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US9180231B2 - Negative pressure device - Google Patents

Negative pressure device Download PDF

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Publication number
US9180231B2
US9180231B2 US13/144,264 US201013144264A US9180231B2 US 9180231 B2 US9180231 B2 US 9180231B2 US 201013144264 A US201013144264 A US 201013144264A US 9180231 B2 US9180231 B2 US 9180231B2
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United States
Prior art keywords
negative pressure
reservoir
wound
valve
pressure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related, expires
Application number
US13/144,264
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English (en)
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US20110275964A1 (en
Inventor
Bryan Greener
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Smith and Nephew PLC
TJ Smith and Nephew Ltd
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Smith and Nephew PLC
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Application filed by Smith and Nephew PLC filed Critical Smith and Nephew PLC
Assigned to T.J. SMITH & NEPHEW LIMITED reassignment T.J. SMITH & NEPHEW LIMITED ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: GREENER, BRYAN
Assigned to SMITH & NEPHEW PLC reassignment SMITH & NEPHEW PLC ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: T.J. SMITH & NEPHEW LIMITED
Publication of US20110275964A1 publication Critical patent/US20110275964A1/en
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Assigned to SMITH & NEPHEW PLC reassignment SMITH & NEPHEW PLC ADDRESS CHANGE Assignors: SMITH & NEPHEW PLC
Assigned to SMITH & NEPHEW PLC reassignment SMITH & NEPHEW PLC CORRECTIVE ASSIGNMENT TO CORRECT THE ASSIGNEE ADDRESS PREVIOUSLY RECORDED AT REEL: 049420 FRAME: 0895. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Assignors: SMITH & NEPHEW PLC
Expired - Fee Related legal-status Critical Current
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Classifications

    • A61M1/0031—
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/71—Suction drainage systems
    • A61M1/74—Suction control
    • A61M1/0088—
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/64—Containers with integrated suction means
    • A61M1/68—Containers incorporating a flexible member creating suction
    • A61M1/682—Containers incorporating a flexible member creating suction bulb-type, e.g. nasal mucus aspirators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/71—Suction drainage systems
    • A61M1/74—Suction control
    • A61M1/743—Suction control by changing the cross-section of the line, e.g. flow regulating valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/90—Negative pressure wound therapy devices, i.e. devices for applying suction to a wound to promote healing, e.g. including a vacuum dressing
    • A61M1/96—Suction control thereof

Definitions

  • the present invention relates to an apparatus and method for providing negative pressure at a wound site.
  • the present invention relates to an apparatus including a source of negative pressure which acts as a negative pressure reservoir to continually or repeatedly “top up” an applied negative pressure so that negative pressure applied at a wound site can be maintained within desired limits for a relatively long period of time.
  • powered systems which include a vacuum generation source such as a pump of some type have been developed and many examples of such systems are used today for the management of wounds.
  • a vacuum generation source such as a pump of some type
  • many of these systems are not convenient for discreet use by a patient as they are large, can be heavy and are often noisy.
  • production costs associated with such systems are substantial due largely to the cost of materials and complexity of assembly.
  • apparatus for providing negative pressure at a wound site comprising:
  • a method of providing negative pressure at a wound site comprising the steps of:
  • a reduced pressure device can create a safe reduced pressure at the site of application (i.e. no greater than 200 mmHg below ambient atmospheric pressure) that is connected by at least one valve to at least one further negative pressure reservoir.
  • a high vacuum i.e. greater than 200 mmHg below ambient atmospheric pressure
  • a desired negative pressure level at the wound site can be set and maintained.
  • Certain embodiments of the present invention utilise multiple negative pressure reservoirs each of which is independently connected via a control valve and conduit to a contact chamber formed at a wound site. This has the advantage that the user is able to select the appropriate pressure for the wound. Multiple valves set at different pressures e.g. 50 mmHg, 75 mmHg and 100 mmHg can be attached to a single reservoir to allow the user to select a pressure by isolation or lock down of the 2 valves not in use with simple shut off valves. Also malfunction of an individual control valve does not disable the whole system.
  • Certain embodiments of the present invention utilise a series of negative pressure reservoirs cascading one into another and eventually a contact chamber and separated by respective control valves.
  • This has the advantage that a safety mechanism is built into the device such that a single failure (e.g. debris in the valve) of a valve does not result in the wound being exposed to excessive possibly dangerous pressures.
  • the largest reservoir is the one set at the most negative pressure in order to get maximum longevity of therapy for size of product.
  • the mechanical properties of each reservoir can be tailored to provide optimal vacuum performance over a specified negative pressure range.
  • FIG. 1 illustrates a wound site
  • FIGS. 2A and 2B illustrate a collapsible negative pressure reservoir
  • FIG. 3 illustrates a series arrangement of negative pressure reservoirs
  • FIG. 4 illustrates separate negative pressure reservoirs connected in a parallel arrangement to a contact chamber formed at a wound site.
  • FIG. 1 illustrates a location 10 where topical negative wound therapy (NPWT) is to be applied at a wound site.
  • FIG. 1 illustrates a cutaway (approximately half shown) view of a drape 11 which, in use, is located over and around a wound site 12 .
  • the drape 11 acts as a dressing covering the wound and may be any type of dressing normally employed with NPWT and, in very general terms, may comprise, for example a semi-permeable flexible, self-adhesive drape material as is known in the dressings art to cover the wound and seal with surrounding sound tissue 13 to create a sealed cavity or void over the wound.
  • This sealed cavity or void is referred to hereinafter as a wound chamber 14 .
  • a chamber is taken to mean an enclosed volume of any geometry.
  • the chamber may be of fixed or flexible geometry.
  • wound packer material may be used in the cavity between a wound bed and the drape to enable an even vacuum distribution to be achieved over the area of the wound.
  • the packer material can be any suitable material as will be understood by those skilled in the art for example, a porous foam or gauze material that remains porous to fluid under the levels of vacuum created and which permits transfer of fluid across the entirety of the wound area. It is to be noted that the invention is not restricted to the particular geometry of the lumen entry design shown.
  • An aspiration conduit 15 is located through a pinched section 16 of the drape 11 so as to provide a sealed tubular conduit under the drape into the wound site.
  • the wound packer and aspiration conduit thus cooperate to resist crushing under the levels of vacuum created at the wound site and permit transfer of wound exudates across the wound area to the aspiration conduit sealed to the flexible cover drape which extends over the wound.
  • the aspiration conduit may be a plain flexible tube, for example, having a single lumen therethrough and made from a plastics material compatible with raw tissue.
  • the aspiration conduit may alternatively have a plurality of lumens therethrough to achieve specific objectives.
  • a portion of the tube sited within the wound chamber may aptly have a structure to enable continued aspiration and evacuation of wound exudate without becoming constricted or blocked even at the high levels of negative pressure envisaged.
  • the negative pressure range for the apparatus embodying the present invention may be between about ⁇ 50 mmHg and ⁇ 200 mmHg (note that these pressures are relative to normal ambient atmospheric pressure thus, ⁇ 200 mmHg would be around 560 mmHg in practical terms).
  • the pressure range may be between about ⁇ 75 mmHg and ⁇ 150 mmHg.
  • a pressure range of up to ⁇ 75 mmHg, up to ⁇ 80 mmHg or over ⁇ 80 mmHg can be used.
  • a pressure range of below ⁇ 75 mmHg could be used.
  • a pressure range of over ⁇ 100 mmHg could be used or over ⁇ 150 mmHg.
  • the pressure of the wound chamber is between ⁇ 125 mmHg and ⁇ 20 mmHg. It will thus be appreciated that negative pressure is taken to mean a pressure that is less than ambient atmospheric pressure.
  • the aspiration conduit 15 thus has an end proximate to the dressing and wound site. At a distal end remote from the dressing and wound site the aspiration conduit is secured to a valve 17 . This in turn is connected via a conduit to a negative pressure reservoir 18 and further control valve 19 . A fluid communication path is thus established between the valve 19 , negative pressure reservoir 18 , reservoir valve 17 and wound chamber 14 .
  • a wound chamber 14 defined at a wound site under a drape
  • certain embodiments of the present invention can be utilised to maintain a negative pressure in a wound chamber which is a rigid structure or partly rigid structure such as a cup device placed over a wound site.
  • FIGS. 2 a and 2 b illustrate a negative pressure reservoir 18 in more detail according to a particular embodiment of the present invention.
  • the reservoir 18 is formed from a flexible body 20 having a wound site side orifice 21 connected to a tube connected to the reservoir valve in a sealed manner and a pump side orifice 22 connected to a conduit 23 connected to the control valve 19 .
  • Filler material 24 is located within the flexible body 20 .
  • the filler material 24 illustrated as many collapsible and expandable beads prevents total collapse into a zero volume for the negative pressure reservoir 18 when the reservoir is pumped so as to produce a negative pressure.
  • the filler material is selected so that expansion occurs over the whole range of pressures experienced in the negative pressure reservoir. This can be achieved by using a single resilient material having a characteristic which makes the filler expand over a broad pressure range or by providing filler materials of different materials. For example some of the beads 24 may be manufactured of a material which expands over a particular pressure range whilst other beads are manufactured of a different material which expands over a different pressure range.
  • Absorber material is aptly held in the negative pressure reservoir.
  • the absorber material can be any type of material able to absorb wound exudate or other liquid being drawn from the wound site into the reservoir 18 through the aspiration tube 15 and reservoir valve 17 .
  • the absorber 25 is aptly an absorber gel such as ISOLYSELTM.
  • the absorbent can be separated from the filler material (as shown) or be integral therewith.
  • FIG. 2 b illustrates the negative pressure reservoir 18 in an expanded mode in which the negative pressure stored has become less negative. This occurs for example as a negative pressure at a wound site drops due to leakage around the periphery of the drape 11 or pinched region 16 . When this occurs a pressure differential across the reservoir valve 17 causes the valve to open. The negative pressure in the reservoir thus acts to “top up” the negative pressure in the wound site chamber. Wound exudate may of course be drawn into the reservoir. As the negativity of the negative pressure established in the negative pressure reservoir 18 reduces the resilience of the filler material 24 is such that the expandable body 20 expands outwardly. This is illustrated by the diameter of the beads 24 shown in FIG. 2 a expanding in FIG. 2 b as well as the general expansion of the bag like body. FIG. 2 b also illustrates how the absorbent material 25 absorbs liquid so as to expand also within the reservoir 18 .
  • a fluid tight connection which might be either a tight friction fit or a fitting which requires some securing mechanism such as a jubilee clip or the like.
  • Further examples of possible methods of connection may be adhesive, welding or use of a snap together connector for example as manufactured by Colder Products.
  • a drape is located over a wound site which may optionally include wound packer material.
  • a wound chamber is duly formed.
  • the aspiration tube 15 provides a fluid communication path into this wound chamber 14 .
  • the reservoir valve 17 and control valve 19 are opened and a pump (not shown) is used to provide a desired negative pressure at the wound site.
  • the reservoir valve 17 is closed. This can be an automatic process or can be carried out manually.
  • the pump continues to evacuate the reservoir 18 to a desired, far more negative, pressure. This causes the flexible body 20 in the form of a bag and filler to collapse into the state shown in FIG. 2 a .
  • the control valve 19 is closed. This can be an automatic process or can be manually achieved. Thereafter the pump is removed from the system.
  • the negative pressure reservoir valve 17 is selected to open and close automatically responsive to a pressure difference between the pressure in the aspiration tube 15 and wound site and the tubing and negative pressure reservoir 18 .
  • the reservoir valve 17 opens providing a fluid communication path between the wound chamber and the negative pressure reservoir. The result is that the wound chamber pressure becomes more negative whilst the negativity of the negative pressure in the reservoir 18 reduces.
  • the valve 17 opens and closes continually or repeatedly so as to deplete the source of negative pressure in the reservoir. During this period of time the negative pressure applied at the wound site is maintained as much as possible within desired negative pressure ranges.
  • a safe reduced pressure of, for example, no greater than 200 mmHg below ambient atmospheric pressure is created and applied at the site of application.
  • the valves connecting the reservoir to the wound site are fail safe and will only open when there is a loss of vacuum within the wound chamber. Furthermore the valves are selected so as to close when the pressure at the wound site reaches a desired target specified by the pressure valve manufacturer.
  • An example of a vacuum pressure regulation valve of a type suitable according to certain embodiments of the present invention is the VRD-ANB-CD vacuum regulator as supplied by Beswick EngineeringTM. It will be appreciated that other fluid flow control valves used to turn on and off a flow of fluid can be utilised according to certain embodiments of the present invention.
  • FIG. 3 illustrates an alternative embodiment of the present invention in which the wound chamber 34 at a wound site is in fluid communication with three separate negative pressure reservoirs 38 1-3 via respective fluid communication paths through respective reservoir valves 37 1-3 .
  • An advantage of connecting multiple negative pressure reservoirs independently to a wound chamber is that such parallel connections offer a degree of functional redundancy which can be important if one or more connecting valves becomes dysfunctional or parts of the wound chamber become physically separated (for example by local compression).
  • An advantage also is that the provision of multiple negative pressure reservoirs means that the negative pressure originally set in each reservoir can be independently selected. For example as illustrated in FIG.
  • a negative pressure given the subscript 1 in the first negative pressure reservoir 38 1 has a first value ⁇ V 1 whilst a negative pressure value in the second and third negative pressure reservoirs 38 2 , 38 3 have respective values ⁇ V 2 and ⁇ V 3 .
  • FIG. 4 illustrates an alternative embodiment of the present invention in which a wound chamber 44 is in a series connection with three negative pressure reservoirs 48 1-3 by cascading a series of negative pressure reservoirs each separated from one another by respective reservoir valves 47 1-3 .
  • the reservoir 48 1 in direct communication with the wound chamber 44 may be at the same or greater negative pressure than the wound chamber.
  • a second negative pressure reservoir 48 2 connected to the first negative pressure reservoir 48 1 by reservoir valve 47 2 may be at the same or greater negative pressure than the first negative pressure reservoir.
  • the third negative pressure reservoir 48 3 which is connected to the second negative pressure reservoir 48 2 by a respective reservoir valve 47 3 may be at the same or more negative pressure than the second negative pressure reservoir.

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  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Otolaryngology (AREA)
  • External Artificial Organs (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Surgical Instruments (AREA)
US13/144,264 2009-01-12 2010-01-08 Negative pressure device Expired - Fee Related US9180231B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0900423.5A GB0900423D0 (en) 2009-01-12 2009-01-12 Negative pressure device
GB0900423.5 2009-01-12
PCT/GB2010/050020 WO2010079359A1 (fr) 2009-01-12 2010-01-08 Dispositif à pression négative

Related Parent Applications (1)

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PCT/GB2010/050020 A-371-Of-International WO2010079359A1 (fr) 2009-01-12 2010-01-08 Dispositif à pression négative

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US14/881,022 Continuation US10716881B2 (en) 2009-01-12 2015-10-12 Negative pressure device

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US20110275964A1 US20110275964A1 (en) 2011-11-10
US9180231B2 true US9180231B2 (en) 2015-11-10

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US14/881,022 Active 2031-07-22 US10716881B2 (en) 2009-01-12 2015-10-12 Negative pressure device
US16/503,279 Active 2033-01-14 US11964093B2 (en) 2009-01-12 2019-07-03 Negative pressure device

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US16/503,279 Active 2033-01-14 US11964093B2 (en) 2009-01-12 2019-07-03 Negative pressure device

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US (3) US9180231B2 (fr)
EP (1) EP2385849B1 (fr)
CN (1) CN102361656B (fr)
AU (2) AU2010204175B2 (fr)
CA (1) CA2749023A1 (fr)
GB (1) GB0900423D0 (fr)
WO (1) WO2010079359A1 (fr)
ZA (1) ZA201104604B (fr)

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US9844472B2 (en) 2012-05-22 2017-12-19 Smith & Nephew Plc Wound closure device
US9962295B2 (en) 2012-07-16 2018-05-08 Smith & Nephew, Inc. Negative pressure wound closure device
US10117782B2 (en) 2012-05-24 2018-11-06 Smith & Nephew, Inc. Devices and methods for treating and closing wounds with negative pressure
US10159604B2 (en) 2010-04-27 2018-12-25 Smith & Nephew Plc Wound dressing and method of use
US10179073B2 (en) 2014-01-21 2019-01-15 Smith & Nephew Plc Wound treatment apparatuses
US10201642B2 (en) 2014-01-21 2019-02-12 Smith & Nephew Plc Collapsible dressing for negative pressure wound treatment
US10220125B2 (en) 2012-02-03 2019-03-05 Smith & Nephew Plc Apparatuses and methods for wound therapy
US10245185B2 (en) 2011-06-07 2019-04-02 Smith & Nephew Plc Wound contacting members and methods
US10328187B2 (en) 2007-07-02 2019-06-25 Smith & Nephew Plc Systems and methods for controlling operation of negative pressure wound therapy apparatus
US10405861B2 (en) 2011-02-04 2019-09-10 University Of Massachusetts Negative pressure wound closure device
US10548778B2 (en) 2018-04-02 2020-02-04 Ic Surgical, Inc. Negative pressure pumps and related methods
US10556045B2 (en) 2014-12-30 2020-02-11 Smith & Nephew, Inc. Synchronous pressure sampling and supply of negative pressure in negative pressure wound therapy
US10575991B2 (en) 2015-12-15 2020-03-03 University Of Massachusetts Negative pressure wound closure devices and methods
US10624794B2 (en) 2018-02-12 2020-04-21 Healyx Labs, Inc. Negative pressure wound therapy systems, devices, and methods
US10660992B2 (en) 2013-10-21 2020-05-26 Smith & Nephew, Inc. Negative pressure wound closure device
US10682446B2 (en) 2014-12-22 2020-06-16 Smith & Nephew Plc Dressing status detection for negative pressure wound therapy
US10695472B2 (en) 2008-03-13 2020-06-30 Smith & Nephew Plc Vacuum closure device
US10814049B2 (en) 2015-12-15 2020-10-27 University Of Massachusetts Negative pressure wound closure devices and methods
US11027051B2 (en) 2010-09-20 2021-06-08 Smith & Nephew Plc Pressure control apparatus
US11096832B2 (en) 2016-09-27 2021-08-24 Smith & Nephew Plc Wound closure devices with dissolvable portions
US11123476B2 (en) 2017-06-14 2021-09-21 Smith & Nephew, Inc. Fluid removal management and control of wound closure in wound therapy
US11123226B2 (en) 2012-05-22 2021-09-21 Smith & Nephew Plc Apparatuses and methods for wound therapy
US11135351B2 (en) 2016-08-30 2021-10-05 Smith & Nephew Plc Systems and methods for applying reduced pressure therapy
US11166726B2 (en) 2011-02-04 2021-11-09 University Of Massachusetts Negative pressure wound closure device
AU2017292876B2 (en) * 2016-07-08 2022-01-20 Convatec Technologies Inc. Fluid collection apparatus
US11253639B2 (en) 2011-11-02 2022-02-22 Smith & Nephew Plc Reduced pressure therapy apparatuses and methods of using same
US11324876B2 (en) 2017-06-13 2022-05-10 Smith & Nephew Plc Collapsible structure and method of use
US11375923B2 (en) 2017-08-29 2022-07-05 Smith & Nephew Plc Systems and methods for monitoring wound closure
US11395873B2 (en) 2017-06-14 2022-07-26 Smith & Nephew, Inc. Control of wound closure and fluid removal management in wound therapy
US11419767B2 (en) 2013-03-13 2022-08-23 University Of Massachusetts Negative pressure wound closure device and systems and methods of use in treating wounds with negative pressure
US11439539B2 (en) 2015-04-29 2022-09-13 University Of Massachusetts Negative pressure wound closure device
US11471586B2 (en) 2015-12-15 2022-10-18 University Of Massachusetts Negative pressure wound closure devices and methods
US11583623B2 (en) 2017-06-14 2023-02-21 Smith & Nephew Plc Collapsible structure for wound closure and method of use
US11590030B2 (en) 2017-08-07 2023-02-28 Smith & Nephew Plc Wound closure device with protective layer and method of use
US11607344B2 (en) 2017-07-27 2023-03-21 Smith & Nephew Plc Customizable wound closure device and method of use
US11617684B2 (en) 2016-11-02 2023-04-04 Smith & Nephew, Inc. Wound closure devices
US11724020B2 (en) 2017-06-14 2023-08-15 Smith & Nephew Plc Collapsible sheet for wound closure and method of use
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GB0803564D0 (en) 2008-02-27 2008-04-02 Smith & Nephew Fluid collection
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US10188776B2 (en) * 2010-09-20 2019-01-29 Smith & Nephew Plc Negative pressure device
WO2012161723A1 (fr) 2011-05-24 2012-11-29 Kalypto Medical, Inc. Dispositif constitué de modules de commande et de pompe, permettant d'obtenir une pression négative pour le traitement de plaies
US9067003B2 (en) 2011-05-26 2015-06-30 Kalypto Medical, Inc. Method for providing negative pressure to a negative pressure wound therapy bandage
TW201328740A (zh) * 2012-01-11 2013-07-16 Apex Medical Corp 具緩衝單元的負壓傷口照護系統
US9427505B2 (en) 2012-05-15 2016-08-30 Smith & Nephew Plc Negative pressure wound therapy apparatus
GB201216928D0 (en) 2012-09-21 2012-11-07 I2R Medical Ltd Portable medical device system
EP2968704B1 (fr) * 2013-03-14 2020-07-15 KCI Licensing, Inc. Traitement par pression négative à capacité de profil dynamique
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EP3710074B1 (fr) 2017-11-16 2024-03-20 ConvaTec Limited Appareil de recueil de fluide
WO2019164963A1 (fr) * 2018-02-20 2019-08-29 Emory University Procédés, systèmes et dispositifs d'extraction de lait maternel
EP4196020A4 (fr) 2020-08-13 2024-07-17 Merit Medical Systems, Inc. Dispositif gonflable de compression d'artère radiale comprenant un bracelet de serrage et procédé d'utilisation
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US20160095966A1 (en) 2016-04-07
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CN102361656A (zh) 2012-02-22
CN102361656B (zh) 2015-01-28
CA2749023A1 (fr) 2010-07-15
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AU2010204175B2 (en) 2015-07-16
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US10716881B2 (en) 2020-07-21
EP2385849A1 (fr) 2011-11-16
EP2385849B1 (fr) 2018-09-05

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