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US3663582A - Hexachlorocyclopentadiene adducts of unsaturated amides - Google Patents

Hexachlorocyclopentadiene adducts of unsaturated amides Download PDF

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US3663582A
US3663582A US878922A US3663582DA US3663582A US 3663582 A US3663582 A US 3663582A US 878922 A US878922 A US 878922A US 3663582D A US3663582D A US 3663582DA US 3663582 A US3663582 A US 3663582A
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heptene
hexachloro
octylbicyclo
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Robert R Mod
Frank C Magne
Eveld L Skau
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US Department of Agriculture USDA
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids

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  • This invention relates to certain new nitrogen-containing compounds, more particularly to N-substituted and N,N-disubstituted amides, the acyl moieties of which are the acyl moieties of the hexachlorocyclopentadiene adducts of either 9-octadeceonic or IO-undecenoic acids.
  • the compounds which are the subject of this invention are characterized by the fact that as growth inhibitors they are effective against a variety of bacteria, yeasts, and molds, some of which are pathogenic. They are also useful as plasticizers.
  • the compounds which are the subject of this invention include N-acyl derivatives of the following primary and secondary amines and cyclic imines: dimethylamine, diethylamine, dibutylamine, N methyl propylamine, N-methyl-butylamine, allylamine, N-methyl-allylamine, N,N-bis (2-ethoxyethy1)amine, N-ethyl 2 ethoxyethylamine, N-ethyl-3-ethoxyropylamine, pyrrolidine, piperidine, 2-methylpiperidine, morpholine, azaibicyclo[3.2.2] nonane, piperazine, N-methylpiperazine, and benylamine, the acyl group being that of the hexachlorocyclopentadiene adduct of either 9-octadecenoic or IO-undecen'oic acid.
  • N,N-dibutyl 8 (1,4,5,6,7,7-hexachloro-3-octylbidyclo [2.2.11-5-hepteue-2-yl) octanamide N,N dimethyl-8-(1,4,5,6,7,7-hexachloro-3-octylbicyclo [2.2.1]-5-heptene-2-yl)octanamide N,N-diethyl 8 (1,4,5,6,7,7-hexacholo-3-octylbicyc1o [2.2.1]-5-heptene-2-yl)octanamide 3,663,582 Patented May 16, 1972 N-methyl N allyl-841,4,5,6,7,7-hexachloro-3-octylbieyclo [2.2.
  • the compounds of this invention were screened for their antimicrobial activity against two bacteria-Bacillus sp., and Pseudomonas sp.--and a number of pathogenic yeasts or molds.Aspergillus flavus, Candida albicans, Microsporum gypseum, T richophylon rubrum, and Trichophyton violaceum.
  • Difco Bacto Dehydrated nutrient Agar at pH 6.8, Difco Bacto Dehydrated Yeast Morphological Agar at pH 4.5, and Difco Dehydrated Mycological Agar at pH 7.0 were used to test the inhibition of the bacteria, yeast, and mold cultures, respectively.
  • the micro-organisms used were obtained from stock cultures. Seeded agar plates were used to measure the atnibacterial activity against bacteria. Hardened agar plates inoculated either by streaking or pouring the culture onto the plates were employed in the activity estimations against molds. Standard size (6.5 mm.) paper discs wetted with the test compound were placed on the surface of the agar plates inoculated with the test organisms. When streaked plates were used the test compounds were added onto the specified areas.
  • EXAMPLE 1 The hexachlorocyclopentadiene adduct of oleoyl chloride was prepared by reacting, under a nitrogen blanket, grams of oleoyl chloride with 145.2 grams of hexachlorocyclopentadiene in a flask equipped with a condenser for 28 hours at 135 C. Since neither hexachlorocyclopentadiene nor the adduct absorbs bromine, iodine values were used to determine the percentage of the oleoyl chloride converted. The reaction mixture showed a 75% conversion to the adduct. The excess hexachlorocyclopentadiene was removed by stripping at reduced pressure.
  • N,N-dibutyl amide of the hexachlorocyclopentadiene adduct of oleic acid was prepared by dissolving 14.6 grams of dibutylamine and 11.4 grams of triethylamine in benzene and adding dropwise with stirring 57 grams of the oleoyl chloride adduct prepared by the procedure of Example 1. After stirring for an additional hour, the reaction mixture was filtered, washed successively with dilute hydrochloric acid and water, dried over anhydrous sodium sulfate, percolated through a column of activated alumina to remove residual free acid, and stripped. N,N- dibutyloleamide was removed by two urea clathrations.
  • This formulation was milled, molded, and tested.
  • the resulting molded plasticized resin showed no evidence of exudation or migration to the surface during shelf storage of 30 days and had the following properties: tensile strength, 3380 (3130) p.s.i.; 100% modulus, 3140 (1640) p.s.i.; elongation, 260 (360) percent; brittle point, +3 (-31) C.; volatility loss 0.03 (1.5) percent; soapy water extractability 0.00 (3.0) percent.
  • the corresponding properties using the control plasticizer, di-2ethylhexyl phthalate (DOP), in the same formulation are given in parenthesis.
  • the compound is therefore a good compatible primary plasticizer giving a plasticized stock showing extremely low volatility loss and soapy water extractability.
  • the platsicized resin was also less flammable than DOP.
  • EXAMPLE 3 The N,N-dimethylarnide of the hexachlorocyclopentadiene adduct of oleic acid was prepared by the procedure of Example 2 using 1.1 grams of anhydrous dimethylamine, 2.4 grams of methylamine, and 12 grams of the oleoylchloride adduct prepared by the procedure of Example 1.
  • EXAMPLE 5 The N-methyl-N-butyl amide of the hexachlorocyclopentadiene adduct of oleic acid was prepared by the procedure of Example 2 using 2.5 grams of N-methylbutylamine, 2.9 grams of triethylamine and grams of the oleoyl chloride adduct prepared by the procedure of Example 1. The product, N-methyl-N-butyl-8-(1,4,5,6,7,7- hexachloro 3 octyl bicyclo [2.2.
  • EXAMPLE 6 The N-methyl-N-allyl amide of the hexachlorocyclopentadiene adduct of oleic acid was prepared by the procedure of Example 2 using 3.4 grams of N-methylallylamine, 4.9 grams of triethylamine and 25 grame of the oleoyl chloride adduct prepared by the procedure of Example 1.
  • EXAMPLE 7 The N-bis(2 ethoxyethyl) amide of the hexachlorocyclopentadiene adduct of oleic acid was prepared by the procedure of Example 2 using 5 grams of bis(2-ethoxyethyl) amine, 3.1 grams of triethylamine and 13.6 grams of the oleoyl chloride adduct prepared by the procedure of Example 1.
  • EXAMPLE 10 The piperidide of the hexachlorocyclopentadiene adduct of oleic acid was prepared by the procedure of Example 2 using 2.8 grams of piperidine, 3.3 grams of triethylamine, and 15 grams of the oleoyl chloride adduct prepared by the procedure of Example 1.
  • EXAMPLE 1 1 The Z-methylpiperidide of the hexachlorocyclopentadiene adduct of oleic acid was prepared by the procedure of Example 2 using 3.2 grams of 2-n1ethylpiperidine, 3.3 grams of triethylamine, and 15 grams of the oleoyl chloride adduct prepared by the procedure of Example 1.
  • EXAMPLE 12 The morpholide of the hexachlorocyclopentadiene adduct of oleic acid was prepared by the procedure of Example 2 by using 2.2 grams of morpholine, 2.3 grams of triethylamine, and 11 grams of the oleoyl chloride adduct prepared by the procedure of Example 1.
  • EXAMPLE 13 The N-allyl amide of the hexachlorocyclopentadiene adduct of oleic acid was prepared by the procedure of Example 2 using 1.7 grams of allylamine, 2.9 grams of triethylamine, and 15 grams of the oleoylchloride adduct prepared by the procedure of Example 1.
  • EXAMPLE 15 The N-benzyl amide of the hexachlorocyclopentadiene adduct of oleic acid was prepared by the procedure of Example 2 using 3.1 grams of benzylamine, 2.9 grams of triethylamine, and 15 grams of the oleoyl chloride adduct prepared by the procedure of Example 1.
  • N-methyl-N-propyl amide of the hexachlorocyclopentadiene adduct of IO-undecenamide was prepared by reacting under a nitrogen blanket 7 grams of N-methyl- N-propyl-IO-undecenamide with 8 grams of hexachlorocyclopentadiene in a flask equipped with a condenser for hours at 135 C. The reaction mixture was dissolved in methyl alcohol and filtered. Unreacted hexachlorocyclopentadiene was removed by stripping under reduced pressure. Unreacted amide was removed by two urea clathrations.
  • EXAMPLE 18 The hexachlorocyclopentadiene adduct of IO-undecenoyl chloride was prepared from IO-undecenoyl chloride by the procedure of Example 1. Aliquots of the product, 9- (1,4,5,6,7,7 hexachlorobicyclo[2.2.1] 5-heptene-2-y1) nonanoyl chloride, were used to prepare the N-substituted amides of Examples 19 and 20.
  • N,N-dibutyl 8 (1,4,5,6,7,7 hexachloro 3- octylbicyclo[2.2.1]-5-heptene-2-yl)octanamide.
  • N,N-dimethyl 8 (1,4,5,6,7,7 hexachloro 3- octylbicyclo[2.2.l]-5-heptene-2-yl)octanamide.
  • N,N-diethyl 8 (1,4,5,6,7,7 hexachloro 3- octylbicyclo[2.2.1]-5-heptene-2-y1)octanamide.
  • N-methyl-N-butyl 8 (1,4,5,6,7,7 hexachloro 3- octylbicyclo[2.2.1]-5-heptene-2-yl)octanamide.
  • N-ethyl-N 3 ethoxypropyl 8 (1,4,5,6,7,7- hexachloro 3 octylbicyclo[2.2.1] 5 heptene 2 yl) octanamide.
  • N-allyl 8 (1,4,5,6,7,7 hexachloro 3-octylbicyclo- [2.2.1]-5-heptene-2-yl)octanamide.
  • N-methyl-N-propyl 9 (1,4,5,6,7,7-hexachlorobicyclo[2.2.1]-5-heptene-2-yl)nonanamide.

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  • Organic Chemistry (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

THIS INVENTION RELATES TO CERTAIN NEW NITROGEN-CONTAINING COMPOUNDS, MORE PARTICULARLY TO N-SUBSTITUTED AND N,N-DISTITUTED AMIDES, THE ACYL MOIETIES OF WHICH ARE THE ACYL MOIETIES OF THE HEXACHLOROCYCLOPENTADIENE ADDUCTS OF EITHER 9-OCTADECEONIC OR 10-UNDECENOIC ACIDS. THE COMPOUNDS WHICH ARE THE SUBJECT OF THIS INVENTION ARE CHARACTERIZED BY THE FACT THAT AS GROWTH INHIBITORS THEY ARE EFFECTIVE AGAINST A VARIETY OF BACTERIA, YEASTS, AND MOLDS, SOME OF WHICH ARE PATHOGENIC. THEY ARE ALSO USEFUL AS PLASTICIZERS.

Description

United States Patent Oflice 3,663,582 HEXACHLOROCYCLOPENTADIENE ADDUCTS F UNSATURATED AMIDES Robert R. Mod, Frank C. Magne, and Eveld L. Skau,
New Orleans, La., assignors to the United States of America as represented by the Secretary of Agriculture N0 Drawing. Filed Nov. 21, 1969, Ser. No. 878,922 Int. Cl. C07c 103/19 U.S. Cl. 260-404 10 Claims ABSTRACT OF THE DISCLOSURE This invention relates to certain new nitrogen-containing compounds, more particularly to N-substituted and N,N-disubstituted amides, the acyl moieties of which are the acyl moieties of the hexachlorocyclopentadiene adducts of either 9-octadeceonic or IO-undecenoic acids.
The compounds which are the subject of this invention are characterized by the fact that as growth inhibitors they are effective against a variety of bacteria, yeasts, and molds, some of which are pathogenic. They are also useful as plasticizers.
A non-exclusive, irrevocable, royalty-free license in the invention herein described, throughout the world for all purposes of the United States Government, with the power to grant sublicenses for such purposes, is hereby granted to the Government of the United States of America.
The compounds which are the subject of this invention include N-acyl derivatives of the following primary and secondary amines and cyclic imines: dimethylamine, diethylamine, dibutylamine, N methyl propylamine, N-methyl-butylamine, allylamine, N-methyl-allylamine, N,N-bis (2-ethoxyethy1)amine, N-ethyl 2 ethoxyethylamine, N-ethyl-3-ethoxyropylamine, pyrrolidine, piperidine, 2-methylpiperidine, morpholine, azaibicyclo[3.2.2] nonane, piperazine, N-methylpiperazine, and benylamine, the acyl group being that of the hexachlorocyclopentadiene adduct of either 9-octadecenoic or IO-undecen'oic acid.
The compounds which are the subject of this invention are:
N,N-dibutyl 8 (1,4,5,6,7,7-hexachloro-3-octylbidyclo [2.2.11-5-hepteue-2-yl) octanamide N,N dimethyl-8-(1,4,5,6,7,7-hexachloro-3-octylbicyclo [2.2.1]-5-heptene-2-yl)octanamide N,N-diethyl 8 (1,4,5,6,7,7-hexacholo-3-octylbicyc1o [2.2.1]-5-heptene-2-yl)octanamide 3,663,582 Patented May 16, 1972 N-methyl N allyl-841,4,5,6,7,7-hexachloro-3-octylbieyclo [2.2. 1 -5 -heptene-2-yl) octanamide N,N-bis(2-ethoxyethyl) 8 (1,4,5, 6,7,7-hexachloro-3- octylbicyclo [2.2. 1 -5-heptene-2-yl octanamide N-[8(1,4,5, 6,7,7-hexachloro 3 octylbicyclo[2.2.1]- 5 -heptene-2-yl) octanoyl] pyrrolidine CHgCHgCHzOCaH;
0 Hz- Ha N-['8-(1,4,5,6,7,7-hexachloro 3 octylbicyclo[2.2.1]- 5-heptene-2-y1) octanoyl] piperidine N[4841,4,5,*6,7,7-hexach1oro 3 octylbicyclo[2.2.ll- 5-heptene-2-y1)octanoyl]-2-methylpiperidine N-['8-(l,4,5,6,7,7 hexachloro 3 octylbicyclo[2.2.1]- S-heptene-Z-yl)octanoyl1morpholine N-[8-(1,4,5,6,7,7-hexachloro 3 octylbicyclo[2.2.l]- 5 heptene 2 yl)octanoy11-3-azabicyclo[3.2.2]nonane CH3(CHr)1-CH-CH(CH2)1CONHCH CH=OH N allyl 8 (1,4,5,6,7,7 hexachloro-3-octylbicyclo- [2.2. 1 -5-heptene-2-yl octanarnide 3 N benzyl 8 (1,4,5,6,7,7-hexachloro-3-octylbicyclo- [2.2.1]-5-heptene-2-yl)octanamide CCI=C61 N [8 (1,4,5,6,7,7-hexachloro-3-octylbicyclo[2.2.1]- 5 -heptene-2-yl octanoyl] -N-methylpiperazine CH --CH(CHz)aCON N methyl N propyl 9 (l,4,5,6,7,7-hexachlorobicyclo[2.2.1]--heptene-2-yl)nonanamide N [9-(1,4,5,6,7,7 hexachlorobicyclo[2.2.1] 5-heptene-2-yl) nonanoyl] piperidine CHZCHZ NOC(CH CHCH The diluent or extender must be inert with respect to the compound involved and since this is the only significant requirement, a wide variety of these agents is operable, among which are petroleum jellies, various alcohols, polyols, vegetable oils, and the like.
The compounds of this invention were screened for their antimicrobial activity against two bacteria-Bacillus sp., and Pseudomonas sp.--and a number of pathogenic yeasts or molds.Aspergillus flavus, Candida albicans, Microsporum gypseum, T richophylon rubrum, and Trichophyton violaceum.
Difco Bacto Dehydrated nutrient Agar at pH 6.8, Difco Bacto Dehydrated Yeast Morphological Agar at pH 4.5, and Difco Dehydrated Mycological Agar at pH 7.0 were used to test the inhibition of the bacteria, yeast, and mold cultures, respectively. The micro-organisms used were obtained from stock cultures. Seeded agar plates were used to measure the atnibacterial activity against bacteria. Hardened agar plates inoculated either by streaking or pouring the culture onto the plates were employed in the activity estimations against molds. Standard size (6.5 mm.) paper discs wetted with the test compound were placed on the surface of the agar plates inoculated with the test organisms. When streaked plates were used the test compounds were added onto the specified areas.
To eliminate any error which could result from an insufiicient number of tests, a minimum of three experiments employing duplicate plates was used for measuring the antimicrobial activity of each compound.
All test plates were incubated at the optimum growing temperature for each organism. Zones of inhibition were compared with those of the controls after periodic readings after 3, 5, and 7 days. The 7-day readings compiled in Table I show that the compounds were effective as growth 1nh1b1tors against specific organisms.
TABLE I Antimicrobial activity B Microorganisms A B C D E F G Example No.:
2 o o o o O 0 0 O O +=Zone of inhibition extends up to 0.5 cm. from disc; 0 o=0rganlsm failed to grow on disc; o=Slight growth of organism on disc; =No inhibition detectable.
b A=Aspcrgillus flavus; B Candida albz'cans; C Trichophyton rubrum; D=Trich0phyton violaceum; E=Microsporum gypscum; F=Bacillus sp.; G =Pseudomonas sp.
Specific examples showing the preparation of each of the new compounds being claimed are set forth below along with appropriate data in Table l which establish the growth inhibiting properties of the claimed compounds.
EXAMPLE 1 The hexachlorocyclopentadiene adduct of oleoyl chloride was prepared by reacting, under a nitrogen blanket, grams of oleoyl chloride with 145.2 grams of hexachlorocyclopentadiene in a flask equipped with a condenser for 28 hours at 135 C. Since neither hexachlorocyclopentadiene nor the adduct absorbs bromine, iodine values were used to determine the percentage of the oleoyl chloride converted. The reaction mixture showed a 75% conversion to the adduct. The excess hexachlorocyclopentadiene was removed by stripping at reduced pressure. Aliquots of the product, 8-(1,4,5,6,7,7-hexachloro-3-octylbicycl0[2.2.1]-5-heptene-2-yl) octanoyl chloride, were used to prepare the corresponding N-substituted amides described in Examples 2 to 16.
EXAMPLE 2 The N,N-dibutyl amide of the hexachlorocyclopentadiene adduct of oleic acid was prepared by dissolving 14.6 grams of dibutylamine and 11.4 grams of triethylamine in benzene and adding dropwise with stirring 57 grams of the oleoyl chloride adduct prepared by the procedure of Example 1. After stirring for an additional hour, the reaction mixture was filtered, washed successively with dilute hydrochloric acid and water, dried over anhydrous sodium sulfate, percolated through a column of activated alumina to remove residual free acid, and stripped. N,N- dibutyloleamide was removed by two urea clathrations. The product obtained by stripping the filtrate was dissolved in commercial hexane and residual urea was removed by washing with hydrochloric acid and water. The solution was dried over anhydrous sodium sulfate, filtered, and stripped. The product, N,N-dibutyl 8-(1,4,5,6,7,7- hexachloro 3-octylbicyclo[2.2.1]-5-heptene-2-yl)octam ide, gave the following analysis (percent): C, 55.56 (theory 55.86); H, 7.62 (theory 7.71); N, 1.95 (theory 2.10); Cl, 40.84 (theory 40.59).
This compound was tested as a plasticizer for vinyl chloride-vinyl acetate (:5) copolymer resin in the following formulation:
Percent Vinyl cholride resin 63.5 Plasticizer 35.0 Stearic acid 0.5
Basic lead carbonate 1.0
This formulation was milled, molded, and tested. The resulting molded plasticized resin showed no evidence of exudation or migration to the surface during shelf storage of 30 days and had the following properties: tensile strength, 3380 (3130) p.s.i.; 100% modulus, 3140 (1640) p.s.i.; elongation, 260 (360) percent; brittle point, +3 (-31) C.; volatility loss 0.03 (1.5) percent; soapy water extractability 0.00 (3.0) percent. The corresponding properties using the control plasticizer, di-2ethylhexyl phthalate (DOP), in the same formulation are given in parenthesis. The compound is therefore a good compatible primary plasticizer giving a plasticized stock showing extremely low volatility loss and soapy water extractability. The platsicized resin was also less flammable than DOP.
EXAMPLE 3 The N,N-dimethylarnide of the hexachlorocyclopentadiene adduct of oleic acid was prepared by the procedure of Example 2 using 1.1 grams of anhydrous dimethylamine, 2.4 grams of methylamine, and 12 grams of the oleoylchloride adduct prepared by the procedure of Example 1. The product, N,N-dimethyl-8 (l,4,5,6,7,7-hexachloro- 3-octylbicyclo[2.2.1]-5-heptene-2-yl)octanamide, gave the following analysis (percent): C, 51.50 (theory 51.56)); H, 6.73 (theory 6.75); N, 2.17 (theory 2.40); Cl, 36.48 (theory 36.53).
' EXAMPLE 4 The N,N-diethyl amide of the hexachlorocyclopentadiene adduct of oleic acid was prepared by the procedure of Example 2 using 2.7 grams of diethylamine, 3.7 grams of triethylamine and 17 grams of the oleoyl chloride adduct prepared by the procedure of Example 1. The product, N,N diethyl 8 (1,4,5,6,7,7-hexachloro-3-octylbicyclo [2.2.1] 5-heptene-2-yl)octanamide, gave the following analysis (percent): C, 55.09 (theory 53.12); H, 7.79 (theory 7.10), N, 2.50 (theory 2.20) Cl, 34.58 (theory 34.86).
EXAMPLE 5 The N-methyl-N-butyl amide of the hexachlorocyclopentadiene adduct of oleic acid was prepared by the procedure of Example 2 using 2.5 grams of N-methylbutylamine, 2.9 grams of triethylamine and grams of the oleoyl chloride adduct prepared by the procedure of Example 1. The product, N-methyl-N-butyl-8-(1,4,5,6,7,7- hexachloro 3 octyl bicyclo [2.2. l]-5-heptene-2-yl)octamide, gave the following analysis (percent): C, 55.77 (theory 53.86); H, 7.61 (theory 7.26); N, 2.26 (theory 2.24); CI, 32.07 (theory 34.07).
EXAMPLE 6 The N-methyl-N-allyl amide of the hexachlorocyclopentadiene adduct of oleic acid was prepared by the procedure of Example 2 using 3.4 grams of N-methylallylamine, 4.9 grams of triethylamine and 25 grame of the oleoyl chloride adduct prepared by the procedure of Example 1. The product, N-methyl-N-ally1-8-(1,4,5,6,7,7-hexachloro- 3-octylbicyclo[2.2.1]-5-heptene-2-yl)octanamide, gave the following analysis (percent): C, 53.90 (theory 53.30); H, 7.22 (theory 6.79) N, 2.42 (theory 2.30); CI, 32.84 (theory 34.97).
EXAMPLE 7 The N-bis(2 ethoxyethyl) amide of the hexachlorocyclopentadiene adduct of oleic acid was prepared by the procedure of Example 2 using 5 grams of bis(2-ethoxyethyl) amine, 3.1 grams of triethylamine and 13.6 grams of the oleoyl chloride adduct prepared by the procedure of Example 1. The product, N,N-bis(2-ethoxyethyl)-8-(1, 4,5 ,6,7,7-hexach1oro-3-octylbicyclo [2.2. 1 1 -5 -heptene-2yl) octanamide, gave the following analysis (percent): C, 55.71, (theory 53.32); H, 7.96 (theory 7.36); N, 2.32 (theory 2.44) Cl, 26.52 (theory 30.47).
6 EXAMPLE 8 The N-ethyl-N-ethoxypropyl amide of the hexachlorocyclopentadiene adduct of oleic acid was prepared by the procedure of Example 2 using 3.8 grams of N-ethyl-N-3- ethoxypropylamine, 2.9 grams of triethylamine and 15 grams of the oleoyl chloride adduct prepared by the procedure of Example 1. The product, N-ethyl-N-3-ethoxypropyl 8 (1,4,5,6,7,7-hexachloro-3-octylbicyclo[2.2.1]- 5 heptene-2-yl)octanamide, gave the following analysis (percent): C, 55.60 (theory 53.90); H, 7.70 (theory 7.39); N, 2.15 (theory 2.10); C1, 29.63 (theory 31.83).
EXAMPLE 9 N [8 (1,4,5,6,7,7-hexachloro-3-octylbicyclo[2.2.1]- 5-heptene-2-yl)octanoyljpyrrolidine was prepared by the method of Example 2 using 2.1 grams of pyrrolidine, 2.9 grams of triethylamine and 15 grams of the oleoyl chloride adduct prepared by the procedure of Example 1. The product, N [8-(1,4,5,6,7,7-hexachloro-3-octylbicyclo[2. 2.1]-5-heptene-2-yl)octanoyl]pyrrolidine gace the following analysis (percent): C, 53.34 (theory 53.30); H, 6.78 (theory 6.79); N, 2.21 (theory 2.30); Cl, 35.13 (theory 34.97).
EXAMPLE 10 The piperidide of the hexachlorocyclopentadiene adduct of oleic acid was prepared by the procedure of Example 2 using 2.8 grams of piperidine, 3.3 grams of triethylamine, and 15 grams of the oleoyl chloride adduct prepared by the procedure of Example 1. The product, N- [8 (l,4,5,6,7,7 hexachloro-3-octylbicyclo[2.2.1]-5-heptene-Z-yl)octanoylJpiperidine, gave the following analysis (percent): C, 56.46 (theory 54.03); H, 7.90 (theory 6.96); N, 2.24 (theory 2.25); Cl, 29.92 (theory 34.08).
EXAMPLE 1 1 The Z-methylpiperidide of the hexachlorocyclopentadiene adduct of oleic acid was prepared by the procedure of Example 2 using 3.2 grams of 2-n1ethylpiperidine, 3.3 grams of triethylamine, and 15 grams of the oleoyl chloride adduct prepared by the procedure of Example 1. The product, N [8 (l,4,5,6,7,7 hexachloro-3-octylbicyclo [2.2.1]-5-heptene-2-yl)octanoyl]-2-methylpiperidine, gave the following analysis (percent): C, 57.28 (theory 54.73); H, 7.77 (theory 7.13); N, 2.49 (theory 2.20); Cl, 28.95 (theory 28.95)
EXAMPLE 12 The morpholide of the hexachlorocyclopentadiene adduct of oleic acid was prepared by the procedure of Example 2 by using 2.2 grams of morpholine, 2.3 grams of triethylamine, and 11 grams of the oleoyl chloride adduct prepared by the procedure of Example 1. The product, N- [8 (l,4,5,6,7,7 hexachloro 3-octylbicyclo[2.2.1]-5- heptene 2-yl)octanoy11morpholine, gave the following analysis (percent): C, 52.67 (theory 51.93); H, 6.80 (theory 6.62); N, 2.40 (theory 2.24); Cl, 32.83 (theory 34.08).
EXAMPLE 13 The N-allyl amide of the hexachlorocyclopentadiene adduct of oleic acid was prepared by the procedure of Example 2 using 1.7 grams of allylamine, 2.9 grams of triethylamine, and 15 grams of the oleoylchloride adduct prepared by the procedure of Example 1. The product, N allyl 8-(1,4,5,6,7,7-hexachloro-3-octylbicyclo[2.2.1]- 5-heptene-2-yl)octanamide, gave the following analysis (percent): C, 53.38 (theory 52.54); H, 6.72 (theory 6.61); N, 2.31 (theory 2.35); Cl, 34.71 (theory 35.80).
EXAMPLE 15 The N-benzyl amide of the hexachlorocyclopentadiene adduct of oleic acid was prepared by the procedure of Example 2 using 3.1 grams of benzylamine, 2.9 grams of triethylamine, and 15 grams of the oleoyl chloride adduct prepared by the procedure of Example 1. The product, N benzyl 8-(1,4,5,6,7,7-hexachloro-3-octylbicyclo[2.2.1]-5-heptene-2-yl)octamide, gave the following analysis (percent): C, 55.88 (theory 55.91); H, 6.56 (theory 6.41); N, 2.11 (theory 2.17); Cl, 33.16 (theory 33.02).
EXAMPLE 16 N [8-(1,4,5,6,7,7-hexachloro-3-octylbicyclo[2.2.1]-5- heptene-Z-yl octanoyl] -N'-methylpiperazine was prepared by adding dropwise with stirring 25.6 grams of the oleoyl chloride adduct of Example 1 to a benzene solution of 5 grams of N-methylpiperazine and 5.1 grams of triethylene. After stirring for an additional hour the reaction mixture was filtered. The filtrate was dried over sodium sulfate, percolated through activated alumina to remove residual acid chloride adduct, and stripped. 25 grams of the product was added to a hot solution of methanol containing 100 grams of urea. The solution was allowed to cool to room temperature and stored at C. overnight. The urear-complexed crystals were filtered and pressed dry after which an additional 100 grams of urea was dissolved in the filtrate. The crystallization and filtration were repeated. The product obtained by stripping the methanol from the filtrate was dissolved in chloroform, filtered to remove residual urea, and stripped. The product, N [8-(1,4,5,6,7,7-hexachloro-3-octylbicyclo[2.2.1]- heptene-Z-yl)octanoyl]-N'-methylpiperazine, gave the following analysis (percent): C, 53.99 (theory 52.76); H, 7.15 (theory 6.96); N, 5.34 (theory 4.40); Cl, 29.95
(theory 33.38).
EXAMPLE 17 The N-methyl-N-propyl amide of the hexachlorocyclopentadiene adduct of IO-undecenamide was prepared by reacting under a nitrogen blanket 7 grams of N-methyl- N-propyl-IO-undecenamide with 8 grams of hexachlorocyclopentadiene in a flask equipped with a condenser for hours at 135 C. The reaction mixture was dissolved in methyl alcohol and filtered. Unreacted hexachlorocyclopentadiene was removed by stripping under reduced pressure. Unreacted amide was removed by two urea clathrations. The product, N methyl N-propy1-9-(1,4,5,6,7,7- hexachlorobicyclo[2.2.1] 5-heptene-2-yl)nonamide, gave the following analysis (percent): C, 48.80 (theory 46.90); H, 6.31 (theory 5.71); N, 2.92 (theory 2.74); Cl, 40.92 .(theory 41.54).
EXAMPLE 18 The hexachlorocyclopentadiene adduct of IO-undecenoyl chloride was prepared from IO-undecenoyl chloride by the procedure of Example 1. Aliquots of the product, 9- (1,4,5,6,7,7 hexachlorobicyclo[2.2.1] 5-heptene-2-y1) nonanoyl chloride, were used to prepare the N-substituted amides of Examples 19 and 20.
EXAMPLE 19 The piperidide of the hexachlorocyclopentadiene adduct of IO-undecenoic acid was prepared by the procedure of Example 2 using 3.6 grams of piperidine, 4.3 grams of triethylamine, and 20 grams of the IO-undecenoyl chloride adduct prepared in Example 18. The product N-[9-(1,4, 5,6,7,7 hexachlorobicyclo[2.2.1] 5 heptene 2 yl) nonanoyl]piperidine, gave the following analysis (percent): C, 48.01 (theory 48.12); H, 5.63 (theory 5.58); N, 2.50 (theory 2.67); Cl, 40.84 (theory 40.59).
EXAMPLE 20 N,N'-bis[9 (1,4,5,6,7,7 hexachlorobicyclo[2.2.l]- 5-heptene-2-yl)nonanoyl]piperazine was prepared by the procedure of Example 2 using 1.8 grams anhydrous piperazine, 4.3 grams triethylamine, and 20 grams of the 10-octadecenoyl chloride adduct prepared in Example 18. The product, N,N-bis[9 (1,4,5,6,7,7 hexachlorobicyclo[2.2.1] 5 heptene 2 yl)nonanoyl]piperazine, gave the following analysis (percent): C, 44.90 (theory 44.84); H, 5.01 (theory 4.81); N, 2.73 (theory 2.91); CI, 44.30 (theory 44.63).
The results of the screening evaluation of the products of Examples 2 to 17, 19 and 20, compiled in Table I, show their effectiveness as growth inhibitors against specific organisms.
We claim:
1. N,N-dibutyl 8 (1,4,5,6,7,7 hexachloro 3- octylbicyclo[2.2.1]-5-heptene-2-yl)octanamide.
2. N,N-dimethyl 8 (1,4,5,6,7,7 hexachloro 3- octylbicyclo[2.2.l]-5-heptene-2-yl)octanamide.
3. N,N-diethyl 8 (1,4,5,6,7,7 hexachloro 3- octylbicyclo[2.2.1]-5-heptene-2-y1)octanamide.
4. N-methyl-N-butyl 8 (1,4,5,6,7,7 hexachloro 3- octylbicyclo[2.2.1]-5-heptene-2-yl)octanamide.
5. N-methyl-N-allyl-S (1,4,5,6,7,7 hexachloro 3- octylbicyclo[2.2.1]-5-heptene-2-y1)octanamide.
6. N,N-bis(2 ethoxyethyl)-8-(1,4,5,6,7,7-hexachloro- 3-octylbicyclo [2 .2. 1 -5-heptene-2-yl octanamide.
7. N-ethyl-N 3 ethoxypropyl 8 (1,4,5,6,7,7- hexachloro 3 octylbicyclo[2.2.1] 5 heptene 2 yl) octanamide.
8. N-allyl 8 (1,4,5,6,7,7 hexachloro 3-octylbicyclo- [2.2.1]-5-heptene-2-yl)octanamide.
9. N-benzyl 8 -(l,4,5,6,7,7 hexachloro 3-octylbicyclo[2.2.1]-5-heptene-2-yl)octanamide.
10. N-methyl-N-propyl 9 (1,4,5,6,7,7-hexachlorobicyclo[2.2.1]-5-heptene-2-yl)nonanamide.
References Cited UNITED STATES PATENTS 6/1958 Soloway 260557 2/1959 Bloch 260-557 US. Cl. X.R.
260239 BA; 247.7 E, 268 C, 293.56, 326.5, 543 L; 424-172
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