UY23600A1 - Procedimiento para la preparacion de benzodiazepinas - Google Patents
Procedimiento para la preparacion de benzodiazepinasInfo
- Publication number
- UY23600A1 UY23600A1 UY23600A UY23600A UY23600A1 UY 23600 A1 UY23600 A1 UY 23600A1 UY 23600 A UY23600 A UY 23600A UY 23600 A UY23600 A UY 23600A UY 23600 A1 UY23600 A1 UY 23600A1
- Authority
- UY
- Uruguay
- Prior art keywords
- compound
- formula
- amine
- benzodiazepines
- reacting
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Procedimiento para la preparación de benzodiazepinas de fórmula general (I) (figura 1), y sales de adición ácida farmacéuticamente aceptables, carbamatos, ureas y amidas de los mismos, donde el anillo Z se selecciona de un grupo representado en la figura 2, donde uno o más átomos de carbono del anillo Z pueden estar sustituidos por F; Cl o alquilo inferior; el procedimiento comprende: la reacción de un compuesto de fórmula (II) (figura 2), sucesivamente con P2S5 y una amina, o bien haciendo reaccionar un compuesto de fórmula (II) con una amina en un disolvente inerte a la reacción, en presencia de un ácido de Lewis, y cuando se desea una amida de un compuesto de fórmula (I), se neutraliza dicho compuesto con un ácido orgánico, y cuando se desea un carbamato o una urea del mismo, se hace reaccionar un compuesto de fórmula (I) con el producto de la reacción estequiométrica entre el fosgeno y un alcohol o amina tanto alifáticos o aromáticos. Ejemplo no limitante: 7-cloro-N-metil-5-(1H-1,2,3-triazol-5-il)-3H-1,4-benzodiazepin-2-amina. Estas benzodiazepinas conforme a lo descrito pueden utilizarse como agentes terapéuticamente activos, especialmente como agentes antivirósicos, en particular para el tratamiento, terapia y profilaxis del Sida y enfermedades afines al mismo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US89919092A | 1992-06-16 | 1992-06-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UY23600A1 true UY23600A1 (es) | 1993-12-09 |
Family
ID=25410597
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UY23600A UY23600A1 (es) | 1992-06-16 | 1993-06-15 | Procedimiento para la preparacion de benzodiazepinas |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP0574781A2 (es) |
| JP (1) | JPH0656825A (es) |
| KR (1) | KR940005612A (es) |
| CN (1) | CN1081442A (es) |
| AU (1) | AU4123093A (es) |
| BG (1) | BG97868A (es) |
| BR (1) | BR9302359A (es) |
| CA (1) | CA2098063A1 (es) |
| CZ (1) | CZ115893A3 (es) |
| FI (1) | FI932767L (es) |
| HU (1) | HUT64536A (es) |
| IL (1) | IL105977A0 (es) |
| IS (1) | IS4035A (es) |
| LT (1) | LT3028B (es) |
| MX (1) | MX9303422A (es) |
| NO (1) | NO932204L (es) |
| PL (1) | PL299312A1 (es) |
| SI (1) | SI9300288A (es) |
| SK (1) | SK61593A3 (es) |
| UY (1) | UY23600A1 (es) |
| ZA (1) | ZA934077B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2126794C1 (ru) | 1992-03-11 | 1999-02-27 | Нархекс Лимитед | Аминопроизводные оксо- или гидроксизамещенных гидразинов, способ их получения и фармацевтические композиции для ингибирования ретровирусной протеазы |
| DE69333270T2 (de) | 1992-03-11 | 2004-08-05 | Narhex Ltd. | Aminderivate von oxo- und hydroxy- substituierten kohlenwasserstoffen |
| US5888992A (en) | 1992-03-11 | 1999-03-30 | Narhex Limited | Polar substituted hydrocarbons |
| US6071895A (en) | 1992-03-11 | 2000-06-06 | Narhex Limited | Polar-substituted hydrocarbons |
| IL110898A0 (en) * | 1993-09-10 | 1994-11-28 | Narhex Australia Pty Ltd | Polar-substituted hydrocarbons |
| CN2504706Y (zh) * | 2001-09-25 | 2002-08-07 | 闽祥实业有限公司 | 具有触摸控制功能的平板显示屏 |
| WO2004103360A1 (ja) | 2003-05-22 | 2004-12-02 | Lead Chemical Co.,Ltd. | 抗ウイルス作用を有する化合物および配合剤 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL279830A (es) | 1961-06-20 | |||
| US5141735A (en) * | 1990-06-18 | 1992-08-25 | Hoffman-La Roche, Inc. | Substituted amino-benzodiazepines having anitviral activity |
| EP0475231A1 (en) * | 1990-09-10 | 1992-03-18 | F. Hoffmann-La Roche Ag | Benzodiazepines |
| EP0491218A1 (en) * | 1990-12-17 | 1992-06-24 | F. Hoffmann-La Roche Ag | Benzodiazepinones |
-
1993
- 1993-05-28 SI SI9300288A patent/SI9300288A/sl unknown
- 1993-06-05 EP EP93109079A patent/EP0574781A2/en not_active Withdrawn
- 1993-06-08 MX MX9303422A patent/MX9303422A/es unknown
- 1993-06-09 ZA ZA934077A patent/ZA934077B/xx unknown
- 1993-06-09 CA CA002098063A patent/CA2098063A1/en not_active Abandoned
- 1993-06-10 IL IL105977A patent/IL105977A0/xx unknown
- 1993-06-11 AU AU41230/93A patent/AU4123093A/en not_active Abandoned
- 1993-06-11 HU HU9301704A patent/HUT64536A/hu unknown
- 1993-06-14 BG BG97868A patent/BG97868A/xx unknown
- 1993-06-14 SK SK615-93A patent/SK61593A3/sk unknown
- 1993-06-15 UY UY23600A patent/UY23600A1/es unknown
- 1993-06-15 JP JP5167332A patent/JPH0656825A/ja active Pending
- 1993-06-15 LT LTIP657A patent/LT3028B/lt not_active IP Right Cessation
- 1993-06-15 BR BR9302359A patent/BR9302359A/pt not_active Application Discontinuation
- 1993-06-15 KR KR1019930010851A patent/KR940005612A/ko not_active Withdrawn
- 1993-06-15 PL PL29931293A patent/PL299312A1/xx unknown
- 1993-06-15 NO NO932204A patent/NO932204L/no unknown
- 1993-06-15 CN CN93107340A patent/CN1081442A/zh active Pending
- 1993-06-15 CZ CZ931158A patent/CZ115893A3/cs unknown
- 1993-06-15 IS IS4035A patent/IS4035A/is unknown
- 1993-06-16 FI FI932767A patent/FI932767L/fi not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| FI932767A7 (fi) | 1993-12-17 |
| IS4035A (is) | 1993-12-17 |
| SI9300288A (sl) | 1993-12-31 |
| FI932767A0 (fi) | 1993-06-16 |
| FI932767L (fi) | 1993-12-17 |
| EP0574781A2 (en) | 1993-12-22 |
| HU9301704D0 (en) | 1993-09-28 |
| JPH0656825A (ja) | 1994-03-01 |
| MX9303422A (es) | 1994-06-30 |
| IL105977A0 (en) | 1993-10-20 |
| EP0574781A3 (es) | 1994-04-06 |
| ZA934077B (en) | 1993-12-16 |
| BR9302359A (pt) | 1994-01-11 |
| LTIP657A (en) | 1994-05-15 |
| HUT64536A (en) | 1994-01-28 |
| KR940005612A (ko) | 1994-03-21 |
| CA2098063A1 (en) | 1993-12-17 |
| SK61593A3 (en) | 1994-01-12 |
| PL299312A1 (en) | 1994-01-10 |
| CN1081442A (zh) | 1994-02-02 |
| BG97868A (en) | 1994-05-27 |
| AU4123093A (en) | 1993-12-23 |
| CZ115893A3 (en) | 1994-01-19 |
| NO932204L (no) | 1993-12-17 |
| NO932204D0 (no) | 1993-06-15 |
| LT3028B (en) | 1994-08-25 |
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