[go: up one dir, main page]

US3158109A - Multi-layer tablet making machines - Google Patents

Multi-layer tablet making machines Download PDF

Info

Publication number
US3158109A
US3158109A US255967A US25596763A US3158109A US 3158109 A US3158109 A US 3158109A US 255967 A US255967 A US 255967A US 25596763 A US25596763 A US 25596763A US 3158109 A US3158109 A US 3158109A
Authority
US
United States
Prior art keywords
die
sampling
powder
punch
layer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US255967A
Other languages
English (en)
Inventor
Frank T Stott
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
John Holroyd and Co Ltd
Original Assignee
John Holroyd and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by John Holroyd and Co Ltd filed Critical John Holroyd and Co Ltd
Application granted granted Critical
Publication of US3158109A publication Critical patent/US3158109A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B30—PRESSES
    • B30B—PRESSES IN GENERAL
    • B30B15/00—Details of, or accessories for, presses; Auxiliary measures in connection with pressing
    • B30B15/32—Discharging presses
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C43/00—Compression moulding, i.e. applying external pressure to flow the moulding material; Apparatus therefor
    • B29C43/32—Component parts, details or accessories; Auxiliary operations
    • B29C43/50—Removing moulded articles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B30—PRESSES
    • B30B—PRESSES IN GENERAL
    • B30B11/00—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses
    • B30B11/02—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space
    • B30B11/08—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space co-operating with moulds carried by a turntable
    • B30B11/085—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space co-operating with moulds carried by a turntable for multi-layer articles

Definitions

  • Sheets-Sheet 4 INVENTOR FRANK THOMAS STOTT ATTORNEY.
  • This invention concerns multi-layer tablet making machines, that is to say machines for producing compressed tablets composed of two or more superimposed layers. More particularly, the invention concerns machines (hereinafter referred to as a machine of the type described) comprising a plurality of dies each of which successively receives a plurality of powder fills (the number of which corresponds to the desired number of layers in the finished tablet) which fills are tamped or individually pre-compressed prior to the successive fill entering into the die.
  • the tamping of the individual fills is effected, inter alia, to ensure a clear delineation, between the individual layers in the finished tablets, which is clearly visible where powders of different colours are employed for successive fills.
  • the extent to which the individual fills are compressed is critical. If too little tamping or pre-compression is effected, it does not consolidate the respective powder fill and clear separation of the layers does not occur.
  • the tamping pressure is too great, the corresponding layer is highly consolidated to produce a very hard layer. In this event, the layers present such a hard surface to the subsequent fill that the latter will not, when compressed, adhere to the previously formed layer. The layers of the finished tablet, therefore, are not adequately bonded together, and they will separate easily.
  • An object of the present invention is to provide an arrangement wherein this dificulty is overcome, and with this object in view the present invention provides a multilayer tablet making machine of the type described wherein the tamped layer or layers can be sampled characterised by compression means permitting the sampled layer or layers to be subjected to compression sufficient to ensure the integrity thereof, prior to ejection from the respective die.
  • the machine comprises a rotary die table having a plurality of dies spaced therearound and having an upper and lower punch associated with each die, a plurality of powder feeding stations past which the dies are moved, upon rotation of the die table, to feed successive powder fills to each die, means for controlling the positions of the upper and lower punches in their dies as the die table rotates, so as to raise each upper punch as its 3,158,1fi9 Patented Nov. 24, 1964 die reaches each powder feeding station, and, between successive powder feeding stations, a pair of tamping rollers between which the upper and lower punches pass so as to tamp successive fills.
  • the compression means permitting the sampled layer or layers to be subject to compression sufficient to ensure the integrity thereof may conveniently comprise means for displacing one of the tamping rollers of the respective pair towards the other.
  • the upper tampiug roller is so displaced.
  • the displaceable tamping roller is preferably carried upon a shiftable mounting, and the means for displacing the same may advantageously be hydraulically operated.
  • a sampling cam selectively displaceable into or out of the path of the lower punches after the latter have passed the corresponding tamping rollers.
  • such sampling cam is also hydraulically operable, and in such instance both the hydraulically displaceable tamping roller and the corresponding hydraulically displaceable sampling cam may conveniently be connected to a common operating device to displace both arrangements simultaneously.
  • FIG. 1 is a front elevation of a preferred embodiment of multi-layer tablet making machine constructed in accordance with the invention
  • FIG. 2 is a plan view, with certain parts omitted so as to show the lower cam track of the machine, corresponding to FIG. 1;
  • FIGS. 30 and 3b together are a development showing a development of the cams, cam tracks, tamping rolls and pressure rolls, which act upon the punches as the die table revolves.
  • FIGS. 3a and 312 will be referred to together as FIG. 3;
  • FIG. 4 is a diagram showing details of one pair of tamping rollers and its associated sampling cam, these eing illustrated in their positions for normal tablet production;
  • FIG. 5 is a view similar to FIG. 4 but showing the tamping rollers and sampling cam in their positions for layer sampling;
  • FIG. 6 is an enlarged fragmentary sectional view showing the means by which the ends of the lower punches are held flush with the die table.
  • FIG. 7 is a fragmentary sectional view of the line 77 of FIG. 6.
  • a base or frame It supporting a vertical column 11 around which is rotatable a circular die table 12 around which are disposed a plurality of tablet dies 13 (see FIGS. 4 and 5) which extend vertically through the die table 12.
  • an upper flange 14 Disposed above the die table 12 and integral with the latter is an upper flange 14 (FIG. 1) having disposed therearound a plurality of upper punches 15 (FIGS. 4 and 5), one aligned with each die 13, each extending through the upper flange 14 and engaging, by a head 16 at its top, with an upper cam track 17 (FIG.
  • the upper level of the die table 12 is indicated at 18 in FIG. 3.
  • a lower flange 19 (FIG. 1) carrying a plurality of lower punches 20 (FIGS. 4 and 5), one in register with each die 13, a toe 21 on the lower end of each lower punch 3 20 running along a cam track 22 (FIG. 3) which similarly raises and lowers the lower punches Ztl.
  • three tablet material feed stations each comprising a feed shoe 23 supported from the machine base 10 and disposed above the die table 12, a respective powder hopper 24 being disposed above and terminating in an outlet 25 leading to the feed shoe 23.
  • the latter may, if desired, incorporate agitators, rotors or the like (not shown) so as to ensure mobility of the material being fed and, consequently, efficient filling of the dies 13.
  • a first pair of tamping rollers Arranged between the first and second of the material feed stations are a first pair of tamping rollers namely an upper tamping roller 26 disposed above the upper flange and a lower tamping roller 27 disposed below the lower flange.
  • the upper tamping roller 26 is carried upon a mounting 28 which is arranged upon the underside of a stationary platform 29 disposed above the upper flange 14.
  • the mounting 28 is arranged so as to be vertically movable relative to such platform.
  • the mounting 2.3 is pivoted on a fulcrum 30 connected to the platform 29 and is spring-loaded upwards as by spring 28 so as to tend to abut the underside of the platform 29, as shown in FIG.
  • the housing 33 comprises a vertical passage into which the plunger 31 projects and which has a ball 34 disposed in the upper end thereof.
  • Such passage joins with a horizontal passage containing a hydraulic piston 35 and a second bail 3d which abuts the ball 34 in the vertical passage.
  • a pressure fluid line 37 connects with the horizontal passage at the side of the piston 35 remote from the balls 36, 34 so that when pressure fluid is fed to the piston 35, the latter is displaced so as to displace the balls 36, 34, resulting in corresponding downward movement of the plunger 31.
  • the latter produces corresponding downward movement of the mounting 28, and therefore the upper tamping roller 26 is displaced downwards, as shown in FIG. 5.
  • the lower tamping roller 27 is disposed in a recess 38 (FIG. 3) in the lower cam track 22 of the machine and is carried by a displaceable U-shaped mounting 39 the end of which remote from the roller 27 is inclined and abuts against a wedge 49 which is displaceable by a handoperable screw 41 threaded into a body part 42 wherein the mounting 39 and wedge 46 are disposed. Rotation of the screw 41 causes movement of the wedge 44 across the end of the mounting 39, with corresponding adjustment of the height of the lower tamping roller 27 relative to the lower cam track 22.
  • a bolt 43 extending through the wedge 40 and the screw 41 is surrounded by a spring 44 abutting against ,a nut 45 on the bolt 43 and the screw 41, so that the spring 44 acts to maintain the wedge 46 in engagement with the confronting end of the screw 41 in the normal operating cycle. In the event of an overload occurring spring 44 allows the wedge 48 to retract from the end of the mounting 39.
  • a sampling cam 46 is mushroom shaped to provide a head 47 disposed in a recess 48 (see FIGS. 4 and in the lower cam track 22 and a shank 49 slidable in a socket 50 below such cam track. This is shown in detail in FIG. 3, and diagrammatically in FIGS. 4 and 5. Axially disposed below the socket 50 and aligned with the shank 49 is the piston rod 51 of a sampling ram 52 (FIGS.
  • a second pair of tampingrollers 26a, 27a substantially similar to the first tamping rollers 26, 27, with a second sampling cam 46a similar to the first sampling cam 46, these being connected by hydraulic lines to a second selector 54.
  • the parts associated with the tamping rollers 26a, 27a and sampling cam 46a which are similar to those associated with the tamping rollers 26, 27 and sampling cam 46 have been allocated similar reference numerals with the index letter it added thereto, and need not be described further, since they act in exactly the same way as the parts already described.
  • the lower cam track 22 has a raised finished tablet ejection portion 59, in correspondence with such tablet ejecting portion, the upper cam track has an upper punch raising portion 69.
  • the die 13 is moved towards the first material feed station, and as it approaches the latter the upper punch 15 is raised by the upper punch raising portion 66 of the upper cam track 17, out of the die 13.
  • the die moves under the first feed shoe 23 at the right hand side of FIG. 3b and receives a first fill of powder therefrom.
  • the lower punch 26 is raised by a predetermined amount by a first weight adjustment cam 61 so that a small amount of the powder in the die 13 is ejected as the die 13 moves past the rear wall 23a of the shoe 23. This ensures a constant fill of powder in each die 13.
  • the upper punch 15 is then lowered by a pull down part 62 of the upper cam track 17 so that its lower end enters into the die 13, whereafter the two punches 15 and 20 pass between the first tamping rollers 26 and 27 which are in the FIG. 4 positions and act to consolidate the first fill.
  • the die 13 then moves on past the first sampling cam 46, which will be in the lowered position of FIG. 4, to the second material feed station whereat a second pow der fill is received by the die 13 from the second feed shoe 23 shown at the left hand side of FIG. 3b and the right hand side of FIG. 3a, after raising of the upper punch by a second upper punch raising portion 63 of the upper cam track 17.
  • the lower punch 20 is raised by a second weight adjustment cam 64 to eject a small amount ofthe second fill and thereupon the upper punch 15 is lowered by a second pull down part 65 of the upper cam track 17 onto the second fill, whereupon the upper and lower punches 15, 20 pass between the second tamping rollers 26a, 27a.
  • This serves to consolidate the second fill as a layer on top of the consolidated layer from the first fill, both the fills being compressed between the punches 15, 29.
  • the die 13 passes to and under the third material filling station whereat a third fill of powder enters the die 13 (the upper punch 15 having previously been raised by a third upper cam raising portion 66 of the upper cam track 17) the amount of the fill being maintained constant by a third weight adjustment cam 67 raising the lower punch 25) as previously described.
  • the upper punch 15 is then lowered by a pull down part 63 of the upper cam track 17 whereupon the punches 15, 20 pass between the final tablet pressure rollers 57, 58 which applies a high pressure to all the fills in the die 13 to form a strong, highly coherent tablet in the die 13.
  • the upper punch is raised by the raising portion 60, as also is the lower punch by the tablet ejecting portion 59 of the lower track 22, the lower punch 20 raising the tablet to the level of the top 18 of the die table 12, to encounter a take-01f plate 69 or the like extending across the table 12 obliquely to the path of the tablet, so that the latter is deflected into path 7ila of a feed-off chute 70 (see FIG. 2).
  • the machine can, in addition to being used for producing three-layer tablets, be employed for producing two-layer tablets (in which case material will be provided only in two of the material feed station hoppers 24) or for producing single layer tablets (in which case powder will be provided only in one of the hoppers 24).
  • sampling of the layers can be eifected after tamping of the first layer or after tamping of the second layer.
  • the first selector 54 is actuated by the lever 56 to raise the first sampling cam 4-6 and the second sampling cam 46a and to lower the upper tamping roller as shown in FIG. 5.
  • the material in each die 13 whose punches 15', 20 move between the first pair of tamping rollers 26, 27 are compressed to a much higher degree than would otherwise be the case.
  • FIGS. 6 and '7 show the manner in which the tip of the lower punch is held flush with the die table.
  • a radial hole 86 is provided in the die table 12 in correspondence with each punch 29 and a plastic plug 82 disposed in such radial hole and urged inwardly by a flat spring 84 merely presses on the punch and applies friction thereto so that the punch will remain in any position to which it is brought by the usual cams. With the lower punch 28 in this position, no powder enters the die as it passes under the shoe 23 of the second feeding station.
  • the lower punch 29 is pulled down by a pull down part 74 of the lower cam track 22 after leaving the second feed station and prior to reaching the second tamping rollers 26a, 27a. If the lower punch 20 were allowed to pass under the feed shoe 23 of the third feeding station in the lowered position, then a fill of the third layer material, equivalent in volume to the total volume of the three separate layers, would be taken in the die 13.
  • a slave cylinder 75 under the second layer sampling earn the and pipes into the same hydraulic circuit as the ram 52 of the first sampling cam 46 lifts the second sampling cam 46a which raises the lower punch 29 flush with the surface level 18 of the die table 12, allowing the die 13 to pass under the shoe 23 of the third feed station without any intake of powder.
  • a hydraulic pressure switch 76 (FIGS. 4 and 5) operates a reject gate 77 pivoted to the final chute 70 to move the reject gate 77 to a position wherein the product from the die 13 is deflected by the take-off plate 69 and the reject gate 77 into the path 70b of the chute 7t).
  • Pressure switch 76 actuates a solenoid 79 connected to reject gate 77 'by a flexible coupling 81 to efiect movement of said gate into reject position. This automatically prevents an inferior table-t from mixing with the good tablets and reflects such inferior tablets into the reject path 70b of the chute 70.
  • Similar sampling operations can be carried out at the second pair of tamping rollers 26a, 27a and the second sampling cam 46a, it being appreciated, of course, that the sampling is effected here only when no sampling is being carried out at the first sampling cam 46.
  • the tamping rollers 26a, 27a serve to compress both the first and second layers into a coherent tablet which is ejected into a second sampling chute 72a. Weight determination of the second layer can, therefore, be effected by comparison with the sampled first layers.
  • a multi-layer table-t making machine comprising, a rotary die table having a plurality of dies spaced therearound and having an upper and lower punch associated with each die, a plurality of powder feeding stations past which the dies are moved upon rotation of the die table to feed successive powder fills to each die, means for controlling the positions of the upper and lower punches in their dies as the die table rotates so as to raise each upper punch as its die reaches each powder feeding station, sampling means for sampling any of the successive powder fills, and adjustable compression means for causing a light compression of a powder fill between a die and its corresponding punch in said die table at a location between said powder feeding stations and their corresponding sampling means in response to the condition of said corresponding sampling means during normal machine operation when said corresponding sampling means is inoperative and when said sampling means is in an operative condition for eflecting a stronger compression of the powder fill sutficient to ensure the integrity thereof prior to its ejection from the respective die.
  • a multi-layer tablet making machine as set forth in claim 2 wherein, for sampling the layer or layers, there is provided, between successive powder feeding stations, a sampling cam selectively displaceable into or out of the path of the lower punches after the latter have passed the corresponding tamping rollers.

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)
  • Basic Packing Technique (AREA)
US255967A 1962-02-21 1963-02-04 Multi-layer tablet making machines Expired - Lifetime US3158109A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB6666/62A GB952006A (en) 1962-02-21 1962-02-21 Multi-layer tablet making machines

Publications (1)

Publication Number Publication Date
US3158109A true US3158109A (en) 1964-11-24

Family

ID=9818606

Family Applications (1)

Application Number Title Priority Date Filing Date
US255967A Expired - Lifetime US3158109A (en) 1962-02-21 1963-02-04 Multi-layer tablet making machines

Country Status (3)

Country Link
US (1) US3158109A (de)
DE (1) DE1289742B (de)
GB (1) GB952006A (de)

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2363432A1 (fr) * 1976-08-31 1978-03-31 Fette Wilhelm Gmbh Machine a fabriquer les comprimes
US4243362A (en) * 1979-06-04 1981-01-06 Globe-Union Inc. Composite molding apparatus for articles from two materials having a rotary mold block which includes pins for providing core areas
US4298563A (en) * 1978-10-19 1981-11-03 Ptx-Pentronix, Inc. Apparatus and method for compacting prismatic or pyramidal articles from powder material
EP0457578A1 (de) * 1990-05-15 1991-11-21 L. Perrigo Company Kapselförmige Tablette
EP0460293A1 (de) * 1990-06-08 1991-12-11 Wilhelm Fette GmbH Rundlauf-Tablettiermaschine
US5158728A (en) * 1991-04-12 1992-10-27 Elizabeth-Hata International, Inc. Multi-layer medicinal tablet forming machine and method for using the same
US5213738A (en) * 1990-05-15 1993-05-25 L. Perrigo Company Method for making a capsule-shaped tablet
DE4218122C1 (de) * 1992-06-02 1994-01-20 Fette Wilhelm Gmbh Verfahren zum Pressen von Zweischichttabletten in einer Doppelrundläuferpresse und Vorrichtung zur Durchführung des Verfahrens
EP0586060A3 (de) * 1992-08-24 1994-04-27 Morton International, Inc. Gaserzeugende Körper ausgestattet mit aufgepresster Verbrennungsinhibitorschicht
US5322655A (en) * 1993-02-19 1994-06-21 Thomas Engineering, Inc. Method for monitoring and controlling the weights of each layer of a multilayer tablet
US5476017A (en) * 1993-10-15 1995-12-19 Acutrol Co. Unit dose bulk material sampling apparatus
EP0893239A1 (de) * 1997-07-23 1999-01-27 KILIAN & Co. GmbH Rundlauf-Tablettenpresse
US20090152751A1 (en) * 2007-12-14 2009-06-18 Fette Gmbh Method for testing multilayer tablets
WO2011051626A1 (fr) * 2009-10-30 2011-05-05 Medelpharm Installation pour la réalisation d'un produit solide à partir d'un ou de plusieurs matériaux pulvérulents
US8936810B2 (en) 1998-06-03 2015-01-20 Alza Corporation Methods and apparatus for determining formulation orientation of multi-layered pharmaceutical dosage forms
US9000038B2 (en) 1996-11-12 2015-04-07 Alza Corporation Methods and devices for providing prolonged drug therapy
US9839212B2 (en) 2015-04-16 2017-12-12 Bio-Lab, Inc. Multicomponent and multilayer compacted tablets
CN109968726A (zh) * 2019-05-08 2019-07-05 聊城泰合制药装备有限公司 一种用于双色鱼饵成型的旋转式压片机
US11927507B2 (en) 2018-04-12 2024-03-12 Pharma and Nutraceutical PD Pty Ltd Sampling device

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4018453A1 (de) * 1990-06-08 1991-12-12 Fette Wilhelm Gmbh Tablettiermaschine
DE102011101286B4 (de) 2011-05-10 2013-10-17 Fette Compacting Gmbh Rundläuferpresse und Verfahren zum Betreiben einer Rundläuferpresse
CN115752668A (zh) * 2022-10-31 2023-03-07 上海汇像信息技术有限公司 微量粉末漏斗

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2944493A (en) * 1956-11-23 1960-07-12 Stokes F J Corp Multi-layer tablet manufacture
US2997741A (en) * 1959-01-20 1961-08-29 John Holroyd & Company Ltd Rotary compacting machines

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1023191B (de) * 1954-04-15 1958-01-23 John Holroyd & Co Ltd Verfahren und Vorrichtung zum Herstellen ueberzogener Tabletten
GB796810A (en) * 1954-09-02 1958-06-18 Evans Medical Supplies Ltd Improvements relating to apparatus for compressing a coating of comminuted material around a preformed core
DE1111340B (de) * 1960-02-15 1961-07-20 Kilian & Co G M B H Verfahren und Vorrichtung zum Herstellen von mehrschichtigen Tabletten

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2944493A (en) * 1956-11-23 1960-07-12 Stokes F J Corp Multi-layer tablet manufacture
US2997741A (en) * 1959-01-20 1961-08-29 John Holroyd & Company Ltd Rotary compacting machines

Cited By (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2363432A1 (fr) * 1976-08-31 1978-03-31 Fette Wilhelm Gmbh Machine a fabriquer les comprimes
US4298563A (en) * 1978-10-19 1981-11-03 Ptx-Pentronix, Inc. Apparatus and method for compacting prismatic or pyramidal articles from powder material
US4243362A (en) * 1979-06-04 1981-01-06 Globe-Union Inc. Composite molding apparatus for articles from two materials having a rotary mold block which includes pins for providing core areas
US5213738A (en) * 1990-05-15 1993-05-25 L. Perrigo Company Method for making a capsule-shaped tablet
EP0457578A1 (de) * 1990-05-15 1991-11-21 L. Perrigo Company Kapselförmige Tablette
US5089270A (en) * 1990-05-15 1992-02-18 L. Perrigo Company Capsule-shaped tablet
EP0460293A1 (de) * 1990-06-08 1991-12-11 Wilhelm Fette GmbH Rundlauf-Tablettiermaschine
US5460827A (en) * 1991-04-12 1995-10-24 Elizabeth-Hata International, Inc. Elongated cylindrical medicinal tablet having two layers
US5158728A (en) * 1991-04-12 1992-10-27 Elizabeth-Hata International, Inc. Multi-layer medicinal tablet forming machine and method for using the same
US5350548A (en) * 1992-06-02 1994-09-27 Wilhelm Fette Gmbh Method and apparatus for making two-layer tablets in a twin rotor pressing machine
DE4218122C1 (de) * 1992-06-02 1994-01-20 Fette Wilhelm Gmbh Verfahren zum Pressen von Zweischichttabletten in einer Doppelrundläuferpresse und Vorrichtung zur Durchführung des Verfahrens
EP0586060A3 (de) * 1992-08-24 1994-04-27 Morton International, Inc. Gaserzeugende Körper ausgestattet mit aufgepresster Verbrennungsinhibitorschicht
US5682013A (en) * 1992-08-24 1997-10-28 Morton International, Inc. Gas generant body having pressed-on burn inhibitor layer
US5322655A (en) * 1993-02-19 1994-06-21 Thomas Engineering, Inc. Method for monitoring and controlling the weights of each layer of a multilayer tablet
US5476017A (en) * 1993-10-15 1995-12-19 Acutrol Co. Unit dose bulk material sampling apparatus
US9029416B2 (en) 1996-11-12 2015-05-12 Alza Corporation Methods and devices for providing prolonged drug therapy
US9000038B2 (en) 1996-11-12 2015-04-07 Alza Corporation Methods and devices for providing prolonged drug therapy
EP0893239A1 (de) * 1997-07-23 1999-01-27 KILIAN & Co. GmbH Rundlauf-Tablettenpresse
US8936810B2 (en) 1998-06-03 2015-01-20 Alza Corporation Methods and apparatus for determining formulation orientation of multi-layered pharmaceutical dosage forms
US20090152751A1 (en) * 2007-12-14 2009-06-18 Fette Gmbh Method for testing multilayer tablets
US8454868B2 (en) * 2007-12-14 2013-06-04 Fette Gmbh Method for testing multilayer tablets
EP2070692A3 (de) * 2007-12-14 2011-05-04 Fette GmbH Verfahren zum Prüfen von Mehrschichttabletten
US8668483B2 (en) 2009-10-30 2014-03-11 Medelpharm Facility for producing a solid product using one or more powder materials
WO2011051626A1 (fr) * 2009-10-30 2011-05-05 Medelpharm Installation pour la réalisation d'un produit solide à partir d'un ou de plusieurs matériaux pulvérulents
US9839212B2 (en) 2015-04-16 2017-12-12 Bio-Lab, Inc. Multicomponent and multilayer compacted tablets
US11927507B2 (en) 2018-04-12 2024-03-12 Pharma and Nutraceutical PD Pty Ltd Sampling device
CN109968726A (zh) * 2019-05-08 2019-07-05 聊城泰合制药装备有限公司 一种用于双色鱼饵成型的旋转式压片机

Also Published As

Publication number Publication date
DE1289742B (de) 1969-02-20
GB952006A (en) 1964-03-11

Similar Documents

Publication Publication Date Title
US3158109A (en) Multi-layer tablet making machines
US3191232A (en) Hydraulic compacting press
US5158728A (en) Multi-layer medicinal tablet forming machine and method for using the same
US3172156A (en) Compacting press
EP0310594A1 (de) Verfahren zum Beschicken einer Presse zur Herstellung von Reibbelägen
US3154812A (en) Hydraulic briquetting press
US2218196A (en) Brick press
US3811808A (en) Weighed charge system for a brick press
US3168759A (en) Core punch and bottom stop therefor
US2944493A (en) Multi-layer tablet manufacture
US1925050A (en) Molding machine and method of
US2888715A (en) Proportional pressing
US2700938A (en) Apparatus and method for tablet production
GB2145654A (en) Production of granulates
US3764244A (en) Apparatus for compacting granular material
US2970554A (en) Tablet press
US2823419A (en) Machine for pressing tantalum capacitor elements
US3806302A (en) Isostatic molding machine
US3179998A (en) Variable impact tile press
US2906214A (en) Pill press apparatus
US2748424A (en) Rotary pelleting press modification
US4080128A (en) Apparatus for the production of compacts of layerwise different composition, for heavy duty electric contacts
JPS6364277B2 (de)
GB1581890A (en) Tabletting machine
US582794A (en) Pill-machine