US3395162A - Process for the preparation of amides - Google Patents
Process for the preparation of amides Download PDFInfo
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- US3395162A US3395162A US304674A US30467463A US3395162A US 3395162 A US3395162 A US 3395162A US 304674 A US304674 A US 304674A US 30467463 A US30467463 A US 30467463A US 3395162 A US3395162 A US 3395162A
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11C—FATTY ACIDS FROM FATS, OILS OR WAXES; CANDLES; FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS, OILS, OR FATTY ACIDS OBTAINED THEREFROM
- C11C3/00—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom
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- one method disclosed in the prior art to produce fatty acid dihydroxyalkyl amides essentially free of amide-ester is to hold the final reaction mixture containing the amide and substantial amounts of the amideester for at least two days at temperatures below 55 C. in the presence of an alkali metal catalyst. During this holding period, much of the amide-ester by-product is converted to the dihydroxyalkyl amide. The use of an aging period is time-consuming and therefore uneconomical.
- Another method developed to produce fatty acid dihydroxyalkyl amides [free of deleterious amounts of amide-ester is to condense fatty acid esters with secondary amines in the presence of a catalyst selected from the group of alkali metals, their amides and alkoxides at temperatures of 200-280 F. and thereafter slowly cool the reaction mixture to storage temperatures. At the end of the slow cooling step the amide-ester is at a level which is insutficient to interfere with the foaming properties of the amide.
- An object of the present invention is to provide a rapid and efficient method of preparing substantially colorless and odorless fatty acid dihydroxyalkyl amides from fatty acid esters of glycerol.
- Another object is the preparation of dihydroxyalkyl amides without using holding periods or a slow cooling step.
- Still another object of the invention is to provide a process for the production of dihydroxyalkyl amides free of substantial amounts of by-products which tend to inhibit the foaming properties of the amides.
- a fatty acid ester of glycerol with an excess of a dihydroxyalkyl amine at temperatures of about 65 C. to about 100 C. in the presence of at least about 0.02 mole of an alkali metal hydroxide catalyst per mole of ester group.
- the glyceride is added gradually to the heated mixture of the catalyst and the amine under conditions such that at all times during the reaction there is maintained an excess of free amine relative to the glyceride.
- the formation of the amide-ester is largely suppressed under the conditions of the present process thereby yield- RCON tates Patent Patented July 30, 1968 ing a product having a relatively low level of this impurity without the necessity of using a holding period or a slow cooling step.
- the product is also substantially free of undesirable odors, has an acceptable color and is admirably suited for use in formulating detergent compositions.
- the glycerol esters used in the process are mono-, dior triglycerides derived from higher fatty acids and mixtures of these acids.
- the fatty acid radical generally contains about 8 to about 18 carbon atoms and may be derived from acids including palmitic, stearic, lauric and myristic.
- glycerol monostearate, glycerol distearate, mixed monoand diglycerides of stearic acid or steariclauric acids can all be utilized in the invention.
- the esters employed are naturally occurring triglycerides fats and oils such as coconut oil, palm kernel oil, lard, tallow, soy bean oil, etc. Refined coconut oil is a particularly preferred triglyceride. Mixtures of the mono-, diand triglycerol esters may also be employed.
- the secondary amine is a dihydroxyalkyl amine such as diethanolamine, dipropanolamine, diisopropanolamine, dibutanolamine, diisobutanolamine, etc. which are dihydroxy lower alkyl amines.
- These amines have two alkyl radicals each joining a hydroxyl group to the same nitro gen atom which contains a replaceable hydrogen. It is vitally important to the successful operation of the present process that the amine be present in excess during the reaction. At least 1.1 moles of amine per mole of ester group is necessary, and it is preferred to utilize a ratio of about 1.3 moles of amine for each mole of ester group. Higher levels can also be used, if desired.
- the fatty acid ester of glycerol is preferably added gradually to the reaction mixture.
- the reaction mixture may be cooled to storage temperatures.
- the catalyst used in the process of the invention is an alkali metal hydroxide. While sodium hydroxide is preferred, other alkali metal hydroxides such as potassium hydroxide and lithium hydroxide can also be utilized.
- An important advantage in the use of alkali metal hydroxides as catalysts is that selected species of these reagents are relatively inexpensive in comparison to catalysts such as the sodium alkoxides conventionally used in preparing fatty acid alkanolamides.
- the hydroxide catalysts are unexpectedly superior in terms of providing a substantially odorfree, colorless product with a low amideester content.
- a level of hydroxide catalyst of at least about 0.02 mole per mole of ester group is necessary to provide a product having an acceptable amide-ester content.
- a preferred amount of catalyst is about 0.06 mole per mole of ester group.
- the maximum amount of catalyst depends upon a number of factors. Thus, at any given reaction temperature the hydroxide has a limited solubility in the reaction medium. Undissolved catalyst is not only ineflicient from an economical standpoint but may also cause plugging of lines and equipment and lead to soap formation which has a deleterious effect upon the foam stabilizing properties of the amide product. In general, the upper limit :on the level of catalyst is about 0.2 mole per mole of ester group. If free fatty acids are present in the glycerol ester, the proportion of catalyst present in the reaction medium as discussed above would be in addition to the amount required to neutralize the fatty acids.
- Reaction temperatures ranging from about 65 C. to about 100 C. should be employed. A preferred temperature range is C. to C. Temperatures above about C. are undesirable since high levels of amideester are obtained and the product exhibits a darker color as the reaction temperature increases.
- EXAMPLE 7 The same procedure as in Example was followed except that the reaction temperature was 70 C. The amideester content of the product was only 2%. The product was essentially odorless and pale yellow in color.
- EXAMPLE 8 The same procedure as in Example 5 was followed except that the reaction temperature was 65 C. The amideester content of the product was only 2%. The product was essentially odorless and pale yellow in color.
- EXAMPLE 9 The same procedure as in Example 5 was followed except that the molar ratio of diethanolamine to coconut oil was 3.3 to 1.0 (i.e., 1.1 moles of diethanolamine per ester group in the glyceride). The amide-ester content of the product was 7%. The product was essentially odorless and pale yellow in color.
- EXAMPLE 10 EXAMPLE 11 The procedure of Example 5 was again followed employing a reaction temperature of 100 C. The amideester content of the product was 7%. The product was odorless and pale yellow although the color was slightly darker than the product of Example 10.
- the product When the process was repeated using a reaction temperature of 115 C., the product had a relatively high amide-ester content of 12%. The product was also darker in color than the products obtained by using reaction temperatures of 85 C. and 100 C.
- EXAMPLE 12 A mixture of coconut monoand di-glycerides was first prepared by reacting 658 g. (1 mole) of refined, bleached and deodorized coconut oil with 184 g. (2.0 moles) of glycerol at C. for three hours in the presence of 4 g. (0.1 mole) of powdered sodium hydroxide and under agitation. The mixed glycerides, 846 g., were then gradually added to a mixture of 405 g. (3.85 moles) of diethanolamine (molar ratio of amine to ester groups, 1.3) and 4 g. (0.1 mole) of powdered sodium hydroxide (molar ratio of total NaOH per ester group 0.07) at 80 C. and under agitation.
- the reaction mixture was maintained at reaction temperatures for an hour and then cooled.
- the amide-ester content of the product was 6%.
- the product was essentially odorless and very light (pale yellow) in color.
- fatty acid dihydroxyalkyl amides are obtained which are essentially odorless, light in color and exhibit low amide-ester levels without the necessity of using holding periods or a slow cooling step.
- Products made with sodium methoxide as the catalyst according to the above procedure were characterized by a sweet ester odor which rendered the products unsuitable for many applications. This compares unfavorably with the results obtained by the procedure of the present invention wherein an essentially odorless product was produced which also had an acceptable amide-ester content.
- a method for the production of fatty acid dihydroxyalkyl amides which comprises reacting a higher fatty acid ester of glycerol containing fatty acids of about 8 to 18 carbon atoms and mixtures thereof and a secondary dihydroxy lower alkyl amine at temperatures of about 65 C. to about 100 C.
- reaction temperature is about 80 C. to 90 C.
- a method for the production of fatty acid dihydroxyalkyl amides which comprises gradually adding refined coconut oil to diethanolamine in a molar proportion of about 1 to 3.85 at a temperature of about 80 C. in the presence of about 0.15 to 0.20 mole of sodium hydroxide per mole of coconut oil, the reaction conditions being maintained so that at all times there exists in the reaction medium an excess of amine relative to coconut oil, to obtain coconut oil diethanolamine free of substantial amounts of interfering by-products.
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Description
3,395,162 PROCESS FOR THE PREPARATION OF AMIDES Vincent Lamberti, Teaneck, N.J., assignor to Lever Brothers Company, New York, N.Y., a corporation of Maine No Drawing. Filed Aug. 26, 1963, Ser. No. 304,674 6 Claims. (Cl. 260404) R1011 RiOOCR RiOH 2RC ON EN R OH RzOH RzOH whe e R-CO is a higher fatty acyl radical and R and R are alkylene radicals. Since the presence of the amideester is deleterious to the foaming properties of detergent compositions containing the fatty acid dihydroxyalkyl amide, it is desirable to prepare the amide under conditions to suppress the formation of the undesirable amideester.
For example, one method disclosed in the prior art to produce fatty acid dihydroxyalkyl amides essentially free of amide-ester is to hold the final reaction mixture containing the amide and substantial amounts of the amideester for at least two days at temperatures below 55 C. in the presence of an alkali metal catalyst. During this holding period, much of the amide-ester by-product is converted to the dihydroxyalkyl amide. The use of an aging period is time-consuming and therefore uneconomical.
Another method developed to produce fatty acid dihydroxyalkyl amides [free of deleterious amounts of amide-ester is to condense fatty acid esters with secondary amines in the presence of a catalyst selected from the group of alkali metals, their amides and alkoxides at temperatures of 200-280 F. and thereafter slowly cool the reaction mixture to storage temperatures. At the end of the slow cooling step the amide-ester is at a level which is insutficient to interfere with the foaming properties of the amide.
An object of the present invention is to provide a rapid and efficient method of preparing substantially colorless and odorless fatty acid dihydroxyalkyl amides from fatty acid esters of glycerol.
Another object is the preparation of dihydroxyalkyl amides without using holding periods or a slow cooling step.
Still another object of the invention is to provide a process for the production of dihydroxyalkyl amides free of substantial amounts of by-products which tend to inhibit the foaming properties of the amides.
These and other objects and advantages of the invention are attained by reacting a fatty acid ester of glycerol with an excess of a dihydroxyalkyl amine at temperatures of about 65 C. to about 100 C. in the presence of at least about 0.02 mole of an alkali metal hydroxide catalyst per mole of ester group. In a preferred embodiment, the glyceride is added gradually to the heated mixture of the catalyst and the amine under conditions such that at all times during the reaction there is maintained an excess of free amine relative to the glyceride.
The formation of the amide-ester is largely suppressed under the conditions of the present process thereby yield- RCON tates Patent Patented July 30, 1968 ing a product having a relatively low level of this impurity without the necessity of using a holding period or a slow cooling step. The product is also substantially free of undesirable odors, has an acceptable color and is admirably suited for use in formulating detergent compositions.
The glycerol esters used in the process are mono-, dior triglycerides derived from higher fatty acids and mixtures of these acids. The fatty acid radical generally contains about 8 to about 18 carbon atoms and may be derived from acids including palmitic, stearic, lauric and myristic. Thus, glycerol monostearate, glycerol distearate, mixed monoand diglycerides of stearic acid or steariclauric acids can all be utilized in the invention. Preferably, the esters employed are naturally occurring triglycerides fats and oils such as coconut oil, palm kernel oil, lard, tallow, soy bean oil, etc. Refined coconut oil is a particularly preferred triglyceride. Mixtures of the mono-, diand triglycerol esters may also be employed.
The secondary amine is a dihydroxyalkyl amine such as diethanolamine, dipropanolamine, diisopropanolamine, dibutanolamine, diisobutanolamine, etc. which are dihydroxy lower alkyl amines. These amines have two alkyl radicals each joining a hydroxyl group to the same nitro gen atom which contains a replaceable hydrogen. It is vitally important to the successful operation of the present process that the amine be present in excess during the reaction. At least 1.1 moles of amine per mole of ester group is necessary, and it is preferred to utilize a ratio of about 1.3 moles of amine for each mole of ester group. Higher levels can also be used, if desired.
As an aid in maintaining a relatively large excess of amine when the process is carried out as a batch operation, the fatty acid ester of glycerol is preferably added gradually to the reaction mixture. When the reaction is complete, the reaction mixture may be cooled to storage temperatures.
The catalyst used in the process of the invention is an alkali metal hydroxide. While sodium hydroxide is preferred, other alkali metal hydroxides such as potassium hydroxide and lithium hydroxide can also be utilized. An important advantage in the use of alkali metal hydroxides as catalysts is that selected species of these reagents are relatively inexpensive in comparison to catalysts such as the sodium alkoxides conventionally used in preparing fatty acid alkanolamides. In addition, the hydroxide catalysts are unexpectedly superior in terms of providing a substantially odorfree, colorless product with a low amideester content.
A level of hydroxide catalyst of at least about 0.02 mole per mole of ester group is necessary to provide a product having an acceptable amide-ester content. A preferred amount of catalyst is about 0.06 mole per mole of ester group. The maximum amount of catalyst depends upon a number of factors. Thus, at any given reaction temperature the hydroxide has a limited solubility in the reaction medium. Undissolved catalyst is not only ineflicient from an economical standpoint but may also cause plugging of lines and equipment and lead to soap formation which has a deleterious effect upon the foam stabilizing properties of the amide product. In general, the upper limit :on the level of catalyst is about 0.2 mole per mole of ester group. If free fatty acids are present in the glycerol ester, the proportion of catalyst present in the reaction medium as discussed above would be in addition to the amount required to neutralize the fatty acids.
Reaction temperatures ranging from about 65 C. to about 100 C. should be employed. A preferred temperature range is C. to C. Temperatures above about C. are undesirable since high levels of amideester are obtained and the product exhibits a darker color as the reaction temperature increases.
3 The following examples are illustrative of the present invention.
EXAMPLE 1 Refined, bleached and deodorized coconut oil, 658 parts, was added gradually to a mixture of 405 parts of diethanolamine (molar ratio of amine to oil=3.85) and 4.95 parts of powdered sodium hydroxide (molar ratio of NaOH to oil=0.l24) at 80 C. and under agitation. After the addition of the coconut oil was complete, the reaction mixture was maintained at reaction temperatures for an hour and then cooled. The amide-ester content (all esters calculated as amide-ester and determined by infrared analysis) of the product was found to be 3%. The product was essentially odorless and very light (pale yellow) in color.
EXAMPLES 2-6 The same procedure as in Example 1 was used except that the catalyst level was varied as follows:
Molar Ratio of NaOH Percent Amide-Ester To Coconut Oil In Product Exagnplc No.:
The results show that the molar ratio of catalyst to ester group must be above a minimum level in order to obtain a product having an acceptable amide-ester content.
EXAMPLE 7 The same procedure as in Example was followed except that the reaction temperature was 70 C. The amideester content of the product was only 2%. The product was essentially odorless and pale yellow in color.
EXAMPLE 8 The same procedure as in Example 5 was followed except that the reaction temperature was 65 C. The amideester content of the product was only 2%. The product was essentially odorless and pale yellow in color.
EXAMPLE 9 The same procedure as in Example 5 was followed except that the molar ratio of diethanolamine to coconut oil was 3.3 to 1.0 (i.e., 1.1 moles of diethanolamine per ester group in the glyceride). The amide-ester content of the product was 7%. The product was essentially odorless and pale yellow in color.
EXAMPLE 10 EXAMPLE 11 The procedure of Example 5 was again followed employing a reaction temperature of 100 C. The amideester content of the product was 7%. The product was odorless and pale yellow although the color was slightly darker than the product of Example 10.
When the process was repeated using a reaction temperature of 115 C., the product had a relatively high amide-ester content of 12%. The product was also darker in color than the products obtained by using reaction temperatures of 85 C. and 100 C.
EXAMPLE 12 A mixture of coconut monoand di-glycerides was first prepared by reacting 658 g. (1 mole) of refined, bleached and deodorized coconut oil with 184 g. (2.0 moles) of glycerol at C. for three hours in the presence of 4 g. (0.1 mole) of powdered sodium hydroxide and under agitation. The mixed glycerides, 846 g., were then gradually added to a mixture of 405 g. (3.85 moles) of diethanolamine (molar ratio of amine to ester groups, 1.3) and 4 g. (0.1 mole) of powdered sodium hydroxide (molar ratio of total NaOH per ester group 0.07) at 80 C. and under agitation. After the addition, of the glyceride mixture was complete, the reaction mixture was maintained at reaction temperatures for an hour and then cooled. The amide-ester content of the product was 6%. The product was essentially odorless and very light (pale yellow) in color.
It will be observed from the above disclosure that the invention involves a novel combination of several critical features to provide surprising and unexpected results. Thus, a fatty acid ester of glycerol and a dihydroxyalkyl amine are reacted under the following critical conditions:
(a) Using an alkali metal hydroxide catalyst;
(b) Using a reaction temperature of between about 65 to C.;
(c) Employing an excess of amine relative to the glyceride;
(d) Employing at least about 0.02 mole of alkali metal hydroxide per mole of ester group.
By following these conditions, fatty acid dihydroxyalkyl amides are obtained which are essentially odorless, light in color and exhibit low amide-ester levels without the necessity of using holding periods or a slow cooling step.
Products made with sodium methoxide as the catalyst according to the above procedure were characterized by a sweet ester odor which rendered the products unsuitable for many applications. This compares unfavorably with the results obtained by the procedure of the present invention wherein an essentially odorless product was produced which also had an acceptable amide-ester content.
As additional evidence of the unexpected nature of the invention, products have been prepared using NaOH as a catalyst and methyl esters of coconut oil (lauricmyristic acids in ratio of 80:20) as reactants at 80 C. These products had a very high amide-ester level (about 12%) in comparison to amides obtained in accordance with the principles of the present invention.
While the working examples all disclose the preferred embodiment of operating the process batch-wise, it should be realized that the method of the invention can be operated continuously. The particular operating conditions to be employed in a continuous operation can be readily determined by those skilled in the art bearing in mind that the critical conditions of temperature, type and level of catalyst and excess amine as discussed above must be observed.
.It will occur to those skilled in the art that there are many modifications to the invention as specifically described herein. It is intended to include all such modifications within the scope of the appended claims.
I claim:
1. A method for the production of fatty acid dihydroxyalkyl amides which comprises reacting a higher fatty acid ester of glycerol containing fatty acids of about 8 to 18 carbon atoms and mixtures thereof and a secondary dihydroxy lower alkyl amine at temperatures of about 65 C. to about 100 C. in the presence of at least about 0.02 mole of an alkali metal hydroxide catalyst per mole of ester group, with an upper limit of 0.2 mole of catalyst per mole of ester group in addition to the amount required to neutralize any free fatty acid present in the glycerol ester, the total mole proportions of amine to ester group being at least 1.1 to 1.0 respectively, the reaction conditions being maintained so that at all times there exists in the reaction medium an excess of amine relative to the fatty acid glycerol ester.
2. A process according to claim 1 in which the ester of glycerol is a triglyceride.
3. A process according to claim 2 in which the triglyceride is coconut oil.
4. The process of claim 1 in which the catalyst is sodium hydroxide.
5. The process of claim 1 in which the reaction temperature is about 80 C. to 90 C.
6. A method for the production of fatty acid dihydroxyalkyl amides which comprises gradually adding refined coconut oil to diethanolamine in a molar proportion of about 1 to 3.85 at a temperature of about 80 C. in the presence of about 0.15 to 0.20 mole of sodium hydroxide per mole of coconut oil, the reaction conditions being maintained so that at all times there exists in the reaction medium an excess of amine relative to coconut oil, to obtain coconut oil diethanolamine free of substantial amounts of interfering by-products.
References Cited UNITED STATES PATENTS 2,844,609 7/ 1958 Tesoro 260404 2,863,888 12/1958 Schunman 260404 3,040,075 6/ 1962 Lohr 260404 FOREIGN PATENTS 781,549 8/ 1957 Great Britain.
5 NICHOLAS S. RIZZO, Primary Examiner.
F. A. MIKA, Assistant Examiner.
UNITED STATES PATENT OFFICE CERTIFICATE OF CORRECTION Patent No. 3 ,395 ,162 July 30 1968 Vincent Lamberti It is certified that error appears in the above identified patent and that said Letters Patent are hereby corrected as shown below:
Column 6, line 10, insert the following reference:
3 ,107 ,258 10/1963 Lamberti et a1 Signed and sealed this 13th day of January 1970.
(SEAL) Attest:
Edward M. Fletcher, Jr.
Attesting Officer Commissioner of Patents WILLIAM E. scHUYLEfii, JR.
Claims (1)
1. A METHOD FOR THE PRODUCTION OF FATTY ACID DIHYDROXYALKYL AMIDES WHICH COMPRISES REACTING A HIGHER FATTY ACID ESTER OF GLYCEROL CONTAINING FATTY ACIDS OF ABOUT 8 TO 18 CARBON ATOMS AND MIXTURES THEREOF AND A SECONDARY DIHYDROXY LOWER ALKYL AMINE AT TEMPERATURES OF ABOUT 65*C. TO ABOUT 100*C. IN THE PRESENCE OF AT LEAST ABOUT 0.02 MOLE OF AN ALKALI METAL HYDROXIDE CATALYST PER MOLE OF ESTER GROUP, WITH AN UPPER LIMIT OF 0.2 MOLE OF CATALYST PER MOLE OF ESTER GROUP IN ADDITION TO THE AMOUNT REQUIRED TO NEUTRALIZE ANY FREE FATTY ACID PRESENT IN THE GLYCEROL ESTER, THE TOTAL MOLE PROPORTIONS OF AMINE TO ESTER GROUP BEING AT LEAST 1.1 TO 1.0 RESPECTIVELY, THE REACTION CONDITIONS BEING MAINTAINED SO THAT AT ALL TIMES THERE EXISTS IN THE REACTION MEDIUM AN EXCESS OF AMINE RELATIVE TO THE FATTY ACID GLYCEROL ESTER.
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Cited By (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3519661A (en) * | 1964-08-26 | 1970-07-07 | Us Agriculture | N,n-disubstituted amides |
| US3538123A (en) * | 1969-04-10 | 1970-11-03 | Us Agriculture | N,n-bis(2 - ethoxyethyl)epoxystearamide as a primary plasticizer for vinyl-type resins |
| WO1995022519A1 (en) * | 1994-02-17 | 1995-08-24 | The Procter & Gamble Company | Synthesis of polyhydroxy fatty acid amides from triglycerides |
| US5496857A (en) * | 1994-03-17 | 1996-03-05 | Targosz; Eugene F. | Whitefly insecticide |
| WO1996018601A1 (en) * | 1994-12-12 | 1996-06-20 | The Procter & Gamble Company | Synthesis of fatty n-alkyl amides |
| FR2768732A1 (en) * | 1997-09-25 | 1999-03-26 | Inst Francais Du Petrole | PROCESS FOR THE MANUFACTURE OF AN EMULSIFYING AND DISPERSING SURFACE AGENT FROM POLYMERIZED OIL AND AMINO ALCOHOL |
| US20100010244A1 (en) * | 2006-10-09 | 2010-01-14 | Clariant Finance (Bvi)Limited | Method For Producing Fatty Acid Alkanol Amides |
| US20100076040A1 (en) * | 2006-10-09 | 2010-03-25 | Clariant Finance Wickhams Cay | Method For Producing Bisbenzoxazoles |
| US20100116642A1 (en) * | 2006-10-09 | 2010-05-13 | Clariant Finance (Bvi) Limited | Method For Producing Alkaline Fatty Acid Amides |
| US20110083956A1 (en) * | 2008-04-04 | 2011-04-14 | Clariant Finance (Bvi) Limited | Continuous Method For Producing Fatty Acid Alkanol Amides |
| US20110083957A1 (en) * | 2008-04-04 | 2011-04-14 | Clariant Finance (Bvi) Limited | Continuous Method For Producing Amides Of Aliphatic Hydroxycarboxylic Acids |
| US20110089019A1 (en) * | 2008-04-04 | 2011-04-21 | Clariant Finance (Bvi) Limited | Continuous Method For Producing Amides of Aromatic Carboxylic Acids |
| US20110092722A1 (en) * | 2008-04-04 | 2011-04-21 | Clariant Finance (Bvi) Limited | Continuous Method For Producing Fatty Acid Amides |
| US20110089021A1 (en) * | 2008-04-04 | 2011-04-21 | Clariant Finance (Bvi) Limited | Method For Producing Amides In The Presence Of Superheated Water |
| US20110089020A1 (en) * | 2008-04-04 | 2011-04-21 | Clariant Finance (Bvi) Limited | Continuous Method for Producing Amides of Ethylenically Unsaturated Carboxylic Acids |
| US20110137081A1 (en) * | 2008-04-04 | 2011-06-09 | Clariant Finance (Bvi) Limited | Continuous Method For Producing Amides Of Low Aliphatic Carboxylic Acids |
| US8067635B2 (en) | 2006-10-09 | 2011-11-29 | Clariant Finance (Bvi) Limited | Method for producing tertiary amides of alkylphenyl carboxylic acids |
| US8974743B2 (en) | 2009-06-30 | 2015-03-10 | Clariant Finance (Bvi) Limited | Device for continuously carrying out chemical reactions at high temperatures |
| US9000197B2 (en) | 2009-09-22 | 2015-04-07 | Clariant Finance (Bvi) Limited | Continuous transesterification method |
| US9039870B2 (en) | 2006-10-09 | 2015-05-26 | Clariant Finance (Bvi) Limited | Method for producing alkaline (meth)acrylamides |
| US9221938B2 (en) | 2010-12-30 | 2015-12-29 | Clariant Finance (Bvi) Limited | Polymers carrying hydroxyl groups and ester groups and method for the production thereof |
| US9243116B2 (en) | 2010-12-30 | 2016-01-26 | Clariant International Ltd. | Method for modifying polymers comprising hydroxyl groups |
| US9302245B2 (en) | 2009-09-22 | 2016-04-05 | Clariant International Ltd. | Apparatus for continuously carrying out heterogeneously catalyzed chemical reactions at elevated temperatures |
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| GB781549A (en) * | 1954-12-29 | 1957-08-21 | Colgate Palmolive Co | Process for preparing fatty acid di-hydroxyalkyl amides, and products of such process |
| US2844609A (en) * | 1955-06-29 | 1958-07-22 | Onyx Oil & Chemical Company | Preparation of amides |
| US2863888A (en) * | 1954-09-28 | 1958-12-09 | Colgate Palmolive Co | Process for the production of fatty acid hydroxy amides |
| US3040075A (en) * | 1957-06-20 | 1962-06-19 | Andrew Jergens Co | Method of making fatty alkanol amides |
-
1963
- 1963-08-26 US US304674A patent/US3395162A/en not_active Expired - Lifetime
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2863888A (en) * | 1954-09-28 | 1958-12-09 | Colgate Palmolive Co | Process for the production of fatty acid hydroxy amides |
| GB781549A (en) * | 1954-12-29 | 1957-08-21 | Colgate Palmolive Co | Process for preparing fatty acid di-hydroxyalkyl amides, and products of such process |
| US2844609A (en) * | 1955-06-29 | 1958-07-22 | Onyx Oil & Chemical Company | Preparation of amides |
| US3040075A (en) * | 1957-06-20 | 1962-06-19 | Andrew Jergens Co | Method of making fatty alkanol amides |
Cited By (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3519661A (en) * | 1964-08-26 | 1970-07-07 | Us Agriculture | N,n-disubstituted amides |
| US3538123A (en) * | 1969-04-10 | 1970-11-03 | Us Agriculture | N,n-bis(2 - ethoxyethyl)epoxystearamide as a primary plasticizer for vinyl-type resins |
| WO1995022519A1 (en) * | 1994-02-17 | 1995-08-24 | The Procter & Gamble Company | Synthesis of polyhydroxy fatty acid amides from triglycerides |
| US5496857A (en) * | 1994-03-17 | 1996-03-05 | Targosz; Eugene F. | Whitefly insecticide |
| WO1996018601A1 (en) * | 1994-12-12 | 1996-06-20 | The Procter & Gamble Company | Synthesis of fatty n-alkyl amides |
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