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US3322114A - Apparatus for securing a sample of blood plasma for testing - Google Patents

Apparatus for securing a sample of blood plasma for testing Download PDF

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Publication number
US3322114A
US3322114A US379498A US37949864A US3322114A US 3322114 A US3322114 A US 3322114A US 379498 A US379498 A US 379498A US 37949864 A US37949864 A US 37949864A US 3322114 A US3322114 A US 3322114A
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United States
Prior art keywords
bottle
blood
plasma
needle
sample
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Expired - Lifetime
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US379498A
Inventor
Portnoy Joseph
George S Warner
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Hynson Westcott and Dunning Inc
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Hynson Westcott and Dunning Inc
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Priority to US379498A priority Critical patent/US3322114A/en
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150015—Source of blood
    • A61B5/15003—Source of blood for venous or arterial blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150053—Details for enhanced collection of blood or interstitial fluid at the sample site, e.g. by applying compression, heat, vibration, ultrasound, suction or vacuum to tissue; for reduction of pain or discomfort; Skin piercing elements, e.g. blades, needles, lancets or canulas, with adjustable piercing speed
    • A61B5/150061—Means for enhancing collection
    • A61B5/150099—Means for enhancing collection by negative pressure, other than vacuum extraction into a syringe by pulling on the piston rod or into pre-evacuated tubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150381—Design of piercing elements
    • A61B5/150389—Hollow piercing elements, e.g. canulas, needles, for piercing the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150381—Design of piercing elements
    • A61B5/150503—Single-ended needles
    • A61B5/150519—Details of construction of hub, i.e. element used to attach the single-ended needle to a piercing device or sampling device
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150534—Design of protective means for piercing elements for preventing accidental needle sticks, e.g. shields, caps, protectors, axially extensible sleeves, pivotable protective sleeves
    • A61B5/15058—Joining techniques used for protective means
    • A61B5/150587—Joining techniques used for protective means by friction fit
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150534—Design of protective means for piercing elements for preventing accidental needle sticks, e.g. shields, caps, protectors, axially extensible sleeves, pivotable protective sleeves
    • A61B5/150694—Procedure for removing protection means at the time of piercing
    • A61B5/150717—Procedure for removing protection means at the time of piercing manually removed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150755—Blood sample preparation for further analysis, e.g. by separating blood components or by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/153—Devices specially adapted for taking samples of venous or arterial blood, e.g. with syringes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M5/2422—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule
    • A61M5/2425—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule by compression of deformable ampoule or carpule wall
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers

Definitions

  • the invention resides in a composition of an anticoagulant and a lectin in a suitable container such as a disposable syringe to which a sample of blood may be added whereby the blood cells are coagulated by the lectin while clotting of the blood is prevented by the anticoagulant and the blood plasma is separated.
  • the tests described in said patent require only a small amount of plasma such as the quantity available from only a few drops of blood that readily may be obtained e.g. by puncturing a finger of a person with a lancet but for some tests or for carrying out a plurality of tests more plasma frequently is needed and it is an object of our invention to provide apparatus that is adapted to obtain and deliver from a few drops up to several cubic centimeters of blood plasma.
  • the invention resides primarily in a hypodermic needle of a suitable diameter and length for extracting blood from a person or animal secured to the neck of a bottle or container of a suitable transparent or at least translucent plastic such as polyethylene, said bottle containing an anticoagulant such as heparin or one of the salts of ethylenediaminetetraacetic acid and a lectin or phytoagglutinin material such as that extracted from Phaseolzzs commzmis or Phaseolus vulgaris.
  • an anticoagulant such as heparin or one of the salts of ethylenediaminetetraacetic acid and a lectin or phytoagglutinin material such as that extracted from Phaseolzzs commzmis or Phaseolus vulgaris.
  • said bottle may contain 1 mg. of lectin and 1 mg. ethylenediaminetetraacetic acid.
  • the needle is secured to a hub which in turn is detachably secured to the bottle and the apparatus comprises also a dispensing nozzle adapted to be applied to the bottle after the needle has been detached, said dispensing nozzle optionally containing a filter.
  • FIG. 1 is an exploded side elevational view of the bottle containing a mass of a mixture of anticoagulant and lectin, the needle and its hub and a protective cap for the needle and
  • FIG. 2 is a sectional view of the dispensing nozzle provided with a filter.
  • the needle protective cap 2 is the hypodermic needle
  • 3 is the needle hub
  • 5 is a mass of anticoagulant and lectin
  • 6 is the neck of the bottle.
  • the needle cap, needle and hub are all well known and need not be described.
  • the bottle 4 is formed of a flexible and elastic or resilient plastic such as polyethylene, the wall of the bottle being of such thickness that it retains its normal shape e.g. cylindrical but is readily deformable i.e. collapsed by the pressure of the thumb and finger of the operator and will return to its original shape when the pressure is released.
  • the wall of the bottle should be sufficiently resilient to create a slight suction and thus to draw blood through the needle into the bottle but not so resilient as to prevent collapsing 3,322,114 Patented May 30, 1967 "ice by the pressure of the fingers or to create sutficient suction on the vein from which blood is being drawn to cause collapse of the vein.
  • a bottle the wall of which is sufficiently rigid to maintain its shape and requires only gentle pressure of the thumb and finger to collapse it will, due to its resilient tendency to return to its original shape when the pressure is relaxed, create sufiicient suction to draw blood from the vein of a human or animal but not sufiicient ordinarily to collapse the vein.
  • Anticoagulants and phytoagglutinins or lectins are well known and the kinds and quantities thereof required to prevent clotting (anticoagulant) and to cause agglomeration of the blood cells (lectin) of the kind and quantity of the blood sample are well known and need not be discussed.
  • lectins and their uses We refer to the book entitled Introduction to Immunochemical Specificity by William C. Boyd, John Wiley & Sons, 1962.
  • the anticoagulant and lectin may be introduced into the bottle 4 either separately or mixed with each other, in either liquid or solid form, and either through the neck of the bottle or through the bottom end of the bottle before it is closed and sealed.
  • the dispensing nozzle 7 may be of the same shape'as the hub 3 of the needle, and as appears in FIG. 2, contains a filter 8 and has a short neck 9 which serves to deliver a drop of plasma of a suitable size for the spot .test described in Patent No. 3,074,853.
  • the filter 8 may be formed of a variety of filter materials such as pressed glass fiber, pressed nitrocellulose fiber, non-absorbent cotton, filter paper or the like and may be formed by packing loose fiber into the conical end of the nozzle or by cutting a disc from a filter in sheet form and inserting it in the conical space.
  • the filter should be such as will remove solid particles such as blood cells from the plasma but not so difiicultly pervious that the pressure required to force the plasma through the filter will effect hemolysis of the blood cells. It is within the scope of our invention to impregnate the filter with lectin 0r anticoagulant or both to render it more effective i.e. to assist in maintaining the plasma uncoagulated and in agglomerating the blood cells and preventing their passage through the filter. It is also within the scope of our invention to omit the filter.
  • the apparatus is used as follows.
  • the bottle 4 containing the lectin and anticoagulant is partially collapsed by the pressure of the thumb and finger and the needle 2 which is attached by its hub 3 to the neck 6 of the bottle is inserted into a vein of a person or animal and the pressure on the bottle released whereupon blood flows through the needle into the bottle and the bottle returns to its normal uncompressed shape.
  • the needle is then withdrawn from the vein and the contents of the bottle shaken to effect mixing of the blood with the lectin and anticoagulant and then allowed to stand whereupon.
  • the agglomerated blood cells separate and settle to the bottom of the bottle leaving a supernatant layer of clear plasma.
  • some of the clear plasma generally can be discharged through the needle or the needle may be removed and the plasma discharged through the neck 6. However it is preferred to replace the needle by the dispensing nozzle 7 and to discharge the plasma from the bottle through the filter 8. If preferred the neck of the plastic bottle can be cut-off thereby forming a small test tube from which clear plasma can be removed with a capillary tube.
  • the whole apparatus is inexpensive and disposable and is not intended for reuse.
  • a device for drawing a sample of blood and separating plasma therefrom comprising a bottle having a transparent or translucent, flexible and resilient side wall capable of being collapsed by the pressure exerted by the thumb and finger of the operator and of returning to its normal shape when said pressure is released, a hypodermic needle attached to said bottle for aspirating blood from a vein of a person or animal into said bottle and an anti coagulant and a lectin in said bottle of a kind and in quantity suflicient to prevent clotting and to cause agglomeration of the cells of the kind and quantity of blood to be delivered into said bottle and to cause the separation of plasma from the collected blood.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Analytical Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Description

May 30, 1967 omov ET AL APPARATUS FOR SECURING A SAMPLE OF BLOOD PLASMA FOR TESTING Filed July 1, 1964 I NVEN TOR WIk/V' ATTORNEYS Jaw/v POR77VOY BYEVMQWQLP United States Patent 3,322,114 APPARATUS FOR SECURING A SAMPLE OF BLOOD PLASMA FOR TESTING Joseph Portnoy and George S. Warner, Baltimore, Md.,
assignors to Hynson, Westcott & Dunning, Incorporated, a corporation of Maryland Filed July 1, 1964, Ser. No. 379,498
3 Claims. (Cl. 128-2) ABSTRACT OF THE DISCLOSURE The invention resides in a composition of an anticoagulant and a lectin in a suitable container such as a disposable syringe to which a sample of blood may be added whereby the blood cells are coagulated by the lectin while clotting of the blood is prevented by the anticoagulant and the blood plasma is separated.
Samples of blood plasma of humans and various animals are required for carrying out a variety of tests such as those described in US. Patent No. 3,074,853.
The tests described in said patent require only a small amount of plasma such as the quantity available from only a few drops of blood that readily may be obtained e.g. by puncturing a finger of a person with a lancet but for some tests or for carrying out a plurality of tests more plasma frequently is needed and it is an object of our invention to provide apparatus that is adapted to obtain and deliver from a few drops up to several cubic centimeters of blood plasma.
The invention resides primarily in a hypodermic needle of a suitable diameter and length for extracting blood from a person or animal secured to the neck of a bottle or container of a suitable transparent or at least translucent plastic such as polyethylene, said bottle containing an anticoagulant such as heparin or one of the salts of ethylenediaminetetraacetic acid and a lectin or phytoagglutinin material such as that extracted from Phaseolzzs commzmis or Phaseolus vulgaris. For example, in the separation of plasma from swine blood said bottle may contain 1 mg. of lectin and 1 mg. ethylenediaminetetraacetic acid.
In the preferred form of our invention the needle is secured to a hub which in turn is detachably secured to the bottle and the apparatus comprises also a dispensing nozzle adapted to be applied to the bottle after the needle has been detached, said dispensing nozzle optionally containing a filter.
The invention is illustrated in the accompanying drawings in which:
FIG. 1 is an exploded side elevational view of the bottle containing a mass of a mixture of anticoagulant and lectin, the needle and its hub and a protective cap for the needle and FIG. 2 is a sectional view of the dispensing nozzle provided with a filter.
Referring to the drawings 1 is the needle protective cap, 2 is the hypodermic needle, 3 is the needle hub, 4 the bottle, 5 is a mass of anticoagulant and lectin and 6 is the neck of the bottle. The needle cap, needle and hub are all well known and need not be described. The bottle 4 is formed of a flexible and elastic or resilient plastic such as polyethylene, the wall of the bottle being of such thickness that it retains its normal shape e.g. cylindrical but is readily deformable i.e. collapsed by the pressure of the thumb and finger of the operator and will return to its original shape when the pressure is released. The wall of the bottle should be sufficiently resilient to create a slight suction and thus to draw blood through the needle into the bottle but not so resilient as to prevent collapsing 3,322,114 Patented May 30, 1967 "ice by the pressure of the fingers or to create sutficient suction on the vein from which blood is being drawn to cause collapse of the vein. We have found that a bottle the wall of which is sufficiently rigid to maintain its shape and requires only gentle pressure of the thumb and finger to collapse it will, due to its resilient tendency to return to its original shape when the pressure is relaxed, create sufiicient suction to draw blood from the vein of a human or animal but not sufiicient ordinarily to collapse the vein.
Anticoagulants and phytoagglutinins or lectins are well known and the kinds and quantities thereof required to prevent clotting (anticoagulant) and to cause agglomeration of the blood cells (lectin) of the kind and quantity of the blood sample are well known and need not be discussed. For a disclosure of lectins and their uses We refer to the book entitled Introduction to Immunochemical Specificity by William C. Boyd, John Wiley & Sons, 1962.
The anticoagulant and lectin may be introduced into the bottle 4 either separately or mixed with each other, in either liquid or solid form, and either through the neck of the bottle or through the bottom end of the bottle before it is closed and sealed.
The dispensing nozzle 7 may be of the same shape'as the hub 3 of the needle, and as appears in FIG. 2, contains a filter 8 and has a short neck 9 which serves to deliver a drop of plasma of a suitable size for the spot .test described in Patent No. 3,074,853. The filter 8 may be formed of a variety of filter materials such as pressed glass fiber, pressed nitrocellulose fiber, non-absorbent cotton, filter paper or the like and may be formed by packing loose fiber into the conical end of the nozzle or by cutting a disc from a filter in sheet form and inserting it in the conical space. The filter should be such as will remove solid particles such as blood cells from the plasma but not so difiicultly pervious that the pressure required to force the plasma through the filter will effect hemolysis of the blood cells. It is within the scope of our invention to impregnate the filter with lectin 0r anticoagulant or both to render it more effective i.e. to assist in maintaining the plasma uncoagulated and in agglomerating the blood cells and preventing their passage through the filter. It is also within the scope of our invention to omit the filter.
The apparatus is used as follows.
The bottle 4 containing the lectin and anticoagulant is partially collapsed by the pressure of the thumb and finger and the needle 2 which is attached by its hub 3 to the neck 6 of the bottle is inserted into a vein of a person or animal and the pressure on the bottle released whereupon blood flows through the needle into the bottle and the bottle returns to its normal uncompressed shape. The needle is then withdrawn from the vein and the contents of the bottle shaken to effect mixing of the blood with the lectin and anticoagulant and then allowed to stand whereupon.
the agglomerated blood cells separate and settle to the bottom of the bottle leaving a supernatant layer of clear plasma. By careful manipulation some of the clear plasma generally can be discharged through the needle or the needle may be removed and the plasma discharged through the neck 6. However it is preferred to replace the needle by the dispensing nozzle 7 and to discharge the plasma from the bottle through the filter 8. If preferred the neck of the plastic bottle can be cut-off thereby forming a small test tube from which clear plasma can be removed with a capillary tube.
The whole apparatus is inexpensive and disposable and is not intended for reuse.
We claim:
1. A device for drawing a sample of blood and separating plasma therefrom comprising a bottle having a transparent or translucent, flexible and resilient side wall capable of being collapsed by the pressure exerted by the thumb and finger of the operator and of returning to its normal shape when said pressure is released, a hypodermic needle attached to said bottle for aspirating blood from a vein of a person or animal into said bottle and an anti coagulant and a lectin in said bottle of a kind and in quantity suflicient to prevent clotting and to cause agglomeration of the cells of the kind and quantity of blood to be delivered into said bottle and to cause the separation of plasma from the collected blood.
2. A device for drawing a sample of blood and sepjarating plasma therefrom as defined in claim 1 in which said dispensing nozzle contains a filter.-
References Cited UNITED STATES PATENTS 2,722,257 11/1955 Lockhart 5. 128-216 X 2,982,286 5/1961 Welch 128216 3,045,494 7/ 1962 Gerarde 128216 X 3,089,489 5/1963 Dunmire 128-216 3,181,529 5/1965 Wilburn 1282 3,192,925 7/1965 Cunningham 128216 3,224,434 12/ 1965 Molomut 1282 RTCHARD A. GAUDET, Primary Examiner. V
S. BROD'ER, Assistant Examiner.

Claims (1)

1. A DEVICE FOR DRAWING A SAMPLE OF BLOOD AND SEPARATING PLASMA THEREFROM COMPRISING A BOTTLE HAVING A TRANSPARENT OR TRANSLUCENT, FLEXIBLE AND RESILIENT SIDE WALL CAPABLE OF BEING COLLAPSED BY THE PRESSURE EXERTED BY THE THUMB AND FINGER OF THE OPERATOR AND OF RETURNING TO ITS NORMAL SHAPE WHEN SAID PRESSURE IS RELEASED, A HYDPODERMIC NEEDLE ATTACHED TO SAID BOTTLE FOR ASPIRATING BLOOD FROM A VEIN OF A PERSON OR ANIMAL INTO SAID BOTTLE AND AN ANTICOAGULANT AND A LECTIN IN SAID BOTTLE OF A KIND AND IN QUANTITY SUFFICIENT TO PREVENT CLOTING AND TO CAUSE AGGLOMERATION OF THE CELLS OF THE KIND AND QUANTITY OF BLOOD TO BE DELIVERED INTO SAID BOTTLE AND TO CAUSE THE SEPARATION OF PLASMA FROM THE COLLECTED BLOOD.
US379498A 1964-07-01 1964-07-01 Apparatus for securing a sample of blood plasma for testing Expired - Lifetime US3322114A (en)

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Cited By (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3424148A (en) * 1964-05-12 1969-01-28 Jacques Blomet Device for taking blood samples
US3460529A (en) * 1965-06-30 1969-08-12 Gino Leucci Sterile device for extracting urine samples and the like and package for same
US3481477A (en) * 1965-03-02 1969-12-02 Andrew F Farr Apparatus for filtering out clear liquid from suspended solids
US3513829A (en) * 1967-08-11 1970-05-26 Brunswick Corp Fluid collecting structure
US3518804A (en) * 1966-10-27 1970-07-07 Horace W Gerarde Pipette assembly having precise quantity stabilized reagent in liquid form and method of preparing same
US3539300A (en) * 1967-10-23 1970-11-10 Schering Corp Body fluid collector and separator having improved flow rate
US3596652A (en) * 1968-10-14 1971-08-03 Bio Science Labor Fluid separatory device
US3640267A (en) * 1969-12-15 1972-02-08 Damon Corp Clinical sample container
US3718133A (en) * 1971-01-12 1973-02-27 Damon Corp Container unit for liquid samples
US3800780A (en) * 1972-02-23 1974-04-02 Angelika Elliott Vacuum indicator
US3817239A (en) * 1972-05-12 1974-06-18 D Kuntz Urine monitor
US3951798A (en) * 1974-02-25 1976-04-20 Glasrock Products, Inc. Container filter combination
US3978846A (en) * 1975-01-02 1976-09-07 Bailey Donald L Syringe for taking blood samples
US4014797A (en) * 1973-12-11 1977-03-29 Burron Medical Products, Inc. Intravenous injection apparatus and needle adapter with filter and method of making same
US4014653A (en) * 1974-12-26 1977-03-29 Denver Chemical Manufacturing Company Micro-filter
US4172448A (en) * 1977-07-25 1979-10-30 Sherwood Medical Industries Inc. Fluid sampling device
US4180060A (en) * 1972-08-18 1979-12-25 Boehringer Mannheim Gmbh Device for staining biological materials
US4227527A (en) * 1978-10-23 1980-10-14 Baxter Travenol Laboratories, Inc. Sterile air vent
US4259187A (en) * 1979-06-07 1981-03-31 Baxter Travenol Laboratories, Inc. Intravenous fluid filter
US4266559A (en) * 1979-04-02 1981-05-12 American Hospital Supply Corporation Blood sampler
US4266558A (en) * 1979-04-02 1981-05-12 American Hospital Supply Corporation Method of collecting and dispensing a blood sample
US4298011A (en) * 1979-09-07 1981-11-03 Mangurten Henry H Blood sample collector
WO1983000281A1 (en) * 1981-07-27 1983-02-03 American Hospital Supply Corp Ventable sample collection device
US4511352A (en) * 1984-05-14 1985-04-16 Alza Corporation Parenteral delivery system with in-line container
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US4871360A (en) * 1981-07-31 1989-10-03 Alza Corporation System for intravenous delivery of a beneficial drug at a regulated rates
US4741734A (en) * 1981-10-09 1988-05-03 Alza Corporation Releasing means for adding agent using releasing means to IV fluid
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