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US5597576A - Oil-based transparent gels - Google Patents

Oil-based transparent gels Download PDF

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Publication number
US5597576A
US5597576A US08/274,447 US27444794A US5597576A US 5597576 A US5597576 A US 5597576A US 27444794 A US27444794 A US 27444794A US 5597576 A US5597576 A US 5597576A
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branch
viscosity
oil
fatty alcohols
formulation
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US08/274,447
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Calogero Genova
Francesco Buosi
Sandra Guarnerio
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Enichem Augusta Industriale SRL
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Enichem Augusta Industriale SRL
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/042—Gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/25—Silicon; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
    • A61Q1/02—Preparations containing skin colorants, e.g. pigments
    • A61Q1/04—Preparations containing skin colorants, e.g. pigments for lips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/005—Preparations for sensitive skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/06—Preparations for care of the skin for countering cellulitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/02—Preparations for cleaning the hair
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/26—Optical properties
    • A61K2800/262—Transparent; Translucent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/30—Characterized by the absence of a particular group of ingredients
    • A61K2800/31—Anhydrous

Definitions

  • This invention relates to oil-based transparent gels characterised by a wide viscosity range, for use in the pharmaceutical and cosmetics sectors.
  • the gels contain tartaric acid or malic acid diesters of C 12 -C 13 single-branch fatty alcohols, possibly mixed with oils and other compounds such as silica and polyalcohols.
  • Lipogels are physico-chemical structures which, if obtained in clear form, enable formulations to be prepared having a consistency similar to or even better than creams or modern gel emulsions, without the use of cellulose methacrylic polymers or other compounds typical of aqueous systems.
  • Transparent lipogels have a particularly pleasing appearance, and compared with aqueous formulations have the advantage of not requiring preservatives and of being able to be used in very small quantity.
  • lipogels Another important advantage of lipogels is the ability to obtain lipid structures with differing performance in terms of skin feeling, greasiness and the possibility of inserting liposoluble and water-soluble active principles, these being characteristics which facilitate the development of final applications.
  • the literature describes various processes for preparing transparent lipogels.
  • Japanese patent 63223083 describes the preparation of transparent lipogels by heating mixtures formed from terpenes, paraffins and/or polyalcohols (oil base) and ionic surfactants deriving from fatty acids to 80° C., followed by slow cooling.
  • the need to heat the mixtures results however in a considerable increase in the preparation costs of such formulations.
  • Japanese patent 4059716 describes transparent lipogels prepared by cold-mixing pyrogenic silica with a non-ionic surfactant and a oily component consisting of a malic ester and olive oil.
  • the formulations obtained have however only a moderate viscosity (7.5 Pa.s) which limits their use for specific applications.
  • An alternative method consists of using the vegetable origin gelling agent for oily components known by the commercial name of GP-100®, marketed by Ajinomoto, which enables transparent gels to be obtained without the presence of adjuvants.
  • the preparation method again comprises heating the mixture to about 80°-85° C.
  • the gelling agent cost is high and the consistency of the gels obtained is rather low.
  • the present invention therefore provides transparent lipogels for cosmetics and pharmaceutical use having the following composition:
  • tartaric acid diester of C 12 -C 13 single-branch fatty alcohols in a quantity of between 46 and 95 wt %
  • sweet almond oil in a quantity of between 1 and 46%
  • PEG polyethyleneglycol 200
  • glycerin in a quantity of between 1 and 10%.
  • the viscosity of the gels of our invention varies considerably in relation to the composition of the different systems and can be regulated on the basis of the type of silica and type of co-gelling agent (polyalcohol), hence enabling the field of final applications to be widened.
  • the tartaric or malic acid diesters of C 12 -C 13 single-branch fatty alcohols are completely compatible with the most widely used cosmetics excipients in the preparation of formulations, even in high proportion (1:1, w/w), these including for example white oils, vegetable oils (jojoba, sweet almond), solid and liquid solar filters (EU-SOLEX and PARSOL CMX respectively) and Cosmacol esters (EOI and ECI).
  • Body products such as anticellulitis, etc.
  • gels and detergents for the hair, hands and body can be prepared, as well as bath oils.
  • topical medicaments can be formulated as lipogels, which have the advantage of making their application more pleasant than traditional ointment formulations.
  • Topical medicaments can consequently be prepared with corticosteroids or antimycotics, or galenic preparations be produced containing sulphur, zinc oxide, resorcinol, ichthyol etc.
  • galenic preparations be produced containing sulphur, zinc oxide, resorcinol, ichthyol etc.
  • antimycotic, antiseptic and detergent preparations they contribute considerably to the active principle, with no interference with preservatives.
  • the lipogels of the present invention could also be of interest for other products, such as shoe creams, wood polishing products, hand washing pastes and in other sectors where solid or semi-solid lipid structures are required.
  • the tartaric acid diester of C 12 -C 13 single-branch fatty alcohols is known by the name COSMACOL ETI® and is marketed by ENICHEM AUGUSTA INDUSTRIALE, Milan;
  • the malic acid diester of C 12 -C 13 single-branch fatty alcohols is known by the name COSMACOL EMI® and is marketed by ENICHEM AUGUSTA INDUSTRIALE, Milan;
  • the 2-ethyl-hexanoic acid alkyl (C 12 -C 13 single-branch) ester is known by the name COSMACOL EOI® and is marketed by ENICHEM AUGUSTA INDUSTRIALE, Milan;
  • benzophenone-6 is known by the name EUSOLEX® 4360 and is marketed by MERCK;
  • ethylhexyl-p-methoxy-cinnamate is known by the name PARSOL MCX® and is marketed by GIVAUDAN.
  • the transparent gels are prepared under cold conditions by mild mechanical agitation. Heating to 35°-40° C. is necessary only if glycerin is used.
  • the last stage of the preparation consists of adding the co-gelling agent (polyalcohols) in the desired quantity, followed by agitation of the mixture.
  • the pyrogenic silica can be used either as such (hence hydrophilic) or silanized (hence hydrophobic).
  • the minimum pyrogenic silica concentration which enables transparent gels to be obtained is less than 3 wt % for the hydrophilic type, whereas for the silanized type (hydrophobic) it is greater than 3.5 wt % but less than 5 wt %.
  • composition ET19 according to the invention 100 g of the composition ET19 according to the invention were prepared, it consisting of:
  • composition was prepared by mixing components a and b together under cold conditions using a mechanical stirrer or turboagitator. While agitating the obtained homogeneous solution with a turbomixer at moderate speed, component c and finally component d were added.
  • the viscosity (expressed in Pascal/second) was determined as described on page 6.

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  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Dermatology (AREA)
  • Chemical & Material Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Emergency Medicine (AREA)
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  • Inorganic Chemistry (AREA)
  • Cosmetics (AREA)
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Abstract

Oil-based gels are described containing tartaric or malic acid diesters possibly mixed with oils, and other components such as silica and polyalcohols. The gels are characterized by a wide viscosity range and can find application in the preparation of formulations for cosmetics and pharmaceutical use.

Description

This invention relates to oil-based transparent gels characterised by a wide viscosity range, for use in the pharmaceutical and cosmetics sectors.
The gels contain tartaric acid or malic acid diesters of C12 -C13 single-branch fatty alcohols, possibly mixed with oils and other compounds such as silica and polyalcohols.
Lipogels are physico-chemical structures which, if obtained in clear form, enable formulations to be prepared having a consistency similar to or even better than creams or modern gel emulsions, without the use of cellulose methacrylic polymers or other compounds typical of aqueous systems.
Transparent lipogels have a particularly pleasing appearance, and compared with aqueous formulations have the advantage of not requiring preservatives and of being able to be used in very small quantity.
Another important advantage of lipogels is the ability to obtain lipid structures with differing performance in terms of skin feeling, greasiness and the possibility of inserting liposoluble and water-soluble active principles, these being characteristics which facilitate the development of final applications.
However the preparation of gels with the required properties is not always easy.
The literature describes various processes for preparing transparent lipogels.
For example, Japanese patent 63223083 describes the preparation of transparent lipogels by heating mixtures formed from terpenes, paraffins and/or polyalcohols (oil base) and ionic surfactants deriving from fatty acids to 80° C., followed by slow cooling. The need to heat the mixtures results however in a considerable increase in the preparation costs of such formulations.
Japanese patent 4059716 describes transparent lipogels prepared by cold-mixing pyrogenic silica with a non-ionic surfactant and a oily component consisting of a malic ester and olive oil. The formulations obtained have however only a moderate viscosity (7.5 Pa.s) which limits their use for specific applications. An alternative method consists of using the vegetable origin gelling agent for oily components known by the commercial name of GP-100®, marketed by Ajinomoto, which enables transparent gels to be obtained without the presence of adjuvants. However the preparation method again comprises heating the mixture to about 80°-85° C. In addition the gelling agent cost is high and the consistency of the gels obtained is rather low.
We have now found that it is possible to obtain transparent lipogels characterised by a wide viscosity range by mixing tartaric or malic acid esters, possibly containing oils or any cosmetics excipient, with other compounds such as silica and polyalcohols under cold conditions, in determined proportions.
The present invention therefore provides transparent lipogels for cosmetics and pharmaceutical use having the following composition:
A) an ester chosen from:
tartaric acid diester of C12 -C13 single-branch fatty alcohols in a quantity of between 46 and 95 wt %,
malic acid diester of C12 -C13 single-branch fatty alcohols in a quantity of between 87 and 93 wt %;
B) an oil or ester chosen from:
2-ethyl-hexanoic acid alkyl (C12 -C13 single-branch) ester,
2-hydroxy-1,2,3-propanetricarboxylic acid alkyl (C12 -C13 single-branch) triester,
white oil,
jojoba oil,
benzophenone-6,
ethylhexyl-p-methoxy-cinnamate,
sweet almond oil, in a quantity of between 1 and 46%;
C) hydrophilic or hydrophobic pyrogenic silica in a quantity of between 2.8 and 7.0%;
D) a polyalcohol chosen from:
polyethyleneglycol 200 (PEG),
ethyleneglycol,
1,2-propyleneglycol,
glycerin, in a quantity of between 1 and 10%.
The viscosity of the gels of our invention varies considerably in relation to the composition of the different systems and can be regulated on the basis of the type of silica and type of co-gelling agent (polyalcohol), hence enabling the field of final applications to be widened.
The tartaric or malic acid diesters of C12 -C13 single-branch fatty alcohols are completely compatible with the most widely used cosmetics excipients in the preparation of formulations, even in high proportion (1:1, w/w), these including for example white oils, vegetable oils (jojoba, sweet almond), solid and liquid solar filters (EU-SOLEX and PARSOL CMX respectively) and Cosmacol esters (EOI and ECI).
It should also be noted that the dermotoxicological safety of the key products (Cosmacol esters, silica and glycols) makes these gels a useful addition for the formulator in ensuring certain success of both cosmetics and pharmaceutical preparations. Their possible uses in the cosmetics sector include the preparation of protective products, such as:
Sun creams with a predetermined sun protection factor
Water-repellent creams for professional use
Hand barrier creams
Face and lip creams, particularly protective for sensitive skin
Manual massage creams
Body products such as anticellulitis, etc.
In addition gels and detergents for the hair, hands and body can be prepared, as well as bath oils.
In the pharmaceutical sector, because of their special properties these lipogels can replace traditional ointments with considerable advantages, including bioavailability.
For example all topical medicaments can be formulated as lipogels, which have the advantage of making their application more pleasant than traditional ointment formulations.
Topical medicaments can consequently be prepared with corticosteroids or antimycotics, or galenic preparations be produced containing sulphur, zinc oxide, resorcinol, ichthyol etc. In specific or general antimycotic, antiseptic and detergent preparations they contribute considerably to the active principle, with no interference with preservatives.
The lipogels of the present invention could also be of interest for other products, such as shoe creams, wood polishing products, hand washing pastes and in other sectors where solid or semi-solid lipid structures are required.
All the components used in preparing the formulations are available commercially, and specifically:
the tartaric acid diester of C12 -C13 single-branch fatty alcohols is known by the name COSMACOL ETI® and is marketed by ENICHEM AUGUSTA INDUSTRIALE, Milan;
The malic acid diester of C12 -C13 single-branch fatty alcohols is known by the name COSMACOL EMI® and is marketed by ENICHEM AUGUSTA INDUSTRIALE, Milan;
the 2-ethyl-hexanoic acid alkyl (C12 -C13 single-branch) ester is known by the name COSMACOL EOI® and is marketed by ENICHEM AUGUSTA INDUSTRIALE, Milan;
the 2-hydroxy-1,2,3-propanetricarboxylic acid alkyl (C12 -C13 single-branch) triester is known by the name COSMACOL ECI® and is marketed by ENICHEM AUGUSTA INDUSTRIALE, Milan;
benzophenone-6 is known by the name EUSOLEX® 4360 and is marketed by MERCK;
ethylhexyl-p-methoxy-cinnamate is known by the name PARSOL MCX® and is marketed by GIVAUDAN.
The transparent gels are prepared under cold conditions by mild mechanical agitation. Heating to 35°-40° C. is necessary only if glycerin is used.
It is also possible to prepare a base (consisting of Cosmacol ester and pyrogenic silica in the desired concentration) having the characteristics of a transparent viscous fluid, to which the various cosmetics excipients are added until a final formulation suitable for the required type of application is obtained.
In this case, the last stage of the preparation consists of adding the co-gelling agent (polyalcohols) in the desired quantity, followed by agitation of the mixture.
The obtaining of transparent gels is strictly dependent on the type of lipo-gelling agent used and on the chosen oil base. In addition there seems to be a particular compatibility between the esters of our invention and the various types of polyalcohol. In this respect, low polyalcohol concentrations are generally sufficient to obtain a transparent system. The required concentration is 1-2% on average.
The pyrogenic silica can be used either as such (hence hydrophilic) or silanized (hence hydrophobic). The minimum pyrogenic silica concentration which enables transparent gels to be obtained is less than 3 wt % for the hydrophilic type, whereas for the silanized type (hydrophobic) it is greater than 3.5 wt % but less than 5 wt %.
The viscosity of the formulations was determined by a BROOKFIELD rotary viscometer fitted with an RV=7 spindle at a spindle speed of 50 rpm or 20 rpm, the appearance of the formulations being evaluated visually.
The following examples are given to better illustrate the present invention and are not to be considered as limitative of its scope, which is defined by the accompanying claims.
EXAMPLE 1
100 g of the composition ET19 according to the invention were prepared, it consisting of:
a) 85.8 g of COSMACOL ETI
b) 4.5 g of HYDROPHILIC PYROGENIC SILICA (WACKER HDK V15)
c) 4.7 g of COSMACOL EOI
d) 5.0 g of 1,2-PROPYLENEGLYCOL
The composition was prepared by mixing components a and b together under cold conditions using a mechanical stirrer or turboagitator. While agitating the obtained homogeneous solution with a turbomixer at moderate speed, component c and finally component d were added.
The appearance of the obtained compositions was determined visually: F=fluid, GT=transparent gel, GO=opaque gel. The viscosity (expressed in Pascal/second) was determined as described on page 6.
EXAMPLE 2
Following the procedure described in Example 1, a series of lipogels were prepared having the composition and viscosity and transparency characteristics given in the following tables (1-1a-1b-1c-1d-2-2a-2b).
The results show that only by mixing the components in determined proportions is it possible to obtain transparent formulations of particular viscosity.
The formulations with the required properties are marked with an asterisk.
                                  TABLE 1
__________________________________________________________________________
LIPOGELS WITH COSMACOL ETI
          ET1
             ET2
                ET3
                   ET4
                      ET5
                         ET6
                            ET7
                               ET8
                                  ET9
                                     ET10
                                         ET11
Component % by weight
__________________________________________________________________________
Cosmacol ETI
          96 93.1
                91.1
                   96.5
                      93.1
                         90.2
                            87.4
                               85.5
                                  94.0
                                     93.6
                                         92.1
Hydrophobic silica
          2  1.9
                1.9
                   2.0
                      4.9
                         4.8
                            4.6
                               4.5
                                  5.0
                                     4.9 6.9
PEG 200   2  5  7  -- 2  5  8  10 1  --  1
Glycerin  -- -- -- 1.5
                      -- -- -- -- -- 1.5 --
APPEARANCE
          F  F  F  F  GT*
                         GT*
                            GT*
                               GT*
                                  GT*
                                     G0  GT*
VISCOSITY
(50 rpm)              15.2
                         14.0
                            12.8
                               11.6
                                  12,0
                                     10.8
                                         37.6
(20 rpm,) 3.2
             3.0
                3.0
                   2.0
__________________________________________________________________________

                                  TABLE 1a
__________________________________________________________________________
LIPOGELS WITH COSMACOL ETI
          ET12
              ET13
                  ET14
                      ET15
                          ET16
                              ET17
                                  ET18
                                      ET38
                                          ET39
                                              ET40
Component % by weight
__________________________________________________________________________
Cosmacol ETI
          91.1
              90.2
                  85.6
                      95.5
                          91.7
                              93.1
                                  90.2
                                      92.1
                                          92.1
                                              92.1
Hydrophobic silica
          6.9 6.8 6.4 3.5 3.3 4.9 4.8 --  --  --
Hydrophilic silica
          --  --  --  --  --  --  --  6.9 6.9 6.9
PEG 200   2   3   8   1   5   --  --  1   --  --
Propyleneglycol
          --  --  --  --  --  2   5   --  1   --
Glycerin  --  --  --  1.5 --  --  --  --  --  1
APPEARANCE
          GT* GT* GT* F   F   F   F   GT* GT* GT*
VISCOSITY
(50 rpm)  36.0
              32.0
                  25.6
                      --  --  --  --  68.0
                                          36.8
                                              64.0
(20 rpm)              5.0 5.8 5.0 7.5
__________________________________________________________________________

                                  TABLE 1b
__________________________________________________________________________
LIPOGELS WITH COSMACOL ETI
          ET20
              ET21
                  ET22
                      ET23
                          ET24
                              ET25
                                  ET26
                                      ET27
                                          ET28
Component % by weight
__________________________________________________________________________
Cosmacol ETI
          90.4
              90.8
                  89.5
                      90.9
                          90.6
                              95.0
                                  94.1
                                      93.6
                                          89.0
Hydrophilic silica
          4.8 4.5 5.5 38  3.9 4.0 3.9 3.9 3.9
PEG 200   4.8 4.8 5.0 --  --  --  --  --  --
Propyleneglycol
          --  --  --  5.4 --  --  --  --  7.2
Glycerin  --  --  --  --  1.5 1.0 2.0 2.5 --
APPEARANCE
          GT* GT* GT* GT* GT* GT* GT* GT* GT*
VISCOSITY 18.4
              13.5
                  21.6
                      --  25.0
                              20.0
                                  18.0
                                      26.5
                                          --
(50 rpm)
__________________________________________________________________________

                                  TABLE 1c
__________________________________________________________________________
LIPOGELS WITH COSMACOL ETI
          ET19
              ET29
                  ET30
                      ET31
                          ET32
                              ET33
                                  ET34
                                      ET35
                                          ET36
Component % by weight
__________________________________________________________________________
Cosmacol ETI
          85.8
              88.5
                  88.5
                      88.5
                          88.5
                              95.5
                                  94.9
                                      93.8
                                          89.2
Hydrophobic silica
          --  4.7 4.7 4.7 4.7 --  --  --  --
Hydrophilic silica
          5.0 --  --  --  --  3.0 2.9 2.9 2.8
PEG 200   4.5 2.0 2.0 2.0 2.0 --  2.2 --  --
Propyleneglycol
          --  --  --  --  --  --  --  3.3 3.2
Glycerin  --  --  --  --  --  1.5 --  --  --
Cosmacol EOI
          4.7 --  --  --  --  --  --  --  --
Cosmacol ECI
          --  4.9 --  --  --  --  --  --  --
White oil --  --  --  4.9 --  --  --  --  --
Jojoba oil
          --  --  4.9 --  --  --  --  --  4.8
Eusolex 4360
          --  --  --  --  4.9 --  --  --  --
APPEARANCE
          GT* GT* GT* GT* GT* GT* GT* GT* GT*
VISCOSITY 22.5
              13.2
                  16.0
                      13.6
                          13.0
                              10.4
                                  8.0 6.5 5.6
(50 rpm)
__________________________________________________________________________

                                  TABLE 1d
__________________________________________________________________________
LIPOGELS WITH COSMACOL ETI
          ET37
              ET41
                  ET42
                      ET43
                          ET45
                              ET46
                                  ET47
                                      ET48
Component % by weight
__________________________________________________________________________
Cosmacol ETI
          89.2
              87.5
                  91.1
                      83.7
                          46.0
                              46.0
                                  46.0
                                      46.0
Hydrophilic silica
          2.8 6.6 6.9 6.3 3.5 3.2 3.2 3.2
PEG 200   --  1.0 --  --  1.0 --  1.0 --
Propyleneglycol
          3.2 --  1.0 0.9 --  1.0 --  1.0
White oil 4.8 --  --  --  49.5
                              49.5
                                  --  --
Jojoba oil
          --  --  --  --  --  --  49.5
                                      49.5
Almond oil
          --  4.0 --  --  --  --  --  --
Eusolex 4360
          --  --  1   --  --  --  --  --
Parsol MCX
          --  --  --  9.0 --  --  --  --
APPEARANCE
          GT* GT* GT* GT* GT* GT* GT* GT*
VISCOSITY 5.2 63.0
                  60.0
                      20.0
                          8.0 7.2 7.6 6.4
(50 rpm)
__________________________________________________________________________

                                  TABLE 2
__________________________________________________________________________
TRANSPARENT GELS WITH COSMACOL EMI
          EM1
             EM2
                EM3
                   EM4
                      EM5
                         EM6
                            EM7
                               EM8
                                  EM9
                                     EM10
                                         EM11
Component % by weight
__________________________________________________________________________
Cosmacol EMI
          92.9
             90.2
                87.4
                   93.6
                      93.1
                         89.8
                            91.7
                               96.0
                                  93.1
                                     90.2
                                         94.1
Hydrophobic silica
          4.9
             4.8
                4.6
                   4.9
                      4.9
                         4.7
                            4.8
                               2.0
                                  1.9
                                     1.8 4.9
PEG 200   2.2
             5.0
                8.0
                   -- -- -- -- 2.0
                                  5.0
                                     8.0 1.0
Glycerin  -- -- -- 1.5
                      -- -- -- -- -- --  --
Ethylene glycol
          -- -- -- -- 2.0
                         5.5
                            3.5
                               -- -- --  --
APPEARANCE
          GT*
             GT*
                GT*
                   G0 GT*
                         G0*
                            G0*
                               F  F  F   GT*
VISCOSITY
(50 rpm)  12.0
             12.0
                16.0
                   10.5
                      12.0
                         7.2
                            13.6
                               -- -- --  8.0
(20 rpm,) -- -- -- -- -- -- -- 2.5
                                  2.5
                                     2.5 --
__________________________________________________________________________

              TABLE 2a
______________________________________
TRANSPARENT GELS WITH COSMACOL EMI
          EM12  EM13    EM18    EM19  EM20
Component   % by weight
______________________________________
Cosmacol EMI
            90.3    90.2    88.4  91.0  92.2
Hydrophilic silica
            4.7     5.1     6.7   6.9   6.9
PEG 200     5.0     4.7     --    2.2   --
Glycerin    --      --      --    --    0.9
Propylene glycol
            --      --      4.9   --    --
APPEARANCE  GT*     GT*     F     GT*   G0
VISCOSITY
(50 rpm)    23.0    11.0    --    4.8   7.6
(20 rpm,)   --      --      6.0   --    --
______________________________________

              TABLE 2b
______________________________________
TRANSPARENT GELS WITH COSMACOL EMI
            EM14      EM15    EM17
Component     % by weight
______________________________________
Cosmacol EMI  88.5        88.5    88.5
Hydrophobic silica
              4.7         4.7     4.7
PEG 200       2.0         2.0     2.0
Cosmacol ECI  4.9         --      --
Jojoba oil    --          4.9     --
White oil     --          --      4.9
APPEARANCE    GT*         GT*     GT*
VISCOSITY
(50 rpm)      7.2         7.6     6.0
(20 rpm,)     --          --      --
______________________________________

Claims (11)

We claim:
1. A transparent lipogel formulation for cosmetic and pharmaceutical use, characterised by a viscosity of between 4.8 and 68 Pa.s and consisting essentially of:
A) an ester selected from the group consisting of:
--tartaric acid diester of C12 -C13 single-branch fatty alcohols in a quantity of between 46 and 95 wt %, and
--malic acid diester of C12 -C13 single-branch fatty alcohols in a quantity of between 87 and 95 wt %;
B) an oil or ester selected from the group consisting of:
--2-ethyl-hexanoic acid alkyl (C12 -C13 single-branch) ester,
--2-hydroxy-1,2,3-propanetricarboxylic acid alkyl (C12 -C13 single-branch) triester,
--white oil,
--jojoba oil,
--benzophenone-6
--ethylhexyl-p-methoxy-cinnamate, and
--sweet almond oil,
in a quantity of between 0 and 46 wt %;
C) hydrophilic or hydrophobic pyrogenic silica in a quantity of between 2.8 and 7.0 wt. %;
D) a polyalcohol selected from the group consisting of:
--polyethyleneglycol 200 (PEG),
--ethyleneglycol,
--1,2-propyleneglycol, and
--glycerin,
in a quantity of between 1 and 10 wt %, said components A), B), C) and D) being present in amounts that result in a transparent lipogel.
2. A formulation in accordance with claim 1, characterised by a viscosity of between 11 and 36 Pa.s and having the following composition:
A) tartaric acid diester of C12 -C13 single-branch fatty alcohols in a quantity of between 85 and 95 wt %;
C) hydrophobic pyrogenic silica in a quantity of between 4.5 and 7.0 wt %;
D) polyethyleneglycol 200 in a quantity of between 2 and 10 wt %.
3. A formulation in accordance with claim 1, characterised by a viscosity of between 13 and 68 Pa.s and having the following composition:
A) tartaric acid diester of C12 -C13 single-branch fatty alcohols in a quantity of between 89 and 95 wt %;
C) hydrophilic pyrogenic silica in a quantity of between 3.6 and 7.0 wt %;
D) polyethyleneglycol 200 in a quantity of between 1 and 5 wt %.
4. A formulation in accordance with claim 1, characterised by a viscosity of between 13 and 68 Pa.s and having the following composition:
A) tartaric acid diester of C12 -C13 single-branch fatty alcohols in a quantity of between 89 and 96 wt %;
C) hydrophilic pyrogenic silica in a quantity of between 3.9 and 4.0 wt %;
D) glycerin in a quantity of between 1 and 2.5 wt %.
5. A formulation in accordance with claim 1, characterised by a viscosity of between 13 and 68 Pa.s and having the following composition:
A) tartaric acid diester of C12 -C13 single-branch fatty alcohols 89.0 wt %
C) hydrophilic pyrogenic silica 3.9 wt %
D) 1,2-propyleneglycol 7.2 wt %.
6. A formulation in accordance with claim 1, characterised by a viscosity of 22.5 Pa.s and having the following composition:
A) tartaric acid diester of C12 -C13 single-branch fatty alcohols 85.8 wt %
B) 2-ethyl-hexanoic acid alkyl (C12 -C13 single-branch) ester 4.7 wt %
C) hydrophilic pyrogenic silica 5.0 wt %
D) polyethyleneglycol 200 4.5 wt %.
7. A formulation in accordance with claim 1, characterised by a viscosity of between 13.0 and 16 Pa.s and having the following composition:
A) tartaric acid diester of C12 -C13 single-branch fatty alcohols 88.5 wt %
B) an oil or ester selected from the group consisting of:
--2-hydroxy-1,2,3-propanetricarboxylic acid alkyl (C12 -C13 single-branch) triester,
--benzophenone-6,
--white oil, and
--jojoba oil, in a quantity of 4.9 wt %;
C) hydrophobic pyrogenic silica 4.7 wt %
D) polyethyleneglycol 200 2.0 wt %.
8. A formulation in accordance with claim 1, characterised by a viscosity of between 5.2 and 63 Pa.s and having the following composition:
A) tartaric acid diester of C12 -C13 single-branch fatty alcohols in a quantity of between 46 and 95.5 wt %;
B) an oil or ester selected from the group consisting of:
--white oil,
--jojoba oil,
--benzophenone-6, and
--ethylhexyl-p-methoxy-cinnamate, in a quantity of between 1 and 49.5 wt. %;
C) hydrophilic pyrogenic silica in a quantity of between 2.9 and 6.9 wt %;
D) a polyalcohol selected from the group consisting of:
--polyethyleneglycol 200,
--1,2-propyleneglycol, and
--glycerin, in a quantity of between 1 and 3.3 wt %.
9. A formulation in accordance with claim 1, characterised by viscosity of between 12 and 16 Pa.s and having the following composition:
A) malic acid diester of C12 -C13 single-branch fatty alcohols in a quantity of between 90.2 and 94.1 wt %;
C) hydrophobic pyrogenic silica in a quantity of between 4.6 and 4.9 wt %;
D) a polyalcohol selected from the group consisting of:
--polyethyleneglycol 200, and
--ethyleneglycol, in a quantity of between 2 and 8 wt %.
10. A formulation in accordance with claim 1, characterised by a viscosity of between 4.8 and 23.0 Pa.s and having the following composition:
A) malic acid diester of C12 -C13 single-branch fatty alcohols in a quantity of between 90.2 and 94.1 wt %;
C) hydrophilic pyrogenic silica in a quantity of between 4.7 and 6.9 wt %;
D) polyethyleneglycol 200, in a quantity of between 4.8 and 23 wt %.
11. A formulation in accordance with claim 1, characterised by a viscosity of between 6.0 and 7.6 Pa.s and having the following composition:
A) malic acid diester of C12 -C13 single-branch fatty alcohols in a quantity of 88.5 wt %;
B) an oil or ester selected from the group consisting of:
--2-hydroxy-1,2,3-propanetricarboxylic acid alkyl (C12 -C13 single-branch) triester,
--white oil, and
--jojoba oil, in a quantity of 4.9 wt %;
C) hydrophobic pyrogenic silica in a quantity of 4.7 wt %;
D) polyethyleneglycol 200, in a quantity of 2 wt %.
US08/274,447 1993-07-21 1994-07-13 Oil-based transparent gels Expired - Fee Related US5597576A (en)

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ITMI931610A IT1270953B (en) 1993-07-21 1993-07-21 TRANSPARENT OIL-BASED GELS

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US5736505A (en) * 1996-08-30 1998-04-07 Dragoco, Inc. Non-alcoholic perfume or cologne
US20020103280A1 (en) * 1999-10-26 2002-08-01 Lassila Kevin Rodney Malic acid diester surfactants
US20050050636A1 (en) * 2003-09-04 2005-03-10 Hiroto Setokawa Pillow
US20050223493A1 (en) * 2003-09-04 2005-10-13 Sumitomo Rubber Industries, Ltd. Pillow
US20060069167A1 (en) * 2004-09-30 2006-03-30 Jutaro Shudo 1-chloro-2,4-dinitrobenzene gel compositions and methods for using the same
US20060111451A1 (en) * 2004-09-30 2006-05-25 Jutaro Shudo 1-Chloro-2,4-dinitrobenzene gel compositions and methods for using the same
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Publication number Priority date Publication date Assignee Title
US5736505A (en) * 1996-08-30 1998-04-07 Dragoco, Inc. Non-alcoholic perfume or cologne
US20020103280A1 (en) * 1999-10-26 2002-08-01 Lassila Kevin Rodney Malic acid diester surfactants
US6969738B2 (en) 1999-10-26 2005-11-29 Air Products And Chemicals, Inc. Malic acid diester surfactants
US20050050636A1 (en) * 2003-09-04 2005-03-10 Hiroto Setokawa Pillow
US20050223493A1 (en) * 2003-09-04 2005-10-13 Sumitomo Rubber Industries, Ltd. Pillow
US20060069167A1 (en) * 2004-09-30 2006-03-30 Jutaro Shudo 1-chloro-2,4-dinitrobenzene gel compositions and methods for using the same
US20060111451A1 (en) * 2004-09-30 2006-05-25 Jutaro Shudo 1-Chloro-2,4-dinitrobenzene gel compositions and methods for using the same
CN101005813B (en) * 2004-09-30 2010-11-03 帝国制药美国公司 1-chloro-2, 4-dinitrobenzene gel compositions and methods of use thereof
US8080261B2 (en) * 2004-09-30 2011-12-20 Teikoku Pharma Usa, Inc. 1-chloro-2,4-dinitrobenzene non-aqueous gel compositions and methods for using the same
US20110021398A1 (en) * 2008-05-30 2011-01-27 Evonik Stockhausen Gmbh Skin and hand cleansers
US8211841B2 (en) 2008-05-30 2012-07-03 Evonik Stockhausen Gmbh Skin and hand cleansers

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IT1270953B (en) 1997-05-26
SK88694A3 (en) 1995-03-08
CZ174994A3 (en) 1995-02-15
ITMI931610A0 (en) 1993-07-21

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