydroxamic acids
BR0115482A (en) Improved sacralose composition and process for its preparation
BR0013885A (en) Perfected tablets
TR200003315T2 (en) New pharmaceutical composition suitable for emergency use and its preparation method
CU22953A3 (en) PROCEDURE FOR THE PREPARATION OF 8-METOXYCHINOLONCARBOXYLIC ACIDS
DE60038560D1 (en) Process for the fermentative production of L-arginine
BR0212772A (en) Process for the preparation of repaglinide
JO2249B1 (en) Synthesis of 3,6-dialkyl-5,6-dihdro-4-hydroxy-2h-pyran-2-one
BR0212390A (en) Process for the preparation of cilastatin
ATE365036T1 (en) CREATINESTER PRONUTRIENT COMPOUNDS AND FORMULATIONS
DE60141311D1 (en) Process for the production of diaphragms
NO20014885D0 (en) Process for the preparation of an amide compound
CY1105526T1 (en) SYNTHESIS PROCEDURE AND INTERMEDIATES OF PYRIDIN-2-YL-METHYNAMINE
ID24138A (en) FERMENTATIVE PRODUCTION PROCESS OF L-AMINO ACIDS
PT1001929E (en) PROCESS FOR THE MANUFACTURE OF 3-CYANO-2,4-DIHALOGENE-5-FLUOROBENZOIC ACIDS
DE50114758D1 (en) PROCESS FOR THE PRODUCTION OF INDOLES
BRPI0113727B8 (en) PROCESS FOR THE PRODUCTION OF HALO-4-PHENOXYQUINOLINES.
DE50102835D1 (en) METHOD FOR THE PRODUCTION OF DINITRODIAZAALKANES AND INTERMEDIATE PRODUCTS THEREFOR
BG104964A (en) IMPROVED METHOD FOR PREPARING PHARMACEUTICAL VALUES OF NORBEZOMORPHORINE DERIVATIVES
NO20020328L (en) Process for the preparation of 4-cyano-2-aminomethylthiazole
HN1999000042A (en) PROCEDURE FOR THE PREPARATION OF HYDROXAMIC ACIDS

Legal Events

Date Code Title Description
109 Application deemed to be withdrawn

Effective date: 20141001