UY25144A1 - DERIVATIVES OF 2- (4-ARIL OR HETEROARIL-PIPERAZIN-1-ILMETIL) -1H -INDOL - Google Patents
DERIVATIVES OF 2- (4-ARIL OR HETEROARIL-PIPERAZIN-1-ILMETIL) -1H -INDOLInfo
- Publication number
- UY25144A1 UY25144A1 UY25144A UY25144A UY25144A1 UY 25144 A1 UY25144 A1 UY 25144A1 UY 25144 A UY25144 A UY 25144A UY 25144 A UY25144 A UY 25144A UY 25144 A1 UY25144 A1 UY 25144A1
- Authority
- UY
- Uruguay
- Prior art keywords
- alkyl
- trifluoromethyl
- dopamine
- piperazin
- mammal
- Prior art date
Links
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 abstract 4
- 241000124008 Mammalia Species 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 229960003638 dopamine Drugs 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- HHOWJZHPIBYIAE-UHFFFAOYSA-N 2-[[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]methyl]-1h-indole Chemical compound FC(F)(F)C1=CC=CC(N2CCN(CC=3NC4=CC=CC=C4C=3)CC2)=C1 HHOWJZHPIBYIAE-UHFFFAOYSA-N 0.000 abstract 1
- 101100495911 Arabidopsis thaliana CHR10 gene Proteins 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 102000003962 Dopamine D4 receptors Human genes 0.000 abstract 1
- 108090000357 Dopamine D4 receptors Proteins 0.000 abstract 1
- 208000028017 Psychotic disease Diseases 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 230000002526 effect on cardiovascular system Effects 0.000 abstract 1
- 208000030533 eye disease Diseases 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- 239000000018 receptor agonist Substances 0.000 abstract 1
- 229940044601 receptor agonist Drugs 0.000 abstract 1
- 208000019116 sleep disease Diseases 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
- 230000002792 vascular Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Addiction (AREA)
- Anesthesiology (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
Se trata de compuestos de fórmula l (como por ejemplo: 2-[4-(3-trifluorometil-fenil)-piperazin-1-ilmetil]-1H-indol) o la sal farmacéuticamente aceptable del mismo, donde la lines discontinua representa un doble enlace opcional; a es 0 ó 1 cuando a es 0, X puede formar un doble enlace opcional con el carbono adyacente a V; T es N ó CH; V es CHR10; X es N o CR11; Y, Z pueden ser N ó CR12;. R1 es H, F, Cl, Br, trifluorometilo, trifluorometoxi, CN, o alquilo; R2, R6, R7, R8 y R9 están cada uno de ellos seleccionados entre H, F, Cl, CN, alquilo ó alcoxilo; R3 y R4 significan H ó alquilo y R5 es H, alcoxi, trifluorometilo, CN, alquilo o R13CO. Un procedimiento para tratar un trastorno del sistema de dopamina en un mamifero,el cual incluye trastornos psicóticos, del movimiento, gastrointestinales, abuso de sustancias químicas, trastornos vasculares y cardiovasculares, oculares y del sueno, que comprende la administración a dicho mamifero de un cantidad de un compuesto selectivo del receptor D4 de dopamina o una sal farmacéuticamente aceptable del mismo, junto con uno o más agonistas del receptor D1, D3, o D5 de la dopamina, que es eficaz para dicho trastorno.These are compounds of formula l (such as: 2- [4- (3-trifluoromethyl-phenyl) -piperazin-1-ylmethyl] -1H-indole) or the pharmaceutically acceptable salt thereof, where the dashed lines represent a optional double bond; a is 0 or 1 when a is 0, X can form an optional double bond with the carbon adjacent to V; T is N or CH; V is CHR10; X is N or CR11; Y, Z can be N or CR12 ;. R1 is H, F, Cl, Br, trifluoromethyl, trifluoromethoxy, CN, or alkyl; R2, R6, R7, R8 and R9 are each selected from H, F, Cl, CN, alkyl or alkoxy; R3 and R4 signify H or alkyl and R5 is H, alkoxy, trifluoromethyl, CN, alkyl or R13CO. A method of treating a disorder of the dopamine system in a mammal, which includes psychotic, movement, gastrointestinal, chemical abuse, vascular and cardiovascular, eye and sleep disorders, comprising administering to said mammal an amount of a dopamine D4 receptor selective compound or a pharmaceutically acceptable salt thereof, together with one or more dopamine D1, D3, or D5 receptor agonists, which is effective for said disorder.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5576497P | 1997-08-15 | 1997-08-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UY25144A1 true UY25144A1 (en) | 2000-12-29 |
Family
ID=22000003
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UY25144A UY25144A1 (en) | 1997-08-15 | 1998-08-17 | DERIVATIVES OF 2- (4-ARIL OR HETEROARIL-PIPERAZIN-1-ILMETIL) -1H -INDOL |
Country Status (30)
| Country | Link |
|---|---|
| EP (1) | EP1003739A2 (en) |
| JP (1) | JP2002536291A (en) |
| KR (1) | KR20010022507A (en) |
| CN (1) | CN1265660A (en) |
| AP (1) | AP9801321A0 (en) |
| AR (1) | AR017019A1 (en) |
| AU (1) | AU8457298A (en) |
| BG (1) | BG104069A (en) |
| BR (1) | BR9811557A (en) |
| CA (1) | CA2297486C (en) |
| CO (1) | CO4960656A1 (en) |
| DZ (1) | DZ2583A1 (en) |
| EA (1) | EA200000023A1 (en) |
| HR (1) | HRP980441A2 (en) |
| HU (1) | HUP0003425A3 (en) |
| ID (1) | ID23803A (en) |
| IL (1) | IL133960A0 (en) |
| IS (1) | IS5336A (en) |
| MA (1) | MA24632A1 (en) |
| NO (1) | NO20000722D0 (en) |
| OA (1) | OA11286A (en) |
| PA (1) | PA8457001A1 (en) |
| PE (1) | PE106299A1 (en) |
| PL (1) | PL338947A1 (en) |
| SK (1) | SK1352000A3 (en) |
| TN (1) | TNSN98151A1 (en) |
| TR (1) | TR200000414T2 (en) |
| UY (1) | UY25144A1 (en) |
| WO (1) | WO1999009025A2 (en) |
| ZA (1) | ZA987304B (en) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EE04588B1 (en) * | 1997-10-27 | 2006-02-15 | Neurosearch A/S | Heteroaryl diazacycloalkanes as cholinergic ligands for acetylcholine nicotine receptors, their use as pharmaceuticals and pharmaceutical composition containing them |
| EP0953567A3 (en) * | 1998-04-29 | 2003-04-02 | Pfizer Products Inc. | Bicyclic substituted piperazine-, piperidine- and tetrahydropyridine derivatives, their preparation and their use as agents with central dopaminergic (dopamine D4 receptor) activity |
| DE60011817T2 (en) | 1999-12-30 | 2005-07-14 | H. Lundbeck A/S | 4-PHENYL-1-PIPERAZINYL, -PIPERIDINYL AND -ETRAHYDROPYRIDYL DERIVATIVES |
| GB0017952D0 (en) * | 2000-07-22 | 2000-09-13 | Univ Manchester | Treatment of dyskinesia |
| EP1177792A3 (en) | 2000-07-27 | 2002-10-23 | Pfizer Products Inc. | Dopamine D4 Ligands for the treatment of novelty-seeking disorders |
| US6803362B2 (en) | 2001-03-09 | 2004-10-12 | Ortho-Mcneil Pharmaceutical Inc. | Heterocyclic compounds |
| PL377087A1 (en) | 2002-09-06 | 2006-01-23 | Janssen Pharmaceutica, N.V. | Heterocyclic compounds |
| WO2004108671A1 (en) * | 2003-06-06 | 2004-12-16 | Suven Life Sciences Limited | Substituted indoles with serotonin receptor affinity, process for their preparation and pharmaceutical compositions containing them |
| EP1731505B1 (en) | 2004-03-30 | 2015-01-14 | Takeda Pharmaceutical Company Limited | Alkoxyphenylpropanoic acid derivatives |
| US7618980B2 (en) | 2004-07-14 | 2009-11-17 | Bristol-Myers Squibb Company | Pyrrolo(oxo)quinolines as 5HT ligands |
| US7572805B2 (en) | 2004-07-14 | 2009-08-11 | Bristol-Myers Squibb Company | Pyrrolo(oxo)isoquinolines as 5HT ligands |
| JO2769B1 (en) | 2005-10-26 | 2014-03-15 | جانسين فارماسوتيكا ان. في | Fast Dissociting Dopamine 2 Receptor Antagonists |
| JO2642B1 (en) * | 2006-12-08 | 2012-06-17 | جانسين فارماسوتيكا ان. في | Fast Dissociating Dopamine 2 Receptor Antagonists |
| JO2849B1 (en) * | 2007-02-13 | 2015-03-15 | جانسين فارماسوتيكا ان. في | Fast -Dissociating Dopamine 2 Receptor Antagonists |
| MX2009011416A (en) | 2007-04-23 | 2009-11-05 | Janssen Pharmaceutica Nv | Thia(dia)zoles as fast dissociating dopamine 2 receptor antagonists. |
| CN101663292A (en) | 2007-04-23 | 2010-03-03 | 詹森药业有限公司 | 4-Alkoxypyridazine derivatives as rapidly dissociating dopamine 2 receptor antagonists |
| BRPI0915834A2 (en) | 2008-07-03 | 2015-11-03 | Janssen Pharmaceutica Nv | Substituted 6- (1-piperazinyl) -pyridazines as 5-ht6 receptor antagonists |
| AU2009275887B2 (en) | 2008-07-31 | 2013-06-20 | Janssen Pharmaceutica Nv | Piperazin-1-yl-trifluoromethyl-substituted-pyridines as fast dissociating dopamine 2 receptor antagonists |
| CN109843872B (en) * | 2017-09-20 | 2022-08-30 | 杭州英创医药科技有限公司 | Polycyclic compounds as IDO inhibitors and/or IDO-HDAC dual inhibitors |
| WO2021216665A1 (en) * | 2020-04-22 | 2021-10-28 | Anima Biotech Inc. | Collagen 1 translation inhibitors and methods of use thereof |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB944443A (en) * | 1959-09-25 | 1900-01-01 | ||
| ATE148464T1 (en) * | 1991-07-03 | 1997-02-15 | Upjohn Co | SUBSTITUTED INDOLES AS ANTI-AIDS PHARMACEUTICAL PREPARATIONS |
| JPH05255089A (en) * | 1991-12-18 | 1993-10-05 | Sanwa Kagaku Kenkyusho Co Ltd | Antiviral agent |
| JPH08502958A (en) * | 1992-10-23 | 1996-04-02 | メルク シヤープ エンド ドーム リミテツド | Dopamine receptor subtype ligand |
| GB9305644D0 (en) * | 1993-03-18 | 1993-05-05 | Merck Sharp & Dohme | Therapeutic agents |
| US5576336A (en) * | 1993-03-18 | 1996-11-19 | Merck Sharp & Dohme Limited | Indole derivatives as dopamine D4 antagonists |
| US5814644A (en) * | 1993-04-15 | 1998-09-29 | Merck Sharp & Dohme, Ltd. | Indole derivatives as dopamine D4 antagonists |
| DE4414113A1 (en) * | 1994-04-22 | 1995-10-26 | Merck Patent Gmbh | 3-indolylpiperidines |
| TW406075B (en) * | 1994-12-13 | 2000-09-21 | Upjohn Co | Alkyl substituted piperidinyl and piperazinyl anti-AIDS compounds |
| ZA968661B (en) * | 1995-11-17 | 1998-04-14 | Upjohn Co | Oxazolidinone antibacterial agent with tricyclic substituents. |
| TW504510B (en) * | 1996-05-10 | 2002-10-01 | Janssen Pharmaceutica Nv | 2,4-diaminopyrimidine derivatives |
-
1998
- 1998-08-05 IL IL13396098A patent/IL133960A0/en unknown
- 1998-08-05 AU AU84572/98A patent/AU8457298A/en not_active Abandoned
- 1998-08-05 CN CN98807831A patent/CN1265660A/en active Pending
- 1998-08-05 BR BR9811557-0A patent/BR9811557A/en not_active IP Right Cessation
- 1998-08-05 JP JP2000509706A patent/JP2002536291A/en active Pending
- 1998-08-05 EA EA200000023A patent/EA200000023A1/en unknown
- 1998-08-05 AP APAP/P/1998/001321A patent/AP9801321A0/en unknown
- 1998-08-05 EP EP98935229A patent/EP1003739A2/en not_active Withdrawn
- 1998-08-05 PL PL98338947A patent/PL338947A1/en unknown
- 1998-08-05 KR KR1020007001093A patent/KR20010022507A/en not_active Ceased
- 1998-08-05 HU HU0003425A patent/HUP0003425A3/en unknown
- 1998-08-05 WO PCT/IB1998/001198 patent/WO1999009025A2/en not_active Ceased
- 1998-08-05 CA CA002297486A patent/CA2297486C/en not_active Expired - Fee Related
- 1998-08-05 SK SK135-2000A patent/SK1352000A3/en unknown
- 1998-08-05 ID IDW20000197A patent/ID23803A/en unknown
- 1998-08-05 TR TR2000/00414T patent/TR200000414T2/en unknown
- 1998-08-10 PE PE1998000717A patent/PE106299A1/en not_active Application Discontinuation
- 1998-08-10 PA PA19988457001A patent/PA8457001A1/en unknown
- 1998-08-12 MA MA25210A patent/MA24632A1/en unknown
- 1998-08-12 DZ DZ980193A patent/DZ2583A1/en active
- 1998-08-12 TN TNTNSN98151A patent/TNSN98151A1/en unknown
- 1998-08-13 AR ARP980104021A patent/AR017019A1/en unknown
- 1998-08-14 CO CO98046788A patent/CO4960656A1/en unknown
- 1998-08-14 HR HR60/055,764A patent/HRP980441A2/en not_active Application Discontinuation
- 1998-08-14 ZA ZA9807304A patent/ZA987304B/en unknown
- 1998-08-17 UY UY25144A patent/UY25144A1/en not_active Application Discontinuation
-
2000
- 2000-01-10 BG BG104069A patent/BG104069A/en unknown
- 2000-01-11 IS IS5336A patent/IS5336A/en unknown
- 2000-02-08 OA OA1200000030A patent/OA11286A/en unknown
- 2000-02-14 NO NO20000722A patent/NO20000722D0/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| HRP980441A2 (en) | 1999-04-30 |
| WO1999009025A3 (en) | 1999-04-15 |
| IL133960A0 (en) | 2001-04-30 |
| NO20000722L (en) | 2000-02-14 |
| SK1352000A3 (en) | 2000-08-14 |
| AR017019A1 (en) | 2001-08-22 |
| CN1265660A (en) | 2000-09-06 |
| IS5336A (en) | 2000-01-11 |
| PE106299A1 (en) | 1999-11-02 |
| ZA987304B (en) | 2000-02-14 |
| OA11286A (en) | 2003-10-22 |
| HUP0003425A2 (en) | 2001-10-28 |
| JP2002536291A (en) | 2002-10-29 |
| EP1003739A2 (en) | 2000-05-31 |
| CO4960656A1 (en) | 2000-09-25 |
| EA200000023A1 (en) | 2000-08-28 |
| NO20000722D0 (en) | 2000-02-14 |
| DZ2583A1 (en) | 2003-02-22 |
| AU8457298A (en) | 1999-03-08 |
| BR9811557A (en) | 2000-08-22 |
| PL338947A1 (en) | 2000-12-04 |
| TR200000414T2 (en) | 2000-08-21 |
| CA2297486C (en) | 2005-05-03 |
| KR20010022507A (en) | 2001-03-15 |
| AP9801321A0 (en) | 2000-02-14 |
| WO1999009025A2 (en) | 1999-02-25 |
| ID23803A (en) | 2000-05-11 |
| MA24632A1 (en) | 1999-04-01 |
| HUP0003425A3 (en) | 2002-02-28 |
| PA8457001A1 (en) | 2000-09-29 |
| TNSN98151A1 (en) | 2005-03-15 |
| BG104069A (en) | 2001-05-31 |
| CA2297486A1 (en) | 1999-02-25 |
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